Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2084981578', 'doi': 'https://doi.org/10.1126/science.2237443', 'title': 'Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord', 'display_name': 'Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord', 'publication_year': 1990, 'publication_date': '1990-11-16', 'ids': {'openalex': 'https://openalex.org/W2084981578', 'doi': 'https://doi.org/10.1126/science.2237443', 'mag': '2084981578', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2237443'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.2237443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066046626', 'display_name': 'Marysia Placzek', 'orcid': 'https://orcid.org/0000-0002-4106-9229'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marysia Placzek', 'raw_affiliation_strings': ['Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055429344', 'display_name': 'Marc Tessier‐Lavigne', 'orcid': 'https://orcid.org/0000-0003-4403-1514'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marc Tessier-Lavigne', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103355630', 'display_name': 'Toshiya Yamada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Toshiya Yamada', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027365948', 'display_name': 'Thomas M. Jessell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Jessell', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074064199', 'display_name': 'Jane Dodd', 'orcid': 'https://orcid.org/0000-0003-4211-8827'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane Dodd', 'raw_affiliation_strings': ['Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.044, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 298, 'citation_normalized_percentile': {'value': 0.987733, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '250', 'issue': '4983', 'first_page': '985', 'last_page': '988'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/notochord', 'display_name': 'Notochord', 'score': 0.99041855}, {'id': 'https://openalex.org/keywords/floor-plate', 'display_name': 'Floor plate', 'score': 0.9769201}, {'id': 'https://openalex.org/keywords/neuroepithelial-cell', 'display_name': 'Neuroepithelial cell', 'score': 0.7966028}, {'id': 'https://openalex.org/keywords/neurulation', 'display_name': 'Neurulation', 'score': 0.57519794}, {'id': 'https://openalex.org/keywords/neural-development', 'display_name': 'Neural Development', 'score': 0.538928}, {'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.500202}, {'id': 'https://openalex.org/keywords/organogenesis', 'display_name': 'Organogenesis', 'score': 0.49210924}], 'concepts': [{'id': 'https://openalex.org/C2776133846', 'wikidata': 'https://www.wikidata.org/wiki/Q243469', 'display_name': 'Notochord', 'level': 4, 'score': 0.99041855}, {'id': 'https://openalex.org/C78577261', 'wikidata': 'https://www.wikidata.org/wiki/Q3391691', 'display_name': 'Floor plate', 'level': 2, 'score': 0.9769201}, {'id': 'https://openalex.org/C2780594696', 'wikidata': 'https://www.wikidata.org/wiki/Q1127402', 'display_name': 'Neural tube', 'level': 3, 'score': 0.9215703}, {'id': 'https://openalex.org/C200707615', 'wikidata': 'https://www.wikidata.org/wiki/Q13652744', 'display_name': 'Neuroepithelial cell', 'level': 4, 'score': 0.7966028}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67342454}, {'id': 'https://openalex.org/C197849852', 'wikidata': 'https://www.wikidata.org/wiki/Q2314823', 'display_name': 'Neural plate', 'level': 4, 'score': 0.665605}, {'id': 'https://openalex.org/C102225024', 'wikidata': 'https://www.wikidata.org/wiki/Q1388375', 'display_name': 'Neurulation', 'level': 5, 'score': 0.57519794}, {'id': 'https://openalex.org/C30503417', 'wikidata': 'https://www.wikidata.org/wiki/Q958938', 'display_name': 'Organogenesis', 'level': 3, 'score': 0.49210924}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.48430172}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4297014}, {'id': 'https://openalex.org/C2778961482', 'wikidata': 'https://www.wikidata.org/wiki/Q25241', 'display_name': 'Vertebrate', 'level': 3, 'score': 0.41524455}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.2560292}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.24422568}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.2369824}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.1904042}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.16475466}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.084846735}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.08036789}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.052673787}], 'mesh': [{'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D004627', 'descriptor_name': 'Embryonic Induction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008648', 'descriptor_name': 'Mesoderm', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009672', 'descriptor_name': 'Notochord', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002490', 'descriptor_name': 'Central Nervous System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004627', 'descriptor_name': 'Embryonic Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008648', 'descriptor_name': 'Mesoderm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009672', 'descriptor_name': 'Notochord', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.2237443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2237443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1490707732', 'https://openalex.org/W1502467673', 'https://openalex.org/W1502842089', 'https://openalex.org/W1837022361', 'https://openalex.org/W1909841064', 'https://openalex.org/W1926789599', 'https://openalex.org/W1945116336', 'https://openalex.org/W1948235020', 'https://openalex.org/W1966448485', 'https://openalex.org/W1972604738', 'https://openalex.org/W1981451611', 'https://openalex.org/W1982031676', 'https://openalex.org/W1989500686', 'https://openalex.org/W1998354909', 'https://openalex.org/W2017248827', 'https://openalex.org/W2017690818', 'https://openalex.org/W2030850073', 'https://openalex.org/W2034923907', 'https://openalex.org/W2036728049', 'https://openalex.org/W2041059509', 'https://openalex.org/W2041551922', 'https://openalex.org/W2048083836', 'https://openalex.org/W2048969857', 'https://openalex.org/W2059886675', 'https://openalex.org/W2062509603', 'https://openalex.org/W206782820', 'https://openalex.org/W2075312842', 'https://openalex.org/W2081748379', 'https://openalex.org/W2085525561', 'https://openalex.org/W2086913146', 'https://openalex.org/W2091261982', 'https://openalex.org/W2096133068', 'https://openalex.org/W2120648798', 'https://openalex.org/W2131065802', 'https://openalex.org/W2140034535', 'https://openalex.org/W2159032420', 'https://openalex.org/W2197412176', 'https://openalex.org/W2347017761', 'https://openalex.org/W2406823485', 'https://openalex.org/W2462522178', 'https://openalex.org/W2887438214', 'https://openalex.org/W4239927990', 'https://openalex.org/W4243279772', 'https://openalex.org/W4253966021', 'https://openalex.org/W4322393517', 'https://openalex.org/W654190839'], 'related_works': ['https://openalex.org/W4388708681', 'https://openalex.org/W4285236920', 'https://openalex.org/W3184018328', 'https://openalex.org/W2344662702', 'https://openalex.org/W2080032008', 'https://openalex.org/W2048395347', 'https://openalex.org/W2043025001', 'https://openalex.org/W2021378522', 'https://openalex.org/W1993888492', 'https://openalex.org/W1979062316'], 'abstract_inverted_index': {'The': [0], 'floor': [1, 27, 44, 102], 'plate': [2, 45, 57], 'is': [3], 'a': [4, 33, 90], 'specialized': [5], 'group': [6], 'of': [7, 39, 48, 54, 79, 100], 'midline': [8, 68], 'neuroepithelial': [9], 'cells': [10, 53, 71], 'that': [11, 89], 'appears': [12], 'to': [13, 35], 'regulate': [14], 'cell': [15], 'differentiation': [16], 'and': [17, 58, 67], 'axonal': [18], 'growth': [19], 'in': [20, 42, 51, 83], 'the': [21, 37, 40, 55, 75, 80, 94, 97, 101], 'developing': [22], 'vertebrate': [23], 'nervous': [24], 'system.': [25], 'A': [26], 'plate-specific': [28], 'chemoattractant': [29, 50, 76], 'was': [30, 61], 'used': [31], 'as': [32], 'marker': [34], 'examine': [36], 'role': [38], 'notochord': [41, 81, 95], 'avian': [43], 'development.': [46, 84], 'Expression': [47], 'this': [49], 'lateral': [52], 'neural': [56, 59, 69], 'tube': [60, 70], 'induced': [62], 'by': [63], 'an': [64], 'ectopic': [65], 'notochord,': [66], 'did': [72], 'not': [73], 'express': [74], 'after': [77], 'removal': [78], 'early': [82], 'These': [85], 'results': [86], 'provide': [87], 'evidence': [88], 'local': [91], 'signal': [92], 'from': [93], 'induces': [96], 'functional': [98], 'properties': [99], 'plate.': [103]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084981578', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-14T00:00:21.898203', 'created_date': '2016-06-24'}