Publication Information

{'id': 'https://openalex.org/W2108376610', 'doi': 'https://doi.org/10.1186/1471-2164-13-106', 'title': 'Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria', 'display_name': 'Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria', 'publication_year': 2012, 'publication_date': '2012-03-21', 'ids': {'openalex': 'https://openalex.org/W2108376610', 'doi': 'https://doi.org/10.1186/1471-2164-13-106', 'mag': '2108376610', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22435897', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3362770'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2164-13-106', 'pdf_url': 'https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-106', 'source': {'id': 'https://openalex.org/S28614077', 'display_name': 'BMC Genomics', 'issn_l': '1471-2164', 'issn': ['1471-2164'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-106', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071619932', 'display_name': 'Katarzyna Modrzynska', 'orcid': 'https://orcid.org/0000-0002-0877-3564'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Katarzyna Kinga Modrzynska', 'raw_affiliation_strings': ['Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087335049', 'display_name': 'Alison M. Creasey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alison Creasey', 'raw_affiliation_strings': ['Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070235523', 'display_name': 'Laurence Loewe', 'orcid': 'https://orcid.org/0000-0002-6253-9269'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}, {'id': 'https://openalex.org/I2802999273', 'display_name': 'Wisconsin Institutes for Discovery', 'ror': 'https://ror.org/05gbven85', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802999273']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurence Loewe', 'raw_affiliation_strings': ['Laboratory of Genetics and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Genetics and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, USA', 'institution_ids': ['https://openalex.org/I135310074', 'https://openalex.org/I2802999273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015231557', 'display_name': 'Timothée Cezard', 'orcid': 'https://orcid.org/0000-0002-5626-270X'}, 'institutions': [{'id': 'https://openalex.org/I4210137845', 'display_name': 'Edinburgh Genomics', 'ror': 'https://ror.org/02z3r7t23', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210137845']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Timothee Cezard', 'raw_affiliation_strings': ['The GenePool, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'The GenePool, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210137845', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055500192', 'display_name': 'Sofia Trindade Borges', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210160509', 'display_name': 'Infraestruturas de Portugal (Portugal)', 'ror': 'https://ror.org/05ksj8h20', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I4210160509']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Sofia Trindade Borges', 'raw_affiliation_strings': ['Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Malaria, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Malaria, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I4210160509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065164931', 'display_name': 'Axel Martinelli', 'orcid': 'https://orcid.org/0000-0003-2662-7162'}, 'institutions': [{'id': 'https://openalex.org/I4210160509', 'display_name': 'Infraestruturas de Portugal (Portugal)', 'ror': 'https://ror.org/05ksj8h20', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I4210160509']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Axel Martinelli', 'raw_affiliation_strings': ['Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I4210160509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081463344', 'display_name': 'Louise Rodrigues', 'orcid': 'https://orcid.org/0000-0002-8354-2686'}, 'institutions': [{'id': 'https://openalex.org/I4210160509', 'display_name': 'Infraestruturas de Portugal (Portugal)', 'ror': 'https://ror.org/05ksj8h20', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I4210160509']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Louise Rodrigues', 'raw_affiliation_strings': ['Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I4210160509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005367389', 'display_name': 'Pedro Cravo', 'orcid': 'https://orcid.org/0000-0003-1675-4504'}, 'institutions': [{'id': 'https://openalex.org/I4210160509', 'display_name': 'Infraestruturas de Portugal (Portugal)', 'ror': 'https://ror.org/05ksj8h20', 'country_code': 'PT', 'type': 'company', 'lineage': ['https://openalex.org/I4210160509']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Pedro Cravo', 'raw_affiliation_strings': ['Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Centro de Malaria e Outras Doenças Tropicais/IHMT/UEI Biologia Molecular, Lisbon, Portugal', 'institution_ids': ['https://openalex.org/I4210160509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060637041', 'display_name': 'Mark Blaxter', 'orcid': 'https://orcid.org/0000-0003-2861-949X'}, 'institutions': [{'id': 'https://openalex.org/I4210137845', 'display_name': 'Edinburgh Genomics', 'ror': 'https://ror.org/02z3r7t23', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210137845']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mark Blaxter', 'raw_affiliation_strings': ['The GenePool, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'The GenePool, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210137845', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017056576', 'display_name': 'Richard Carter', 'orcid': 'https://orcid.org/0000-0001-9625-7182'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard Carter', 'raw_affiliation_strings': ['Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065731602', 'display_name': 'Peter Hunt', 'orcid': 'https://orcid.org/0000-0001-5679-2404'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210129072', 'display_name': 'Centre for Immunity, Infection and Evolution', 'ror': 'https://ror.org/03qp5ww24', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129072']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Paul Hunt', 'raw_affiliation_strings': ['Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I98677209', 'https://openalex.org/I4210129072']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5065731602'], 'corresponding_institution_ids': ['https://openalex.org/I98677209', 'https://openalex.org/I4210129072'], 'apc_list': {'value': 1570, 'currency': 'GBP', 'value_usd': 1925, 'provenance': 'doaj'}, 'apc_paid': {'value': 1570, 'currency': 'GBP', 'value_usd': 1925, 'provenance': 'doaj'}, 'fwci': 3.16, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.949919, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9689, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10695', 'display_name': 'Parasites and Host Interactions', 'score': 0.9578, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plasmodium-chabaudi', 'display_name': 'Plasmodium chabaudi', 'score': 0.6410127}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8778473}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.81012386}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.67628884}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.65574646}, {'id': 'https://openalex.org/C2780789526', 'wikidata': 'https://www.wikidata.org/wiki/Q7201860', 'display_name': 'Plasmodium chabaudi', 'level': 5, 'score': 0.6410127}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.6183842}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.61533886}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5346163}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.53450406}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.527626}, {'id': 'https://openalex.org/C2775867548', 'wikidata': 'https://www.wikidata.org/wiki/Q1897162', 'display_name': 'Parasitemia', 'level': 4, 'score': 0.09038049}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.07634309}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D023281', 'descriptor_name': 'Genomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': True}, {'descriptor_ui': 'D016788', 'descriptor_name': 'Plasmodium chabaudi', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D026905', 'descriptor_name': 'Amino Acid Transport Systems', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016788', 'descriptor_name': 'Plasmodium chabaudi', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016788', 'descriptor_name': 'Plasmodium chabaudi', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2164-13-106', 'pdf_url': 'https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-106', 'source': {'id': 'https://openalex.org/S28614077', 'display_name': 'BMC Genomics', 'issn_l': '1471-2164', 'issn': ['1471-2164'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362770', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22435897', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1471-2164-13-106', 'pdf_url': 'https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-106', 'source': {'id': 'https://openalex.org/S28614077', 'display_name': 'BMC Genomics', 'issn_l': '1471-2164', 'issn': ['1471-2164'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1694215848', 'https://openalex.org/W1865107143', 'https://openalex.org/W1972177048', 'https://openalex.org/W1973235308', 'https://openalex.org/W1981089872', 'https://openalex.org/W1984709389', 'https://openalex.org/W1990258353', 'https://openalex.org/W1997925660', 'https://openalex.org/W2002000006', 'https://openalex.org/W2004243069', 'https://openalex.org/W2009259923', 'https://openalex.org/W2009872985', 'https://openalex.org/W2014429457', 'https://openalex.org/W2016924391', 'https://openalex.org/W2021180751', 'https://openalex.org/W2025363484', 'https://openalex.org/W2030308130', 'https://openalex.org/W2030396234', 'https://openalex.org/W2033518384', 'https://openalex.org/W2036512457', 'https://openalex.org/W2039013541', 'https://openalex.org/W2042135186', 'https://openalex.org/W2045910215', 'https://openalex.org/W2045975186', 'https://openalex.org/W2050052884', 'https://openalex.org/W2053978095', 'https://openalex.org/W2055874928', 'https://openalex.org/W2056639403', 'https://openalex.org/W2064110684', 'https://openalex.org/W2074450319', 'https://openalex.org/W2075997329', 'https://openalex.org/W2080669003', 'https://openalex.org/W2083971633', 'https://openalex.org/W2085127571', 'https://openalex.org/W2092370541', 'https://openalex.org/W2094331166', 'https://openalex.org/W2100419926', 'https://openalex.org/W2102882733', 'https://openalex.org/W2103441770', 'https://openalex.org/W2105761183', 'https://openalex.org/W2105919772', 'https://openalex.org/W2112113834', 'https://openalex.org/W2120504701', 'https://openalex.org/W2129965217', 'https://openalex.org/W2132923209', 'https://openalex.org/W2140502796', 'https://openalex.org/W2142619120', 'https://openalex.org/W2143279537', 'https://openalex.org/W2145956786', 'https://openalex.org/W2147122298', 'https://openalex.org/W2159120144', 'https://openalex.org/W2160795241', 'https://openalex.org/W2171182913', 'https://openalex.org/W2174382638', 'https://openalex.org/W2308758515', 'https://openalex.org/W2333050857'], 'related_works': ['https://openalex.org/W2465887096', 'https://openalex.org/W2416468153', 'https://openalex.org/W2414493761', 'https://openalex.org/W2366318376', 'https://openalex.org/W2184471406', 'https://openalex.org/W2166046803', 'https://openalex.org/W2144038468', 'https://openalex.org/W2113822524', 'https://openalex.org/W2026268919', 'https://openalex.org/W1141749753'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Drug': [2], 'resistance': [3, 25, 73, 94, 119, 134, 249, 312, 322, 342], 'in': [4, 31, 54, 74, 95, 120, 130, 212, 252, 340, 343], 'the': [5, 12, 21, 55, 91, 96, 114, 147, 161, 204, 223, 226, 244, 316], 'malaria': [6, 100, 126], 'parasite': [7, 127], 'Plasmodium': [8], 'falciparum': [9, 77, 350], 'severely': [10], 'compromises': [11], 'treatment': [13], 'and': [14, 37, 48, 165, 189, 229, 319, 325, 348], 'control': [15], 'of': [16, 20, 34, 39, 71, 85, 93, 117, 124, 184, 203, 225, 237, 247, 292, 300, 310, 321], 'malaria.': [17], 'A': [18, 52, 171], 'knowledge': [19], 'critical': [22, 148, 241, 336], 'mutations': [23, 211, 219, 304], 'conferring': [24, 243, 263, 307], 'to': [26, 44, 135, 180, 233, 288, 323], 'particular': [27], 'drugs': [28], 'is': [29, 250], 'important': [30], 'understanding': [32], 'modes': [33], 'drug': [35, 50, 196, 268, 293], 'action': [36], 'mechanisms': [38, 320], 'resistances.': [40], 'They': [41], 'are': [42, 105, 220, 230], 'required': [43], 'design': [45], 'better': [46], 'therapies': [47], 'limit': [49], 'resistance.': [51, 89, 239], 'mutation': [53, 242], 'gene': [56], '(': [57], 'pfcrt': [58], ')': [59], 'encoding': [60], 'a': [61, 68, 82, 157, 166, 255], 'membrane': [62], 'transporter': [63], 'has': [64, 137], 'been': [65, 138], 'identified': [66, 207], 'as': [67, 267], 'principal': [69], 'determinant': [70], 'chloroquine': [72, 88, 118, 136, 238, 248, 311, 324, 341], 'P': [75], '.': [76, 351], ',': [78, 104, 254], 'but': [79], 'we': [80, 112], 'lack': [81], 'full': [83], 'account': [84], 'higher': [86], 'level': [87, 133, 246], 'Furthermore,': [90], 'determinants': [92], 'other': [97, 326], 'major': [98], 'human': [99, 344], 'parasite,': [101], 'P.': [102, 128, 346, 349], 'vivax': [103, 347], 'not': [106], 'known.': [107], 'To': [108], 'address': [109], 'these': [110, 216, 290], 'questions,': [111], 'investigated': [113], 'genetic': [115, 158, 317], 'basis': [116], 'an': [121], 'isogenic': [122], 'lineage': [123], 'rodent': [125], 'chabaudi': [129], 'which': [131], 'high': [132, 296], 'progressively': [139, 193], 'selected': [140], 'under': [141], 'laboratory': [142], 'conditions.': [143], 'Results': [144], 'Loci': [145], 'containing': [146], 'genes': [149, 214, 302], 'were': [150], 'mapped': [151, 272], 'by': [152], 'Linkage': [153], 'Group': [154], 'Selection,': [155], 'using': [156, 274], 'cross': [159], 'between': [160], 'high-level': [162], 'chloroquine-resistant': [163, 205], 'mutant': [164], 'genetically': [167], 'distinct': [168], 'sensitive': [169], 'strain.': [170], 'novel': [172], 'high-resolution': [173], 'quantitative': [174], 'whole-genome': [175], 're-sequencing': [176], 'approach': [177], 'was': [178], 'used': [179, 287], 'reveal': [181, 289], 'three': [182, 199, 301], 'regions': [183], 'selection': [185, 227, 294], 'on': [186, 198, 215], 'chr11,': [187], 'chr03': [188], 'chr02': [190], 'that': [191], 'appear': [192], 'at': [194, 222, 295], 'increasing': [195], 'doses': [197], 'chromosomes.': [200, 217], 'Whole-genome': [201], 'sequencing': [202], 'parent': [206], 'just': [208], 'four': [209], 'point': [210], 'different': [213, 235, 308], 'Three': [218], 'located': [221], 'foci': [224], 'valleys': [228], 'therefore': [231], 'predicted': [232], 'confer': [234], 'levels': [236, 309], 'The': [240, 298], 'first': [245], 'found': [251], 'aat1': [253], 'putative': [256], 'aminoacid': [257], 'transporter.': [258], 'Conclusions': [259], 'Quantitative': [260, 280], 'trait': [261], 'loci': [262], 'selectable': [264], 'phenotypes,': [265], 'such': [266], 'resistance,': [269], 'can': [270, 285], 'be': [271, 286, 333], 'directly': [273], 'progressive': [275], 'genome-wide': [276, 281], 'linkage': [277], 'group': [278], 'selection.': [279], 'short-read': [282], 'genome': [283], 'resequencing': [284], 'signatures': [291], 'resolution.': [297], 'identities': [299], '(and': [303], 'within': [305], 'them)': [306], 'generate': [313], 'insights': [314], 'regarding': [315], 'architecture': [318], 'drugs.': [327], 'Importantly,': [328], 'their': [329], 'orthologues': [330], 'may': [331], 'now': [332], 'evaluated': [334], 'for': [335], 'or': [337], 'accessory': [338], 'roles': [339], 'malarias': [345]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2108376610', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}], 'updated_date': '2024-12-12T07:46:08.634508', 'created_date': '2016-06-24'}