Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2047825019', 'doi': 'https://doi.org/10.1002/(sici)1099-1573(199911)13:7<593::aid-ptr520>3.0.co;2-f', 'title': 'Application of the elevated plus-maze test in mice for evaluation of the content of Honokiol in water extracts of magnolia', 'display_name': 'Application of the elevated plus-maze test in mice for evaluation of the content of Honokiol in water extracts of magnolia', 'publication_year': 1999, 'publication_date': '1999-11-01', 'ids': {'openalex': 'https://openalex.org/W2047825019', 'doi': 'https://doi.org/10.1002/(sici)1099-1573(199911)13:7<593::aid-ptr520>3.0.co;2-f', 'mag': '2047825019', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10548753'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1099-1573(199911)13:7<593::aid-ptr520>3.0.co;2-f', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206789554', 'display_name': 'Phytotherapy Research', 'issn_l': '0951-418X', 'issn': ['0951-418X', '1099-1573'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109977291', 'display_name': 'Hisashi Kuribara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165735259', 'display_name': 'Gunma University', 'ror': 'https://ror.org/046fm7598', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I165735259']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hisashi Kuribara', 'raw_affiliation_strings': ['Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan', 'institution_ids': ['https://openalex.org/I165735259']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080443952', 'display_name': 'Eiko Kishi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165735259', 'display_name': 'Gunma University', 'ror': 'https://ror.org/046fm7598', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I165735259']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eiko Kishi', 'raw_affiliation_strings': ['Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan', 'institution_ids': ['https://openalex.org/I165735259']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041914090', 'display_name': 'Naoko Hattori', 'orcid': 'https://orcid.org/0000-0002-3142-8400'}, 'institutions': [{'id': 'https://openalex.org/I4210090349', 'display_name': 'Tsumura Research Institute (Japan)', 'ror': 'https://ror.org/0095dm157', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210090349']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoko Hattori', 'raw_affiliation_strings': ['Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami‐machi, Inashiki‐gun, Ibaraki 300‐1192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami‐machi, Inashiki‐gun, Ibaraki 300‐1192, Japan', 'institution_ids': ['https://openalex.org/I4210090349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111475062', 'display_name': 'Mitsutoshi Yuzurihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090349', 'display_name': 'Tsumura Research Institute (Japan)', 'ror': 'https://ror.org/0095dm157', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210090349']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mitsutoshi Yuzurihara', 'raw_affiliation_strings': ['Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami‐machi, Inashiki‐gun, Ibaraki 300‐1192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Central Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami‐machi, Inashiki‐gun, Ibaraki 300‐1192, Japan', 'institution_ids': ['https://openalex.org/I4210090349']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030628555', 'display_name': 'Yūji Maruyama', 'orcid': 'https://orcid.org/0000-0001-5425-0791'}, 'institutions': [{'id': 'https://openalex.org/I165735259', 'display_name': 'Gunma University', 'ror': 'https://ror.org/046fm7598', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I165735259']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Maruyama', 'raw_affiliation_strings': ['Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3‐39‐22 Showa‐machi, Maebashi‐shi, Gunma 371‐8511, Japan', 'institution_ids': ['https://openalex.org/I165735259']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4430, 'currency': 'USD', 'value_usd': 4430, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.022, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.825397, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '13', 'issue': '7', 'first_page': '593', 'last_page': '596'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13677', 'display_name': 'Magnolia and Illicium research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13677', 'display_name': 'Magnolia and Illicium research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9729, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11989', 'display_name': 'Oxidative Organic Chemistry Reactions', 'score': 0.9531, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/honokiol', 'display_name': 'Honokiol', 'score': 0.9990101}, {'id': 'https://openalex.org/keywords/magnolol', 'display_name': 'Magnolol', 'score': 0.9958224}, {'id': 'https://openalex.org/keywords/magnolia-officinalis', 'display_name': 'Magnolia officinalis', 'score': 0.98220575}, {'id': 'https://openalex.org/keywords/platycladus', 'display_name': 'Platycladus', 'score': 0.42621523}, {'id': 'https://openalex.org/keywords/elevated-plus-maze', 'display_name': 'Elevated plus maze', 'score': 0.42279112}], 'concepts': [{'id': 'https://openalex.org/C2781334404', 'wikidata': 'https://www.wikidata.org/wiki/Q5896650', 'display_name': 'Honokiol', 'level': 2, 'score': 0.9990101}, {'id': 'https://openalex.org/C2781009524', 'wikidata': 'https://www.wikidata.org/wiki/Q6732002', 'display_name': 'Magnolol', 'level': 2, 'score': 0.9958224}, {'id': 'https://openalex.org/C2780759288', 'wikidata': 'https://www.wikidata.org/wiki/Q1042288', 'display_name': 'Magnolia officinalis', 'level': 4, 'score': 0.98220575}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.5285049}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5261873}, {'id': 'https://openalex.org/C2777765862', 'wikidata': 'https://www.wikidata.org/wiki/Q62903', 'display_name': 'Anxiolytic', 'level': 3, 'score': 0.50484926}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46224308}, {'id': 'https://openalex.org/C2776869931', 'wikidata': 'https://www.wikidata.org/wiki/Q33482', 'display_name': 'Platycladus', 'level': 2, 'score': 0.42621523}, {'id': 'https://openalex.org/C173586616', 'wikidata': 'https://www.wikidata.org/wiki/Q5359685', 'display_name': 'Elevated plus maze', 'level': 3, 'score': 0.42279112}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3703477}, {'id': 'https://openalex.org/C188947578', 'wikidata': 'https://www.wikidata.org/wiki/Q200253', 'display_name': 'Traditional Chinese medicine', 'level': 3, 'score': 0.20943731}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2014991}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.116093844}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.107816786}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017705', 'descriptor_name': 'Lignans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018782', 'descriptor_name': 'Maze Learning', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001713', 'descriptor_name': 'Biphenyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018782', 'descriptor_name': 'Maze Learning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014867', 'descriptor_name': 'Water', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1099-1573(199911)13:7<593::aid-ptr520>3.0.co;2-f', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S206789554', 'display_name': 'Phytotherapy Research', 'issn_l': '0951-418X', 'issn': ['0951-418X', '1099-1573'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10548753', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.81, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 6, 'referenced_works': ['https://openalex.org/W2013102013', 'https://openalex.org/W2014598010', 'https://openalex.org/W2032058764', 'https://openalex.org/W2035743528', 'https://openalex.org/W2041561931', 'https://openalex.org/W380863662'], 'related_works': ['https://openalex.org/W3148953490', 'https://openalex.org/W2393509608', 'https://openalex.org/W2385275126', 'https://openalex.org/W2384403401', 'https://openalex.org/W2383477593', 'https://openalex.org/W2375002555', 'https://openalex.org/W2358984200', 'https://openalex.org/W2121959229', 'https://openalex.org/W2108431862', 'https://openalex.org/W2004729403'], 'abstract_inverted_index': {'In': [0], 'our': [1], 'previous': [2], 'study': [3, 39], 'using': [4], 'an': [5, 24, 111], 'improved': [6], 'elevated': [7, 224], 'plus-maze': [8, 225], 'in': [9, 20, 159, 174, 210, 236], 'mice,': [10], 'the': [11, 17, 28, 45, 115, 133, 161, 175, 190, 194, 198, 205, 214, 223, 232], 'oriental': [12], 'herbal': [13], 'medicine': [14], 'Saiboku-to': [15], 'prolonged': [16], 'time': [18], 'spent': [19], 'open': [21], 'arms,': [22], 'showing': [23], 'anxiolytic': [25, 46, 112, 123, 163, 195], 'effect,': [26], 'and': [27, 50, 68, 71, 78, 81, 93, 106, 127, 145, 154, 203], 'effect': [29, 113, 196, 215], 'was': [30, 40, 178], 'mainly': [31], 'caused': [32], 'by': [33, 180], 'honokiol': [34, 49, 66, 76, 91, 188, 235], 'derived': [35], 'from': [36, 63, 73, 88], 'magnolia.': [37, 237], 'This': [38], 'carried': [41], 'out': [42], 'to': [43, 141], 'compare': [44], 'potentials': [47, 124], 'of': [48, 53, 125, 136, 143, 167, 197, 201, 216, 231, 234], 'water': [51, 199], 'extracts': [52], 'three': [54], 'magnolia': [55, 202, 211], 'samples;': [56], 'two': [57], 'being': [58, 83], 'Kara-koboku': [59], '(Magnolia': [60, 85], 'officinalis)': [61], '(KA:': [62], 'Zhejiang-sheng,': [64], 'China;': [65, 75], '0.25%': [67], 'magnolol': [69, 79, 94, 209], '1.16%,': [70], 'KB:': [72], 'Sichuan-sheng,': [74], '1.72%': [77], '1.71%),': [80], 'one': [82], 'Wa-koboku': [84], 'obovata)': [86], '(WA:': [87], 'Iwate-ken,': [89], 'Japan;': [90], '0.32%': [92], '0.81%).': [95], 'Seven': [96], 'daily': [97], 'treatments': [98], 'with': [99, 114], '0.1-1': [100], 'mg/kg': [101, 108, 129, 147, 156, 169], 'honokiol,': [102, 148], 'but': [103], 'not': [104], '0.2': [105, 146, 168], '1': [107], 'magnolol,': [109, 137], 'revealed': [110], 'peak': [116], 'potential': [117, 164], 'at': [118, 151], '0.': [119], '2': [120], 'mg/kg.': [121], 'The': [122], '40': [126], '80': [128], 'KA,': [130], 'which': [131], 'contained': [132], 'highest': [134], 'amount': [135], 'were': [138], 'almost': [139, 160], 'equivalent': [140], 'those': [142], '0.1': [144], 'respectively.': [149], 'KB,': [150], '11.6': [152], 'mg/kg,': [153], '62.5': [155], 'WA': [157], 'resulted': [158], 'same': [162], 'as': [165], 'that': [166, 187, 204, 222], 'honokiol.': [170, 217], 'No': [171], 'significant': [172], 'change': [173], 'ambulatory': [176], 'activity': [177], 'produced': [179], 'any': [181], 'drug': [182], 'treatment.': [183], 'These': [184], 'results': [185], 'suggest': [186], 'is': [189, 219, 227], 'chemical': [191], 'responsible': [192], 'for': [193, 229], 'extract': [200], 'other': [206], 'chemicals': [207], 'including': [208], 'scarcely': [212], 'influence': [213], 'It': [218], 'also': [220], 'considered': [221], 'test': [226], 'applicable': [228], 'evaluation': [230], 'content': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047825019', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2024-12-11T19:24:01.105754', 'created_date': '2016-06-24'}