Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2104407210', 'doi': 'https://doi.org/10.1146/annurev.neuro.21.1.445', 'title': 'REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE', 'display_name': 'REGIONALIZATION OF THE PROSENCEPHALIC NEURAL PLATE', 'publication_year': 1998, 'publication_date': '1998-03-01', 'ids': {'openalex': 'https://openalex.org/W2104407210', 'doi': 'https://doi.org/10.1146/annurev.neuro.21.1.445', 'mag': '2104407210', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9530503'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.neuro.21.1.445', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131371711', 'display_name': 'Annual Review of Neuroscience', 'issn_l': '0147-006X', 'issn': ['0147-006X', '1545-4126'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016994439', 'display_name': 'John L.R. Rubenstein', 'orcid': 'https://orcid.org/0000-0002-4414-7667'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John L. R. Rubenstein', 'raw_affiliation_strings': ['Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, California 94143-0984'], 'affiliations': [{'raw_affiliation_string': 'Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, California 94143-0984', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081821746', 'display_name': 'Kenji Shimamura', 'orcid': 'https://orcid.org/0000-0001-7102-6513'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenji Shimamura', 'raw_affiliation_strings': ['Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, California 94143-0984'], 'affiliations': [{'raw_affiliation_string': 'Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, California 94143-0984', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100760099', 'display_name': 'Salvador Martı́nez', 'orcid': 'https://orcid.org/0000-0002-9320-4103'}, 'institutions': [{'id': 'https://openalex.org/I80180929', 'display_name': 'Universidad de Murcia', 'ror': 'https://ror.org/03p3aeb86', 'country_code': 'ES', 'type': 'funder', 'lineage': ['https://openalex.org/I80180929']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Salvador Martinez', 'raw_affiliation_strings': ['Department of Morphology, Faculty of Medicine, University of Murcia, Murcia, 30100, Spain', 'UNIVERSIDAD DE MURCIA ,'], 'affiliations': [{'raw_affiliation_string': 'Department of Morphology, Faculty of Medicine, University of Murcia, Murcia, 30100, Spain', 'institution_ids': ['https://openalex.org/I80180929']}, {'raw_affiliation_string': 'UNIVERSIDAD DE MURCIA ,', 'institution_ids': ['https://openalex.org/I80180929']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056031438', 'display_name': 'Luis Puelles', 'orcid': 'https://orcid.org/0000-0002-9541-7073'}, 'institutions': [{'id': 'https://openalex.org/I80180929', 'display_name': 'Universidad de Murcia', 'ror': 'https://ror.org/03p3aeb86', 'country_code': 'ES', 'type': 'funder', 'lineage': ['https://openalex.org/I80180929']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Luis Puelles', 'raw_affiliation_strings': ['Department of Morphology, Faculty of Medicine, University of Murcia, Murcia, 30100, Spain', 'UNIVERSIDAD DE MURCIA ,'], 'affiliations': [{'raw_affiliation_string': 'Department of Morphology, Faculty of Medicine, University of Murcia, Murcia, 30100, Spain', 'institution_ids': ['https://openalex.org/I80180929']}, {'raw_affiliation_string': 'UNIVERSIDAD DE MURCIA ,', 'institution_ids': ['https://openalex.org/I80180929']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.207, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 546, 'citation_normalized_percentile': {'value': 0.900926, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '21', 'issue': '1', 'first_page': '445', 'last_page': '477'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11677', 'display_name': 'Congenital heart defects research', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/forebrain', 'display_name': 'Forebrain', 'score': 0.8528971}, {'id': 'https://openalex.org/keywords/floor-plate', 'display_name': 'Floor plate', 'score': 0.746085}, {'id': 'https://openalex.org/keywords/notochord', 'display_name': 'Notochord', 'score': 0.58283794}], 'concepts': [{'id': 'https://openalex.org/C2779715522', 'wikidata': 'https://www.wikidata.org/wiki/Q507027', 'display_name': 'Forebrain', 'level': 3, 'score': 0.8528971}, {'id': 'https://openalex.org/C78577261', 'wikidata': 'https://www.wikidata.org/wiki/Q3391691', 'display_name': 'Floor plate', 'level': 2, 'score': 0.746085}, {'id': 'https://openalex.org/C197849852', 'wikidata': 'https://www.wikidata.org/wiki/Q2314823', 'display_name': 'Neural plate', 'level': 4, 'score': 0.6957347}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.68277454}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.63686776}, {'id': 'https://openalex.org/C2776133846', 'wikidata': 'https://www.wikidata.org/wiki/Q243469', 'display_name': 'Notochord', 'level': 4, 'score': 0.58283794}, {'id': 'https://openalex.org/C533869091', 'wikidata': 'https://www.wikidata.org/wiki/Q75855', 'display_name': 'Cerebrum', 'level': 3, 'score': 0.5599864}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.4328089}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.37742236}, {'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.37123972}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.18167982}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.13335696}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.1253744}], 'mesh': [{'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016548', 'descriptor_name': 'Prosencephalon', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005314', 'descriptor_name': 'Embryonic and Fetal Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016548', 'descriptor_name': 'Prosencephalon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.neuro.21.1.445', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131371711', 'display_name': 'Annual Review of Neuroscience', 'issn_l': '0147-006X', 'issn': ['0147-006X', '1545-4126'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9530503', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'score': 0.79, 'display_name': 'Life below water'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 142, 'referenced_works': ['https://openalex.org/W1441505456', 'https://openalex.org/W146694943', 'https://openalex.org/W1496979921', 'https://openalex.org/W1518066461', 'https://openalex.org/W1540044666', 'https://openalex.org/W1567515623', 'https://openalex.org/W1588404026', 'https://openalex.org/W1606017150', 'https://openalex.org/W1751159137', 'https://openalex.org/W1767712531', 'https://openalex.org/W1888661686', 'https://openalex.org/W1890963650', 'https://openalex.org/W1902497723', 'https://openalex.org/W191342842', 'https://openalex.org/W1922106993', 'https://openalex.org/W1926770385', 'https://openalex.org/W1944789371', 'https://openalex.org/W1953764490', 'https://openalex.org/W1957841482', 'https://openalex.org/W1963911559', 'https://openalex.org/W1965444020', 'https://openalex.org/W1966435498', 'https://openalex.org/W1966895008', 'https://openalex.org/W1969596044', 'https://openalex.org/W1970642341', 'https://openalex.org/W1971075145', 'https://openalex.org/W1972255525', 'https://openalex.org/W1975439759', 'https://openalex.org/W1982087641', 'https://openalex.org/W1983493520', 'https://openalex.org/W1988930958', 'https://openalex.org/W1990500865', 'https://openalex.org/W1992865216', 'https://openalex.org/W1996808202', 'https://openalex.org/W2002821352', 'https://openalex.org/W2006136865', 'https://openalex.org/W2007535582', 'https://openalex.org/W2011678874', 'https://openalex.org/W2015038624', 'https://openalex.org/W2017173986', 'https://openalex.org/W2017204222', 'https://openalex.org/W2018496368', 'https://openalex.org/W2019907249', 'https://openalex.org/W2019997163', 'https://openalex.org/W2021031034', 'https://openalex.org/W2021103771', 'https://openalex.org/W2021186319', 'https://openalex.org/W2029846973', 'https://openalex.org/W2030180991', 'https://openalex.org/W2030712054', 'https://openalex.org/W2038158007', 'https://openalex.org/W2039493143', 'https://openalex.org/W2040773128', 'https://openalex.org/W2044084549', 'https://openalex.org/W2047837497', 'https://openalex.org/W2053212962', 'https://openalex.org/W2054379936', 'https://openalex.org/W2056418457', 'https://openalex.org/W2056918647', 'https://openalex.org/W2059614045', 'https://openalex.org/W2059755209', 'https://openalex.org/W2060708053', 'https://openalex.org/W2061191160', 'https://openalex.org/W2061230077', 'https://openalex.org/W2062457936', 'https://openalex.org/W2063852715', 'https://openalex.org/W2064792767', 'https://openalex.org/W2065200502', 'https://openalex.org/W2065774443', 'https://openalex.org/W2067315256', 'https://openalex.org/W2070259920', 'https://openalex.org/W2073288043', 'https://openalex.org/W2074210550', 'https://openalex.org/W2074626858', 'https://openalex.org/W2081939122', 'https://openalex.org/W2082759522', 'https://openalex.org/W2083777249', 'https://openalex.org/W2084137155', 'https://openalex.org/W2084329240', 'https://openalex.org/W2085525561', 'https://openalex.org/W2087178090', 'https://openalex.org/W2090204791', 'https://openalex.org/W2092423326', 'https://openalex.org/W2092692873', 'https://openalex.org/W2094145003', 'https://openalex.org/W2096548029', 'https://openalex.org/W2097888799', 'https://openalex.org/W2098069596', 'https://openalex.org/W2098667096', 'https://openalex.org/W2100836659', 'https://openalex.org/W2102428207', 'https://openalex.org/W2103168913', 'https://openalex.org/W2103206509', 'https://openalex.org/W2104407051', 'https://openalex.org/W2104789206', 'https://openalex.org/W2105165411', 'https://openalex.org/W2106250127', 'https://openalex.org/W2107683644', 'https://openalex.org/W2107735240', 'https://openalex.org/W2112302721', 'https://openalex.org/W2113320664', 'https://openalex.org/W2124123743', 'https://openalex.org/W2125068279', 'https://openalex.org/W2126245868', 'https://openalex.org/W2127312018', 'https://openalex.org/W2127510589', 'https://openalex.org/W2133571580', 'https://openalex.org/W2134327910', 'https://openalex.org/W2134376090', 'https://openalex.org/W2136317649', 'https://openalex.org/W2136633961', 'https://openalex.org/W2138526982', 'https://openalex.org/W2138596308', 'https://openalex.org/W2138643777', 'https://openalex.org/W2147977861', 'https://openalex.org/W2147988623', 'https://openalex.org/W2148316867', 'https://openalex.org/W2149200808', 'https://openalex.org/W2150553522', 'https://openalex.org/W2156659930', 'https://openalex.org/W2162581376', 'https://openalex.org/W2168870153', 'https://openalex.org/W2171329030', 'https://openalex.org/W2171508208', 'https://openalex.org/W2183066763', 'https://openalex.org/W2183822742', 'https://openalex.org/W2184674120', 'https://openalex.org/W2187208469', 'https://openalex.org/W2226645062', 'https://openalex.org/W2261459112', 'https://openalex.org/W2281602208', 'https://openalex.org/W2320629447', 'https://openalex.org/W2373226512', 'https://openalex.org/W2396242620', 'https://openalex.org/W2397027487', 'https://openalex.org/W2415069483', 'https://openalex.org/W2416249938', 'https://openalex.org/W2489546502', 'https://openalex.org/W2499143130', 'https://openalex.org/W2505768127', 'https://openalex.org/W2738128030', 'https://openalex.org/W4235679393'], 'related_works': ['https://openalex.org/W2796106', 'https://openalex.org/W2363598208', 'https://openalex.org/W230989899', 'https://openalex.org/W2182146986', 'https://openalex.org/W2084981578', 'https://openalex.org/W2080032008', 'https://openalex.org/W2043082186', 'https://openalex.org/W2039158609', 'https://openalex.org/W2020486468', 'https://openalex.org/W1593258843'], 'abstract_inverted_index': {'Recent': [0], 'embryological': [1, 130], 'studies': [2, 33, 133], 'are': [3, 22], 'beginning': [4], 'to': [5, 17, 24, 79], 'establish': [6], 'that': [7, 21, 34, 60, 74, 138], 'the': [8, 12, 36, 45, 65, 75, 80, 92, 100, 104, 116, 121, 136, 140, 144], 'underlying': [9], 'organization': [10, 43], 'of': [11, 44, 91, 99, 103, 123, 143], 'forebrain': [13], 'may': [14, 109], 'be': [15, 110], 'reduced': [16], 'relatively': [18], 'simple': [19], 'elements': [20], 'common': [23], 'all': [25], 'vertebrates.': [26], 'We': [27], 'begin': [28], 'this': [29], 'chapter': [30, 56], 'by': [31, 112], 'reviewing': [32], 'describe': [35], 'similarities': [37], 'in': [38, 49, 64, 89, 115], 'prospective': [39], 'fate': [40, 126], 'and': [41, 53, 94, 128, 131], 'molecular': [42], 'developing': [46], 'neural': [47, 106, 118], 'plate': [48, 96, 107], 'fish,': [50], 'frogs,': [51], 'chickens,': [52], 'mice.': [54], 'The': [55], 'next': [57], 'addresses': [58], 'mechanisms': [59, 137], 'regulate': [61], 'regional': [62], 'specification': [63], 'anterior': [66, 78, 117], 'central': [67, 87], 'nervous': [68], 'system.': [69], 'There': [70], 'is': [71, 134], 'now': [72], 'evidence': [73], 'axial': [76], 'mesendoderm': [77], 'notochord': [81], '(the': [82], 'prechordal': [83], 'plate)': [84], 'has': [85], 'a': [86], 'role': [88], 'induction': [90], 'floor': [93], 'basal': [95], 'primordia': [97], '(hypothalamus)': [98], 'forebrain.': [101, 145], 'Patterning': [102], 'anterolateral': [105], '(telencephalon)': [108], 'regulated': [111], 'FGF8': [113], 'produced': [114], 'ridge.': [119], 'Thus,': [120], 'synthesis': [122], 'information': [124], 'from': [125], 'mapping': [127], 'experimental': [129], 'genetic': [132], 'illuminating': [135], 'generate': [139], 'different': [141], 'components': [142]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2104407210', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-26T03:25:08.821842', 'created_date': '2016-06-24'}