Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins

Name: Work Video:
Duration: 3 min 30 s
Hyun Ae Woo; Woojin Jeong; Tong‐Shin Chang; Kwang Joo Park; Sung Jun Park; Jeong Soo Yang; Sue Goo Rhee
{'id': 'https://openalex.org/W2101032933', 'doi': 'https://doi.org/10.1074/jbc.c400496200', 'title': 'Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins', 'display_name': 'Reduction of Cysteine Sulfinic Acid by Sulfiredoxin Is Specific to 2-Cys Peroxiredoxins', 'publication_year': 2004, 'publication_date': '2004-12-09', 'ids': {'openalex': 'https://openalex.org/W2101032933', 'doi': 'https://doi.org/10.1074/jbc.c400496200', 'mag': '2101032933', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15590625'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400496200', 'pdf_url': 'http://www.jbc.org/article/S0021925820761727/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820761727/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016556468', 'display_name': 'Hyun Ae Woo', 'orcid': 'https://orcid.org/0000-0002-3483-1203'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hyun Ae Woo', 'raw_affiliation_strings': ['Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea', 'Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea', 'institution_ids': ['https://openalex.org/I138925566']}, {'raw_affiliation_string': 'Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102999433', 'display_name': 'Woojin Jeong', 'orcid': 'https://orcid.org/0000-0003-1280-0067'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Woojin Jeong', 'raw_affiliation_strings': ['¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': '¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085515614', 'display_name': 'Tong‐Shin Chang', 'orcid': 'https://orcid.org/0000-0003-4472-5436'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tong-Shin Chang', 'raw_affiliation_strings': ['¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': '¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068441099', 'display_name': 'Kwang Joo Park', 'orcid': 'https://orcid.org/0000-0001-5870-1836'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kwang Joo Park', 'raw_affiliation_strings': ['¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': '¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056463929', 'display_name': 'Sung Jun Park', 'orcid': 'https://orcid.org/0000-0001-6897-8740'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sung Jun Park', 'raw_affiliation_strings': ['¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': '¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102143018', 'display_name': 'Jeong Soo Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeong Soo Yang', 'raw_affiliation_strings': ['Laboratory of Biophysical Chemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biophysical Chemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210106489', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020834497', 'display_name': 'Sue Goo Rhee', 'orcid': 'https://orcid.org/0000-0002-4740-4956'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sue Goo Rhee', 'raw_affiliation_strings': ['¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': '¶ Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 7.247, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 310, 'citation_normalized_percentile': {'value': 0.932763, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '280', 'issue': '5', 'first_page': '3125', 'last_page': '3128'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11884', 'display_name': 'Redox biology and oxidative stress', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11884', 'display_name': 'Redox biology and oxidative stress', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11641', 'display_name': 'Insect and Pesticide Research', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sulfinic-acid', 'display_name': 'Sulfinic acid', 'score': 0.85408413}, {'id': 'https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase', 'display_name': 'Glyceraldehyde 3-phosphate dehydrogenase', 'score': 0.6064481}, {'id': 'https://openalex.org/keywords/peroxiredoxin', 'display_name': 'Peroxiredoxin', 'score': 0.49577627}], 'concepts': [{'id': 'https://openalex.org/C2780731314', 'wikidata': 'https://www.wikidata.org/wiki/Q420304', 'display_name': 'Sulfinic acid', 'level': 2, 'score': 0.85408413}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.7821778}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.68511146}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.67460716}, {'id': 'https://openalex.org/C134792803', 'wikidata': 'https://www.wikidata.org/wiki/Q424886', 'display_name': 'Glyceraldehyde 3-phosphate dehydrogenase', 'level': 4, 'score': 0.6064481}, {'id': 'https://openalex.org/C2780416994', 'wikidata': 'https://www.wikidata.org/wiki/Q419462', 'display_name': 'Peroxiredoxin', 'level': 4, 'score': 0.49577627}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.26610875}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.20933753}, {'id': 'https://openalex.org/C162008176', 'wikidata': 'https://www.wikidata.org/wiki/Q419305', 'display_name': 'Peroxidase', 'level': 3, 'score': 0.06936669}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400496200', 'pdf_url': 'http://www.jbc.org/article/S0021925820761727/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c400496200', 'pdf_url': 'http://www.jbc.org/article/S0021925820761727/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1270671049', 'https://openalex.org/W1576616161', 'https://openalex.org/W1967099953', 'https://openalex.org/W1968991720', 'https://openalex.org/W1970519591', 'https://openalex.org/W1973129732', 'https://openalex.org/W1983397667', 'https://openalex.org/W1989369141', 'https://openalex.org/W1993058298', 'https://openalex.org/W2008203769', 'https://openalex.org/W2011948827', 'https://openalex.org/W2017265125', 'https://openalex.org/W2017642315', 'https://openalex.org/W2021422282', 'https://openalex.org/W2021769399', 'https://openalex.org/W2029253559', 'https://openalex.org/W2043929237', 'https://openalex.org/W2049713754', 'https://openalex.org/W2051546433', 'https://openalex.org/W2054730594', 'https://openalex.org/W2056184839', 'https://openalex.org/W2059129711', 'https://openalex.org/W2065846398', 'https://openalex.org/W2067138633', 'https://openalex.org/W2076218928', 'https://openalex.org/W2084893631', 'https://openalex.org/W2088411222', 'https://openalex.org/W2092463196', 'https://openalex.org/W2098048169', 'https://openalex.org/W2136573391', 'https://openalex.org/W2147785354', 'https://openalex.org/W2167424909', 'https://openalex.org/W2335883500', 'https://openalex.org/W2797816625', 'https://openalex.org/W4243512717'], 'related_works': ['https://openalex.org/W4285269377', 'https://openalex.org/W4280592879', 'https://openalex.org/W33306441', 'https://openalex.org/W2945425255', 'https://openalex.org/W2806150378', 'https://openalex.org/W2282253714', 'https://openalex.org/W2142412838', 'https://openalex.org/W2098048169', 'https://openalex.org/W2067588809', 'https://openalex.org/W2023511690'], 'abstract_inverted_index': {'Cysteine': [0, 216], 'residues': [1, 24, 217, 240, 976, 1461, 1604, 3996], 'of': [2, 25, 38, 50, 57, 60, 70, 86, 96, 108, 131, 139, 154, 157, 162, 165, 176, 186, 218, 241, 254, 266, 273, 276, 286, 302, 312, 324, 347, 355, 370, 373, 378, 381, 392, 402, 435, 483, 491, 581, 589, 658, 675, 801, 805, 889, 949, 969, 974, 1063, 1086, 1097, 1106, 1135, 1147, 1150, 1203, 1357, 1402, 1445, 1462, 1601, 1605, 1642, 1657, 1661, 1676, 1687, 1690, 1698, 1704, 1720, 1725, 1730, 2176, 2190, 2263, 2266, 2275, 2323, 2387, 2404, 2459, 2474, 2484, 2492, 2506, 2524, 2535, 2542, 2554, 2587, 2623, 2626, 2635, 2644, 2656, 2670, 2679, 2681, 2693, 2701, 2705, 2718, 2735, 2744, 2772, 2788, 2790, 2799, 2815, 2838, 2853, 2871, 2883, 2887, 2923, 2936, 2942, 2960, 3003, 3011, 3023, 3069, 3087, 3116, 3148, 3163, 3214, 3269, 3281, 3284, 3289, 3299, 3338, 3377, 3512, 3519, 3541, 3546, 3596, 3612, 3619, 3665, 3700, 3741, 3749, 3780, 3782, 3802, 3832, 3835, 3930, 3935, 3938, 3944, 3955, 3987, 3992, 4001, 4069, 4075, 4109, 4122, 4144, 4151, 4158, 4162, 4191, 4215, 4221, 4224, 4340, 4369, 4396, 4403, 4423, 4432, 4523, 4577, 4587, 4615], 'certain': [3, 219], 'peroxiredoxins': [4, 220, 676], '(Prxs)': [5, 221, 677], 'undergo': [6, 222], 'reversible': [7, 223, 1267], 'oxidation': [8, 224, 443, 482, 595, 1087, 1257, 1444, 2569, 2781, 2787, 3067, 4421], 'to': [9, 32, 48, 62, 93, 119, 192, 225, 248, 264, 278, 309, 335, 408, 439, 485, 586, 612, 644, 649, 653, 682, 922, 925, 953, 1003, 1007, 1014, 1022, 1028, 1055, 1067, 1187, 1194, 1258, 1264, 1411, 1447, 1453, 1456, 1596, 1644, 1667, 1683, 1700, 1715, 2114, 2116, 2121, 2124, 2183, 2279, 2400, 2419, 2562, 2598, 2651, 2769, 2811, 2948, 2973, 2996, 3103, 3131, 3137, 3179, 3191, 3217, 3241, 3533, 3538, 3576, 3657, 3817, 3826, 3989, 4048, 4055, 4082, 4237, 4274, 4279, 4282, 4292, 4330, 4352, 4365, 4375, 4535, 4537, 4554], 'sulfinic': [10, 33, 58, 84, 204, 226, 249, 274, 300, 420, 470, 605, 668, 1188, 1259, 1412, 1448, 1597, 1614, 1645, 1688, 1706, 1722, 2264, 2321, 2568, 2630, 2654, 2742, 2816, 2885, 3085, 3663, 4123, 4160, 4222, 4338, 4394, 4420], 'acid': [11, 205, 227, 421, 464, 471, 479, 669, 1105, 1140, 1189, 1260, 1413, 1449, 1618, 1646, 1723, 3995], '(Cys-SO2H)': [12, 228], 'and': [13, 76, 126, 134, 168, 202, 229, 292, 342, 350, 384, 418, 473, 574, 593, 606, 652, 892, 917, 964, 972, 1019, 1038, 1093, 1125, 1364, 1567, 1708, 1738, 1873, 2137, 2196, 2314, 2396, 2408, 2411, 2417, 2471, 2489, 2566, 2589, 2591, 2659, 2710, 2726, 2778, 2835, 2848, 2894, 2966, 3062, 3110, 3155, 3175, 3196, 3231, 3274, 3287, 3292, 3360, 3390, 3439, 3454, 3499, 3568, 3598, 3616, 3621, 3653, 3766, 3812, 3822, 3848, 3865, 3882, 3898, 4003, 4059, 4090, 4114, 4132, 4154, 4165, 4181, 4229, 4272, 4281, 4304, 4319, 4391, 4413, 4438, 4484, 4494, 4540, 4574, 4607], 'the': [14, 55, 83, 87, 97, 120, 160, 163, 230, 271, 299, 303, 313, 336, 376, 379, 445, 449, 453, 459, 466, 474, 587, 638, 672, 802, 886, 890, 900, 909, 918, 967, 970, 1008, 1015, 1023, 1033, 1064, 1084, 1126, 1133, 1138, 1148, 1180, 1350, 1602, 1655, 1685, 1696, 1702, 1721, 2117, 2188, 2261, 2270, 2273, 2324, 2401, 2425, 2469, 2487, 2504, 2522, 2531, 2555, 2585, 2592, 2618, 2624, 2627, 2633, 2641, 2645, 2653, 2668, 2671, 2677, 2690, 2702, 2719, 2755, 2763, 2813, 2859, 2872, 2884, 2902, 2907, 2914, 2920, 2924, 2943, 2957, 2970, 2974, 2987, 3028, 3084, 3117, 3157, 3161, 3188, 3212, 3267, 3279, 3297, 3419, 3515, 3542, 3556, 3587, 3610, 3617, 3662, 3668, 3689, 3730, 3742, 3750, 3790, 3795, 3800, 3840, 3844, 3851, 3883, 3894, 3921, 3933, 3953, 3975, 3998, 4067, 4073, 4106, 4129, 4139, 4149, 4159, 4219, 4243, 4261, 4337, 4366, 4372, 4393, 4419, 4424, 4428, 4447, 4478, 4555, 4584, 4613], 'reduction': [15, 63, 164, 185, 231, 279, 380, 401, 1703, 1719, 2636, 2814, 2882, 2988, 4121, 4157, 4203, 4220], 'reaction': [16, 232, 1352, 2308, 2720, 2989, 3033], 'is': [17, 190, 233, 406, 437, 577, 1074, 1082, 1117, 1128, 1183, 1192, 1663, 2760, 2767, 2994, 3277, 3295, 3648, 3706, 4206, 4492, 4518, 4546], 'catalyzed': [18, 234, 1354, 2990], 'by': [19, 64, 188, 235, 280, 404, 496, 615, 1046, 1078, 1088, 1121, 1130, 1158, 1167, 1355, 1653, 2329, 2478, 2496, 2573, 2602, 2762, 2784, 2794, 2820, 2898, 2917, 2929, 2969, 2991, 3074, 3077, 3173, 3198, 3437, 3452, 3463, 3586, 3708, 4097, 4204, 4240, 4407], 'sulfiredoxin': [20, 81, 236, 297, 1362], '(Srx).': [21, 237], 'Specific': [22, 238, 2389, 2786], 'Cys': [23, 239, 883, 898, 975, 1036, 1041, 1446, 1460, 1603, 2532, 2751, 3642, 4431], 'various': [26, 242, 1705, 4064, 4307, 4578], 'other': [27, 243, 1065, 1464, 4404], 'proteins': [28, 61, 197, 244, 277, 413, 1607, 1662, 2326, 2427, 2621, 2875, 3118, 3170, 3180, 3339, 3449, 3733, 4405], 'are': [29, 245, 493, 597, 807, 920, 956, 1044, 1593, 2609, 2617, 3467, 3474, 4117, 4563, 4610], 'also': [30, 246, 598, 1083, 1408, 1594, 2108, 2740, 2842, 3475, 3842, 4290, 4582], 'oxidized': [31, 247, 1186, 1595, 2186, 2325, 2416, 2864, 2961, 3820, 4448], 'acid,': [34, 250, 489, 1057, 1615], 'suggesting': [35, 251], 'that': [36, 46, 175, 184, 212, 252, 262, 391, 400, 428, 584, 604, 641, 977, 1043, 1116, 1179, 1712, 2272, 2723, 2830, 2861, 2941, 2986, 3181, 3215, 3288, 3340, 3647, 3756, 3794, 3830, 3923, 3985, 4202, 4387], 'formation': [37, 206, 253, 422, 3611, 3801], 'Cys-SO2H': [39, 187, 255, 403], 'might': [40, 207, 256, 423, 1647], 'be': [41, 208, 257, 424, 613, 650, 683, 1156, 1265, 1454, 3242, 4552], 'a': [42, 258, 881, 914, 1039, 1100, 1114, 1144, 1196, 1266, 1650, 1658, 1668, 1678, 2306, 2507, 2612, 2699, 2809, 3032, 3144, 3218, 3561, 3569, 3604, 3626, 3640, 3659, 3697, 3804, 3807, 3859, 4443, 4521], 'novel': [43, 259], 'posttranslational': [44, 260, 582], 'modification': [45, 261, 583], 'contributes': [47, 263, 585], 'regulation': [49, 265, 588], 'protein': [51, 214, 267, 430, 590, 664, 2510, 3071, 3147, 3159, 3286, 4057, 4426], 'function.': [52, 268, 591], 'To': [53, 269, 2688, 3686], 'examine': [54, 270], 'susceptibility': [56, 272], 'forms': [59, 69, 85, 130, 275, 285, 301, 346, 1109, 2265, 2553, 2643, 2655, 2704, 2743, 2837, 2866, 2870, 2886, 3010, 3086, 3114, 4161, 4223, 4339, 4395], 'Srx,': [65, 281, 514, 550, 2513, 2696, 2939, 3039, 3567], 'we': [66, 282, 1709, 2697, 3695, 3959], 'prepared': [67, 283, 2741, 4271], 'such': [68, 198, 284, 414, 498, 1161, 1677, 4527, 4616], 'all': [71, 287, 812, 3262], 'six': [72, 288, 947, 2556, 3263, 3543, 3751], 'mammalian': [73, 289, 2405, 2412, 2992, 2997, 3004, 3264, 3544, 3752], 'Prx': [74, 94, 98, 109, 111, 132, 135, 140, 166, 169, 177, 194, 200, 290, 310, 314, 325, 327, 348, 351, 356, 382, 385, 393, 410, 416, 803, 878, 903, 950, 1001, 1004, 1010, 1012, 1020, 1026, 1029, 1091, 1094, 1107, 1136, 1175, 1403, 1406, 1457, 1727, 1733, 1969, 2148, 2202, 2267, 2283, 2287, 2406, 2409, 2537, 2558, 2657, 2660, 2706, 2708, 2711, 2724, 2727, 2731, 2818, 2888, 2890, 2892, 2925, 2949, 2962, 2964, 2999, 3012, 3014, 3016, 3090, 3092, 3104, 3106, 3108, 3133, 3224, 3227, 3229, 3232, 3265, 3270, 3272, 3275, 3290, 3293, 3327, 3330, 3574, 3577, 3666, 3753, 3760, 3762, 3764, 3767, 3772, 3775, 3849, 3869, 3871, 3873, 3876, 3902, 3905, 4110, 4112, 4115, 4152, 4163, 4179, 4182, 4210, 4227, 4343, 4354, 4356, 4358, 4398, 4450, 4468, 4488, 4491], 'isoforms': [75, 291, 948, 3545, 3754, 4399, 4469], 'glyceraldehyde-3-phosphate': [77, 293, 517, 553, 1515], 'dehydrogenase': [78, 294, 1516], '(GAPDH).': [79, 295], 'Purified': [80, 296], 'reduced': [82, 151, 298, 367, 495, 614, 1076, 1129, 1157, 2620, 2642, 2672], 'four': [88, 121, 304, 337, 2646, 2750], '2-Cys': [89, 122, 193, 305, 338, 409, 1009, 1017, 1172, 1726, 1938, 2179, 2536, 2544, 2647, 2817, 2998, 3088, 3132, 3139, 3324, 3791, 3824, 3928, 3939, 3946, 4124, 4209, 4225, 4341, 4397, 4409, 4449, 4467, 4482, 4487], 'members': [90, 306], '(Prx': [91, 307, 951, 2181, 2560], 'I': [92, 133, 167, 308, 349, 383, 952, 1002, 1027, 2182, 2203, 2561, 2725, 2926, 2950, 3575], 'IV)': [95, 311, 2184], 'family': [99, 315, 804], 'in': [100, 124, 127, 145, 316, 340, 343, 361, 448, 456, 462, 469, 477, 600, 685, 809, 885, 899, 913, 979, 1090, 1201, 1608, 1665, 1670, 1718, 2187, 2305, 2550, 2584, 2876, 3031, 3152, 3253, 3278, 3296, 3349, 3374, 3392, 3483, 3514, 3609, 3703, 3957, 4013, 4066, 4072, 4128, 4138, 4171, 4175, 4187, 4195, 4212, 4231, 4309, 4440, 4533, 4612], 'vitro,': [101, 317], 'but': [102, 137, 171, 318, 353, 387, 1165, 2539, 2729, 2867, 3135, 3769, 3941, 4071, 4400], 'it': [103, 319, 1154, 1191, 4550], 'did': [104, 172, 320, 388, 3784, 3837, 4006], 'not': [105, 138, 173, 321, 354, 389, 611, 1142, 1166, 1451, 1620, 2576, 2686, 2730, 2738, 2803, 2868, 3206, 3251, 3257, 3326, 3770, 3785, 3798, 3838, 4007, 4168, 4185, 4401, 4547], 'affect': [106, 322, 3786, 3839, 4008], 'those': [107, 323, 3891, 4402], 'V,': [110, 326, 1737, 2891, 2963, 3015, 3091, 3107], 'VI,': [112, 328, 1095, 1137, 2410, 2661, 2732, 2893, 2965, 3017, 3093, 3109, 3331, 4228, 4344, 4359], 'or': [113, 142, 179, 329, 358, 395, 487, 662, 1169, 1405, 2073, 2123, 2291, 2486, 2511, 2548, 3018, 3094, 3140, 3496, 3517, 3719, 3729, 3774, 3806, 3875, 3904, 3950, 3974, 3990, 4102, 4174, 4259, 4345, 4360, 4489], 'GAPDH.': [114, 180, 330, 396, 2747, 4361, 4414], 'Furthermore,': [115, 331, 1443, 3814], 'Srx': [116, 158, 189, 332, 374, 405, 1699, 1713, 1844, 1907, 2465, 2583, 2638, 2649, 2736, 2993, 3005, 3150, 3638, 3702, 3783, 3811, 3815, 3847, 3864, 3895, 3924, 3931, 3956, 3973, 4005, 4205, 4216, 4258, 4283, 4388, 4434], 'bound': [117, 333], 'specifically': [118, 334, 1077, 1717, 2831, 4389], 'Prxs': [123, 339, 1939, 2180, 2608, 2694, 3825, 3940, 4125, 4483, 4609], 'vitro': [125, 341, 4014], 'cells.': [128, 344, 4197, 4233], 'Sulfinic': [129, 345, 592, 2177, 2391, 2533, 2552, 2607, 3009, 3936], 'II,': [136, 352, 3273, 3763, 3872, 4113, 4357], 'VI': [141, 178, 201, 357, 394, 417, 1021, 1407, 1739, 2288, 2712, 3276, 3776, 3906, 4153, 4164], 'GAPDH,': [143, 203, 359, 419, 516, 552, 2122, 2413, 3095, 3111], 'present': [144, 360, 808], 'H2O2-treated': [146, 362, 3164], 'A549': [147, 363, 3961, 4196, 4232], 'cells': [148, 364, 686, 945, 3154, 3165, 3255, 3260, 3347, 3384, 3481, 3711, 3836, 3856, 3965, 4045, 4140, 4145, 4173, 4176, 4288, 4562], 'were': [149, 365, 609, 647, 1611, 2128, 2185, 2415, 2516, 2564, 2579, 2596, 2665, 2733, 3025, 3099, 3119, 3171, 3185, 3221, 3332, 3352, 3385, 3421, 3450, 3486, 3531, 3584, 3722, 3734, 4046, 4060, 4079, 4184, 4235, 4270, 4289, 4327], 'gradually': [150, 366, 2639, 2932], 'after': [152, 368, 3446, 3726, 4266], 'removal': [153, 369, 4614], 'H2O2;': [155, 371], 'overexpression': [156, 372, 4217], 'increased': [159, 375, 2278, 4137], 'rate': [161, 377, 4134], 'II': [170, 386, 2149, 3233], 'induce': [174, 390, 4056], 'These': [181, 397, 2983, 3914, 4198], 'results': [182, 398, 2664, 2915, 3915, 4199, 4385], 'suggest': [183, 399], 'specific': [191, 407, 1904, 2423, 2905, 2995, 3082, 3746, 4207, 4335], 'isoforms.': [195, 411], 'For': [196, 412], 'as': [199, 415, 499, 906, 1162, 1613, 2156, 2198, 2334, 2428, 3223, 3527, 3591, 3603, 3625, 4347, 4349, 4442, 4520, 4528, 4530, 4532], 'an': [209, 425, 578, 895, 1069, 1110, 3355, 3967, 4252], 'irreversible': [210, 426, 651], 'process': [211, 427], 'causes': [213, 429], 'damage.': [215, 431], 'The': [432, 666, 1080, 1102, 1400, 1640, 1674, 2320, 2715, 2851, 2881, 3066, 3097, 3236, 3383, 3432, 3594, 4043, 4094, 4286, 4415], 'sulfur': [433], 'atom': [434], 'cysteine': [436, 484, 667], 'able': [438, 921, 1193], 'assume': [440], 'several': [441], 'different': [442, 2691], 'states:': [444], '–2': [446], 'state': [447, 455, 461, 468, 476, 2322, 2570, 2909, 2976, 3068, 4422], 'sulfhydryl': [450], 'group': [451], '(–SH),': [452], '–1': [454], 'disulfide': [457, 486, 1073, 1112, 1127, 1145, 1197, 3805], '(–S–S–),': [458], '0': [460], 'sulfenic': [463, 488, 1056, 1104, 1139], '(–SOH),': [465], '+2': [467], '(–SO2H),': [472], '+4': [475], 'sulfonic': [478, 594, 607, 1617, 2836], '(–SO3H).': [480], 'Reversible': [481], 'both': [490, 2833], 'which': [492, 955, 1058, 1098, 1654, 2398, 2754, 2759, 3447, 3704, 3727, 4267, 4569], 'readily': [494], 'thiols': [497, 617, 1160], 'glutathione': [500, 523, 559, 2125, 4572], '(GSH)': [501], '1The': [502, 538], 'abbreviations': [503, 539], 'used': [504, 540, 2418, 3602, 3624], 'are:': [505, 541], 'GSH,': [506, 542], 'glutathione;': [507, 543], 'Trx,': [508, 544], 'thioredoxin;': [509, 545], 'Prx,': [510, 546, 2545, 2547, 3947, 3949, 4410, 4412], 'peroxiredoxin;': [511, 547], 'DTT,': [512, 548], 'dithiothreitol;': [513, 549], 'sulfiredoxin;': [515, 551], 'dehydrogenase;': [518, 554], 'HA,': [519, 555], 'hemagglutinin': [520, 556, 2118], 'epitope;': [521, 557], 'GST,': [522, 558], 'S-transferase;': [524, 560], 'ESI-MS,': [525, 561], 'electrospray': [526, 562, 2330], 'ionization–mass': [527, 563], 'spectrometry;': [528, 564], 'MALDI-TOF,': [529, 565], 'matrix-assisted': [530, 566, 3199], 'laser': [531, 567, 3200], 'desorption-ionization–time-of-flight;': [532, 568], 'HBSS,': [533, 569, 4303], "Hanks'": [534, 570, 3378], 'balanced': [535, 571, 3379], 'salt': [536, 572, 3380], 'solution.': [537, 573], 'thioredoxin': [575], '(Trx),': [576], 'important': [579], 'type': [580], 'states': [596], 'found': [599, 610, 681, 1263, 3240, 3333], 'proteins.': [601, 2840, 3008], 'However,': [602, 3322], 'given': [603, 3829], 'acids': [608], 'biological': [616], 'under': [618, 656], 'physiological': [619], 'conditions': [620, 657], '(1Jacob': [621], 'C.': [622, 1553], 'Holme': [623], 'A.L.': [624], 'Fry': [625], 'F.H.': [626], 'Org.': [627], 'Biomol.': [628], 'Chem.': [629, 724, 753, 868, 935, 1216, 1242, 1306, 1335, 1429, 1476, 1506, 1579, 1748, 1776, 1804, 1828, 1859, 1885, 1922, 1954, 1979, 2007, 2035, 2059, 2093, 2241, 2373, 2445, 4029, 4632], '2004;': [630, 793, 1392, 1559, 1860, 1923, 4030], '2:': [631], '1953-1956Crossref': [632], 'PubMed': [633, 705, 733, 762, 777, 796, 836, 856, 872, 939, 996, 1223, 1251, 1287, 1315, 1344, 1376, 1395, 1438, 1485, 1510, 1528, 1562, 1588, 1635, 1757, 1785, 1813, 1837, 1868, 1894, 1931, 1963, 1988, 2016, 2044, 2068, 2102, 2171, 2222, 2250, 2354, 2382, 2454, 3317, 3681, 4038, 4461, 4512, 4602, 4641], 'Scopus': [634, 706, 734, 763, 778, 797, 837, 857, 873, 940, 997, 1252, 1288, 1316, 1345, 1377, 1396, 1439, 1486, 1511, 1529, 1563, 1589, 1636, 1758, 1786, 1814, 1838, 1869, 1895, 1932, 1964, 1989, 2017, 2045, 2069, 2103, 2172, 2223, 2251, 2355, 2383, 2455, 3318, 3682, 4039, 4462, 4513, 4603, 4642], '(122)': [635], 'Google': [636, 708, 736, 765, 780, 799, 839, 859, 875, 942, 999, 1224, 1254, 1290, 1318, 1347, 1379, 1398, 1441, 1488, 1513, 1531, 1565, 1591, 1638, 1760, 1788, 1816, 1840, 1871, 1897, 1934, 1966, 1991, 2019, 2047, 2071, 2105, 2174, 2225, 2253, 2357, 2385, 2457, 3320, 3684, 4041, 4464, 4515, 4605, 4644], 'Scholar),': [637, 1348, 1489, 1514, 1532, 1566, 1592, 1841, 1872, 1935, 1967, 2106, 4606], 'hyperoxidation': [639, 1410], 'reactions': [640], 'give': [642], 'rise': [643], 'these': [645, 2519, 2839, 2854, 4188], 'moieties': [646], 'thought': [648], 'occur': [654], 'only': [655, 3323, 3926], 'extreme': [659], 'oxidative': [660], 'stress': [661], 'during': [663, 671, 2780, 2979, 3667], 'isolation.': [665], 'produced': [670, 2843, 4519], 'catalytic': [673, 2756, 3669], 'cycle': [674, 1641, 3670], 'was': [678, 1261, 1619, 1899, 2145, 2150, 2258, 2277, 2297, 2327, 2466, 2571, 2674, 2782, 2792, 2856, 2896, 3072, 3239, 3250, 3434, 3552, 3601, 3623, 4100, 4126, 4135, 4167, 4435], 'nevertheless': [679], 'recently': [680, 1262], 'reducible': [684], '(2Woo': [687, 1269, 2204, 2336], 'H.A.': [688, 711, 1231, 1270, 1293, 1850, 1913, 1941, 2205, 2228, 2337, 2360, 2432, 4020], 'Chae': [689, 718, 1234, 1271, 1300, 1764, 1820, 1948, 1995, 2051, 2206, 2235, 2338, 2367, 2439, 4620], 'H.Z.': [690, 719, 815, 1207, 1235, 1272, 1301, 1765, 1821, 1949, 1996, 2052, 2207, 2236, 2339, 2368, 2440, 4621], 'Hwang': [691, 1232, 1273, 2208, 2340], 'S.C.': [692, 1233, 1274, 2209, 2341], 'Yang': [693, 716, 1275, 1298, 1946, 2210, 2233, 2342, 2365, 2437], 'K.S.': [694, 717, 1227, 1276, 1299, 1947, 2082, 2211, 2234, 2343, 2366, 2438], 'Kang': [695, 712, 843, 983, 1228, 1277, 1294, 1792, 1942, 2023, 2212, 2229, 2344, 2361, 2433, 3304, 4499, 4650], 'S.W.': [696, 713, 844, 984, 1229, 1278, 1295, 1469, 1741, 1763, 1793, 1878, 1943, 1972, 1994, 2024, 2213, 2230, 2345, 2362, 2434, 3305, 4500, 4619, 4651], 'Kim': [697, 714, 849, 989, 1208, 1210, 1236, 1279, 1296, 1768, 1794, 1944, 1999, 2025, 2079, 2214, 2231, 2346, 2363, 2435, 3310, 4505, 4624], 'K.': [698, 817, 850, 990, 1211, 1237, 1280, 1769, 1795, 2000, 2026, 2215, 2347, 3311, 4506, 4625], 'Rhee': [699, 720, 824, 1212, 1238, 1281, 1302, 1744, 1772, 1800, 1822, 1855, 1881, 1918, 1950, 1975, 2003, 2031, 2053, 2089, 2216, 2237, 2348, 2369, 2441, 4025, 4628, 4654], 'S.G.': [700, 721, 825, 842, 982, 1213, 1239, 1282, 1303, 1745, 1773, 1801, 1823, 1856, 1882, 1919, 1951, 1976, 2004, 2032, 2054, 2090, 2217, 2238, 2349, 2370, 2442, 3303, 4026, 4498, 4590, 4629, 4655], 'Science.': [701, 792, 1283, 1391, 2218, 2350], '2003;': [702, 725, 754, 774, 1284, 1307, 1336, 1373, 1430, 1955, 2219, 2242, 2351, 2374, 2446, 3678, 4458], '300:': [703, 1285, 2220, 2352], '653-656Crossref': [704, 1286, 2221, 2353], '(465)': [707, 1289, 2224, 2356], 'Scholar,': [709, 737, 766, 781, 840, 860, 1225, 1291, 1319, 1380, 1761, 1789, 1817, 1992, 2020, 2048, 2226, 2358, 4645], '3Woo': [710, 1292, 2227, 2359], 'H.K.': [715, 1297, 1945, 2232, 2364, 2436], 'J.': [722, 751, 770, 1214, 1240, 1304, 1333, 1369, 1427, 1471, 1474, 1549, 1577, 1746, 1774, 1802, 1826, 1857, 1883, 1920, 1952, 1977, 2005, 2033, 2057, 2091, 2239, 2371, 2443, 3674, 4027, 4454, 4596, 4630], 'Biol.': [723, 752, 867, 934, 1215, 1241, 1305, 1334, 1428, 1475, 1505, 1578, 1747, 1775, 1803, 1827, 1858, 1884, 1921, 1953, 1978, 2006, 2034, 2058, 2092, 2240, 2372, 2444, 4028, 4631], '278:': [726, 755, 1308, 1337, 1431, 1956, 2243, 2375, 2447], '47361-47364Abstract': [727, 1309, 1957, 2244, 2376, 2448], 'Full': [728, 730, 757, 759, 1220, 1246, 1248, 1310, 1312, 1339, 1341, 1433, 1435, 1480, 1482, 1583, 1585, 1752, 1754, 1780, 1782, 1808, 1810, 1832, 1834, 1863, 1865, 1889, 1891, 1926, 1928, 1958, 1960, 1983, 1985, 2011, 2013, 2039, 2041, 2063, 2065, 2097, 2099, 2245, 2247, 2377, 2379, 2449, 2451, 4033, 4035, 4636, 4638], 'Text': [729, 731, 758, 760, 1221, 1247, 1249, 1311, 1313, 1340, 1342, 1434, 1436, 1481, 1483, 1584, 1586, 1753, 1755, 1781, 1783, 1809, 1811, 1833, 1835, 1864, 1866, 1890, 1892, 1927, 1929, 1959, 1961, 1984, 1986, 2012, 2014, 2040, 2042, 2064, 2066, 2098, 2100, 2246, 2248, 2378, 2380, 2450, 2452, 4034, 4036, 4637, 4639], 'PDF': [732, 761, 1222, 1250, 1314, 1343, 1437, 1484, 1587, 1756, 1784, 1812, 1836, 1867, 1893, 1930, 1962, 1987, 2015, 2043, 2067, 2101, 2249, 2381, 2453, 4037, 4640], '(200)': [735, 1317, 1965, 2252, 2384, 2456], '4Chevallet': [738, 1320], 'M.': [739, 1321, 1415, 1623], 'Wagner': [740, 1322, 1416], 'E.': [741, 748, 787, 1323, 1330, 1386, 1417, 1424], 'Luche': [742, 1324, 1418], 'S.': [743, 831, 1325, 1419, 1502, 1627, 1854, 1917, 4024], 'van': [744, 1326, 1420], 'Dorsselaer': [745, 1327, 1421], 'A.': [746, 832, 1328, 1422, 2088], 'Leize-Wagner': [747, 1329, 1423], 'Rabilloud': [749, 1331, 1425], 'T.': [750, 1332, 1426, 1500, 1625], '37146-37153Abstract': [756, 1338, 1432], '(146)': [764, 1346, 1440], '5Biteau': [767], 'B.': [768, 862, 929, 1367, 3672, 4452, 4649], 'Labarre': [769, 1368, 3673, 4453], 'Toledano': [771, 1370, 3675, 4455], 'M.B.': [772, 1371, 3676, 4456], 'Nature.': [773, 1372, 3677, 4457], '425:': [775, 1374, 3679, 4459], '980-984Crossref': [776, 1375, 3680, 4460], '(790)': [779, 1378, 3683, 4463], '6Budanov': [782, 1381], 'A.V.': [783, 1382], 'Sablina': [784, 1383], 'A.A.': [785, 1384], 'Feinstein': [786, 1385], 'Koonin': [788, 1387], 'E.V.': [789, 1388], 'Chumakov': [790, 1389], 'P.M.': [791, 1390], '304:': [794, 1393], '596-600Crossref': [795, 1394], '(613)': [798, 1397], 'Scholar).Members': [800], 'peroxidases': [806], 'organisms': [810], 'from': [811, 1119, 2130, 2146, 2152, 2858, 3160, 3187, 3581, 3736, 3997], 'kingdoms': [813], '(7Chae': [814], 'Robison': [816], 'Poole': [818], 'L.B.': [819], 'Church': [820], 'G.': [821, 823], 'Storz': [822], 'Proc.': [826], 'Natl.': [827], 'Acad.': [828], 'Sci.': [829], 'U.': [830], '1994;': [833], '91:': [834], '7017-7021Crossref': [835], '(697)': [838], '8Rhee': [841], 'Chang': [845, 985, 3306, 4501], 'T.S.': [846, 986, 1846, 1909, 3307, 4016, 4502], 'Jeong': [847, 987, 1847, 1910, 3308, 4017, 4503], 'W.': [848, 988, 1498, 1848, 1911, 2497, 3309, 4018, 4504], 'IUBMB': [851, 991, 3312, 4507], 'Life.': [852, 992, 3313, 4508], '2001;': [853, 993, 1580, 3314, 4509], '52:': [854, 994, 3315, 4510], '35-41Crossref': [855, 995, 3316, 4511], '(511)': [858, 998, 3319, 4514], '9Hofmann': [861], 'Hecht': [863, 930], 'H.J.': [864, 931], 'Flohe': [865, 932], 'L.': [866, 933, 1547], '2002;': [869, 936, 1243, 1477, 1507, 1632], '383:': [870, 937, 1508], '347-364Crossref': [871, 938], '(766)': [874, 941], 'Scholar).': [876, 943, 1000, 1255, 1399, 1442, 1639, 2254, 3321, 3685, 4042, 4465], 'All': [877, 3208, 4560], 'enzymes': [879, 904, 2673, 2819, 4211], 'contain': [880, 894], 'conserved': [882, 897, 1034], 'residue': [884, 2765, 3643], 'NH2-terminal': [887, 1035], 'portion': [888], 'molecule,': [891], 'most': [893], 'additional': [896], 'COOH-terminal': [901, 1040], 'region.': [902], 'exist': [905], 'homodimers,': [907], 'with': [908, 1061, 1113, 1171, 1198, 1349, 2269, 2518, 2521, 2582, 2695, 2713, 2826, 2901, 2913, 2934, 2938, 2946, 2981, 3080, 3101, 3166, 3183, 3194, 3211, 3244, 3335, 3343, 3354, 3370, 3388, 3423, 3443, 3456, 3488, 3509, 3525, 3536, 3555, 3661, 3713, 3724, 3744, 3759, 3771, 3789, 3819, 3850, 3858, 3893, 3927, 3966, 4085, 4146, 4242, 4251, 4260, 4277, 4302, 4314, 4333, 4350, 4474, 4566], 'two': [910, 1358, 2773], 'monomers': [911], 'arranged': [912], 'head-to-tail': [915], 'manner,': [916], 'dimers': [919], 'aggregate': [923], 'further': [924, 1185, 3918], 'form': [926, 1068, 1143, 1195, 3658], 'decamers': [927], '(9Hofmann': [928], 'Mammalian': [944], 'express': [946, 3261], 'VI),': [954], 'classified': [957], 'into': [958, 2468, 2776], 'three': [959, 3441], 'subgroups': [960], '(2-Cys,': [961], 'atypical': [962, 1016, 4408, 4486], '2-Cys,': [963], '1-Cys)': [965], 'on': [966, 2676, 3879, 3909, 4218], 'basis': [968, 2678], 'number': [971], 'position': [973, 2615, 3645], 'participate': [978], 'catalysis': [980], '(8Rhee': [981, 3302, 4497], 'IV': [1005, 1030, 3768, 3877, 4180], 'belong': [1006], 'subgroup,': [1011, 1018], 'V': [1013, 1092, 1108, 1404, 2268, 2407, 2658, 3294, 3328, 3773, 3903, 4183], '1-Cys': [1024, 2546, 3141, 3948, 4411, 4490], 'subgroup.': [1025], 'thus': [1031, 1648, 3916, 4200], 'possess': [1032], '(N-Cys)': [1037], '(C-Cys)': [1042], 'separated': [1045, 1118, 4104], '121': [1047], 'amino': [1048, 1123, 3994], 'acids.': [1049], 'During': [1050], 'catalysis,': [1051], 'peroxides': [1052, 1089], 'oxidize': [1053], 'N-Cys–SH': [1054, 1081, 1401], 'then': [1059, 2580, 3386, 3435, 4061, 4080, 4328], 'reacts': [1060], 'C-Cys–SH': [1062], 'subunit': [1066], 'intermolecular': [1070], 'disulfide.': [1071], 'This': [1072, 1256], 'subsequently': [1075], 'Trx.': [1079, 1131], 'site': [1085, 2757, 4430], 'neither': [1096, 4418], 'contains': [1099, 2749, 3639], 'C-Cys.': [1101], 'resulting': [1103, 1200, 2593, 3580, 3608], 'intramolecular': [1111], 'Cys–SH': [1115, 1152], 'N-Cys': [1120], '104': [1122], 'acids,': [1124], 'In': [1132, 2955], 'case': [1134], 'does': [1141, 1450, 3797], 'because': [1146, 2622, 4105, 4190], 'unavailability': [1149], 'another': [1151], 'nearby;': [1153], 'can': [1155, 4551], 'nonphysiological': [1159], 'dithiothreitol': [1163], '(DTT)': [1164], 'Trx': [1168], 'GSH.Studies': [1170], 'Prxs,': [1173, 3089, 3325, 3792, 4226, 4342], 'mainly': [1174], 'I,': [1176, 1734, 2707, 2889, 3013, 3105, 3230, 3271, 3761, 3870, 4111, 4355], 'have': [1177, 1694, 2107, 2806, 3982], 'indicated': [1178, 2985, 3029, 3468, 4201], 'N-Cys–SOH': [1181], 'intermediate': [1182], 'occasionally': [1184], 'before': [1190, 3365, 3504], 'C-Cys–SH,': [1199], 'inactivation': [1202], 'peroxidase': [1204, 2683], 'activity': [1205, 2684, 3652, 4011], '(10Chae': [1206], 'I.H.': [1209], '1993;': [1217], '268:': [1218], '16815-16821Abstract': [1219], '11Yang': [1226], 'Woo': [1230, 1849, 1912, 4019], '277:': [1244, 1478], '38029-38036Abstract': [1245], '(369)': [1253], 'step': [1268], 'back': [1351], 'being': [1353], 'each': [1356, 3070, 3540, 3582, 3748, 4475], 'ATP-dependent': [1359], 'reductases': [1360, 1689], 'designated': [1361], '(Srx)': [1363], 'sestrin': [1365], '(5Biteau': [1366, 3671, 4451], 'undergoes': [1409], '(4Chevallet': [1414], 'appear': [1452, 1682], 'restricted': [1455], 'enzymes.': [1458], 'Critical': [1459], 'many': [1463], 'proteins,': [1465, 1707], 'including': [1466, 4371], 'α1-antitrypsin': [1467], '(12Griffiths': [1468], 'King': [1470], 'Cooney': [1472], 'C.L.': [1473], '25486-25492Abstract': [1479], '(76)': [1487], 'carbonic': [1490], 'anhydrase': [1491], 'III': [1492, 3291, 4116], '(13Mallis': [1493], 'R.J.': [1494], 'Hamann': [1495], 'M.J.': [1496, 1555], 'Zhao': [1497], 'Zhang': [1499, 1624], 'Hendrich': [1501, 1626], 'Thomas': [1503, 1628], 'J.A.': [1504, 1629], '649-662Crossref': [1509], '(91)': [1512], '(GAPDH)': [1517], '(14Souza': [1518], 'J.M.': [1519], 'Radi': [1520], 'R.': [1521, 1551], 'Arch.': [1522], 'Biochem.': [1523, 2164], 'Biophys.': [1524, 2165], '1998;': [1525, 1749, 1777, 1886, 1980, 2008, 4633], '360:': [1526], '187-194Crossref': [1527], '(144)': [1530], 'protein-tyrosine': [1533], 'phosphatase': [1534], '1B': [1535], '(15Wang': [1536], 'Q.': [1537], 'Dube': [1538], 'D.': [1539], 'Friesen': [1540], 'R.W.': [1541], 'LeRiche': [1542], 'T.G.': [1543], 'Bateman': [1544], 'K.P.': [1545], 'Trimble': [1546], 'Sanghara': [1548], 'Pollex': [1550], 'Ramachandran': [1552], 'Gresser': [1554], 'Huang': [1556], 'Z.': [1557], 'Biochemistry.': [1558], '43:': [1560], '4294-4303Crossref': [1561], '(50)': [1564], 'metalloproteinases': [1568], '(16Fu': [1569], 'X.': [1570], 'Kassim': [1571], 'S.Y.': [1572], 'Parks': [1573], 'W.C.': [1574], 'Heinecke': [1575], 'J.W.': [1576], '276:': [1581], '41279-41287Abstract': [1582], '(404)': [1590], 'acid.': [1598], 'Indeed,': [1599], '1.4%': [1600], 'soluble': [1606, 3285], 'rat': [1609, 1843, 1906, 3038, 4004], 'liver': [1610], 'detected': [1612, 1621, 2610, 2783, 2863, 2928, 2945], 'whereas': [1616, 2940, 3890, 4477], '(17Hamann': [1622], 'Methods': [1630], 'Enzymol.': [1631], '348:': [1633], '146-156Crossref': [1634], '(63)': [1637], 'thiol': [1643], 'represent': [1649], 'redox': [1651, 1672], 'switch': [1652, 1680], 'function': [1656], 'wide': [1659], 'variety': [1660], 'regulated': [1664], 'response': [1666, 4534], 'change': [1669], 'intracellular': [1671], 'status.': [1673], 'operation': [1675], 'thiol-sulfinic': [1679], 'would': [1681], 'require': [1684], 'existence': [1686], 'broad': [1691, 4101], 'specificity.': [1692], 'We': [1693, 2805, 2841, 3981], 'examined': [1695, 2897, 3843], 'ability': [1697], 'catalyze': [1701], 'now': [1710], 'show': [1711], 'appears': [1714], 'act': [1716], 'groups': [1724], 'proteins.EXPERIMENTAL': [1728], 'PROCEDURESMaterials—Preparation': [1729], 'recombinant': [1731, 1842, 1874], 'human': [1732, 1875, 2075, 2154, 2194, 2286, 2464, 2557, 3149, 3566, 3701, 3863, 3962, 3972, 4002, 4257], 'III,': [1735, 2709, 2728, 3228, 3765, 3874], 'IV,': [1736, 3225], '(18Kang': [1740, 1877, 1971], 'Baines': [1742, 1770, 1796, 1879, 1973, 2001, 2027, 4626], 'I.C.': [1743, 1771, 1797, 1880, 1974, 2002, 2028, 4627], '273:': [1750, 1778, 1887, 1981, 2009, 4634], '6303-6311Abstract': [1751, 1888, 1982], '(405)': [1759, 1896, 1990], '19Kang': [1762, 1993], 'Seo': [1766, 1997, 4622, 4652], 'M.S.': [1767, 1791, 1998, 2022, 4623, 4653], '6297-6302Abstract': [1779, 2010, 4635], '(611)': [1787, 2018, 4643], '20Seo': [1790, 2021], 'Lee': [1798, 1851, 1914, 2029, 4021, 4593], 'T.H.': [1799, 2030], '2000;': [1805, 2036, 4599], '275:': [1806, 2037], '20346-20354Abstract': [1807, 2038], '(377)': [1815, 2046], '21Jin': [1818, 2049], 'D.Y.': [1819, 2050], 'Jeang': [1824, 2055], 'K.T.': [1825, 2056], '1997;': [1829, 2060], '272:': [1830, 2061], '30952-30961Abstract': [1831, 2062], '(384)': [1839, 2070], '(22Chang': [1845, 1908, 4015], 'S.M.': [1852, 1915, 4022], 'Park': [1853, 1916, 4023], '279:': [1861, 1924, 4031], '50994-51001Abstract': [1862, 1925, 4032], '(304)': [1870, 1933, 4040], 'Trx1': [1876, 2076], 'Scholar)': [1898, 2072], 'described': [1900, 2157, 2199, 2335, 2429, 3528, 3592], 'previously.': [1901], 'Rabbit': [1902, 2142], 'antisera': [1903], 'for': [1905, 1936, 1968, 2074, 2201, 2260, 2282, 2299, 2390, 2424, 2503, 2906, 3006, 3027, 3083, 3358, 3362, 3367, 3426, 3491, 3501, 3506, 3529, 3565, 3573, 3650, 3716, 3747, 3862, 3868, 3887, 3901, 3920, 3970, 4052, 4063, 4208, 4248, 4255, 4296, 4306, 4336, 4446], 'sulfinylated': [1937, 2426, 3007], '(3Woo': [1940, 2431], 'isoform': [1970], '(23Lee': [2077], 'S.R.': [2078], 'J.R.': [2080], 'Kwon': [2081, 4595], 'Yoon': [2083], 'H.W.': [2084], 'Levine': [2085], 'R.L.': [2086], 'Ginsburg': [2087], '1999;': [2094, 2168], '274:': [2095], '4722-4734Abstract': [2096], '(240)': [2104], 'been': [2109, 3655], 'described.': [2110], 'Mouse': [2111], 'monoclonal': [2112], 'antibodies': [2113, 2422, 2827, 2855, 2904, 2947, 2972, 3081, 3102, 3537, 3745, 4278, 4334, 4351], 'β-actin,': [2115], 'epitope': [2119], '(HA),': [2120], 'S-transferase': [2126], '(GST)': [2127], 'obtained': [2129, 2666, 2916], 'Abcam,': [2131], 'Santa': [2132, 2138], 'Cruz': [2133, 2139], 'Biotechnology,': [2134, 2140], 'Chemicon': [2135], 'International,': [2136], 'respectively.': [2141, 2514, 3096, 3112], 'muscle': [2143, 2293, 2746], 'GAPDH': [2144, 2294, 2549, 2748, 2779, 2791, 2895, 2967, 3019, 4166, 4230, 4346], 'Sigma.': [2147], 'purified': [2151], 'outdated': [2153], 'erythrocytes': [2155], '(24Kristensen': [2158], 'P.': [2159, 4647], 'Rasmussen': [2160], 'D.E.': [2161], 'Kristensen': [2162], 'B.I.': [2163], 'Res.': [2166], 'Commun.': [2167], '262:': [2169], '127-131Crossref': [2170], '(37)': [2173], 'Scholar).Preparation': [2175], 'Proteins—Human': [2178], 'presence': [2189, 2586, 2625, 3518, 4074], 'H2O2': [2191, 2276, 2313, 3373, 3833, 4051, 4070, 4147, 4295, 4544, 4588, 4617], '(1': [2192], 'mm),': [2193], 'Trx1,': [2195], 'DTT': [2197], 'previously': [2200, 2430, 2807, 3983], 'A': [2255, 3530, 4119], 'similar': [2256, 3827], 'procedure': [2257, 2810], 'followed': [2259, 2601, 3076], 'preparation': [2262], 'exception': [2271, 3213], 'concentration': [2274, 3022], '3': [2280], 'mm': [2281, 2312, 2316, 3041, 3046, 3049, 3057, 3060, 3064, 3397, 3402, 3405, 3408, 4050, 4294], 'V.': [2284], 'Recombinant': [2285], '(250': [2289, 2295], 'μg)': [2290, 2296, 4326], 'rabbit': [2292, 2421, 2745], 'incubated': [2298, 2581, 2698, 3026, 3422, 4062, 4305], '10': [2300, 3368, 3375, 3507, 4053, 4297], 'min': [2301, 3369, 3428, 3508, 4054, 4298], 'at': [2302, 2611, 3429, 3644], '30': [2303, 3427], '°C': [2304], '250-μl': [2307], 'mixture': [2309, 2700, 2721, 3034], 'containing': [2310, 3035], '4': [2311, 3510], '50': [2315, 3040], 'Tris-HCl': [2317, 3042, 3398], '(pH': [2318, 3043, 3399], '7.5).': [2319], 'verified': [2328, 2572], 'ionization-mass': [2331], 'spectrometry': [2332, 2798, 3204, 3466], '(ESI-MS)': [2333], 'Scholar).Generation': [2386], 'Antibodies': [2388], 'Proteins—Three': [2392], 'peptides,': [2393], 'AFTPGCSKTH,': [2394], 'DFTPVCTTEL,': [2395], 'KIISNASCTTN,': [2397], 'correspond': [2399], 'oxidation-sensitive': [2402], 'sites': [2403, 2473, 2491], 'respectively,': [2414], 'generate': [2420], 'Scholar).Construction': [2458], 'Expression': [2460], 'Vectors—Complementary': [2461], 'DNA': [2462], 'encoding': [2463], 'cloned': [2467], 'BamHI': [2470, 2490], 'NotI': [2472], 'pEBG-SrfI': [2475], '(kindly': [2476, 2494], 'provided': [2477, 2495, 3917], 'Y.': [2479], 'Liu,': [2480], 'NIA,': [2481], 'National': [2482], 'Institutes': [2483], 'Health)': [2485], 'XbaI': [2488], 'pCGN': [2493], 'Herr,': [2498], 'Cold': [2499], 'Spring': [2500], 'Harbor': [2501], 'Laboratory)': [2502], 'expression': [2505, 3356, 3489, 3714, 3968, 4253], 'GST-Srx': [2508, 3184, 3249, 3359, 3494, 3497], 'fusion': [2509, 3146, 3158, 3732], 'HA-tagged': [2512, 3971, 4256], 'Cells': [2515, 4234], 'transfected': [2517, 3353, 3487, 3712, 3960, 4044, 4287], 'vectors': [2520, 3490, 3715], 'use': [2523], 'FuGENE': [2525], '6': [2526], '(Roche': [2527], 'Applied': [2528], 'Science).RESULTSSrx': [2529], 'Reduces': [2530], 'Acid': [2534], 'Enzymes': [2538, 3134], 'Not': [2540, 3136, 3942], 'That': [2541, 3943], 'Atypical': [2543, 3138, 3945], 'Vitro—': [2551], 'isozymes': [2559], 'VI)': [2563], 'prepared,': [2565], 'their': [2567, 4192], 'ESI-MS': [2574], '(data': [2575, 2685, 2737, 2802, 3205, 3256], 'shown).': [2577, 2687, 2804, 3207, 3258], 'They': [2578], 'MgCl2': [2588], 'ATP,': [2590, 3061], 'assay': [2594], 'mixtures': [2595], 'subjected': [2597, 3190, 3532, 4081, 4236, 4273, 4329], 'two-dimensional': [2599, 2716, 2918], 'PAGE': [2600], 'immunoblot': [2603, 2821, 2877, 2899, 2921, 3078, 3534, 4083, 4275, 4331], 'analysis': [2604, 2717, 2822, 2878, 2900, 3079, 3535, 3740, 4084, 4276, 4332], '(Fig.': [2605, 2879, 2910, 2953, 3234, 3777, 3912, 3979, 4092], '1).': [2606], 'more': [2613], 'acidic': [2614], 'than': [2616], 'corresponding': [2619, 2873, 2903, 2971, 3178, 3216, 3976, 4262], 'negatively': [2628], 'charged': [2629], 'group.': [2631], 'Although': [2632, 4543], 'rates': [2634], 'differed,': [2637], 'regenerated': [2640], 'Prxs.': [2648, 4575], 'failed': [2650], 'reduce': [2652], 'however.': [2662], 'Similar': [2663], 'when': [2667, 3248], 'regeneration': [2669], 'monitored': [2675, 3073], 'recovery': [2680], 'Trx-dependent': [2682], 'confirm': [2689], 'reactivities': [2692], 'sufinic': [2703, 2834], 'Srx.': [2714, 2982, 3344, 4433], 'confirmed': [2722], 'substrates': [2734], 'shown).We': [2739], 'residues,': [2752], 'among': [2753], 'Cys149–SH,': [2758], 'activated': [2761], 'proton-extracting': [2764], 'His176,': [2766], 'sensitive': [2768], 'oxidation.': [2770], 'Incorporation': [2771], 'oxygen': [2774], 'atoms': [2775], 'Tsa1': [2777], 'ESI-MS.': [2785], 'Cys149': [2789], 'revealed': [2793, 2968, 3755], 'collision-induced': [2795], 'dissociation-tandem': [2796], 'mass': [2797, 3203, 3465], 'tryptic': [2800], 'peptides': [2801], 'developed': [2808], 'monitor': [2812], '(after': [2823], 'one-dimensional': [2824], 'PAGE)': [2825], '(anti-2-Cys': [2828], 'Prx-SO2)': [2829], 'recognize': [2832], 'anti-Prx': [2844, 2846, 4088], 'V-SO2,': [2845], 'VI-SO2,': [2847, 4089], 'anti-GAPDH-SO2': [2849, 4091], 'antibodies.': [2850], 'specificity': [2852, 3002, 3954], 'apparent': [2857, 4127, 4169], 'observation': [2860], 'they': [2862], '(sulfinic)': [2865, 3821], 'nonoxidized': [2869, 3823], 'target': [2874], '2).': [2880, 2911, 2954], 'hyperoxidized': [2908, 2975], 'Consistent': [2912], 'analysis,': [2919], 'intensity': [2922], 'band': [2927, 2944, 2958, 3238, 4095], 'anti-2-Cys': [2930, 4086, 4098], 'Prx-SO2': [2931, 4099], 'decreased': [2933], 'time': [2935], 'incubation': [2937, 2980, 3505], 'remained': [2951, 2977], 'unchanged': [2952, 2978], 'contrast,': [2956], 'intensities': [2959], 'data': [2984], 'enzymes.Fig.': [3000], '2Substrate': [3001], '(5': [3020], 'μm': [3021, 3037, 3372, 3521], 'each)': [3024], 'times': [3030, 3442, 4065, 4308, 4368], '1': [3036, 3056, 3059, 3401, 3407, 4049, 4293], '7.5),': [3044], '100': [3045, 3371, 3520], 'KCl,': [3047], '5': [3048, 3063], 'creatine': [3050, 3052], 'phosphate,': [3051], 'phosphokinase': [3053], '(25': [3054], 'milliunits/ml),': [3055], 'MgCl2,': [3058], 'GSH.': [3065], 'SDS-PAGE': [3075, 3453], 'blots': [3098], 'reprobed': [3100], 'Reduced': [3113], '(Re)': [3115], 'similarly': [3120], 'analyzed.View': [3121], 'Large': [3122, 3630, 4377], 'Image': [3123, 3631, 4378], 'Figure': [3124, 3632, 4379], 'ViewerDownload': [3125, 3633, 4380], 'Hi-res': [3126, 3634, 4381], 'image': [3127, 3635, 4382], 'Download': [3128, 3636, 4383], '(PPT)Srx': [3129], 'Binds': [3130], 'Prxs—We': [3142], 'expressed': [3143, 3252], 'GST': [3145, 3492, 3720, 3728, 3731, 3988], '(GST-Srx)': [3151], 'HeLa': [3153, 3254, 3259, 3346, 3480, 3710], 'precipitated': [3156, 3524, 3735], 'lysates': [3162, 3420, 4078, 4269, 4324], 'GSH-agarose': [3167, 3245], 'beads.': [3168], 'Bead-bound': [3169], 'fractionated': [3172, 3451], 'SDS-PAGE,': [3174], 'major': [3176, 3209], 'bands': [3177], 'coprecipitated': [3182], 'excised': [3186], 'gel,': [3189], 'in-gel': [3192], 'digestion': [3193], 'trypsin,': [3195], 'identified': [3197, 3222, 3462, 4437], 'desorption-ionization-time-of-flight': [3201], '(MALDI-TOF)': [3202], 'bands,': [3210], '50-kDa': [3219, 3237], 'protein,': [3220], 'GST-Mu,': [3226], '3A).': [3235], 'associated': [3243, 3334], 'beads': [3246], 'even': [3247], 'enzymes;': [3266], 'abundance': [3268], 'range': [3280, 3298], '3–7': [3282], 'μg/mg': [3283, 3301], '0.3–0.5': [3300], 'nor': [3329, 4427], 'GST-Srx.Fig.': [3336], '3Identification': [3337], 'interact': [3341, 3818], 'physically': [3342], 'A,': [3345], 'grown': [3348, 3482], '100-mm': [3350], 'dishes': [3351, 3485], 'vector': [3357, 3969, 3978, 4254, 4264], 'cultured': [3361, 3500], '24': [3363, 3502], 'h': [3364, 3503, 4250], 'treatment': [3366, 3834], 'ml': [3376, 3511], 'solution': [3381], '(HBSS).': [3382], 'washed': [3387, 3440, 4301], 'HBSS': [3389, 3513], 'disrupted': [3391], 'ice-cold': [3393], 'lysis': [3394, 3444], 'buffer': [3395], '(20': [3396, 4325], '7.4),': [3400], 'EDTA,': [3403], '150': [3404], 'NaCl,': [3406], '4-(2-aminoethyl)benzenesulfonyl': [3409], 'fluoride,': [3410], 'leupeptin': [3411], '(10': [3412, 3415, 4321], 'μg/ml),': [3413], 'aprotinin': [3414], 'μg/ml)).': [3416], 'After': [3417], 'centrifugation,': [3418], 'GSH-Sepharose': [3424, 3526], 'resin': [3425, 3433], 'room': [3430], 'temperature.': [3431], 'isolated': [3436], 'centrifugation': [3438], 'buffer,': [3445], 'bead-bound': [3448], 'stained': [3455, 3885], 'Coomassie': [3457], 'Brilliant': [3458], 'Blue': [3459], 'R-250.': [3460], 'Proteins': [3461, 3523], 'MALDI-TOF': [3464], '(right': [3469], 'lane);': [3470], 'molecular': [3471, 4107], 'size': [3472], 'standards': [3473], 'shown': [3476, 3984, 4363], '(left': [3477], 'lane).': [3478], 'B,': [3479], '60-mm': [3484], '(Mock),': [3493], '(WT),': [3495], '(C99S)': [3498, 3699], 'absence': [3516, 4068], 'H2O2.': [3522], '(α-)': [3539], 'Prx.': [3547, 3813], 'C,': [3548], 'yeast': [3549, 3852, 4441], 'strain': [3550], 'EGY48': [3551], 'sequentially': [3553], 'transformed': [3554, 3857, 3892], 'p8op': [3557], 'lacZ': [3558], 'reporter': [3559], 'plasmid,': [3560], 'pLexA': [3562], 'bait': [3563, 3860, 3896], 'plasmid': [3564, 3572, 3861, 3897], 'pB42AD': [3570, 3622], 'prey': [3571, 3866, 3899], 'VI.': [3578], 'Colonies': [3579], 'transformation': [3583], 'assayed': [3585], 'X-Gal': [3588], 'whole-plate': [3589], 'method': [3590], '(35).': [3593], 'combination': [3595, 3618], 'pLexA/p53': [3597], 'pB42AD/T': [3599], '(Clontech)': [3600], 'positive': [3605], 'control': [3606, 3628, 4130, 4172], '(+),': [3607], 'dark': [3613], 'blue': [3614, 3886], 'colonies,': [3615], 'pLexA/Srx': [3620], 'negative': [3627], '(–).View': [3629], '(PPT)Human': [3637], 'single': [3641], '99': [3646], 'essential': [3649], 'reductase': [3651, 4010, 4445], 'has': [3654], 'proposed': [3656], 'thiosulfinate': [3660, 3808], 'moiety': [3664], 'test': [3687], 'whether': [3688], 'Srx-Prx': [3690], 'interaction': [3691, 3845], 'indeed': [3692], 'involves': [3693], 'Cys99,': [3694], 'constructed': [3696], 'mutant': [3698], 'Cys99': [3705, 3781], 'replaced': [3707], 'Ser.': [3709], 'GST-Srx,': [3717], 'GST-Srx(C99S),': [3718], 'alone': [3721], 'treated': [3723], 'H2O2,': [3725], 'cell': [3737, 4268, 4579], 'lysates.': [3738], 'Immunoblot': [3739], 'precipitates': [3743], 'GST-hSrx': [3757], 'interacted': [3758], '3B).': [3778], 'Mutation': [3779], 'its': [3787, 4009], 'association': [3788, 3796], 'indicating': [3793], 'involve': [3799], 'either': [3803, 4170, 4353, 4485], 'linkage': [3809], 'between': [3810, 3846, 4481], 'appeared': [3816], 'extents,': [3828], 'omission': [3831], 'association.We': [3841], 'two-hybrid': [3853], 'system.': [3854], 'Yeast': [3855], 'plasmids': [3867, 3900], 'grew': [3878, 3907], 'selective': [3880, 3910], 'medium': [3881, 3911, 4311], 'colonies': [3884], 'β-galactosidase': [3888], 'activity,': [3889], 'poorly': [3908], '3C).': [3913], 'support': [3919], 'notion': [3922], 'interacts': [3925], 'Prxs.Overexpression': [3929], 'Promotes': [3932], 'Reduction': [3934], 'Forms': [3937], 'GAPDH—To': [3951], 'study': [3952], 'cells,': [3958, 4131], 'lung': [3963], 'epithelial': [3964], 'empty': [3977, 4263], '4).': [3980, 4093], 'attachment': [3986], 'deletion': [3991], '16': [3993], 'NH2': [3999], 'terminus': [4000], 'measured': [4012], 'exposed': [4047, 4291], 'sulfinylation': [4058, 4150], 'cycloheximide.': [4076], 'Cell': [4077, 4323], 'Prx-SO2,': [4087], 'recognized': [4096], 'partially': [4103], 'sizes': [4108], 'similar.': [4118], 'gradual': [4120], 'this': [4133], 'greatly': [4136], 'expressing': [4141, 4177], 'HA-Srx.': [4142, 4178], 'Treatment': [4143], 'induced': [4148], 'GAPDH;': [4155], 'however,': [4156], 'analyzed': [4186], 'experiments': [4189], 'low': [4193], 'concentrations': [4194], 'cells.Fig.': [4213], '4Effect': [4214], 'transient': [4238, 4585], 'transfection': [4239], 'electroporation': [4241], 'Nucleofector': [4244], 'instrument': [4245], '(Amaxa': [4246], 'Biosystems)': [4247], '36': [4249], '(pCGN),': [4265], 'HA': [4280], '(upper': [4284], 'panels).': [4285], '(0.16': [4299], 'h),': [4300], 'F-12K': [4310], '(Invitrogen)': [4312], 'supplemented': [4313], '10%': [4315], 'fetal': [4316], 'bovine': [4317], 'serum': [4318], 'cycloheximide': [4320], 'μg/ml).': [4322], 'well': [4348, 4531], 'Times': [4362], 'refer': [4364], 'total': [4367], 'incubation,': [4370], '10-min': [4373], 'exposure': [4374, 4536], 'H2O2.View': [4376], '(PPT)DISCUSSIONOur': [4384], 'indicate': [4386], 'binds': [4390], 'reduces': [4392], 'exemplified': [4406], 'binding': [4416], 'requires': [4417], 'substrate': [4425], 'active': [4429], 'first': [4436], 'characterized': [4439], 'sulfinyl': [4444], 'Human': [4466], 'share': [4470], '60–80%': [4471], 'sequence': [4472, 4479], 'identity': [4473, 4480], 'other,': [4476], '∼10': [4493], '30%,': [4495], 'respectively': [4496], 'Scholar).Hydrogen': [4516], 'peroxide': [4517], 'result': [4522], 'normal': [4524], 'cellular': [4525], 'functions': [4526], 'respiration': [4529], 'radiation,': [4538], 'light,': [4539], 'redox-active': [4541], 'drugs.': [4542], 'itself': [4545], 'especially': [4548], 'reactive,': [4549], 'converted': [4553], 'highly': [4556], 'reactive': [4557], 'hydroxyl': [4558], 'radical.': [4559], 'aerobic': [4561], 'therefore': [4564], 'equipped': [4565], 'H2O2-removing': [4567], 'enzymes,': [4568], 'include': [4570], 'catalase,': [4571], 'peroxidases,': [4573], 'Stimulation': [4576], 'surface': [4580], 'receptors': [4581], 'induces': [4583], 'production': [4586], '(25Rhee': [4589], 'Bae': [4591], 'Y.S.': [4592], 'S-R.': [4594], "Science's": [4597], 'STKE.': [4598], '2000:': [4600], 'pe1Crossref': [4601], '(6)': [4604], 'cytosolic': [4608], 'implicated': [4611], '(19Kang': [4618], '26Zhang': [4646], 'Liu': [4648]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2101032933', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-07T15:52:36.915305', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
