Abstract: It is demonstrated that the [3+2] cycloaddition of a nitrone to an alkyne is facile when the lengh of the tether connecting the two reacting sites is appropriate. The resulting [3+2] cycloaddition products, isoxazolidines can be further converted to 3-hydroxy-3-pyrrolin-2-ones and α-keto-β,γ-unsaturated esters by reductive and oxidative cleavage, respectively.
Publication Year: 1991
Publication Date: 1991-06-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 16
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