Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2107720387', 'doi': 'https://doi.org/10.1186/1476-511x-10-60', 'title': 'High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway', 'display_name': 'High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2107720387', 'doi': 'https://doi.org/10.1186/1476-511x-10-60', 'mag': '2107720387', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21504583', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3096990'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-511x-10-60', 'pdf_url': 'https://lipidworld.biomedcentral.com/counter/pdf/10.1186/1476-511X-10-60', 'source': {'id': 'https://openalex.org/S188748365', 'display_name': 'Lipids in Health and Disease', 'issn_l': '1476-511X', 'issn': ['1476-511X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://lipidworld.biomedcentral.com/counter/pdf/10.1186/1476-511X-10-60', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004918276', 'display_name': 'Elena Bravo', 'orcid': 'https://orcid.org/0000-0002-3473-6767'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elena Bravo', 'raw_affiliation_strings': ['Department of Cellular Biology and Neuroscience, Istituto Superiore Sanità, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biology and Neuroscience, Istituto Superiore Sanità, Rome, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011517595', 'display_name': 'Simonetta Palleschi', 'orcid': 'https://orcid.org/0000-0002-2180-0168'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simonetta Palleschi', 'raw_affiliation_strings': ['Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, Rome, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072954162', 'display_name': 'Patricia Aspichueta', 'orcid': 'https://orcid.org/0000-0002-3553-1755'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Patricia Aspichueta', 'raw_affiliation_strings': ['Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077630402', 'display_name': 'Xabier Buqué', 'orcid': 'https://orcid.org/0000-0002-0911-0033'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Xabier Buqué', 'raw_affiliation_strings': ['Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038806758', 'display_name': 'Barbara Rossi', 'orcid': 'https://orcid.org/0000-0002-4358-5243'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Rossi', 'raw_affiliation_strings': ['Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, Rome, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055082002', 'display_name': 'Ainara Cano', 'orcid': 'https://orcid.org/0000-0001-6019-8926'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ainara Cano', 'raw_affiliation_strings': ['Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088864177', 'display_name': 'Mariarosaria Napolitano', 'orcid': 'https://orcid.org/0000-0002-2041-0897'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mariarosaria Napolitano', 'raw_affiliation_strings': ['Department of Cellular Biology and Neuroscience, Istituto Superiore Sanità, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biology and Neuroscience, Istituto Superiore Sanità, Rome, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058642924', 'display_name': 'Begoña Ochoa', 'orcid': 'https://orcid.org/0000-0002-1580-7160'}, 'institutions': [{'id': 'https://openalex.org/I169108374', 'display_name': 'University of the Basque Country', 'ror': 'https://ror.org/000xsnr85', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I169108374']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Begoña Ochoa', 'raw_affiliation_strings': ['Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, University of the Basque Country Faculty of Medicine and Dentistry, Leioa, Spain, Rome, Italy', 'institution_ids': ['https://openalex.org/I169108374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016695439', 'display_name': 'Kathleen M. Botham', 'orcid': 'https://orcid.org/0000-0002-0221-979X'}, 'institutions': [{'id': 'https://openalex.org/I133836048', 'display_name': 'Royal Veterinary College', 'ror': 'https://ror.org/01wka8n18', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I133836048']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Kathleen M Botham', 'raw_affiliation_strings': ['Department of Veterinary Basic Sciences The Royal Veterinary College London UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Basic Sciences The Royal Veterinary College London UK', 'institution_ids': ['https://openalex.org/I133836048']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'apc_paid': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'fwci': 4.218, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 79, 'citation_normalized_percentile': {'value': 0.999899, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': '60', 'last_page': '60'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperhomocysteinemia', 'display_name': 'Hyperhomocysteinemia', 'score': 0.89628977}], 'concepts': [{'id': 'https://openalex.org/C2776523773', 'wikidata': 'https://www.wikidata.org/wiki/Q1093815', 'display_name': 'Hyperhomocysteinemia', 'level': 3, 'score': 0.89628977}, {'id': 'https://openalex.org/C2778772119', 'wikidata': 'https://www.wikidata.org/wiki/Q6058862', 'display_name': 'Fatty liver', 'level': 3, 'score': 0.8199804}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8182144}, {'id': 'https://openalex.org/C2777090595', 'wikidata': 'https://www.wikidata.org/wiki/Q192466', 'display_name': 'Homocysteine', 'level': 2, 'score': 0.80255497}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7571724}, {'id': 'https://openalex.org/C16525657', 'wikidata': 'https://www.wikidata.org/wiki/Q5201183', 'display_name': 'Cystathionine beta synthase', 'level': 4, 'score': 0.756094}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.5611575}, {'id': 'https://openalex.org/C382228', 'wikidata': 'https://www.wikidata.org/wiki/Q849994', 'display_name': 'Clinical chemistry', 'level': 2, 'score': 0.4588753}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40847078}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35958922}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.25990653}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.20328322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19090089}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16506907}], 'mesh': [{'descriptor_ui': 'D004041', 'descriptor_name': 'Dietary Fats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D020138', 'descriptor_name': 'Hyperhomocysteinemia', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D053858', 'descriptor_name': 'Metabolic Networks and Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003541', 'descriptor_name': 'Cystathionine beta-Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003541', 'descriptor_name': 'Cystathionine beta-Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003542', 'descriptor_name': 'Cystathionine gamma-Lyase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003542', 'descriptor_name': 'Cystathionine gamma-Lyase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020138', 'descriptor_name': 'Hyperhomocysteinemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020138', 'descriptor_name': 'Hyperhomocysteinemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008780', 'descriptor_name': 'Methyltransferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008780', 'descriptor_name': 'Methyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008780', 'descriptor_name': 'Methyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065626', 'descriptor_name': 'Non-alcoholic Fatty Liver Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-511x-10-60', 'pdf_url': 'https://lipidworld.biomedcentral.com/counter/pdf/10.1186/1476-511X-10-60', 'source': {'id': 'https://openalex.org/S188748365', 'display_name': 'Lipids in Health and Disease', 'issn_l': '1476-511X', 'issn': ['1476-511X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/7669f2104e084999994b587fe18be265', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3096990', 'pdf_url': 'https://europepmc.org/articles/pmc3096990?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10810/2793', 'pdf_url': 'http://addi.ehu.es/bitstream/10810/2793/1/1476-511X-10-60.pdf', 'source': {'id': 'https://openalex.org/S4306400469', 'display_name': 'Communities in ADDI (Universidad del Pais Vasco)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210131160', 'host_organization_name': 'Material Physics Center', 'host_organization_lineage': ['https://openalex.org/I4210131160'], 'host_organization_lineage_names': ['Material Physics Center'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://researchonline.rvc.ac.uk/id/eprint/4991/', 'pdf_url': 'https://rvc-repository.worktribe.com/preview/1650595/10.1016%20j%20jevs%202023%20104896.pdf', 'source': {'id': 'https://openalex.org/S4306402069', 'display_name': 'RVC Research Online (Royal Veterinary College)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I133836048', 'host_organization_name': 'Royal Veterinary College', 'host_organization_lineage': ['https://openalex.org/I133836048'], 'host_organization_lineage_names': ['Royal Veterinary College'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21504583', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-511x-10-60', 'pdf_url': 'https://lipidworld.biomedcentral.com/counter/pdf/10.1186/1476-511X-10-60', 'source': {'id': 'https://openalex.org/S188748365', 'display_name': 'Lipids in Health and Disease', 'issn_l': '1476-511X', 'issn': ['1476-511X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.69, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W152764626', 'https://openalex.org/W1534724641', 'https://openalex.org/W1577577364', 'https://openalex.org/W1860367105', 'https://openalex.org/W1964968311', 'https://openalex.org/W1967964480', 'https://openalex.org/W1978723895', 'https://openalex.org/W1980338958', 'https://openalex.org/W2008169198', 'https://openalex.org/W2011866072', 'https://openalex.org/W2014468331', 'https://openalex.org/W2015529097', 'https://openalex.org/W2018768907', 'https://openalex.org/W2025041396', 'https://openalex.org/W2025296211', 'https://openalex.org/W2034298464', 'https://openalex.org/W2054847530', 'https://openalex.org/W2059269389', 'https://openalex.org/W2064847057', 'https://openalex.org/W2065204537', 'https://openalex.org/W2072721395', 'https://openalex.org/W2077616550', 'https://openalex.org/W2089663037', 'https://openalex.org/W2095755100', 'https://openalex.org/W2107267410', 'https://openalex.org/W2121140467', 'https://openalex.org/W2128635872', 'https://openalex.org/W2149156931', 'https://openalex.org/W2149997127', 'https://openalex.org/W2168526937', 'https://openalex.org/W2337537622', 'https://openalex.org/W4245957869', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W3143902866', 'https://openalex.org/W2885450922', 'https://openalex.org/W2792925662', 'https://openalex.org/W2290591681', 'https://openalex.org/W2103598423', 'https://openalex.org/W2094115156', 'https://openalex.org/W2083693136', 'https://openalex.org/W2078769171', 'https://openalex.org/W2000228184', 'https://openalex.org/W1993547773'], 'abstract_inverted_index': {'Hyperhomocysteinemia': [0], '(HHcy)': [1], 'causes': [2], 'increased': [3, 166, 198], 'oxidative': [4], 'stress': [5, 16], 'and': [6, 123, 176, 191], 'is': [7, 17, 163, 192], 'an': [8, 183], 'independent': [9], 'risk': [10, 199], 'factor': [11, 25], 'for': [12, 85, 130], 'cardiovascular': [13, 201], 'disease.': [14], 'Oxidative': [15], 'now': [18], 'believed': [19], 'to': [20, 110, 135, 194, 196], 'be': [21], 'a': [22, 69, 76], 'major': [23], 'contributory': [24], 'in': [26, 48, 52, 62, 92, 104, 141, 148, 161, 186], 'the': [27, 35, 44, 88, 93, 105, 111, 127, 131, 138, 142, 149, 197, 205], 'development': [28], 'of': [29, 90, 100, 119, 133, 173, 200], 'non': [30, 56], 'alcoholic': [31, 57], 'fatty': [32, 58], 'liver': [33, 38, 59], 'disease,': [34], 'most': [36], 'common': [37], 'disorder': [39], 'worldwide.': [40], 'In': [41], 'this': [42], 'study,': [43], 'changes': [45], 'which': [46], 'occur': [47], 'homocysteine': [49, 91, 134], '(Hcy)': [50], 'metabolism': [51], 'high': [53, 77, 106, 150, 157, 187], 'fat-diet': [54], 'induced': [55], 'disease': [60, 202], '(NAFLD)': [61], 'rats': [63, 68, 162], 'were': [64, 144], 'investigated.': [65], 'After': [66], 'feeding': [67], 'standard': [70], 'low': [71], 'fat': [72, 78, 107, 158, 188], 'diet': [73, 79, 113], '(control)': [74], 'or': [75], '(57%': [80], 'metabolisable': [81], 'energy': [82], 'as': [83, 108], 'fat)': [84], '18': [86], 'weeks,': [87], 'concentration': [89], 'plasma': [94, 167], 'was': [95, 102], 'significantly': [96, 146], 'raised': [97], 'while': [98], 'that': [99, 156], 'cysteine': [101, 136], 'lowered': [103], 'compared': [109], 'control': [112], 'fed': [114], 'animals.': [115], 'The': [116], 'hepatic': [117, 174], 'activities': [118], 'cystathionine': [120, 124], 'β-synthase': [121], '(CBS)': [122], 'γ-lyase': [125], '(CGS),': [126], 'enzymes': [128], 'responsible': [129], 'breakdown': [132], 'via': [137], 'transsulphuration': [139], 'pathway': [140], 'liver,': [143], 'also': [145], 'reduced': [147], 'fat-fed': [151], 'group.': [152], 'These': [153], 'results': [154], 'indicate': [155], 'diet-induced': [159, 189], 'NAFLD': [160, 190], 'associated': [164, 203], 'with': [165, 204], 'Hcy': [168], 'levels': [169], 'caused': [170], 'by': [171], 'down-regulation': [172], 'CBS': [175], 'CGL': [177], 'activity.': [178], 'Thus,': [179], 'HHcy': [180], 'occurs': [181], 'at': [182], 'early': [184], 'stage': [185], 'likely': [193], 'contribute': [195], 'condition.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2107720387', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-08T03:08:01.969467', 'created_date': '2016-06-24'}