Publication Information

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'cell': [18, 153, 882, 1227, 1453, 1628, 2349, 2459, 2620, 2837, 3519, 3535, 3802, 3923, 4179, 4398], 'line': [19, 154, 883], 'SVR': [20, 45, 70, 155, 180, 205, 884, 1103, 1130, 3406, 3485, 3512, 3586, 3700, 3883, 3927, 3965, 4029, 4052, 4083], 'as': [21, 130, 156, 265, 486, 488, 1091, 1105, 1409, 1476, 1581, 1865, 2413, 2471, 2745, 2947, 3040, 3493, 3642, 3682, 4097, 4213, 4259], 'an': [22, 157, 995, 1692, 3728, 4282], 'effective': [23, 104, 158, 239, 988], 'screen': [24, 159], 'natural': [26, 161, 286, 872, 3491], 'product': [27, 162], 'extracts': [28, 36, 163, 171, 920, 1629, 3418], 'to': [29, 164, 300, 866, 1034, 1036, 1067, 1595, 1685, 1801, 2091, 2154, 2189, 2389, 2517, 2526, 2608, 2700, 2791, 2905, 2910, 3193, 3420, 3423, 3557, 3652, 3665, 3713, 3726, 3732, 3798, 4024, 4137, 4159, 4279, 4313, 4360], 'isolate': [30, 165], 'anti-angiogenesis': [31, 166, 3496], 'and': [32, 88, 120, 125, 167, 223, 255, 260, 285, 346, 382, 386, 469, 749, 869, 980, 987, 1012, 1031, 1061, 1085, 1089, 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1301, 1323, 1816, 1845, 2437, 2862, 2936, 3161, 3221, 3377, 3458, 3474, 3760, 3782, 3848, 3869], 'Scopus': [323, 341, 423, 606, 641, 722, 744, 778, 796, 817, 842, 912, 1189, 1222, 1302, 1324, 1817, 1846, 2438, 2863, 2937, 3162, 3222, 3378, 3459, 3475, 3783, 3849, 3870], '(57)': [324, 779], 'Google': [325, 343, 412, 425, 444, 463, 584, 608, 643, 662, 681, 700, 724, 746, 780, 798, 819, 844, 914, 1191, 1224, 1304, 1326, 1819, 1848, 2440, 2865, 2939, 3140, 3164, 3224, 3380, 3440, 3461, 3477, 3761, 3785, 3851, 3872], 'Scholar,': [326, 413, 426, 445, 585, 644, 663, 682, 701, 725, 781, 799, 820, 1192, 1305, 1820, 3141, 3441, 3462, 3762, 3852], '2Lin': [327, 782], 'J.K.': [328, 783], 'Chen': [329, 784], 'Y.C.': [330, 785], 'Huang': [331, 398, 569, 590, 685, 706, 786, 3125, 3146, 3747, 3767], 'Y.T.': [332, 787], 'Lin-Shiau': [333, 788], 'S.Y.': [334, 789], 'J.': [335, 572, 601, 688, 717, 732, 790, 899, 1176, 1203, 1211, 1312, 2426, 2931, 3128, 3157, 3210, 3434, 3452, 3778, 3838, 3854, 3856], 'Cell.': [336, 791, 3864], 'Biochem.': [337, 792], '1997;': [338, 793], '28/29:': [339, 794], '39-48Crossref': [340, 795], '(165)': [342, 797], 'Scholar).': [344, 464, 609, 747, 845, 915, 1327, 1849, 2441, 2940, 3165, 3381, 3478, 3786, 3873], 'others': [347], 'discovered': [349], 'some': [351], 'these': [353, 849, 3887, 3916, 4132, 4203], 'agents': [355], 'anti-angiogenic': [357, 468, 979, 3729], 'activities,': [358], 'which': [359, 496, 624, 2605, 3119], 'may': [360, 625, 3807], 'account': [361], 'part': [363, 614, 4448], 'for': [364, 998, 1028, 1159, 1371, 1516, 1526, 1588, 1598, 1695, 1867, 1941, 2067, 2113, 2129, 2371, 2407, 2536, 2634, 2644, 2682, 2705, 2822, 2880, 2955, 2994, 3004, 3023, 3030, 3081, 3185, 3503, 3594, 3940, 3977, 4038, 4062, 4305, 4392], 'their': [365, 3504], 'effects.': [367], 'These': [368, 465, 1095, 3688, 3948, 4219, 4242], 'include': [370], 'curcumin': [371], 'Curcuma': [373], 'longa,': [374], 'epicatechin': [375], 'gallate': [376, 611], 'tea,': [378], 'genistein': [379], 'soybeans,': [381], 'resveratrol': [383, 750], 'grapes': [385], 'red': [387], 'wine': [388], '(3Arbiser': [389, 3738], 'J.L.': [390, 886, 1163, 1209, 1828, 3739], 'Klauber': [391, 889, 1166, 3740], 'Rohan': [393, 3742], 'R.': [394, 397, 417, 589, 635, 705, 3145, 3743, 3746, 3766, 3830], 'van': [395, 3744], 'Leeuwen': [396, 3745], 'M.T.': [399, 428, 447, 646, 665, 3748], 'Fisher': [400, 3749], 'C.': [401, 568, 597, 684, 713, 2924, 3124, 3153, 3750, 3774], 'Flynn': [402, 893, 1170, 3751], 'E.': [403, 894, 1171, 3752], 'Byers': [404, 3753], 'H.R.': [405, 1826, 3754], 'Mol.': [406, 3755, 3863], 'Med.': [407, 3756], '1998;': [408, 2859, 3455, 3757], '4:': [409, 3758], '376-383Crossref': [410, 3759], '4Cao': [414], 'Cao': [416, 634], 'Nature.': [418, 636, 812, 1841], '1999;': [419, 637, 903, 1180, 3437], '398:': [420, 638], '381Crossref': [421, 639], '(611)': [424, 642], '5Huang': [427, 645], 'Lysz': [429, 647], 'T.': [430, 432, 648, 650, 896, 1173], 'Ferraro': [431, 649], 'Abidi': [433, 651], 'T.F.': [434, 652], 'Laskin': [435, 653], 'J.D.': [436, 654], 'Conney': [437, 456, 655, 674], 'A.H.': [438, 457, 656, 675, 2848], 'Cancer': [439, 458, 579, 657, 676, 695, 3135], 'Res.': [440, 459, 580, 658, 677, 696, 3136], '1991;': [441, 659, 1813], '51:': [442, 660, 3438], '813-819PubMed': [443, 661], '6Huang': [446, 664], 'Lou': [448, 666], 'Y.R.': [449, 667], 'Ma': [450, 668, 3825], 'W.': [451, 578, 599, 669, 694, 715, 3134, 3155, 3776], 'Newmark': [452, 670], 'H.L.': [453, 671], 'Reuhl': [454, 672], 'K.R.': [455, 673, 1195, 1808], '1994;': [460, 678], '54:': [461, 679], '5841-5847PubMed': [462, 680], 'exert': [467], 'properties': [471], 'through': [472, 615, 4472], 'mechanisms.': [476], 'Curcumin': [477], 'inhibits': [478, 949, 964], 'both': [481, 978, 3622, 4227], 'direct': [482, 4116], 'effects': [483, 507, 3404, 3505, 4352, 4463], 'on': [484, 508, 919, 1099, 1102, 2237, 2489, 2691, 2763, 2977, 3405, 3484, 3506, 3559, 3600, 3699, 4082, 4089, 4118, 4129, 4355, 4397, 4408, 4413, 4466], 'endothelium': [485], 'well': [487, 985], 'inhibiting': [490, 616], 'COP9': [492, 3043, 3071, 3719, 3734], 'signalosome-associated': [493, 3720], 'kinase': [494, 755, 1610, 2025, 2084, 3240, 3243, 3247, 3280, 3736], 'activity,': [495], 'regulates': [497], 'degradation': [499], 'c-Jun': [502, 3066, 3228], 'oncogene': [503], 'consequent': [505], 'downstream': [506], 'synthesis': [510, 629, 4130], 'angiogenic': [514], 'factor,': [515], 'vascular': [516, 526], 'growth': [518, 528, 966, 2206, 2273, 3617, 3803, 3924, 4162, 4316], 'factor': [519, 2207], '(VEGF)': [520], '1The': [521], 'abbreviations': [522], 'are:': [524], 'VEGF,': [525], 'factor;': [529], 'VEGFR,': [530], 'VEGF': [531, 631, 2542, 3020, 4465], 'receptor;': [532], 'HUVEC,': [533], 'umbilical': [535], 'vein': [536], 'cells;': [538], 'PBS,': [539, 1430, 2829], 'phosphate-buffered': [540], 'saline;': [541], 'PI': [542, 1537, 1603, 3891, 4090, 4250, 4372], '3-kinase,': [543], 'phosphatidylinositol': [544], '3-kinase;': [545], 'MAPK,': [546, 1734, 3906], 'mitogen-activated': [547], 'protein': [548, 563, 754, 1673, 2215, 2368, 2601, 2615, 3239, 3242, 3246], 'kinase;': [549, 552, 560, 564], 'MKK,': [550], 'MAPK': [551, 1540, 1609, 1703, 1750, 3792, 3878, 3986, 4009, 4018, 4095, 4253, 4384], 'ANOVA,': [553], 'analysis': [554, 2486, 2500, 2760], 'variance;': [556], 'ERK,': [557], 'extracellular': [558], 'signal-regulated': [559], 'SAPK,': [561], 'stress-activated': [562], 'KDR,': [565], 'VEGFR2.': [566], '(7Pollmann': [567, 3123], 'X.': [570, 591, 686, 707, 3126, 3147, 3768], 'Mall': [571, 687, 3127], 'Bech-Otschir': [573, 689, 3129], 'D.': [574, 587, 690, 703, 801, 807, 888, 1165, 1199, 3130, 3143, 3764], 'Naumann': [575, 691, 3131], 'M.': [576, 692, 892, 1169, 3132, 3447, 3449, 3464, 3816, 4497], 'Dubiel': [577, 598, 693, 714, 3133, 3154, 3775], '2001;': [581, 602, 697, 718, 735, 838, 3137, 3158, 3374, 3779, 3840, 3866], '61:': [582, 698, 3138, 3456], '8416-8421PubMed': [583, 699, 3139], '8Bech-Otschir': [586, 702, 3142, 3763], 'Kraft': [588, 704, 3144, 3765], 'Henklein': [592, 708, 3148, 3769], 'P.': [593, 709, 2421, 2918, 3149, 3205, 3770], 'Kapelari': [594, 710, 3150, 3771], 'Pollmann': [596, 712, 3152, 3773], 'EMBO': [600, 716, 3156, 3777], '20:': [603, 719, 3159, 3780], '1630-1639Crossref': [604, 720, 3160, 3781], '(326)': [607, 723, 3163, 3784], 'Epicatechin': [610], 'works': [612], '26': [621], 'S': [622], 'proteasome,': [623], 'also': [626, 1442], 'regulate': [627], '(4Cao': [632], '7Pollmann': [683], '9Nam': [726], 'S.': [727, 822, 836, 1201, 1296, 2922, 3358, 3372], 'Smith': [728], 'D.M.': [729], 'Dou': [730], 'Q.P.': [731], 'Biol.': [733, 1313, 2427, 2857, 3211, 3865], 'Chem.': [734, 1314, 2428, 3212], '276:': [736], '13322-13330Abstract': [737], 'Full': [738, 740, 906, 908, 1183, 1185, 1216, 1218, 1318, 1320, 2432, 2434, 3216, 3218, 3843, 3845], 'Text': [739, 741, 907, 909, 1184, 1186, 1217, 1219, 1319, 1321, 2433, 2435, 3217, 3219, 3844, 3846], 'PDF': [742, 910, 1187, 1220, 1322, 2436, 3220, 3847], '(477)': [745], 'Genistein': [748], 'are': [751, 2743, 3565, 3581, 3796, 4469, 4487], 'broad': [752], 'spectrum': [753], 'inhibit': [758, 2972, 3733, 4160, 4239, 4314], 'tumor': [759, 4233], 'promotion': [760], '10Mukhopadhyay': [800], 'Tsiokas': [802], 'L.': [803], 'Zhou': [804], 'X.M.': [805], 'Foster': [806], 'Brugge': [808], 'J.S.': [809, 828, 3364], 'Sukhatme': [810], 'V.P.': [811], '375:': [814], '577-581Crossref': [815], '(540)': [818], '11Gupta': [821], 'Hastak': [823, 3359], 'K.': [824, 1307, 1822, 3360], 'Ahmad': [825, 3361], 'Lewin': [827, 3363], 'Mukhtar': [829, 3365], 'H.': [830, 1205, 3366, 3429, 3445, 3466], 'Proc.': [831, 1291, 3367], 'Natl.': [832, 1292, 3368], 'U.': [835, 1295, 3371], '98:': [839, 3375], '10350-10355Crossref': [840, 3376], '(453)': [843, 3379], 'However,': [846], 'few': [847, 2115], 'actually': [851], 'established': [855], 'tumors': [856, 3306], 'vivo.': [858], 'developed': [861], 'simple': [863], 'bioassay': [864, 918], 'amenable': [865], 'large-scale': [867], 'screening': [868], 'fractionation': [870], 'products,': [873], 'namely': [874], '(12Arbiser': [885, 1162], 'Panigrathy': [887, 1164], 'Rupnick': [891, 1168], 'Udagawa': [895, 1172], "D'Amato": [897, 1174], 'R.J.': [898, 1175, 1288], 'Am.': [900, 1177, 1210, 3837], 'Dermatol.': [902, 1179], '40:': [904, 1181], '925-929Abstract': [905, 1182], '(41)': [913, 1190], 'Using': [916], 'seed': [923, 1008], 'cone': [924], 'grandiflora,': [927], 'we': [928, 3555, 3569, 4123, 4307, 4479], 'one': [932], 'components': [936], 'extract': [939, 1042, 2460, 3400], 'molecule': [943, 4278], 'honokiol.': [944, 3560, 4365], 'demonstrate': [946], 'interfering': [952], 'phosphorylation': [954, 2979, 3034, 3901, 3989, 4019, 4048, 4071, 4098], 'VEGFR2': [956, 2192, 2800, 2978, 3036, 4474], 'cells.': [960, 3884, 4297, 4323], 'epithelial': [969, 1244, 4167], 'vitro,': [972], 'thus': [973, 3568], 'demonstrating': [974], 'it': [976, 994, 2160, 2186, 4285], 'has': [977, 4224], 'activity.': [982, 4265], 'tolerated': [986], 'sarcomas': [990], 'mice,': [992], 'making': [993], 'attractive': [996], 'candidate': [997, 4391], 'clinical': [999], 'trials.': [1000], 'Extraction': [1001], 'Grandiflora': [1004], 'Seed': [1005], 'Cones—Magnolia': [1006], 'cones': [1009, 1017], 'were': [1010, 1020, 1087, 1097, 1111, 1122, 1132, 1154, 1256, 1329, 1343, 1380, 1398, 1423, 1427, 1434, 1441, 1483, 1521, 1544, 1584, 1619, 1630, 1663, 1676, 1689, 1721, 1760, 1792, 1854, 1878, 2016, 2062, 2071, 2170, 2217, 2226, 2235, 2276, 2287, 2296, 2353, 2381, 2448, 2469, 2524, 2546, 2640, 2657, 2670, 2698, 2814, 2826, 2878, 2953, 2960, 2984, 3016, 3028, 3112, 3167, 3181, 3289, 3388, 3501, 3603, 3619, 3879, 3929, 4031], 'collected': [1011, 1443, 2641], 'ground.': [1013], 'The': [1014, 1039, 1057, 1075, 1137, 1481, 1602, 1963, 2132, 2145, 2453, 2637, 2667, 2685, 2951, 3076, 3087, 3096, 3578, 3787, 4000, 4077], 'powdered': [1015], '(100': [1018], 'g)': [1019], 'extracted': [1021], '500': [1023, 1073, 1958, 2299], 'ml': [1024, 1882, 1890, 2076, 2663, 2832, 3337], 'boiling': [1026], 'water': [1027, 1066], '30': [1029, 2075, 2881, 2884, 2892, 2941, 3954], 'min': [1030, 1943, 3083], 'then': [1032, 1062, 1078, 1492, 2127, 2159, 2362, 3017, 3092, 4036], 'allowed': [1033], 'cool': [1035], 'room': [1037, 1514, 2065, 2098], 'temperature.': [1038], 'crude': [1040], 'aqueous': [1041], 'clarified': [1044], 'using': [1045, 1233, 1466, 1713, 1743, 1771, 2278, 2383, 2501, 2775, 2962, 3343], '0.45-microfilter': [1047], 'followed': [1048, 1780, 2492, 2766], 'ultrafiltration': [1050], '3000': [1052], 'nominal': [1053], 'limits.': [1056], 'ultrafiltrate': [1058], 'lyophilized': [1060, 1088], 'reconstituted': [1063, 1090], 'distilled': [1065], 'give': [1068], 'final': [1070, 1576, 1622, 3053], 'concentration': [1071], 'mg/ml.': [1074], 'material': [1076], 'fractionated': [1079], 'high': [1081, 4045], 'pressure': [1082, 3412], 'liquid': [1083, 3413], 'chromatography,': [1084], 'fractions': [1086, 1096, 3415, 3421], '10': [1092, 1401, 1566, 1857, 1915, 1919, 1942, 2040, 2068, 2087, 2148, 2329, 2344, 2567, 2582, 2585, 3610], 'mg/ml': [1093, 1366, 1567, 1928, 1931, 1935, 2047], 'solutions.': [1094], 'tested': [1098, 3168, 3182, 3502, 3570, 4308], 'assays': [1101, 3111], 'described': [1106, 1477, 2414, 3041], 'below.': [1107], 'magnolol': [1110, 1403, 3180, 3425, 3500, 3564, 3606, 3674], 'obtained': [1112, 1123, 2227, 3299], 'Wako': [1114], 'Chemical': [1115], 'Company': [1116], '(Tokyo,': [1117], 'Japan),': [1118], 'unsubstituted': [1120, 3579], 'biphenyls': [1121, 3580], 'Aldrich.': [1125], 'Vitro': [1127, 2854], 'Proliferation': [1128], 'Assays—10,000': [1129], 'plated': [1133, 1330, 1381], '24-well': [1135, 2817], 'dishes.': [1136], 'next': [1138, 2146], 'day,': [1139], 'medium': [1141, 1146, 1267, 1552, 2257, 2838], 'replaced': [1143], 'fresh': [1145, 2140, 2834], 'containing': [1147, 1501, 1553, 1637, 2396, 2554, 2710, 3012], 'or': [1150, 1275, 1352, 1404, 1406, 1705, 1735, 1752, 1860, 2485, 2759, 2871, 2891, 2989, 3037, 3320, 3385, 3392, 3895], 'vehicle': [1151, 1347, 2949, 3321], 'controls.': [1152], 'Cells': [1153, 1328, 1583, 2234, 2545, 2877, 3015, 4274], 'incubated': [1155, 1585, 1690, 1761, 2063, 2363, 2406, 2722, 2879, 2954, 3080, 3930, 4032], 'at': [1156, 1258, 1331, 1382, 1513, 1575, 1591, 1621, 1944, 1948, 2064, 2097, 2291, 2358, 2374, 2631, 2650, 3084, 3309, 3539, 3609, 3675, 4044], '37': [1157, 1259, 1592, 2292, 3085], '°C': [1158, 1593, 2360, 2633], '72': [1160], 'h': [1161, 1413, 1416, 1590, 2373, 2409, 2538, 2707, 2996, 3006, 3626, 3662, 3997], '13LaMontagne': [1193], 'Jr.,': [1194, 1287], 'Moses': [1196], 'M.A.': [1197], 'Wiederschain': [1198], 'Mahajan': [1200], 'Holden': [1202], 'Ghazizadeh': [1204], 'Frank': [1206], 'D.A.': [1207], 'Arbiser': [1208], 'Pathol.': [1212, 3839], '2000;': [1213, 1315, 2933], '157:': [1214], '1937-1945Abstract': [1215], '(40)': [1223], 'Scholar),': [1225], 'determined': [1230, 1664, 3105], 'triplicate': [1232], 'Coulter': [1235, 2964], 'Counter': [1236], '(Hialeah,': [1237], 'FL).': [1238], 'Immortalized': [1239], 'K-Ras': [1241], 'rat': [1243], '(RIEpZip': [1246], 'RIEpZipK-Ras12V)': [1248], '(NIH3T3': [1251], 'pZip': [1252], 'NIH3T3': [1254, 1339], 'pZipK-Ras12V)': [1255], 'maintained': [1257], '°C,': [1260, 2293], '10%': [1261, 1276, 1554, 1679, 2250, 2570], 'CO2,': [1262], "Dulbecco's": [1264, 1549], 'modified': [1265, 1391, 1550], "Eagle's": [1266, 1392, 1551], 'supplemented': [1268], '5%': [1270, 1387, 2711], 'fetal': [1271, 1388, 1555, 2251, 2533, 3009], 'calf': [1272, 1277], 'serum': [1273, 1278, 2253, 2535, 3011], '(RIE)': [1274], '(NIH3T3)': [1279], '(14Oldham': [1280], 'S.M.': [1281, 2920], 'Clark': [1282], 'G.J.': [1283], 'Gangarosa': [1284], 'L.M.': [1285], 'Coffey': [1286], 'Der': [1289, 1310], 'C.J.': [1290, 1311], '1996;': [1298], '93:': [1299, 3472], '6924-6928Crossref': [1300], '(134)': [1303], '15Pruitt': [1306], 'Pestell': [1308], 'R.G.': [1309], '275:': [1316], '40916-40924Abstract': [1317], '(25)': [1325], '105/well': [1332], 'six-well': [1334], 'plates.': [1335], 'Vector': [1336], 'Ras-transformed': [1338, 4166, 4191], 'RIE': [1341], 'treated': [1344, 1399, 1855, 2985, 3604], 'either': [1346], '(20': [1348, 2543, 3021], 'μl': [1349, 1496, 1959, 2023, 2041, 2105, 2118, 2149, 2300, 2366, 2674, 2942, 3057], 'Me2SO)': [1351], 'increasing': [1353, 3932], 'concentrations': [1354, 1577, 1623, 1662, 3171, 3541, 3677, 3969, 4046, 4059], '(5,': [1355], '10,': [1356], '20,': [1357, 2404, 2718], '40': [1359, 1900, 2673], 'μg/ml)': [1360, 1505, 2993, 3003], '(from': [1363], '2': [1365, 1649, 1658, 2176, 2282], 'Me2SO': [1367, 1572, 1864], 'stock)': [1368], 'observed': [1370, 3389, 4212], 'morphology': [1372], 'changes': [1373, 3941, 4039], 'after': [1374, 3313], '24': [1375, 1395, 1851, 1869, 2823, 3996], 'h.': [1376, 1870, 2824], 'Apoptosis': [1377], 'Assays—SVR': [1378], '125,000': [1383], 'cells/100-mm': [1384], 'plate': [1385, 2166, 2183, 2908], 'bovine': [1389, 1556, 2252, 2261, 2534, 3010], "serum/Dulbecco's": [1390], 'medium.': [1393, 3014], 'After': [1394, 1511, 1850, 1871, 2013, 2094, 2180, 2442, 2703, 2729], 'h,': [1396, 1852, 2957], 'μg/ml': [1402, 1580, 1659, 2260, 2265, 2322, 2330, 2583, 2586, 2873, 3527, 3724, 3955, 3994], 'left': [1407], 'untreated': [1408], 'control.': [1410, 2950], 'At': [1411, 3624], '18': [1412, 3625], '48': [1415, 2956, 3661], 'treatment,': [1418], 'two': [1419, 3170], 'plates': [1420, 2238, 2818], 'per': [1421], 'condition': [1422], 'analyzed.': [1424, 1456], 'Adherent': [1425], 'washed': [1428, 1484, 1879, 1966, 2658, 2827], 'suspended': [1435, 3323], 'trypsin/EDTA': [1437], 'treatment.': [1438, 4218], 'Floating': [1439], 'centrifugation': [1445, 1490], 'conditioned': [1448], 'medium,': [1449, 1876], 'total': [1452, 3333, 3668], 'population': [1454], 'Cell': [1457, 2377, 2855, 3026, 4343], 'surface': [1458], 'annexin': [1459, 1469, 1502, 1530, 3645, 3685], 'V': [1460, 1470, 1503, 1531, 3686], 'measured': [1462, 3342, 3643], 'flow': [1464, 1524], 'cytometry': [1465, 1525], 'ApoAlert': [1468], 'kit': [1471, 1776], '(Clontech,': [1472], 'Palo': [1473], 'Alto,': [1474], 'CA)': [1475, 1742], 'manufacturer.': [1480], '1×': [1486, 1498, 2676], 'Binding': [1487, 1499], 'Buffer': [1488, 1500, 1893, 1974, 1986, 1999], 'resuspended': [1493, 2020, 2671], '200': [1495], '(0.1': [1504], 'propidium': [1507, 1533, 2043, 3647], 'iodide': [1508, 2044], '(0.5': [1509], 'μg/ml).': [1510], 'incubation': [1512, 2096, 2443, 2730, 3963], 'temperature': [1515, 2066], '15': [1517, 2995], 'min.,': [1518], 'analyzed': [1522, 3939], 'presence': [1528, 3060], 'iodide.': [1534], 'Analysis': [1535], '3-Kinase': [1538], 'Signaling—SVR': [1541], 'cultured': [1545, 2815, 3013], 'low': [1547], 'glucose': [1548], 'serum.': [1557], 'For': [1558, 2347], 'experimental': [1559], 'cultures,': [1560], 'added': [1563, 2110, 2153, 2904], 'stock': [1568], 'solution': [1569], 'made': [1570, 2529, 4255, 4388], '20–45': [1579], 'indicated.': [1582], '1': [1589, 1653, 1903, 1923, 1930, 1934, 1981, 1993, 2010, 2037, 2052, 2264, 2267, 2324, 2340, 2408, 2575, 2578, 2589, 2706, 3005, 3062, 3311], 'prior': [1594], 'harvesting': [1596], 'Western': [1599], 'blot': [1600], 'analysis.': [1601], '3-kinase': [1604, 3789, 3892, 4007, 4091, 4251, 4373], 'inhibitor,': [1605, 1612, 4284], 'LY294002,': [1606], '(MKK1)': [1611], 'U0126': [1613, 3899], '(Cell': [1614, 1708], 'Signaling': [1615, 1709], 'Laboratories,': [1616, 1710], 'Beverly,': [1617, 1711], 'MA)': [1618, 1712], '50': [1625, 1638, 1912, 2309, 2314, 2337, 3174], 'μm.': [1626], 'Whole': [1627], 'prepared': [1631], 'lysing': [1633], 'buffer': [1636, 2026, 2079, 2085, 2679], 'mm': [1639, 1644, 1650, 1654, 1896, 1901, 1904, 1910, 1913, 1916, 1920, 1924, 1982, 1994, 2002, 2011, 2028, 2031, 2034, 2038, 2053, 2325], 'Tris-Cl,': [1640], 'pH': [1641, 1898, 2004, 2050, 2305, 2552], '8.0,': [1642], '250': [1643], 'NaCl,': [1645, 1902, 2008, 2032, 2560], '0.5%': [1646, 1906, 2532, 3008], 'Nonidet': [1647, 1978], 'P-40,': [1648, 1979], 'sodium': [1651, 1917, 1921, 2338, 2341, 2345, 2565, 2580], 'orthovanadate,': [1652, 2342, 2581], 'phenylmethylsulfonyl': [1655, 1925, 2326, 2591], 'fluoride,': [1656, 1926, 2327, 2339], 'pepstatin.': [1660], 'Protein': [1661], 'Bradford': [1667], 'assay': [1668], '(Bio-Rad).': [1669], 'Equal': [1670], 'amounts': [1671, 3933], '(80': [1674], 'μg)': [1675, 2352, 2380], 'resolved': [1677], 'SDS-polyacrylamide': [1680, 2384], 'gel': [1681, 2385, 3097], 'electrophoresis': [1682, 2386], 'transferred': [1684, 2388, 2699], 'nitrocellulose': [1686, 2390, 2701], 'membrane.': [1687, 2702], 'Blots': [1688, 1720, 1759], 'antibody': [1693, 1956, 2356, 2725, 2898, 2988], 'specific': [1694, 4351], 'phosphorylated': [1697, 1731, 4143], 'form': [1698], 'Akt': [1700, 3875, 3903, 3944, 3960, 3988, 4016, 4100], '(Ser-473),': [1701], 'p44/42': [1702, 1733, 1749, 3791, 3877, 3905, 3946, 3985], '(Thr-202/Tyr-204),': [1704], 'Src': [1706, 4002, 4041, 4070], '(Tyr-416)': [1707], '1:5,000': [1715, 1745], 'dilution': [1716, 1746, 1754], 'antibodies.': [1719, 1758], 'stripped': [1722], 'reprobed': [1724], 'recognizes': [1728], 'unphosphorylated': [1729], 'Akt,': [1732], 'v-Src': [1736], '(Oncogene': [1737], 'Research': [1738, 2232, 2812], 'Products,': [1739], 'San': [1740, 2247], 'Diego,': [1741, 2248], '(Akt': [1747], 'antibodies)': [1751], '1:40': [1753], '(v-Src)': [1755], 'horseradish': [1763], 'peroxidase-conjugated': [1764], 'secondary': [1765, 2445, 2733], '(Calbiochem).': [1767], 'Detection': [1768], 'performed': [1770, 2277, 3113], 'Renaissance': [1773], 'chemiluminescent': [1774], 'ECL': [1775, 2451], '(PerkinElmer': [1777], 'Life': [1778], 'Sciences)': [1779], 'autoradiography.': [1782], 'Lipid': [1783], 'Kinase': [1784, 3045, 3176], 'Assays—5': [1785], 'μg': [1786, 2885, 2893, 3063], 'each': [1787, 2092, 2458], 'hemagglutinin-p85': [1789], 'Myc-p110': [1791], 'cotransfected': [1793], 'into': [1794, 2138, 3291], 'embryonic': [1796], 'kidney': [1797], '293': [1798], 'according': [1800, 2909, 3192], 'previously': [1802, 2415, 4481], 'published': [1803], 'methods': [1804], '(16Serunian': [1805], 'L.A.': [1806], 'Auger': [1807], 'Cantley': [1809], 'L.C.': [1810], 'Methods': [1811], 'Enzymol.': [1812], '198:': [1814], '78-87Crossref': [1815], '(130)': [1818], '17Ye': [1821], 'Aghdasi': [1823], 'Luo': [1825], 'Moriarity': [1827], 'Wu': [1829], 'F.Y.': [1830], 'Hong': [1831], 'J.J.': [1832], 'Hurt': [1833], 'K.J.': [1834], 'Bae': [1835], 'S.S.': [1836], 'Suh': [1837], 'P.G.': [1838], 'Snyder': [1839], 'S.H.': [1840], '2002;': [1842], '415:': [1843], '541-544Crossref': [1844], '(146)': [1847], 'μm': [1858, 2081], 'same': [1861], 'volume': [1862, 3054, 3334, 3340], 'control': [1866, 2897, 2907, 3322, 3393, 4434], 'another': [1868], 'removal': [1872], 'culture': [1875], '5': [1881, 1927, 2130, 2311, 2645, 2683], 'ice-cold': [1884, 2302, 2549], 'PBS': [1885, 2395, 2709, 2944], 'twice,': [1886], 'lysed': [1887, 2297, 2547], '0.5': [1889, 1989, 2662, 2831], 'lysis': [1892, 2303, 2550, 2665], 'A': [1894, 2510, 2784, 3531, 4074], '(50': [1895], 'Tris,': [1897], '7.4,': [1899, 2005], 'EDTA,': [1905, 2054, 2312, 2577], 'Triton': [1907, 2317], 'X-100,': [1908, 2318], '1.5': [1909, 2372], 'Na3VO4,': [1911], 'NaF,': [1914, 2574], 'pyrophosphate,': [1918], 'β-glycerophosphate,': [1922], 'aprotinin,': [1929, 2323, 2587], 'leupeptin,': [1932, 2584], 'pepstatin': [1936], 'A)': [1937], 'centrifuged': [1940, 2128], '14,000': [1945, 2651], '×': [1946, 2652, 3286, 3347, 3349], 'g': [1947], '4': [1949, 2359, 2375, 2632, 3524], '°C.': [1950, 2376, 3086], 'P110': [1951], 'immunoprecipitated': [1953], 'anti-Myc': [1955], 'supernatant.': [1962], 'immunoprecipitate': [1964], 'following': [1969, 3190], 'buffers:': [1970], 'three': [1971, 2659], 'times': [1972, 2660, 3979, 4064], 'B': [1975], '(PBS,': [1976, 1988], '1%': [1977, 2316, 2561], 'dithiothreitol);': [1983, 1995], 'twice': [1984, 1997], 'C': [1987], 'm': [1990, 2007, 2177], 'LiCl,': [1991], 'D': [2000], '(10': [2001, 2321, 3002, 3172, 3630], 'Tris-HCl,': [2003, 2029], '0.1': [2006], 'dithiothreitol).': [2012, 2039], 'washing,': [2014], 'samples': [2015, 2061], 'aspirated': [2017], 'completely': [2018], '100': [2022], '(40': [2027], '150': [2030, 2117, 2558], '20': [2033, 3056], 'MgCl2,': [2035, 2569], 'substrate': [2045], '(2': [2046], 'HEPES,': [2049, 2310, 2557], '7.6,': [2051], '0.1%': [2056, 2241, 2402, 2716], 'cholate)': [2057], 'added,': [2059, 2623], 'min.': [2069, 2131, 2636, 2684, 3025], 'Reactions': [2070], 'initiated': [2072], 'adding': [2074], 'reaction': [2078, 2626, 3047, 3077, 3089], '(70': [2080], 'ATP': [2082], 'μCi': [2088], '[γ-32P]ATP/reaction)': [2090], 'sample.': [2093], '10-min': [2095], 'temperature,': [2099], 'mixture': [2101, 2627, 3078, 3090], 'solubilized': [2102], '8': [2104, 3526], '37%': [2107], 'HCl': [2108], 'vortexed': [2112], 'seconds.': [2116], '1:1': [2120], 'CHCl3:CH3OH': [2121], 'introduced': [2123], 'mixed': [2125], 'bottom': [2133], 'organic': [2134], 'layer': [2135], 'removed': [2137], 'tube': [2141], 'air-dried': [2143], 'overnight.': [2144, 2728], 'morning': [2147], 'methanol': [2151], 'dissolve': [2155], 'lipid,': [2157], 'spotted': [2162], 'onto': [2163], 'TLC': [2165, 2182], 'lipids': [2169], 'separated': [2171, 2382, 2688, 3093], '65:35': [2173], '(v/v)': [2174], '2-propanol,': [2175], 'acetic': [2178], 'acid.': [2179], 'dried,': [2185], 'exposed': [2188], 'film.': [2191], 'Phosphorylation': [2193], 'Analysis—Human': [2194], 'recombinant': [2195, 3065], 'VEGF165': [2196], 'purchased': [2198], 'R&D': [2200], 'Systems': [2201], '(Minneapolis,': [2202], 'MN).': [2203], 'Anti-vascular': [2204], 'R2': [2208], '(KDR)': [2209], 'antibody,': [2210, 2213, 2734], 'anti-phosphotyrosine': [2211], '(PY99)': [2212], 'A-G-agarose': [2216, 2369], 'Santa': [2219, 2900], 'Cruz': [2220, 2901], 'Biotechnology': [2221], '(Santa': [2222], 'Cruz,': [2223], 'CA).': [2224, 2509, 2783], 'HUVECs': [2225, 2286, 2983], 'Emory': [2229], 'Skin': [2230, 2810], 'Diseases': [2231], 'Center.': [2233], 'grown': [2236, 2525], 'coated': [2239], 'gelatin': [2242], 'EGM-MV': [2244], 'BulletKit': [2245], '(Clonetics,': [2246], 'CA),': [2249], 'basic': [2256], '12': [2259, 2537], 'brain': [2262], 'extract,': [2263], 'hydrocortisone,': [2266], 'μl/ml': [2268], 'GA-1000,': [2269], 'factor.': [2274], 'Experiments': [2275], 'between': [2280, 3523, 4188], 'passages': [2281], '5.': [2284], 'Growth-arrested': [2285], 'stimulated': [2288, 3018], 'agonists': [2290], 'buffer,': [2304, 2551], '7.4': [2306], '(in': [2307, 2335], 'mm:': [2308, 2336], 'NaCl),': [2315], 'protease': [2319], 'leupeptin),': [2331], 'phosphatase': [2333], 'pyrophosphate).': [2346], 'immunoprecipitation,': [2348], 'lysates': [2350, 3027], '(600': [2351], 'precipitated': [2354], 'overnight': [2357, 2393], '25': [2365, 2555, 2572], 'beads': [2370, 2639, 2656, 2669], 'immunoprecipitates': [2378], '(500': [2379], 'membranes,': [2391], 'blocked': [2392], '6%': [2397], 'nonfat': [2398, 2712], 'dry': [2399, 2713], 'milk': [2400, 2714], 'Tween': [2403, 2717], '(20Alessi': [2416, 3200], 'D.R.': [2417, 3201], 'Cuenda': [2418, 3202], 'Cohen': [2420, 3197, 3204, 3273], 'Dudley': [2422, 3206], 'D.T.': [2423, 3207], 'Saltiel': [2424, 3208], 'A.R.': [2425, 3209], '270:': [2430, 3214], '27489-27494Abstract': [2431, 3215], '(3256)': [2439, 3223], 'proteins': [2447, 2697], 'detected': [2449, 2737], 'chemiluminescence.': [2452, 2740], 'amount': [2454], 'KDR': [2456, 4454, 4491], 'assessed': [2462, 2478, 2752, 3029, 3683], 'immunoblotting': [2464], 'anti-KDR': [2466], 'antibody.': [2467], 'Results': [2468], 'expressed': [2470, 2744], 'mean': [2472, 2746], '±': [2473, 2747], 'S.E.': [2474, 2748], 'Statistical': [2475, 2741, 2749], 'significance': [2476, 2750], "Student's": [2480, 2754], 'paired': [2481, 2755], 'two-tailed': [2482, 2756], 't': [2483, 2757], 'test': [2484, 2758, 4299], 'variance': [2488, 2762], 'untransformed': [2490, 2764], 'comparison': [2494, 2768], 'group': [2496, 2770], 'averages': [2497, 2771], 'contrast': [2499, 2773], 'Super-ANOVA': [2503], 'statistical': [2504, 2778], 'program': [2505, 2779], '(Abacus': [2506, 2780], 'Concepts,': [2507, 2781], 'Berkeley,': [2508, 2782], 'p': [2511, 2785], 'value': [2512, 2786], '<0.05': [2514, 2788], 'considered': [2516, 2790, 4281], 'statistically': [2519, 2793], 'significant.': [2520, 2794], 'Rac': [2521, 2595, 2735, 2803, 2981, 3038], 'Activation': [2522], 'Assay—HUVECs': [2523], 'confluence': [2527], 'quiescent': [2530], 'before': [2539, 2997], 'stimulation': [2540], 'ng/ml).': [2544], '7.5,': [2553], 'mmol/liter': [2556, 2559, 2568, 2573, 2576, 2579, 2590], 'IGEPAL': [2562], 'CA-630,': [2563], '0.25%': [2564], 'deoxycholate,': [2566], 'glycerol,': [2571], 'fluoride.': [2592], 'Activated': [2593], '(GTP-bound)': [2594], 'affinity-precipitated': [2597], 'p21-activated': [2599], 'kinase-1': [2600, 2614], 'binding': [2602, 2616], 'domain': [2603], 'peptide,': [2604], 'binds': [2606], 'only': [2607], 'Rac-GTP': [2609], 'not': [2611, 3409, 3679, 3983, 4066, 4146, 4194, 4211, 4237], 'Rac-GDP.': [2612], 'p21-Activated': [2613], 'domain-agarose': [2617], '(7.5': [2618], 'μg/mg': [2619], 'lysate)': [2621], 'gently': [2629], 'rocked': [2630], '60': [2635, 3082], 'agarose': [2638, 2668], 'pulsing': [2643], 's': [2646], 'microcentrifuge': [2649], 'g,': [2653], 'buffer.': [2666], 'SDS': [2677], 'sample': [2678], 'boiled': [2681], 'supernatant': [2686], 'SDS-PAGE': [2690], '12%': [2693], 'gel,': [2694], 'blocking': [2704], 'membrane': [2720], 'anti-Rac': [2724], '(1:1000': [2726], 'dilution)': [2727], 'enhanced': [2739], 'Analysis—Results': [2742], 'data,': [2765], 'analysis,': [2774], 'SuperANOVA': [2777], 'TRAIL': [2795, 2887, 2969, 2987, 4258, 4376, 4387, 4389, 4407, 4424], 'Inhibition': [2796, 3177, 4340], 'Studies': [2797, 3708], '(Endothelial': [2798], 'Proliferation,': [2799], 'Phosphorylation,': [2801], 'Activation)—Human': [2804], 'dermal': [2805, 4321], 'microvascular': [2806, 2835], '(Emory': [2809], 'Disease': [2811], 'Center)': [2813], '10,000': [2820], 'cells/well': [2821], 'Plates': [2825], '(18Daneker': [2839], 'G.W.': [2840], 'Lund': [2841], 'S.A.': [2842, 3828], 'Caughman': [2843], 'S.W.': [2844], 'Swerlick': [2845], 'R.A.': [2846], 'Fischer': [2847], 'Staley': [2849], 'C.A.': [2850], 'Ades': [2851], 'E.W.': [2852], 'Dev.': [2856], 'Anim.': [2858], '34:': [2860], '370-377Crossref': [2861], '(34)': [2864], 'Scholar)': [2866], '0,': [2868], '1,': [2869], '6,': [2870], '9': [2872], 'added.': [2876], 'min,': [2882], 'antibody/well': [2888], '(Alexis': [2889], '804–296-C100)': [2890], 'isotype': [2895, 4433], 'IgG': [2896, 2991], '(sc-2050,': [2899], 'Biotechnology)': [2902], 'method': [2912, 3195], 'Clarke': [2914], 'et': [2915, 3198], 'al.': [2916, 3199], '(19Clarke': [2917], 'Meintzer': [2919], 'Gibson': [2921], 'Widmann': [2923], 'Garrington': [2925], 'T.P.': [2926], 'Johnson': [2927], 'G.L.': [2928], 'Tyler': [2929], 'K.L.': [2930], 'Virol.': [2932], ':': [2934], '8135-8139Crossref': [2935], '(178)': [2938], 'counted': [2961], 'Counter.': [2965], 'To': [2966, 3910, 4011, 4110, 4148, 4298], 'determine': [2967, 3911, 4012, 4111, 4149], 'whether': [2968, 3912, 4013, 4112, 4150, 4300], 'blockade': [2970], 'could': [2971, 3914], 'effect': [2974, 3572, 3698, 4078, 4088, 4117, 4126, 4394, 4403, 4410], 'activation,': [2982], 'mouse': [2990], '(30': [2992], 'addition': [2999], 'ng/ml)': [3022], '3': [3024, 3317], 'measurement': [3031], 'tyrosine': [3033, 4475], 'above.': [3042], 'Signalosome-associated': [3044], 'Assays—Kinase': [3046], 'carried': [3049], 'out': [3050], '[γ-32P]ATP': [3068], 'isolated': [3070], 'signalosome': [3072, 3735], 'erythrocytes.': [3075], 'complete': [3088], 'SDS-PAGE.': [3095], 'dried': [3099], 'autoradiographed.': [3101], 'Percent': [3102], 'densitometry.': [3107], 'As': [3108, 3612], 'negative': [3109], 'controls,': [3110], 'absence': [3116], 'compounds,': [3118], 'represent': [3120], '100%': [3121], 'Compounds': [3166, 3483, 3599], 'μm).': [3175], 'Assays—Honokiol': [3178], 'vitro': [3184, 3937], 'inhibitory': [3186, 3403, 3715, 4289], 'enzymes': [3191], 'Scholar):': [3225], 'MKK1,': [3226], 'MAPK2/ERK2,': [3227], 'N-terminal': [3229], 'kinase/SAPK1c,': [3230], 'SAPK2a/p38,': [3231], 'SAPK2b/p38b2,': [3232], 'SAPK3/p38g,': [3233], 'SAPK4/p38d,': [3234], 'MAPKAP-K1a,': [3235], 'MAPKAP-K2,': [3236], 'MSK1,': [3237], 'PRAK,': [3238], 'A,': [3241, 3261], 'Ca,': [3244], 'PDK1,': [3245], 'Ba,': [3248], 'SGK,': [3249], 'S6K1,': [3250], 'GSK3b,': [3251], 'ROCK-II,': [3252], 'AMPK,': [3253], 'CHK1,': [3254], 'CK2,': [3255], 'Phosphorylase': [3256], 'kinase,': [3257, 4476], 'Lck,': [3258], 'CSK,': [3259], 'CDK2/cyclin': [3260], 'CK1,': [3262], 'DYRK1a,': [3263], 'PP2a.': [3265], 'acknowledge': [3267], 'assistance': [3269], 'Dr.': [3271], 'Philip': [3272], 'University': [3276], 'Dundee': [3278], 'Vivo': [3283], 'Tumorigenesis—SVR': [3284], '(1': [3285], '106)': [3287], 'injected': [3290], 'flank': [3293], '6-week-old': [3295], 'male': [3297], 'mice': [3298, 3315], 'Charles': [3301], 'River': [3302], 'Breeding': [3303], 'Laboratories.': [3304], 'When': [3305], 'became': [3307], 'visible': [3308], 'approximately': [3310], 'week': [3312], 'inoculation,': [3314], 'received': [3316], 'mg/day': [3318], '20%': [3325], 'Intralipid': [3326], '(Baxter': [3327], 'Healthcare,': [3328], 'Deerfield,': [3329], 'IL)': [3330], '0.3': [3336], 'intraperitoneally.': [3338], 'Tumor': [3339], 'formula': [3345], '(width2': [3346], 'length)': [3348], '0.52': [3350], 'where': [3351], 'width': [3352], 'represents': [3353], 'shortest': [3355], 'dimension': [3356], '(11Gupta': [3357], 'No': [3382], 'loss': [3384], 'other': [3386], 'toxicities': [3387], 'Fractionation': [3395], 'Extracts—Aqueous': [3398], 'displayed': [3401], '(data': [3408, 4145, 4193], 'shown).': [3410, 4147, 4195], 'High': [3411], 'chromatography': [3414], 'corresponded': [3419], 'known': [3422, 3731, 3797, 4369, 4381], '(21Kuribara': [3428], 'Stavinoha': [3430], 'W.B.': [3431], 'Maruyama': [3432], 'Pharm.': [3435], 'Pharmacol.': [3436], '97-103PubMed': [3439], '22Maruyama': [3442], 'Kuribara': [3444], 'Morita': [3446], 'Yuzurihara': [3448], 'Weintraub': [3450], 'S.T.': [3451], 'Nat.': [3453], 'Prod.': [3454], '135-138Crossref': [3457], '(141)': [3460], '23Fujita': [3463], 'Itokawa': [3465], 'Sashida': [3467], 'Yakugaku': [3469], 'Zasshi.': [3470], '1973;': [3471], '429-434Crossref': [3473], '(71)': [3476], 'Effect': [3479], 'Purified': [3481], 'Proliferation—Given': [3486], 'importance': [3489], 'agents,': [3497], 'survival': [3508, 3805], 'steep': [3516], 'decline': [3517], 'seen': [3522, 3538], '(Fig.': [3529, 3576, 3670, 3908, 3998, 4054, 4072, 4337, 4418], '1A).': [3530], 'dose-dependent': [3532, 4176, 4335], 'decrease': [3533], 'higher': [3540, 3547], 'magnolol,': [3543], 'but': [3544, 4235], 'given': [3545], 'potency': [3548], 'assay,': [3554], 'chose': [3556], 'focus': [3558], 'Both': [3561, 3874], 'substituted': [3566], 'hydroxybiphenyls,': [3567], 'non-substituted': [3574], 'hydroxybiphenyls': [3575], '1B).': [3577], 'essentially': [3582], 'inactive': [3583], 'bioassay,': [3587], 'suggesting': [3588], 'substitution': [3591], 'essential': [3593], 'bioactivity.': [3595], 'Effects': [3596], 'Apoptosis—SVR': [3601], 'μg/ml.': [3611], 'noted': [3613], 'above,': [3614], 'cellular': [3616], 'rates': [3618], 'reduced': [3620], 'agents.': [3623], 'treatment': [3629, 3664, 4081, 4135], 'μg/ml),': [3631], 'there': [3632, 4181], '2-fold': [3635], 'increase': [3636, 3655], 'early': [3639, 3657], 'apoptotic': [3640, 3658], 'V-positive,': [3646], 'iodide-negative.': [3648], 'This': [3649], 'increased': [3651], '7.7-fold': [3654], '10.8%': [3666], '2).': [3671], 'contrast,': [3673], 'comparable': [3676, 3725], 'did': [3678, 3982, 4065], 'induce': [3680], 'apoptosis': [3681], 'positivity.': [3687], 'indicate': [3690], 'exerts': [3693], 'much': [3694], 'its': [3696], 'suppressive': [3697], 'induction': [3704, 4382], 'apoptosis.': [3706], 'Mechanistic': [3707], 'Honokiol—Honokiol': [3710], 'kinases': [3721], '13': [3723], 'curcumin,': [3727], 'phosphoinositol': [3788, 4006], 'signal': [3793], 'transduction': [3794], 'pathways': [3795, 3920], 'important': [3800, 3811], 'play': [3808], 'particularly': [3810], 'role': [3812], '(24Sun': [3815], 'Wang': [3817], 'G.': [3818], 'Paciga': [3819], 'J.E.': [3820], 'Feldman': [3821], 'R.I.': [3822], 'Yuan': [3823], 'Z.Q.': [3824], 'X.L.': [3826], 'Shelley': [3827], 'Jove': [3829], 'Tsichlis': [3831], 'P.N.': [3832], 'Nicosia': [3833], 'S.V.': [3834], 'Cheng': [3835], 'J.Q.': [3836], '159:': [3841], '431-437Abstract': [3842], '(405)': [3850], '25Hutchinson': [3853], 'Jin': [3855], 'Cardiff': [3857], 'R.D.': [3858], 'Woodgett': [3859], 'J.R.': [3860], 'Muller': [3861], 'W.J.': [3862], '21:': [3867], '2203-2212Crossref': [3868], '(250)': [3871], 'constitutively': [3880, 3917], 'activated': [3881, 3943], 'Treatment': [3885, 4056, 4420], 'LY294002': [3894], 'MKK': [3897], 'inhibited': [3900, 3959, 3991, 4047, 4102, 4209, 4425], 'respectively': [3907], '3A).': [3909, 4055], 'modulate': [3915], 'signaling': [3919, 4092], 'involved': [3921, 4488], 'survival,': [3926], 'MAPK.': [3947, 4109], 'dose': [3949], 'response': [3950], 'experiments': [3951], '(112.5': [3956], 'μm)': [3957, 3976], 'phosphorylation.': [3961, 4042], 'Although': [3962, 4173], 'lower': [3968, 4058, 4104], '(2.7–13.3': [3972], 'μg/ml;': [3973], 'i.e.': [3974], '10–50': [3975], 'extended': [3978, 4063], '(2–24': [3980], 'h)': [3981], 'affect': [3984], 'phosphorylation,': [3987], '2.7': [3993], 'within': [3995], '3B).': [3999], 'oncoprotein': [4001], 'can': [4003], 'activate': [4004], 'pathways.': [4010], 'due': [4023], 'upstream': [4025], 'Src,': [4028], 'examined': [4037, 4124, 4401], 'c-Src': [4050], 'cause': [4067], '3,': [4073], 'B).': [4076], 'suggested': [4085], 'signaling,': [4096, 4254], 'doses': [4105], 'than': [4106], 'had': [4114, 4436], 'production': [4119], 'inositol': [4121, 4144], 'phosphates,': [4122], 'phosphates.': [4133], 'led': [4136, 4358], '∼50%': [4138], 'levels': [4141], 'directly': [4152], 'Ras,': [4154], 'ability': [4156, 4310], 'immortalized': [4164, 4189], 'mesenchymal': [4169], 'tested.': [4172], 'growth,': [4180], 'no': [4183, 4437], 'significant': [4184], 'difference': [4185], 'morphologic': [4198], 'reversion': [4199], 'occurs': [4201], 'when': [4205], 'Ras': [4206, 4240, 4356], 'specifically': [4208, 4238], 'result': [4215], 'findings': [4220], 'suggest': [4221], 'preneoplastic': [4228], '(immortalized)': [4229], 'neoplastic': [4231], '(Ras-transformed)': [4232], 'does': [4236], 'signaling.': [4241], 'findings,': [4243], 'along': [4244, 4378], 'over': [4252, 4275, 4331], 'us': [4256, 4359], 'consider': [4257], 'intermediary': [4262], 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[4498], 'Fukai': [4500], 'T': [4501]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106265598', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 22}], 'updated_date': '2024-12-24T19:53:32.801791', 'created_date': '2016-06-24'}