Publication Information

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3414, 3508, 3521, 3603, 3609, 3636, 3715, 3732, 3807, 3827, 3855, 3867, 3903, 3915, 3958, 3980, 3993], 'the': [11, 581, 606, 626, 637, 664, 668, 688, 735, 769, 780, 872, 923, 959, 992, 1064, 1105, 1110, 1129, 1150, 1158, 1164, 1179, 1210, 1213, 1226, 1273, 1286, 1293, 1303, 1336, 1378, 1400, 1411, 1422, 1464, 1481, 1487, 1514, 1549, 1553, 1558, 1580, 1584, 1624, 1639, 1685, 1694, 1702, 1714, 1759, 1786, 1795, 1822, 1832, 1850, 1864, 1879, 1885, 1893, 1896, 1899, 1904, 1964, 1976, 2013, 2105, 2155, 2191, 2221, 2224, 2229, 2240, 2244, 2254, 2320, 2327, 2350, 2378, 2389, 2397, 2406, 2427, 2441, 2444, 2455, 2466, 2477, 2505, 2520, 2528, 2543, 2550, 2570, 2598, 2603, 2622, 2644, 2650, 2667, 2720, 2726, 2762, 2777, 2798, 2809, 2821, 2828, 2861, 2869, 2875, 2890, 2921, 2924, 2936, 2944, 2947, 2950, 2960, 3030, 3053, 3063, 3083, 3141, 3163, 3174, 3187, 3206, 3228, 3269, 3305, 3329, 3345, 3352, 3359, 3366, 3382, 3386, 3391, 3394, 3412, 3461, 3468, 3479, 3491, 3495, 3505, 3512, 3519, 3541, 3546, 3555, 3568, 3572, 3577, 3601, 3604, 3607, 3617, 3639, 3677, 3702, 3713, 3723, 3728, 3742, 3764, 3776, 3805, 3839, 3845, 3852, 3860, 3865, 3874, 3882, 3913, 3916, 3937, 3978, 3984, 3991, 4002, 4023, 4029, 4066, 4080], 'etiology': [12], 'and': [13, 26, 32, 51, 57, 75, 82, 121, 127, 134, 141, 149, 155, 166, 187, 193, 200, 207, 220, 239, 245, 264, 270, 288, 295, 334, 340, 347, 354, 362, 368, 379, 400, 406, 413, 420, 433, 457, 465, 471, 478, 485, 500, 506, 517, 530, 539, 546, 573, 591, 618, 631, 696, 707, 762, 765, 798, 802, 887, 970, 977, 1004, 1046, 1114, 1136, 1204, 1230, 1237, 1243, 1343, 1365, 1396, 1466, 1521, 1533, 1601, 1612, 1690, 1774, 1874, 1898, 1918, 1938, 1943, 1947, 1970, 1984, 2031, 2035, 2120, 2202, 2209, 2266, 2308, 2382, 2395, 2417, 2422, 2435, 2500, 2526, 2549, 2576, 2607, 2629, 2660, 2706, 2725, 2759, 2817, 2838, 2844, 2846, 2915, 2962, 2972, 3046, 3069, 3081, 3090, 3128, 3159, 3215, 3271, 3320, 3341, 3410, 3417, 3575, 3582, 3612, 3685, 3705, 3750, 3768, 3870, 3893, 4051], 'comorbidity': [14, 718, 894, 949, 1543, 1664, 1695, 1729, 1760, 1787, 1811, 2127, 2181, 2501], 'genetic': [16, 1919, 3198], 'diseases': [17, 646, 715, 785, 809, 830, 868, 877, 998, 1113, 1162, 1192, 1215, 1229, 1242, 1354, 1367, 1485, 1922, 2018, 2042, 2063, 2101, 2110, 2260, 2381, 2474, 2606, 2648, 2816, 2873, 2903, 2926, 2987, 3100, 3117, 3130, 3203, 3372, 3426, 3436, 3486, 3626, 3637, 3665, 3675, 3698, 3734, 3755, 3928, 3962, 4037, 4071], 'Solip': [18, 20, 231, 233, 446], 'Park': [19, 21, 94, 96, 232, 234, 307, 309, 907, 1498, 2140, 2701], 'School': [22, 47, 117, 183, 235, 260, 330, 396], 'Interdisciplinary': [24, 49, 119, 185, 237, 262, 332, 398, 463], 'Bioscience': [25, 50, 120, 148, 186, 238, 263, 333, 361, 399, 464, 499], 'Bioengineering,': [27, 52, 122, 188, 240, 265, 335, 401, 466], 'Pohang': [28, 53, 78, 123, 137, 151, 162, 189, 203, 216, 241, 266, 291, 336, 350, 364, 375, 402, 416, 429, 467, 481, 502, 513, 526, 542, 548], 'University': [29, 54, 79, 124, 138, 152, 163, 190, 204, 217, 242, 267, 292, 337, 351, 365, 376, 403, 417, 430, 468, 482, 503, 514, 527, 543], 'Science': [31, 56, 81, 126, 140, 154, 165, 192, 206, 219, 244, 269, 294, 339, 353, 367, 378, 405, 419, 432, 470, 484, 505, 516, 529, 545], 'Technology,': [33, 58, 83, 128, 142, 156, 167, 194, 208, 221, 246, 271, 296, 341, 355, 369, 380, 407, 421, 434, 472, 486, 507, 518, 531, 547], 'Pohang,': [34, 59, 84, 129, 143, 157, 168, 195, 209, 222, 247, 272, 297, 342, 356, 370, 381, 408, 422, 435, 473, 487, 508, 519, 532], 'Korea': [35, 60, 85, 103, 130, 144, 158, 169, 196, 210, 223, 248, 273, 298, 316, 343, 357, 371, 382, 409, 423, 436, 474, 488, 495, 509, 520, 533], 'Search': [36, 61, 86, 104, 170, 224, 249, 274, 299, 317, 383, 437], 'for': [37, 62, 87, 105, 171, 225, 250, 275, 300, 318, 384, 438, 1128, 1821, 2426, 2621, 2761, 3973], 'more': [38, 63, 88, 106, 172, 226, 251, 276, 301, 319, 385, 439, 648, 680, 932, 2164, 3407], 'papers': [39, 64, 89, 107, 173, 227, 252, 277, 302, 320, 386, 440], 'by': [40, 65, 90, 108, 174, 228, 253, 278, 303, 321, 387, 441, 671, 733, 1058, 1272, 1322, 1579, 1656, 1803, 2344, 2410, 2807, 2814, 2826, 2991, 3186, 3205], 'this': [41, 66, 91, 109, 175, 229, 254, 279, 304, 322, 388, 442, 1050, 1125, 1819, 2336, 2374, 2447, 2640, 3483], 'author': [42, 67, 92, 110, 176, 230, 255, 280, 305, 323, 389, 443, 592], 'Jae-Seong': [43, 45, 256, 258, 448], 'Yang': [44, 46, 257, 259], 'Young-Eun': [68, 70, 281, 283, 450], 'Shin': [69, 71, 282, 284], 'Division': [72, 131, 145, 197, 211, 285, 344, 358, 410, 424, 536], 'Molecular': [74, 133, 199, 287, 346, 412, 477, 538, 564, 1917], 'Life': [76, 135, 201, 289, 348, 414, 479, 540], 'Science,': [77, 136, 202, 290, 349, 415, 480, 541], 'Juyong': [93, 95, 306, 308, 452], 'Physics': [97, 310], 'Department,': [98, 311, 490], 'Kyung': [99, 312, 491], 'Hee': [100, 313, 492], 'University,': [101, 314, 493], 'Seoul,': [102, 315, 494], 'Sung': [111, 114, 324, 327, 454], 'Key': [112, 115, 325, 328, 455], 'Jang': [113, 116, 326, 329], 'Integrative': [147, 360, 498], 'Biotechnology,': [150, 363, 501], 'Biotechnology': [159, 372], 'Research': [160, 373, 511], 'Center,': [161, 374, 512], 'Sanguk': [177, 181, 390, 394, 458], 'Kim': [178, 182, 391, 395, 459], 'Corresponding': [179, 392], 'Author': [180, 393, 444], 'IT': [213, 426, 523], 'Convergence': [214, 427, 524], 'Engineering,': [215, 428, 525], 'Information': [445], 'Park1,': [447], 'Yang1,': [449], 'Shin2,': [451], 'Park3,': [453], 'Jang1,2,4,5': [456], '1,2,6': [460], '1School': [461], '2Division': [475], '3Physics': [489], '4Division': [496], '5Biotechnology': [510], '6Division': [521], '*Corresponding': [534], 'author.': [535], '790-784,': [549], 'Korea.': [550], 'Tel.:': [551], '+82': [552, 557], '54': [553, 558], '279': [554, 559], '2348;': [555], 'Fax:': [556], '2199;': [560], 'E-mail:': [561], '[email': [562], 'protected]': [563], 'Systems': [565], 'Biology': [566], '(2011)7:494https://doi.org/10.1038/msb.2011.29': [567], 'PDFDownload': [568], 'PDF': [569], 'article': [571], 'text': [572], 'main': [574], 'figures.': [575], 'Peer': [576], 'ReviewDownload': [577], 'summary': [579], 'editorial': [582, 586], 'decision': [583, 587], 'process': [584, 1462, 2231, 3267], 'including': [585, 3681], 'letters,': [588], 'reviewer': [589], 'comments': [590], 'responses': [593], 'to': [594, 597, 611, 650, 767, 891, 940, 945, 965, 989, 991, 1075, 1080, 1097, 1119, 1292, 1386, 1405, 1410, 1445, 1470, 1509, 1548, 1670, 1709, 1785, 1794, 1830, 1848, 1926, 2124, 2172, 2177, 2197, 2251, 2253, 2324, 2361, 2366, 2404, 2541, 2590, 2612, 2713, 2788, 2978, 3079, 3149, 3168, 3173, 3201, 3250, 3275, 3304, 3315, 3336, 3351, 3358, 3466, 3712, 3735, 3775, 3814, 3834, 3932, 3953, 3977, 3990, 4001, 4040, 4043], 'feedback.': [595], 'ToolsAdd': [596], 'favoritesDownload': [598], 'CitationsTrack': [599], 'CitationsPermissions': [600], 'Figures': [601], '&': [602], 'Info': [603], 'Proteins': [604], 'targeting': [605, 2230], 'same': [607, 1488, 2321, 2328, 2456, 2478, 3716, 3724], 'subcellular': [608, 633, 654, 660, 672, 684, 694, 708, 725, 739, 760, 963, 1031, 1059, 1088, 1115, 1137, 1175, 1198, 1219, 1231, 1238, 1263, 1345, 1442, 1562, 1577, 1598, 1613, 1620, 1627, 1657, 1691, 1750, 1772, 1827, 2195, 2234, 2293, 2329, 2345, 2383, 2398, 2437, 2463, 2485, 2494, 2514, 2547, 2578, 2581, 2608, 2630, 2716, 2745, 2805, 2818, 2840, 2854, 2886, 2909, 2930, 2951, 2963, 3071, 3088, 3103, 3247, 3298, 3318, 3419, 3445, 3535, 3558, 3614, 3629, 3654, 3670, 3708, 3758, 3770, 3794, 4010, 4020, 4076], 'tend': [610, 890, 2123, 2323], 'participate': [612], 'in': [613, 682, 943, 958, 974, 997, 1016, 1037, 1143, 1163, 1178, 1185, 1327, 1361, 1374, 1389, 1421, 1427, 1456, 1463, 1486, 1513, 1528, 1537, 1589, 1713, 1745, 1766, 1806, 1810, 1877, 1910, 2175, 2190, 2206, 2217, 2237, 2259, 2278, 2299, 2326, 2420, 2461, 2465, 2476, 2636, 2671, 2685, 2874, 2889, 2896, 2994, 3101, 3124, 3137, 3152, 3195, 3219, 3227, 3233, 3261, 3268, 3287, 3324, 3385, 3443, 3470, 3482, 3511, 3533, 3540, 3619, 3638, 3660, 3668, 3676, 3691, 3722, 3781, 3792, 3823, 3851, 3859, 3864, 3881, 3912, 3919, 3936, 3947, 3983, 4007, 4022, 4047, 4074], 'mutual': [614], 'protein–protein': [615, 838, 1977, 2071], 'interactions': [616, 839, 2072, 3507], '(PPIs)': [617, 840, 2073], 'are': [619, 647, 786, 810, 831, 929, 987, 1117, 1359, 1372, 1384, 1408, 1425, 1452, 1468, 2019, 2043, 2064, 2161, 2249, 2458, 2481, 2610, 2967, 2989, 3122, 3135, 3147, 3171, 3217, 3231, 3257, 3273, 3313, 3537, 3689, 3699, 3862, 3929, 3951, 4038, 4072], 'often': [620], 'functionally': [621, 1453, 3258], 'associated.': [622], 'Here,': [623, 3761], 'we': [624, 711, 1052, 1126, 1566, 1637, 1650, 1825, 2312, 2338, 2376, 2386, 2449, 2619, 2642, 2730, 2940, 2973, 3343, 3400, 3432, 3459, 3561, 3657, 3762, 4063], 'investigated': [625, 2377, 3751], 'relationship': [627, 1227, 1338, 2544], 'between': [628, 704, 758, 794, 867, 935, 1067, 1112, 1228, 1339, 1583, 1597, 1609, 1630, 1835, 1895, 2027, 2100, 2167, 2353, 2380, 2392, 2443, 2493, 2508, 2532, 2545, 2605, 2694, 2835, 3066, 3557, 3848], 'disease-associated': [629, 720, 1039, 1055, 1235, 1245, 1257, 1288, 1382, 1419, 1585, 1735, 1960, 2301, 2341, 2393, 2433, 2574, 2766, 2780, 2812, 3067, 3145, 3225, 3408, 3415, 3462, 3492, 3499, 3509, 3578, 3610], 'proteins': [630, 669, 721, 957, 961, 1040, 1056, 1236, 1246, 1289, 1383, 1403, 1420, 1586, 1703, 1736, 2189, 2193, 2302, 2317, 2342, 2434, 2452, 2575, 2664, 2710, 2781, 2793, 2813, 3068, 3146, 3166, 3226, 3285, 3311, 3323, 3409, 3416, 3493, 3510, 3611, 3714, 3767, 3850, 3899, 3950, 4067], 'their': [632, 1344, 2436, 2577, 2661, 2714, 2852, 2942, 3070, 3418, 3613, 3769], 'localizations,': [634, 695, 1429, 2235, 3235], 'based': [635, 1841, 2656, 2718, 3517, 3544, 3570, 3740], 'on': [636, 871, 1552, 1564, 1693, 1842, 1975, 2104, 2657, 2719, 3518, 3545, 3571, 3576, 3701, 3741], 'assumption': [638], 'that': [639, 698, 713, 779, 938, 1054, 1078, 1084, 1156, 1168, 1352, 1399, 1568, 1652, 1771, 1987, 2012, 2170, 2316, 2340, 2364, 2370, 2451, 2471, 2867, 2879, 2959, 2988, 3115, 3162, 3312, 3361, 3434, 3530, 3584, 3606, 3643, 3659, 3695, 3819, 3844, 3988, 4065], 'protein': [640, 738, 759, 985, 1030, 1102, 1258, 1460, 1473, 1561, 1715, 2247, 2292, 2546, 2595, 3265, 3278, 3377, 3463, 3500, 3514, 3579], 'pairs': [641, 732, 937, 1319, 1326, 1342, 1440, 1505, 1571, 1644, 1654, 1678, 1708, 1873, 2169, 2403, 2414, 2499, 2511, 3245], 'associated': [642, 811, 1704, 2044, 2318, 2453, 2482, 2663, 3376, 3430, 3816, 4068], 'with': [643, 812, 967, 1676, 1705, 1722, 1755, 2045, 2199, 2319, 2454, 2483, 2794, 2803, 3296, 3322, 3373, 3427, 3449, 3490, 3817, 4069], 'phenotypically': [644, 783, 828, 2016, 2061, 2472, 3663, 3696, 3753], 'similar': [645, 784, 829, 2017, 2062, 2473, 3628, 3649, 3664, 3697, 3707, 3754, 3757, 3774], 'likely': [649, 1385, 1469, 2459, 3148, 3274, 3719], 'be': [651, 941, 1035, 1120, 1387, 1446, 1545, 1574, 1710, 2173, 2297, 2613, 2979, 3150, 3251, 3302, 3337, 3815, 3835, 3933, 4041], 'connected': [652, 670, 723, 832, 878, 1057, 1409, 1575, 1655, 2065, 2111, 2343, 2512, 3172], 'via': [653, 724, 833, 1576, 1646, 1718, 2066, 2513], 'localization.': [655, 726, 2515], 'The': [656, 1619], 'spatial': [657, 954, 1159, 2186, 2870], 'constraints': [658], 'from': [659, 824, 1249, 1302, 1309, 1335, 2057, 2666, 3497, 3504, 3567], 'significantly': [662, 3027, 3050, 3836, 3879, 3934], 'strengthened': [663], 'disease': [665, 677, 691, 705, 731, 763, 773, 926, 936, 1076, 1082, 1170, 1270, 1296, 1318, 1325, 1341, 1504, 1516, 1523, 1550, 1570, 1631, 1643, 1653, 1698, 1707, 1724, 1872, 1889, 2158, 2168, 2322, 2362, 2368, 2402, 2408, 2413, 2457, 2479, 2498, 2510, 2524, 2534, 2555, 2564, 2658, 2688, 2695, 2802, 2837, 2881, 3019, 3402, 3531, 3565, 3645, 3679, 3738, 3785, 3876, 3920, 4003, 4014, 4031], 'associations': [666, 3472], 'localizations.': [673, 685, 709, 1199, 1220, 1264, 1376, 2384, 2486, 2819, 2910, 3072, 3139, 3299, 3326, 3655, 3671], 'In': [674, 1377, 1540, 1818, 1962, 2373, 3140, 3999], 'particular,': [675], 'certain': [676, 813, 1381, 1418, 1569, 2046, 3102, 3144, 3224, 3644], 'types': [678, 1018, 2280, 3646], 'were': [679, 722, 869, 1183, 1247, 1266, 1320, 1737, 2102, 2711, 2771, 2894, 3290, 3440, 3487, 3502, 3666], 'prevalent': [681], 'specific': [683, 2995, 3669, 4009], 'We': [686, 727, 1166, 1182, 1200, 1592, 1681, 1700, 1838, 2424, 2468, 2741, 2796, 2877, 2893, 2911, 2957, 3726], 'analyzed': [687, 2797], 'enrichment': [689, 1195, 2906, 2953, 3383, 3631, 3650, 4017], 'phenotypes': [692, 2653], 'within': [693, 1739, 3029, 3052, 4018], 'found': [697, 712, 1167, 1388, 1593, 1651, 1732, 2450, 2492, 2878, 3151, 3658, 3931, 4064], 'there': [699, 928, 2160, 3585], 'exists': [700, 3586], 'significant': [702, 2981, 2998, 3588, 3790], 'correlation': [703, 757, 1596, 1607, 1625, 2490, 3589, 3594], 'classes': [706, 1271, 2480, 3739, 3786, 4004], 'Furthermore,': [710, 1069, 2355, 2385, 2487], 'two': [714, 1439, 1734, 1778, 3244, 3405], 'displayed': [716], 'high': [717], 'when': [719, 1636, 1674, 1733, 1749, 3294, 3447], 'newly': [728], 'explained': [729], '7584': [730, 2533], 'using': [734, 746], 'context': [736], 'localization,': [740, 4011], 'which': [741, 2236, 2439, 2503, 3498], 'had': [742], 'not': [743, 1792, 3291], 'been': [744, 1014, 1091, 1507, 1924, 1954, 2276, 2584, 2682], 'identified': [745, 1321], 'shared': [747, 884, 2117, 2691], 'genes': [748, 796, 814, 1512, 2029, 2047, 2219, 3818], 'or': [749, 841, 1434, 1672, 2074, 2227, 3240, 3406], 'PPIs': [750], 'only.': [751], 'Our': [752, 1146, 1348, 2857, 3111], 'result': [753, 790, 2023], 'establishes': [754], 'direct': [756], 'association,': [764], 'helps': [766, 1847], 'understand': [768], 'mechanism': [770, 924, 1886, 2156], 'human': [772, 1133, 1191, 1515, 1888, 2407, 2573, 2626, 2902, 3513, 3737], 'progression.': [774, 1890, 2565], 'Synopsis': [775], 'It': [776, 1769, 3300], 'was': [777, 1259, 1290, 1300, 1333, 1731, 1753, 2010, 2491, 2785, 2824, 3026, 3049, 3077], 'shown': [778, 1508, 2011], 'emergence': [781, 2014], 'triggered': [787, 2020], 'molecular': [792, 842, 865, 880, 1554, 1581, 1648, 1781, 1804, 1833, 1860, 1865, 2025, 2075, 2098, 2113, 2390, 2506, 2530, 2551, 2692, 2992, 3703, 3717, 3846], 'connections': [793, 866, 881, 934, 1071, 1551, 1582, 1805, 1834, 1861, 2026, 2099, 2114, 2166, 2357, 2391, 2507, 2531, 2552, 3847], 'disease-causing': [795, 1798, 1928, 2028, 2218], '(Oti': [797, 2030], 'Brunner,': [799, 2032], '2007;': [800, 818, 847, 898, 2003, 2033, 2051, 2080, 2131, 4057], 'Zaghloul': [801, 2034], 'Katsanis,': [803, 2036], '2010).': [804, 863, 1048, 2037, 2096, 2310, 2708, 4061], 'From': [805, 2038, 2446], 'genetics,': [807], 'perspective': [808, 827, 2041, 2060], '(Goh': [815, 1277, 2048, 3746], 'et': [816, 820, 845, 849, 853, 857, 861, 896, 900, 904, 908, 981, 1000, 1023, 1042, 1253, 1278, 1314, 1476, 1491, 1495, 1499, 1815, 1914, 1993, 1997, 2001, 2005, 2049, 2053, 2078, 2082, 2086, 2090, 2094, 2129, 2133, 2137, 2141, 2213, 2262, 2285, 2304, 2332, 2676, 2698, 2702, 2734, 3021, 3281, 3474, 3523, 3747, 3830, 3923, 3964, 3996, 4055, 4059], 'al,': [817, 821, 846, 850, 854, 858, 862, 897, 901, 905, 909, 982, 1001, 1024, 1043, 1254, 1279, 1315, 1477, 1492, 1496, 1500, 1816, 1915, 1994, 1998, 2002, 2006, 2050, 2054, 2079, 2083, 2087, 2091, 2095, 2130, 2134, 2138, 2142, 2214, 2263, 2286, 2305, 2333, 2677, 2699, 2703, 2735, 3022, 3282, 3475, 3748, 3831, 3924, 3965, 3997, 4056, 4060], 'Feldman': [819, 2052], '2008),': [822, 2055], 'whereas': [823, 2056, 3197], 'proteomics': [826, 1971, 2059], 'biological': [834, 2067], 'modules': [835, 2068], 'such': [836, 882, 1070, 1392, 1430, 1541, 1934, 2069, 2115, 2356, 2783, 3155, 3212, 3236, 3398, 4078], 'pathways': [843, 889, 976, 2076, 2122, 2208, 4053], '(Lage': [844, 2077, 3473, 3829], 'Jiang': [848, 2081], '2008;': [851, 855, 902, 1002, 1493, 2084, 2088, 2135, 2264, 2700, 3023], 'Wu': [852, 2085], 'Linghu': [856, 2089], '2009;': [859, 906, 1497, 2092, 2139], 'Suthram': [860, 2093], 'These': [864, 2097, 4036], 'observed': [870, 2103, 2470, 2958], 'population': [873, 2106], 'level': [874, 1866, 2107], 'well:': [876, 2109], 'through': [879, 1094, 1930, 2112, 2587], 'genes,': [885, 1799, 2118], 'PPIs,': [886, 2119], 'metabolic': [888, 978, 2121, 2210, 3678], 'show': [892, 2125, 3642, 3788], 'elevated': [893, 2126], '(Rzhetsky': [895, 2128], 'Lee': [899, 1814, 2132], 'Zhernakova': [903, 2136], '2009a,': [910], '2009b).': [911, 2334], 'While': [912, 2144], 'these': [913, 1406, 1438, 2145, 3169, 3243], 'findings': [914, 2146], 'constitute': [915, 2147], 'step': [917, 2149], 'toward': [918, 2150], 'improving': [919, 2151], 'our': [920, 1108, 1634, 1843, 1845, 1882, 2152, 2601, 3362], 'understanding': [921, 1867, 2153, 2405], 'progression,': [927, 2159], 'still': [930, 2162], 'many': [931, 1017, 2163, 2279, 3309, 3661, 3674], 'molecule-level': [933, 2165], 'need': [939, 2171], 'explored': [942, 2174, 2388], 'order': [944, 2176], 'establish': [946, 2178], 'firmer': [948, 2180], 'association.': [950, 2182], 'Subcellular': [951, 1282, 1330, 2183, 2516, 3633], 'provides': [953, 1149, 1973, 2185, 2860], 'information': [955, 1284, 1752, 1829, 1974, 2187], 'cell;': [960, 2192], 'target': [962, 2194], 'localizations': [964, 986, 1060, 1116, 1232, 1443, 1692, 2196, 2248, 2346, 2464, 2579, 2609, 2717, 2746, 2770, 2931, 3089, 3104, 3248, 3333, 3536, 3615, 3795, 4021], 'interact': [966, 2198, 3321], 'appropriate': [968, 2200], 'partners': [969, 1474, 2201, 3279], 'form': [971, 2203], 'functional': [972, 995, 1968, 2204, 2257], 'complexes': [973, 2205, 3501], 'signaling': [975, 2207, 4052], 'processes': [979, 2211, 3921, 4050], '(Au': [980, 2212], '2007).': [983, 1280, 2215, 3476], 'Abnormal': [984, 2246], 'known': [988, 2250, 3314, 3952, 4039], 'lead': [990, 2252], 'loss': [993, 2255], 'effects': [996, 2258], '(Luheshi': [999, 2261], 'Laurila': [1003, 2265], 'Vihinen,': [1005, 2267], '2009).': [1006, 2268, 3222, 3966, 3998], 'For': [1007, 1518, 2269, 2639, 3010, 3180, 3370, 3672], 'example,': [1008, 1519, 2270, 3011, 3181, 3974], 'mis-localizations': [1009, 2271], 'nuclear/cytoplasmic': [1011, 2273], 'transport': [1012, 2274], 'have': [1013, 1506, 1923, 1953, 2275, 2313, 2851, 3627], 'detected': [1015, 2277], 'carcinoma': [1020, 2282], 'cells': [1021, 2283], '(Kau': [1022, 2284], '2004).': [1025, 1949, 2287], 'A': [1026, 2288, 3073], 'proper': [1027, 2233, 2289], 'identification': [1028, 2290], 'can': [1033, 1544, 2295], 'hence': [1034, 2296], 'useful': [1036, 2298], 'discovering': [1038, 2300], '(Giallourakis': [1041, 2303], '2005;': [1044, 1995, 1999, 2306], 'Calvo': [1045, 2307], 'Mootha,': [1047, 2309], 'With': [1049, 2335], 'understanding,': [1051, 2337], 'postulate': [1053, 2339], 'could': [1061, 1572, 2347], 'also': [1062, 1073, 1573, 1801, 2348, 2359, 2387, 2469, 3930], 'explain': [1063, 2349], 'phenotypic': [1065, 2351], 'similarities': [1066, 2352], 'diseases.': [1068, 1837, 2354, 3092], 'may': [1072, 2358], 'couple': [1074, 2360], 'progressions': [1077, 2363], 'contribute': [1079, 2365], 'multiple': [1081, 1484, 2367, 3653, 4019], 'manifestation,': [1083, 2369], 'is,': [1085, 2371], 'comorbidity.': [1086, 2372], 'has': [1090, 2583, 2681], 'extensively': [1092, 2585], 'studied': [1093, 1121, 2586, 2614], 'various': [1095, 1647, 2588, 4048], 'methods': [1096, 1933, 2589, 2845], 'determine': [1098, 2591], 'variety': [1100, 2593], 'functions.': [1103, 2596], 'To': [1104, 1123, 1233, 1556, 1633, 2597, 2616, 2934, 3389, 3477, 3553], 'best': [1106, 2599], 'knowledge,': [1109, 2602], 'connection': [1111, 2604], 'yet': [1118, 1907, 2611], 'systematically.': [1122, 2615], 'resolve': [1124, 2617], 'constructed,': [1127, 2425, 2620], 'first': [1130, 1823, 2428, 2623], 'time,': [1131, 2429, 2624], 'Disease-associated': [1134, 2627, 2709, 3284], 'Localization': [1138, 2631, 3771], '(DPL)': [1139, 2632], 'matrix': [1140, 1148, 1350, 1424, 2431, 2633, 2823, 2859, 3084, 3113, 3230, 3363, 3396, 3413, 3481, 3527, 3543, 3641, 3773, 3778, 3949, 3987, 4025], '(top': [1141, 2634], 'panel': [1142, 1588, 2635, 3780], 'Box': [1144, 1221, 1590, 2637, 3782], '1).': [1145, 1591, 2638, 2740, 2933, 3783], 'DPL': [1147, 1180, 1349, 1379, 1423, 2822, 2858, 2891, 3112, 3142, 3229, 3387, 3395, 3480, 3542, 3640, 3777], "'cellular": [1151, 2862], 'map': [1153, 1981, 2864], "diseases'": [1155, 2866], 'represents': [1157, 1480, 1623, 2868, 2946], 'index': [1160, 2871], 'cell.': [1165, 2467, 2876], 'each': [1169, 2880], 'shows': [1171, 2882], 'unique': [1172, 2853, 2883], 'characteristics': [1173, 2693, 2884], 'profile': [1177, 1294, 2888, 3384, 3632], 'matrix.': [1181, 2892, 3388], 'interested': [1184, 2895], 'determining': [1186, 2897], 'whether': [1187, 2898, 3752], 'subsets': [1188, 2899], '1284': [1190, 1214, 1241, 2647, 2901, 2925, 3091, 3733], 'exhibit': [1193, 2904], 'distinct': [1194, 1447, 1780, 2905, 3252], 'profiles': [1196, 1629, 2856, 2907, 3608, 3710], 'across': [1197, 1216, 2908, 2927, 3317, 3652], 'calculated': [1201, 1334, 2912, 2941], 'pairwise': [1202, 2913], 'correlations': [1203, 2914], 'performed': [1205, 2916, 3078], 'hierarchical': [1207, 2918, 3075], 'clustering': [1208, 2919, 3061, 3076], 'enrichments': [1211, 2922, 3532, 3635, 3791], '10': [1217, 2743, 2792, 2928, 3086], 'different': [1218, 2744, 2929, 3087], '1': [1222, 2416], 'Schematic': [1223], 'overview': [1224], 'build': [1234], 'matrix,': [1240, 1380, 2448, 3143], '1777': [1244, 2662], 'taken': [1248], 'OMIM': [1250, 3355, 3547, 3573], 'database': [1251, 1312, 2674, 3356], '(Hamosh': [1252, 2675], '2005).': [1255, 2678], 'Each': [1256], 'mapped': [1260, 2712], 'onto': [1261], 'relevant': [1262], 'Diseases': [1265, 2850], 'classified': [1267, 1287], 'into': [1268, 1956, 2559, 2830, 3381, 3906], '22': [1269, 3736], 'physiological': [1274, 3743], 'system': [1275], 'affected': [1276, 1802, 3745], '(Middle)': [1281], 'attributed': [1291, 1547], 'classes.': [1297], 'Disease': [1298, 1789, 3765], 'progression': [1299, 1790, 2409, 3866], 'compiled': [1301, 1955], 'hospitalization': [1304], '13': [1306], 'million': [1307], 'patients': [1308], 'US': [1310], 'Medicare': [1311], '(Park': [1313, 2331, 2733], '2009a).': [1316, 1501, 2143], 'Comorbid': [1317], 'calculating': [1323, 3328], 'co-occurring': [1324], 'individual': [1328, 1489], 'patients.': [1329], 'similarity': [1332, 1600, 1622, 2400, 2496, 3556], 'quantitative': [1337], 'comorbid': [1340, 1503, 1706, 1836, 1871, 2412, 2509, 2521, 2554], 'profiles.': [1347, 3760], 'revealed': [1351, 3114], '778': [1353, 3116], '(∼62%,': [1355, 3118], 'P=1.40': [1356, 3119], '×': [1357, 1370, 1617, 3005, 3034, 3057, 3120, 3133, 3456, 3598, 3799, 3812, 3888, 3944], '10−3)': [1358, 1371, 3121, 3134], 'enriched': [1360, 1373, 1426, 2460, 3028, 3051, 3099, 3123, 3136, 3194, 3218, 3232, 3293, 3442, 3667, 3837, 3880, 3935, 4006], 'single': [1363, 3126, 3375], '273': [1366, 3129], '(∼21%,': [1368, 3131], 'P=3.45': [1369, 3132], 'dual': [1375, 1428, 3138, 3234], 'membrane-bounded': [1390, 3153], 'organelles': [1391, 2996, 3154], 'mitochondria,': [1394, 2754, 3157, 3196], 'lysosome,': [1395, 2756, 3158], 'peroxisome,': [1397, 2753, 3160], 'indicating': [1398, 3161, 3600], 'mutations': [1401, 1929, 3164, 3946], 'localized': [1404, 3167, 3858], 'compartments': [1407, 1448, 1455, 2330, 3170, 3253, 3260, 3319, 3446, 4077], 'pathophysiological': [1412, 3175], 'conditions': [1413, 3176], 'those': [1415, 3178], 'organelles.': [1416, 3179], 'Meanwhile,': [1417, 3223, 3873], 'extracellular/plasma': [1432, 3238], 'membrane': [1433, 3239], 'endoplasmic': [1435, 2748], 'reticulum/Golgi.': [1436], 'Although': [1437, 3242, 3327], 'appear': [1444, 3249, 3833], 'at': [1449, 3254], 'first,': [1450, 3255], 'they': [1451, 3256], 'related': [1454, 3259, 3303, 3350, 3625, 3976, 4042], 'close': [1457, 1775, 3262], 'proximity': [1458, 3263], 'during': [1459, 3264], 'translocation': [1461, 3266], 'cell,': [1465, 3270], 'thus': [1467, 3272], 'share': [1471, 1510, 1524, 3276, 3756], 'interacting': [1472, 3277], '(Gandhi': [1475, 3280], '2006).': [1478, 1916, 3283, 3872], 'Comorbidity': [1479], 'co-occurrence': [1482], '(Lee': [1490, 2697], 'Hidalgo': [1494], 'Many': [1502], 'common': [1511, 3969], 'network.': [1517], 'Diabetes': [1520], "Alzheimer's": [1522], 'risk': [1526, 1603, 1611, 1641], 'factor': [1527], 'angiotensin': [1529], 'I': [1530], 'converting': [1531], 'enzyme,': [1532], 'frequently': [1534], 'occur': [1535], 'together': [1536], 'an': [1538, 1979, 2831, 2975, 3563, 4034], 'individual.': [1539], 'instances,': [1542], 'partially': [1546], 'level.': [1555], 'explore': [1557], 'impact': [1559, 1686], 'comorbidity,': [1565], 'hypothesized': [1567], '(bottom': [1587], 'positive': [1595, 2489], 'relative': [1602, 1610, 1640], '(Figure': [1604, 1679, 2932, 3796, 3809, 3885], '3B,': [1605, 3592], "Pearson's": [1606, 3593], 'coefficient': [1608, 3595], 'similarity=0.81,': [1615], 'P=2.96': [1616], '10−5).': [1618, 3457, 3800], 'pairs.': [1632, 1699, 1725, 2535], 'surprise,': [1635], 'compared': [1638, 1675, 1721, 3295, 3448], 'linked': [1645], 'connections,': [1649, 1782], 'showed': [1659, 2997], 'near': [1661], 'three-fold': [1662], 'higher': [1663, 1728], 'tendency': [1665, 1696, 1730, 1761], '(with': [1666], 'link': [1667], 'distances': [1668, 1689], 'equal': [1669], '2': [1671], '3)': [1673], 'random': [1677, 1723, 3450], '3E).': [1680], 'then': [1682], 'assessed': [1683], 'quantitatively': [1684], 'network': [1688, 1717, 1757, 1776, 3516], 'expected': [1701], 'located': [1711, 3721, 3982, 4073], 'closely': [1712], 'interaction': [1716, 3515], 'fewer': [1719], 'links': [1720], 'Indeed,': [1726, 4062], 'positioned': [1738], 'shorter': [1741], 'distance': [1742], '(gray': [1743], 'plots': [1744, 1765], 'Figure': [1746, 1767, 2984, 3008, 3037, 3059, 3422, 3453, 3551, 3591, 3941, 4027], '3F).': [1747, 1768], 'Moreover,': [1748, 3656], 'combined': [1754], 'small': [1756, 2787], 'distances,': [1758, 1777], 'increased': [1762], 'dramatically': [1763], '(orange': [1764], 'suggests': [1770, 3694], 'conceptually': [1779], 'contributed': [1783], 'synergistically': [1784], 'tendency.': [1788], 'is': [1791, 1901, 3193, 3804, 3878, 3975], 'restricted': [1793], 'mutation': [1796], 'but': [1800], "'disease": [1807, 1853], "modules,'": [1808], 'resulting': [1809], '(Fraser,': [1812], '2006;': [1813], '2008).': [1817, 2007, 3925], 'study,': [1820, 2375], 'time': [1824], 'applied': [1826, 2396, 3460], 'elucidate': [1831], 'believe': [1839], 'that,': [1840], 'finding,': [1844], 'approach': [1846, 2540, 2680], 'define': [1849], 'boundaries': [1851], "modules.'": [1854], 'Taken': [1855], 'together,': [1856], 'integration': [1857], 'diverse': [1859, 1931, 4044, 4075], 'should': [1862], 'improve': [1863], 'hitherto': [1869], 'unexplained': [1870, 2561], 'help': [1875], 'us': [1876, 3843], 'expanding': [1878], 'scope': [1880], 'knowledge': [1883], 'Introduction': [1891], 'Establishing': [1892], 'interrelationship': [1894, 2379, 2442], 'genotype': [1897], 'phenotype': [1900], 'one': [1902, 3429], 'most': [1905, 3435], 'challenging': [1906], 'pertinent': [1908], 'problems': [1909], 'biomedical': [1911], 'research': [1912], '(Lamb': [1913], 'studies': [1920, 1941], 'devoted': [1925], 'identifying': [1927, 2808], 'gene-based': [1932, 1951, 1990], 'recombination': [1936], 'mapping': [1937, 2764], 'genome-wide': [1939], 'association': [1940, 2832, 2965, 3621], '(Botstein': [1942], 'Risch,': [1944], '2003;': [1945], 'Broeckel': [1946], 'Schork,': [1948], 'Traditional': [1950], 'approaches': [1952, 1991], 'list': [1958, 2645], 'genes.': [1961], 'addition,': [1963], 'rapid': [1965], 'accumulation': [1966], 'genomics': [1969], 'data': [1972, 3465, 3548, 3574, 3622], 'interactome,': [1978], 'extensive': [1980], 'metabolism,': [1983], 'regulatory': [1985], 'networks': [1986], 'complement': [1988], 'current': [1989], '(Rual': [1992], 'Stelzl': [1996], 'Duarte': [2000], 'Shlomi': [2004], 'Recently,': [2008], 'it': [2009], 'genetics': [2040], 'Mutations': [2216], 'alter': [2220], 'synthesis': [2222], 'gene': [2225], 'product,': [2226], 'change': [2228], 'turn': [2238], 'perturb': [2239], 'cellular': [2241, 4049], 'functions': [2242], 'proteins.': [2245], 'Also,': [2311, 3039], 'previously': [2314, 2560], 'demonstrated': [2315], 'localize': [2325], 'proteins,': [2394, 2767, 3431], 'analyzing': [2411], '(Box': [2415], 'described': [2418], 'further': [2419], 'Materials': [2421, 2843, 3340], 'methods).': [2423], 'describes': [2440], 'two.': [2445], 'particular': [2462, 2484, 3444, 3534, 3793], 'clustered': [2475, 3700], 'measures,': [2502], 'explains': [2504], 'furthermore': [2518], 'enhanced': [2519], 'tendencies': [2522], 'pairs,': [2525, 2556], 'uncovered': [2527], 'hitherto-unknown': [2529], 'This': [2536, 2679, 3526, 3693, 3841], 'constitutes': [2537], 'novel': [2539], 'establishing': [2542], 'offering': [2557], 'insight': [2558], 'mechanisms': [2562], 'Results': [2566], 'Systematic': [2567], 'construction': [2568], 'atlas': [2571], 'this,': [2618], 'purpose,': [2641], 'utilized': [2643], 'representing': [2649], 'grouping': [2651], '(MIM': [2654], 'record)': [2655], 'names': [2659], 'available': [2665], 'Online': [2668], 'Mendelian': [2669], 'Inheritance': [2670], 'Man': [2672], '(OMIM)': [2673], 'widely': [2683], 'used': [2684, 3401, 3488], 'recent': [2686], 'systematic': [2687], 'analyses': [2689], 'subtypes': [2696], '2009a;': [2704], 'Li': [2705], 'Patra,': [2707], 'encoded': [2715], 'Swiss': [2721], 'Prot': [2722], 'annotation': [2723], 'scheme': [2724], 'consensus': [2727], 'predictions': [2729], 'recently': [2731], 'reported': [2732], '2009b;': [2736], 'see': [2737], 'Supplementary': [2738, 2847, 2983], 'File': [2739, 2848], 'considered': [2742, 2772, 2974], '(cytosol,': [2747], 'reticulum': [2749], '(ER),': [2750], 'extracellular,': [2751], 'Golgi,': [2752], 'nucleus,': [2755, 4081], 'plasma': [2757], 'membrane,': [2758], 'others)': [2760], 'although': [2768], 'minor': [2769], 'simply': [2773], "'others'": [2775], 'since': [2776], 'number': [2778, 2810], 'locations': [2784], 'too': [2786], 'analyze': [2789], '(fewer': [2790], 'than': [2791], 'confidence).': [2795], 'covariance': [2799, 2829], 'co-assigning': [2815], 'Then,': [2820], 'built': [2825, 3763], 'transforming': [2827], 'score': [2833], '(AS)': [2834], '(see': [2842, 3339], '2).': [2849], 'validate': [2935], 'reliability': [2937], 'ASs,': [2939], 'Z-values;': [2943], 'Z-value': [2945, 3002], 'significance': [2948], 'disease.': [2956], 'Z-values': [2961], 'localization-disease': [2964], 'scores': [2966], 'indeed': [2968], 'highly': [2969, 3098, 3292, 4005], 'correlated': [2970, 3539], '(R2=0.97),': [2971], 'AS': [2976], '⩾0.05': [2977], 'statistically': [2980, 3789], '(P<0.01;': [2982], '1A).': [2985], 'Specifically,': [2986], 'caused': [2990, 3185, 3204], 'defects': [2993], 'ASs': [2999, 3330], '(AS': [3000], '⩾0.2,': [3001], '>10,': [3003], 'P<1.00': [3004, 3033, 3056], '10−10)': 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