Title: Biodistribution of 1.4‐ and 18‐nm Gold Particles in Rats
Abstract: SmallVolume 4, Issue 12 p. 2108-2111 Communication Biodistribution of 1.4- and 18-nm Gold Particles in Rats† Manuela Semmler-Behnke, Corresponding Author Manuela Semmler-Behnke [email protected] Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany).Search for more papers by this authorWolfgang G. Kreyling, Wolfgang G. Kreyling Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorJens Lipka, Jens Lipka Department of Pharmaceutics and Biopharmacy Philipps-University Marburg Ketzerbach 63, Marburg 35037 (Germany)Search for more papers by this authorStefanie Fertsch, Stefanie Fertsch Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorAlexander Wenk, Alexander Wenk Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorShinji Takenaka, Shinji Takenaka Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorGünter Schmid, Günter Schmid Institute of Inorganic Chemistry University Duisburg-Essen Universitätsstrasse 5-7, Essen 45117 (Germany)Search for more papers by this authorWolfgang Brandau, Wolfgang Brandau Nuclear Chemistry and Radiopharmacy University Hospital Essen Hufelandstr. 55, Essen 45122 (Germany)Search for more papers by this author Manuela Semmler-Behnke, Corresponding Author Manuela Semmler-Behnke [email protected] Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany).Search for more papers by this authorWolfgang G. Kreyling, Wolfgang G. Kreyling Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorJens Lipka, Jens Lipka Department of Pharmaceutics and Biopharmacy Philipps-University Marburg Ketzerbach 63, Marburg 35037 (Germany)Search for more papers by this authorStefanie Fertsch, Stefanie Fertsch Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorAlexander Wenk, Alexander Wenk Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorShinji Takenaka, Shinji Takenaka Helmholtz Zentrum München – German Research Center for Environmental Health Institute for Inhalation Biology Focus Network Nanoparticles and Health Ingolstädter Landstr. 1 Neuherberg/Munich 85764 (Germany)Search for more papers by this authorGünter Schmid, Günter Schmid Institute of Inorganic Chemistry University Duisburg-Essen Universitätsstrasse 5-7, Essen 45117 (Germany)Search for more papers by this authorWolfgang Brandau, Wolfgang Brandau Nuclear Chemistry and Radiopharmacy University Hospital Essen Hufelandstr. 55, Essen 45122 (Germany)Search for more papers by this author First published: 04 December 2008 https://doi.org/10.1002/smll.200800922Citations: 406 † This work was supported in part by EU FP6 PARTICLE_RISK 012912 (NEST), US National Institutes of Health grant HL070542, and Deutsche Forschungsgemeinschaft, Research Group FOR 627. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract 1.4-nm gold nanoparticles (NPs) are observed to cross the air/blood barrier of the lungs much more efficiently than 18-nm gold NPs (see figure). The NP accumulation pattern in the secondary-target organs differs strongly from those seen after direct intravenous injection. From this, it is hypothesized that NPs interact dynamically with proteins and cells, which determines their accumulation in the various organs. References 1 K. Donaldson, V. Stone, C. L. Tran, W. G. Kreyling, P. J. Borm, Occup. 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Meyer-Zaika, S. Franzka, G. Schmid, M. Tsoli, H. Kuhn, Angew. Chem., Int. Ed. 2003, 42, 2853. 11 M. Tsoli, H. Kuhn, W. Brandau, H. Esche, G. Schmid, Small 2005, 1, 841. 12 Y. Pan, S. Neuss, A. Leifert, M. Fischler, F. Wen, U. Simon, G. Schmid, W. Brandau, W. Jahnen-Dechent, Small 2007, 3, 1941. 13 G. Schmid, A. Lehnert, Angew. Chem., Int. Ed. 1989, 28, 780. 14 J. Turkevitch, P. C. Stevenson, J. Hillier, Discuss. Faraday Soc. 1951, 11, 55. 15 M. Semmler, J. Seitz, F. Erbe, P. Mayer, J. Heyder, G. Oberdörster, W. G. Kreyling, Inhalation Toxicol. 2004, 16, 453. 16 M. Semmler-Behnke, S. Takenaka, S. Fertsch, A. Wenk, J. Seitz, P. Mayer, G. Oberdörster, W. G. Kreyling, Environ. Health Perspect. 2007, 115, 728. Citing Literature Volume4, Issue12December 2008Pages 2108-2111 ReferencesRelatedInformation
Publication Year: 2008
Publication Date: 2008-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 472
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