Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2100046750', 'doi': 'https://doi.org/10.1186/1476-4598-10-40', 'title': 'Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer', 'display_name': 'Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer', 'publication_year': 2011, 'publication_date': '2011-04-18', 'ids': {'openalex': 'https://openalex.org/W2100046750', 'doi': 'https://doi.org/10.1186/1476-4598-10-40', 'mag': '2100046750', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21501485', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3100246'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-4598-10-40', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-10-40', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-10-40', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029919899', 'display_name': 'Francesco Crea', 'orcid': 'https://orcid.org/0000-0002-4903-2973'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Francesco Crea', 'raw_affiliation_strings': ['Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031063483', 'display_name': 'Elaine M. Hurt', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elaine M Hurt', 'raw_affiliation_strings': ['MedImmune, Gaithersburg, , USA'], 'affiliations': [{'raw_affiliation_string': 'MedImmune, Gaithersburg, , USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110168749', 'display_name': 'Lesley Mathews', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lesley A Mathews', 'raw_affiliation_strings': ['Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090485508', 'display_name': 'Stephanie Cabarcas‐Petroski', 'orcid': 'https://orcid.org/0000-0002-2310-5273'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephanie M Cabarcas', 'raw_affiliation_strings': ['Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001257378', 'display_name': 'Lei Sun', 'orcid': 'https://orcid.org/0000-0003-4350-3719'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lei Sun', 'raw_affiliation_strings': ['Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102108516', 'display_name': 'Víctor E. Márquez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130649', 'display_name': 'Frederick National Laboratory for Cancer Research', 'ror': 'https://ror.org/03v6m3209', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210130649', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Victor E Marquez', 'raw_affiliation_strings': ['Chemical Biology Laboratory, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Chemical Biology Laboratory, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I4210130649', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083693387', 'display_name': 'Romano Danesi', 'orcid': 'https://orcid.org/0000-0002-4414-8934'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Romano Danesi', 'raw_affiliation_strings': ['Department of Internal Medicine, Division of Pharmacology, Pisa Medical School, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Division of Pharmacology, Pisa Medical School, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012494061', 'display_name': 'William L. Farrar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William L Farrar', 'raw_affiliation_strings': ['Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA'], 'affiliations': [{'raw_affiliation_string': 'Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, USA', 'institution_ids': ['https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3170, 'currency': 'GBP', 'value_usd': 3888, 'provenance': 'doaj'}, 'apc_paid': {'value': 3170, 'currency': 'GBP', 'value_usd': 3888, 'provenance': 'doaj'}, 'fwci': 8.164, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 169, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/du145', 'display_name': 'DU145', 'score': 0.97311556}, {'id': 'https://openalex.org/keywords/prc2', 'display_name': 'PRC2', 'score': 0.8237314}], 'concepts': [{'id': 'https://openalex.org/C2776438761', 'wikidata': 'https://www.wikidata.org/wiki/Q5206280', 'display_name': 'DU145', 'level': 5, 'score': 0.97311556}, {'id': 'https://openalex.org/C2776915012', 'wikidata': 'https://www.wikidata.org/wiki/Q17125871', 'display_name': 'PRC2', 'level': 5, 'score': 0.8237314}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.7789481}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7755947}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7446859}, {'id': 'https://openalex.org/C50171091', 'wikidata': 'https://www.wikidata.org/wiki/Q17917770', 'display_name': 'EZH2', 'level': 4, 'score': 0.6726453}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.50681907}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.4755228}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.44856638}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4441878}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.37465376}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07128912}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07079896}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063146', 'descriptor_name': 'Polycomb-Group Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018874', 'descriptor_name': 'Spheroids, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018874', 'descriptor_name': 'Spheroids, Cellular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-4598-10-40', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-10-40', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100246', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21501485', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/1476-4598-10-40', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-10-40', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1561605754', 'https://openalex.org/W1588226643', 'https://openalex.org/W1935102817', 'https://openalex.org/W1967990571', 'https://openalex.org/W1969198724', 'https://openalex.org/W1974586435', 'https://openalex.org/W1977090021', 'https://openalex.org/W1987317889', 'https://openalex.org/W1996487270', 'https://openalex.org/W2003047394', 'https://openalex.org/W2014688699', 'https://openalex.org/W2025325346', 'https://openalex.org/W2029839795', 'https://openalex.org/W2033696561', 'https://openalex.org/W2035462330', 'https://openalex.org/W2043103956', 'https://openalex.org/W2044232049', 'https://openalex.org/W2067403798', 'https://openalex.org/W2077610561', 'https://openalex.org/W2079135826', 'https://openalex.org/W2079983476', 'https://openalex.org/W2086833517', 'https://openalex.org/W2092657860', 'https://openalex.org/W2102870100', 'https://openalex.org/W2103362277', 'https://openalex.org/W2110411949', 'https://openalex.org/W2111217479', 'https://openalex.org/W2111945749', 'https://openalex.org/W2113634596', 'https://openalex.org/W2115992310', 'https://openalex.org/W2126779839', 'https://openalex.org/W2128064256', 'https://openalex.org/W2131071584', 'https://openalex.org/W2133743991', 'https://openalex.org/W2134678284', 'https://openalex.org/W2137841107', 'https://openalex.org/W2137958038', 'https://openalex.org/W2141417189', 'https://openalex.org/W2149815730', 'https://openalex.org/W2153424791', 'https://openalex.org/W2402153749', 'https://openalex.org/W2425791025', 'https://openalex.org/W4237646278'], 'related_works': ['https://openalex.org/W92953675', 'https://openalex.org/W2954788551', 'https://openalex.org/W294322201', 'https://openalex.org/W2506336108', 'https://openalex.org/W2376303753', 'https://openalex.org/W2365043862', 'https://openalex.org/W2171401288', 'https://openalex.org/W2028082387', 'https://openalex.org/W1998341483', 'https://openalex.org/W1973861095'], 'abstract_inverted_index': {'Polycomb': [0], 'repressive': [1], 'complex': [2], '2': [3], '(PRC2)': [4], 'mediates': [5], 'gene': [6], 'silencing': [7], 'through': [8], 'histone': [9], 'H3K27': [10], 'methylation.': [11], 'PRC2': [12, 36, 68], 'components': [13], 'are': [14, 22], 'over-expressed': [15], 'in': [16, 76, 131, 137, 140, 149], 'metastatic': [17], 'prostate': [18], 'cancer': [19, 25], '(PC),': [20], 'and': [21, 50, 58, 61, 84, 88, 126, 139], 'required': [23], 'for': [24], 'stem': [26], 'cell': [27, 47, 55, 115], '(CSC)': [28], 'self-renewal.': [29], '3-Dezaneplanocin-A': [30], '(DZNeP)': [31], 'is': [32, 134, 148], 'an': [33], 'inhibitor': [34], 'of': [35, 44, 53, 93, 154], 'with': [37, 119], 'broad': [38], 'anticancer': [39], 'activity.we': [40], 'investigated': [41], 'the': [42, 91], 'effects': [43], 'DZNeP': [45, 79, 108, 120, 145], 'on': [46], 'proliferation,': [48], 'tumorigenicity': [49], 'invasive': [51], 'potential': [52], 'PC': [54, 114, 143], 'lines': [56], '(LNCaP': [57], 'DU145).Exploring': [59], 'GEO': [60], 'Oncomine': [62], 'databases,': [63], 'we': [64], 'found': [65], 'that': [66], 'specific': [67], 'genes': [69], '(EED,': [70], 'EZH2,': [71], 'SUZ12)': [72], 'predict': [73], 'poor': [74], 'prognosis': [75], 'PC.': [77], 'Non-toxic': [78], 'concentrations': [80], 'completely': [81], 'eradicated': [82], 'LNCaP': [83], 'DU145': [85], 'prostatosphere': [86], 'formation,': [87], 'significantly': [89, 122], 'reduced': [90], 'expression': [92], 'CSC': [94, 155], 'markers.': [95], 'At': [96], 'comparable': [97], 'doses,': [98], 'other': [99], 'epigenetic': [100], 'drugs': [101], 'were': [102, 121], 'not': [103], 'able': [104, 111], 'to': [105, 112], 'eradicate': [106], 'CSCs.': [107], 'was': [109], 'also': [110], 'reduce': [113], 'invasion.': [116], 'Cells': [117], 'pre-treated': [118], 'less': [123], 'tumorigenic': [124, 156], '(LNCaP)': [125], 'formed': [127], 'smaller': [128], 'tumors': [129], '(DU145)': [130], 'immunocompromised': [132], 'mice.DZNeP': [133], 'effective': [135], 'both': [136], 'vitro': [138], 'vivo': [141], 'against': [142], 'cells.': [144], 'antitumor': [146], 'activity': [147], 'part': [150], 'mediated': [151], 'by': [152], 'inhibition': [153], 'potential.': [157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2100046750', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 26}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-10T19:42:56.808286', 'created_date': '2016-06-24'}