Title: C-(4-[18F]fluorophenyl)-N-phenyl nitrone: A novel 18F-labeled building block for metal free [3+2]cycloaddition
Abstract: Radiofluorination via [3+2]-nitrone-alkene cycloaddition was studied using the model reaction between 18F-labeled C-(4-fluorophenyl)-N-phenyl nitrone ([18F]1) and substituted maleimides 2a–c. [18F]1 was prepared in RCY of 73.6±5.8% and radiochemical purity of >95%. Cycloaddition of [18F]1 to 2a in toluene at 80 °C and in EtOH at 110 °C gave the respective isoxazolidine [18F]5a in >80% RCY at 10 min reaction time. Reaction between [18F]1 and 2b, c also went smoothly to afford the respective cycloaddition products in high radiochemical yields.
Publication Year: 2011
Publication Date: 2011-09-15
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 16
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