Midkine Is Regulated by Hypoxia and Causes Pulmonary Vascular Remodeling

Name: Work Video:
Duration: 3 min 30 s
Paul R. Reynolds; Michael L. Mucenski; Timothy D. Le Cras; William C. Nichols; Jeffrey A. Whitsett
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3759, 3778, 3786, 3795, 3824, 3860, 3870, 3889, 3918, 3928, 3948, 3997, 4007, 4070, 4098, 4111, 4167, 4182, 4201, 4283, 4301], 'a': [5, 196, 224, 415, 524, 804, 898, 917, 1006, 1175, 1329, 1452, 1536, 1587, 1602, 1631, 1637, 1762, 1769, 1805, 1867, 1981, 2056, 2243, 2449, 2692, 2927, 3000, 3008, 3014, 3219, 3387, 3409, 3456, 3491, 3509, 3573, 3618, 3627, 3691, 4115, 4136, 4360], 'precise': [6, 225, 988], 'temporal-spatial': [7, 226, 792], 'pattern': [8, 227, 989], 'during': [9, 35, 228, 254, 536, 765, 1366, 1532, 1556, 2999, 3726, 3743, 3766, 3847, 4010, 4294], 'lung': [10, 69, 117, 229, 288, 336, 491, 651, 741, 770, 799, 912, 976, 982, 1520, 1533, 1677, 2125, 2355, 3268, 3895, 3914, 4031, 4081, 4295], 'morphogenesis;': [11, 230], 'however,': [12, 231], 'its': [13, 232, 801, 905, 987, 993], 'role': [14, 113, 233, 332, 899, 995, 1007, 1331], 'pulmonary': [16, 142, 215, 235, 361, 434, 497, 763, 961, 1015, 1019, 1043, 1089, 1098, 1343, 1409, 1413, 1582, 1611, 2154, 3266, 3343, 3518, 3568, 3800, 3827, 3834, 3936, 4086], 'homeostasis': [17, 236], 'unknown.': [19, 238], 'Increased': [20, 239, 3723], 'MK': [21, 37, 66, 88, 101, 115, 125, 137, 156, 182, 240, 256, 285, 307, 320, 334, 344, 356, 375, 401, 444, 580, 644, 728, 758, 795, 838, 843, 849, 895, 913, 950, 966, 1003, 1550, 1562, 1765, 1936, 1960, 1987, 1995, 2284, 2310, 2465, 2642, 2932, 3724, 3755, 3774, 3792, 3820, 3845, 3856, 3885, 3908, 3944, 3975, 3995, 4039, 4066, 4091, 4109, 4127, 4148, 4161, 4218, 4260, 4282, 4292, 4298, 4352], 'staining': [22, 150, 241, 369, 1993, 2018, 3296, 3304, 3312, 3790, 3821, 3843, 3857, 3886, 3909], 'and': [23, 148, 151, 163, 172, 191, 242, 367, 370, 382, 391, 410, 618, 800, 845, 928, 960, 964, 968, 992, 998, 1011, 1097, 1125, 1224, 1258, 1301, 1370, 1388, 1419, 1528, 1576, 1615, 1628, 1652, 1678, 1685, 1790, 1824, 1859, 1952, 2026, 2068, 2152, 2169, 2180, 2202, 2207, 2250, 2264, 2298, 2332, 2352, 2360, 2395, 2416, 2475, 2497, 2599, 2659, 2682, 2800, 2839, 2850, 2880, 2914, 2921, 2926, 2943, 3013, 3026, 3077, 3177, 3189, 3192, 3203, 3223, 3354, 3366, 3381, 3390, 3434, 3452, 3478, 3483, 3504, 3514, 3558, 3598, 3626, 3657, 3704, 3719, 3730, 3740, 3771, 3799, 3818, 3829, 3839, 3854, 3875, 3905, 3915, 3924, 3927, 3942, 3960, 3986, 4029, 4035, 4045, 4084, 4090, 4151, 4165, 4192, 4232, 4238, 4350, 4367], 'mRNA': [24, 243, 645, 850, 967, 2897, 3945, 3989, 4005, 4040, 4092], 'expression': [25, 38, 64, 153, 160, 212, 244, 257, 283, 372, 379, 431, 793, 924, 951, 970, 991, 1295, 1431, 1551, 1560, 1569, 1594, 1937, 1962, 3961, 3976, 3996, 4006, 4047, 4067, 4093, 4153, 4276, 4293, 4343, 4353], 'were': [26, 121, 245, 340, 814, 1103, 1619, 1782, 1792, 1800, 1875, 1922, 1955, 2030, 2037, 2070, 2159, 2183, 2200, 2217, 2240, 2261, 2287, 2296, 2330, 2384, 2446, 2689, 2702, 2860, 2997, 3021, 3035, 3096, 3120, 3132, 3175, 3210, 3270, 3290, 3347, 3357, 3384, 3459, 3488, 3506, 3553, 3570, 3592, 3596, 3602, 3649, 3721, 4014, 4049, 4094, 4129, 4133], 'observed': [27, 246, 925, 3794, 3823, 3888, 3911], 'the': [29, 49, 68, 76, 87, 94, 100, 104, 112, 129, 134, 152, 159, 164, 184, 199, 248, 268, 287, 295, 306, 313, 319, 323, 331, 348, 353, 371, 378, 383, 403, 418, 649, 726, 739, 762, 797, 834, 910, 953, 974, 978, 1009, 1014, 1039, 1121, 1184, 1259, 1264, 1282, 1294, 1367, 1379, 1405, 1408, 1522, 1544, 1564, 1568, 1578, 1596, 1607, 1610, 1648, 1675, 1719, 1725, 1809, 1813, 1926, 2052, 2257, 2270, 2368, 2376, 2426, 2436, 2461, 2870, 2883, 2905, 2938, 2969, 2974, 2982, 2991, 3083, 3127, 3170, 3186, 3264, 3299, 3307, 3315, 3370, 3445, 3517, 3614, 3673, 3676, 3760, 3779, 3825, 3833, 3861, 3890, 3894, 3913, 3922, 3929, 3934, 3949, 3965, 3998, 4101, 4143, 4146, 4160, 4183, 4199, 4202, 4225, 4245, 4263, 4271, 4284, 4288, 4302, 4309, 4345, 4370], 'lungs': [30, 249, 2799, 3505, 3552, 3761, 3780, 3950, 3999], 'of': [31, 65, 78, 93, 107, 114, 133, 140, 154, 161, 181, 208, 250, 284, 297, 312, 326, 333, 352, 359, 373, 380, 400, 427, 481, 761, 768, 794, 837, 848, 923, 981, 986, 990, 1013, 1038, 1062, 1071, 1078, 1087, 1123, 1183, 1276, 1284, 1296, 1362, 1376, 1407, 1412, 1487, 1561, 1570, 1580, 1609, 1683, 1718, 1724, 1768, 1804, 1808, 1990, 2245, 2283, 2381, 2390, 2435, 2865, 2896, 2912, 2968, 3031, 3042, 3086, 3172, 3199, 3221, 3263, 3298, 3306, 3314, 3341, 3394, 3448, 3512, 3582, 3746, 3762, 3781, 3791, 3802, 3810, 3832, 3842, 3893, 3921, 3933, 3951, 4000, 4019, 4063, 4100, 4119, 4124, 4142, 4145, 4198, 4244, 4277, 4281, 4290, 4305, 4344, 4369], 'hypoxia-susceptible': [32, 251], 'CAST/eiJ': [33, 252, 1073, 1091, 3783, 3804, 3952, 4002, 4008, 4012], 'mice': [34, 120, 253, 339, 1079, 1092, 1102, 1618, 1781, 1799, 1874, 1917, 1929, 1954, 1979, 3383, 3458, 3487, 3750, 3765, 3784, 3805, 3953, 4009, 4013, 4307], 'hypoxia.': [36, 255, 1107, 1213, 1557, 3754, 4011], 'was': [39, 70, 126, 258, 289, 345, 646, 729, 956, 1171, 1552, 1712, 1758, 1938, 1963, 1996, 2049, 2078, 2225, 2267, 2327, 2334, 2347, 2408, 2419, 2430, 2643, 2666, 2795, 2867, 2898, 2934, 2978, 3183, 3352, 3401, 3420, 3545, 3611, 3669, 3698, 3717, 3756, 3775, 3793, 3822, 3858, 3880, 3887, 3910, 3916, 3946, 3977, 4033, 4041, 4068, 4222, 4265, 4299], 'induced': [40, 259, 1211, 1553, 1939, 3758, 3859, 3994], 'by': [41, 72, 189, 260, 291, 408, 803, 904, 1035, 1120, 1212, 1220, 1325, 1335, 1373, 1422, 1451, 1525, 1554, 1589, 1647, 1714, 1760, 1784, 1794, 1802, 1811, 1845, 1866, 1877, 1924, 1940, 1965, 2366, 2645, 2668, 2691, 2881, 2945, 2980, 3023, 3403, 3408, 3547, 3572, 3651, 3671, 4043, 4096, 4252], 'hypoxia': [42, 190, 204, 261, 409, 423, 1030, 1063, 1083, 1115, 1251, 1305, 1539, 1591, 3400, 3744, 3767, 3808, 3850, 3871, 3902, 3993, 4017, 4064, 4097], 'cell': [44, 263, 493, 499, 534, 600, 619, 1574, 2157, 4072, 4102], 'lines': [45, 264, 2158, 4073, 4103], 'vitro.': [47, 266], 'Because': [48, 267, 985], 'transcription': [50, 77, 269, 296, 468, 808, 811, 1289, 1967, 2418, 4128, 4261], 'factor': [51, 270, 462, 530, 1178, 1455], 'hypoxiainducible': [52, 271], 'factor-1α': [53, 272], '(HIF-1α)': [54, 273], 'modulates': [55, 274], 'cellular': [56, 275, 1124, 1300, 3634], 'responses': [57, 276, 1113, 1303, 4209], 'to': [58, 203, 213, 277, 422, 432, 1024, 1105, 1114, 1263, 1278, 1292, 1304, 1392, 1491, 1516, 1519, 1538, 1599, 2118, 2209, 2242, 2425, 2802, 2916, 3003, 3081, 3091, 3359, 3378, 3392, 3443, 3461, 3469, 3622, 3631, 3654, 3753, 3807, 3849, 3882, 3901, 3969, 4016, 4037, 4121, 4189, 4194, 4230, 4234], 'hypoxia,': [59, 278, 4122], 'we': [60, 279, 1000, 1547], 'tested': [61, 280, 4104], 'whether': [62, 281], 'increased': [63, 138, 282, 357, 1036, 1085, 1559, 1567, 1577, 3846, 3963, 3980, 3987, 4095], 'mediated': [71, 290, 903, 1117, 1324, 1421], 'HIF-1α.': [73, 108, 192, 292, 327, 411, 4253], 'HIF-1α': [74, 82, 293, 301, 1208, 1217, 1555, 2485, 2665, 4089, 4107, 4113, 4125, 4156, 4158, 4208, 4256], 'enhanced': [75, 158, 294, 377, 759], 'MK,': [79, 209, 298, 428], 'acting': [80, 299], 'on': [81, 116, 300, 335, 907, 2058, 2448, 3126, 3194, 4065, 4126, 4224], 'regulatory': [83, 302], 'elements': [84, 303, 1271], 'located': [85, 304, 4186, 4227], 'gene': [89, 217, 308, 436, 1430, 1593, 1730, 3033, 4149], 'promoter.': [90, 309], 'Site-directed': [91, 310, 2966], 'mutagenesis': [92, 311, 2967, 2985, 4221], '3′': [95, 314, 1186, 3016], 'HIF': [96, 315, 1269], 'response': [97, 316, 448, 472, 1270, 1454, 1537, 4120], 'element': [98, 317, 477], 'promoter': [102, 321, 1722, 1772, 2933, 4162, 4203, 4314, 4338, 4363], 'blocked': [103, 322, 3658], 'stimulatory': [105, 324], 'effects': [106, 325, 906, 1061, 4123, 4289], 'To': [109, 328, 3260, 3563, 4212], 'directly': [110, 157, 329, 376], 'assess': [111, 330, 3261, 4287], 'morphogenesis,': [118, 337, 1521, 4296], 'transgenic': [119, 338, 1916, 1928, 1934, 1972, 2354, 3365, 3380, 4306], 'generated': [122, 341, 1713, 1759, 1783, 2437, 2903], 'which': [124, 343, 1081, 1425, 1482, 1526, 1590, 2223, 4347], 'respiratory': [130, 185, 200, 349, 404, 419, 1565, 1597, 4303, 4340], 'epithelial': [131, 350, 1527, 1672, 1687, 3797, 3862, 3919, 4341], 'cells': [132, 351, 1344, 1530, 1673, 1688, 2199, 2260, 2286, 2295, 2362, 3798, 3863, 3920, 3932, 4132], 'developing': [135, 354, 650, 798], 'lung.': [136, 355, 3584], 'muscularization': [139, 358, 1037, 1086, 1579, 3262], 'small': [141, 360, 1088, 1581], 'arteries,': [143, 362], 'increasing': [144, 363], 'α-smooth': [145, 168, 364, 387, 451, 2020], 'muscle': [146, 169, 177, 365, 388, 396, 452, 1428, 1447, 1573, 2021, 3831, 3931], 'actin': [147, 366, 2022], 'caldesmon': [149, 368, 2027], 'myocardin.': [155, 374], 'myocardin': [162, 211, 381, 430, 1458, 2570, 2810], 'smooth': [165, 176, 384, 395, 1427, 1572, 3830, 3930], 'muscle-specific': [166, 385], 'genes': [167, 386, 1297], 'actin,': [170, 389], 'calponin,': [171, 390], 'SM-22': [173, 392, 2530], 'vascular': [175, 216, 394, 435, 962, 1016, 3738], 'precursor': [178, 397], 'cells.': [179, 398], 'Expression': [180, 399, 3725, 4280, 4366], 'epithelium': [186, 201, 405, 420, 1566, 1598, 3828, 4304], 'regulated': [188, 407, 1219, 2226, 3407], 'These': [193, 412, 891, 1584], 'data': [194, 413, 892, 1585], 'provide': [195, 414, 1586], 'model': [197, 416, 2235, 2875], 'wherein': [198, 417], 'responds': [202, 421], 'via': [205, 424], 'HIF-1α-dependent': [206, 425], 'regulation': [207, 426, 802, 4368], 'enhancing': [210, 429], 'influence': [214, 433], 'expression.': [218, 437], '1The': [440], 'abbreviations': [441], 'used': [442, 2459], 'are:': [443], 'midkine;': [445], 'HRE,': [446, 3011, 3017], 'HIF-1': [447, 1165], 'element;': [449], 'α-SMA,': [450], 'actin;': [453], 'E,': [454], 'embryonic': [455, 734, 769, 1676], 'day;': [456, 459], 'PN,': [457], 'postnatal': [458, 929, 954, 1368], 'HIF-1α/β,': [460], 'hypoxia-inducible': [461, 1129, 1181], 'α': [463], 'or': [464, 1535, 1755, 1797, 1920, 1932, 3072, 3309, 3349, 4026], 'β;': [465], 'TTF-1,': [466], 'thyroid': [467, 810], 'factor-1;': [469], 'SRF,': [470], 'serum': [471, 1453, 2326], 'factor;': [473], 'CArG,': [474], 'cis-regulatory': [475], 'DNA': [476, 1176, 3087], '(CC(A/T)6GG);': [478], 'FiO2,': [479], 'fraction': [480], 'inspired': [482], 'oxygen;': [483], 'JEG-3,': [484], 'human': [485, 496, 1720, 2153, 2309, 4075, 4085, 4310, 4334], 'placental': [486, 2120, 4076], 'adenocarcinoma;': [487], 'MFLM-4,': [488], 'mouse': [489, 911, 975, 1764, 2123, 2798, 2931, 4079, 4147, 4297], 'fetal': [490, 2124, 2174, 2324, 4080], 'mesenchyme': [492, 764, 2126, 4082], 'line;': [494, 500], 'H-441,': [495], 'adenocarcinoma': [498, 2121, 2155, 4077, 4087], 'rtTA,': [501, 4346], 'reverse': [502, 519, 1726, 1825, 1966, 2417, 2476, 2498], 'tetracycline': [503, 1727, 1776], 'transactivator;': [504], 'RVH,': [505], 'right': [506, 516, 1094, 3180], 'ventricular': [507, 1095], 'hypertrophy;': [508], 'LRP,': [509], 'low': [510], 'density': [511], 'lipoprotein': [512], 'receptor-related': [513], 'protein;': [514], 'RV,': [515], 'ventricle;': [517], 'RT,': [518], 'transcription;': [520], 'CMV,': [521], 'cytomegalovirus.': [522], 'retinoic': [525], 'acid-responsive,': [526], 'heparin': [527], 'binding': [528, 1177, 1275, 1778, 4356], 'growth': [529, 601, 760], 'various': [533, 4071], 'types': [535], 'embryo-genesis': [537], '(1Kadomatsu': [538], 'K.': [539, 559, 624, 774, 2553, 2747, 3529], 'Tomomura': [540], 'M.': [541, 557, 590, 655, 665, 690, 1232, 2557, 2751, 3230, 3234, 3327, 3329], 'Muramatsu': [542, 558, 562, 604, 625, 631, 656, 658, 775, 781], 'T.': [543, 563, 605, 622, 632, 657, 686, 778, 782, 2572, 2603, 2765, 2812, 3236], 'Biochem.': [544, 606, 634], 'Biophys.': [545, 607], 'Res.': [546, 594, 608, 1437, 2540, 2590, 2621, 2735, 2783, 2830], 'Commun.': [547, 609], '1988;': [548], '151:': [549], '1312-1318Crossref': [550], 'PubMed': [551, 613, 639, 672, 704, 720, 828, 886, 944, 1055, 1142, 1160, 1198, 1245, 1317, 1357, 1441, 1477, 1506, 1704, 1748, 1910, 2012, 2110, 2147, 2525, 2544, 2565, 2594, 2625, 2721, 2739, 2759, 2787, 2834, 2961, 3058, 3113, 3164, 3255, 3334, 4328], 'Scopus': [552, 614, 640, 705, 721, 787, 829, 887, 945, 1056, 1143, 1161, 1199, 1246, 1318, 1442, 1478, 1507, 1705, 1749, 1911, 2013, 2111, 2148, 2526, 2545, 2566, 2595, 2626, 2722, 2740, 2760, 2788, 2835, 2962, 3059, 3114, 3165, 3256, 3335, 4329], '(473)': [553], 'Google': [554, 573, 598, 616, 642, 673, 707, 723, 755, 789, 831, 869, 889, 947, 1058, 1145, 1163, 1201, 1248, 1320, 1358, 1444, 1480, 1509, 1707, 1751, 1913, 2015, 2113, 2150, 2528, 2547, 2568, 2597, 2628, 2724, 2742, 2762, 2790, 2837, 2964, 3061, 3116, 3167, 3258, 3337, 3540, 4331], 'Scholar,': [555, 674, 708, 870, 2725, 2743, 2763], '2Tomomura': [556], 'Matsubara': [560], 'S.': [561, 588, 630, 688, 780, 1155, 1240, 1472, 2574, 2605, 2767, 2814, 3250, 3325], 'J.': [564, 633, 678, 696, 878, 1050, 1230, 1352, 1737, 1892, 1899, 2092, 2099, 2514, 2710, 3146, 3153, 3535], 'Biol.': [565, 700, 882, 1138, 1194, 1502, 1700, 1738, 1900, 2100, 2515, 2711, 3109, 3154, 4324], 'Chem.': [566, 1739, 1901, 2101, 2516, 2712, 3155], '1990;': [567], '295:': [568], '10765-10770Abstract': [569], 'Full': [570, 1312, 1314, 1743, 1745, 1905, 1907, 2105, 2107, 2520, 2522, 2716, 2718, 3159, 3161], 'Text': [571, 1313, 1315, 1744, 1746, 1906, 1908, 2106, 2108, 2521, 2523, 2717, 2719, 3160, 3162], 'PDF': [572, 1316, 1747, 1909, 2109, 2524, 2720, 3163], 'Scholar).': [574, 643, 724, 756, 790, 832, 890, 948, 1059, 1164, 1202, 1249, 1321, 1359, 1445, 1510, 1708, 1752, 1914, 2016, 2114, 2629, 2791, 2965, 3062, 3117, 3168, 3259, 3338, 3541, 4332], 'In': [575, 725, 909, 1543, 2115, 2280, 3281, 3375, 4254], 'vitro': [576, 772], 'studies': [577], 'demonstrated': [578, 816], 'that': [579, 894, 1002, 1170, 1179, 1287, 1298, 1338, 1549, 1605, 1985, 3006, 3346, 4215, 4270, 4358], 'promotes': [581], 'angiogenesis': [582], '(3Choundhuri': [583], 'R.I.': [584, 872], 'Zhang': [585], 'H.T.': [586], 'Domini': [587], 'Ziche': [589], 'Bicknell': [591], 'B.': [592, 2131], 'Cancer': [593], '1997;': [595, 636], '57:': [596], '1814-1819PubMed': [597], 'Scholar),': [599, 617, 1481, 2151, 2529, 2548, 2569, 2598], '(4Muramatsu': [602], 'H.': [603, 626, 659, 661, 776, 2137], '1991;': [610], '177:': [611], '652-658Crossref': [612], '(213)': [615], 'migration': [620], '(5Takada': [621], 'Toriyama': [623], 'Song': [627], 'X.-J.': [628], 'Torii': [629, 779], '(Tokyo).': [635], '122:': [637], '453-458Crossref': [638], '(143)': [641], 'detected': [647, 730, 853, 3917, 3947, 4042], '(6Mitsiadis': [652], 'T.A.': [653], 'Salmivirta': [654], 'Rauvala': [660], 'Lehtonen': [662], 'E.': [663, 2551, 2745], 'Jalkanen': [664], 'Thesleff': [666], 'I.': [667], 'Development.': [668], '1995;': [669, 752, 866], '121:': [670], '37-51Crossref': [671], '7Kaplan': [675], 'F.': [676, 2576, 2607, 2769, 2816], 'Comber': [677], 'Sladek': [679], 'R.': [680, 3104], 'Hudson': [681], 'T.J.': [682], 'Muglia': [683], 'L.J.': [684], 'Macrae': [685], 'Gagnon': [687], 'Asada': [689], 'Brewer': [691], 'J.A.': [692, 714, 822, 938, 1698, 1736, 1898, 2006, 2098, 2955, 3052, 3106, 3152, 3244, 3531, 4322], 'Sweezy': [693], 'N.B.': [694], 'Am.': [695, 877, 1351, 3534], 'Respir.': [697, 879], 'Cell': [698, 880], 'Mol.': [699, 881, 1136, 1192, 3107], '2003;': [701, 717, 825, 941, 1052, 1474, 1503, 1902, 2009, 2102, 2591, 2622, 2784, 2831, 2958, 3055, 3156, 3537], '28:': [702], '33-41Crossref': [703], '(48)': [706], '8Reynolds': [709], 'P.R.': [710, 818, 934, 2002, 2951, 3048], 'Mucenski': [711, 819, 935, 2003, 2952, 3049], 'M.L.': [712, 820, 936, 1884, 2004, 2084, 2953, 3050, 3138], 'Whitsett': [713, 821, 937, 1697, 1735, 1897, 2005, 2097, 2954, 3051, 3105, 3151, 3243, 3530, 4321], 'Dev.': [715, 823, 939, 1699, 2007, 2142, 2956, 3053, 4323], 'Dyn.': [716, 824, 940, 2008, 2143, 2957, 3054], '227:': [718, 826, 942, 2010, 2959, 3056], '227-237Crossref': [719, 827, 943, 2011, 2960, 3057], '(39)': [722, 830, 946, 2014, 2963, 3060], 'mouse,': [727], 'as': [731, 733, 1174, 1880, 1957, 1998, 2080, 2289, 2336, 2704, 2947, 3044, 3098, 3134, 3278, 3292, 3317, 3520, 3560, 3964], 'early': [732], 'day': [735], '(E)': [736], '10': [737, 2306, 2414], 'primordial': [740], 'buds': [742], '(9Kurtz': [743, 857], 'A.': [744, 748, 858, 862, 1156, 1241, 1473, 3251], 'Schulte': [745, 859], 'A.M.': [746, 860, 3232], 'Wellstein': [747, 861], 'Crit.': [749, 863], 'Rev.': [750, 864], 'Oncog.': [751, 865], '6:': [753, 867], '151-177PubMed': [754, 868], 'Exogenous': [757], 'branching': [766], 'morphogenesis': [767, 1334], '(10Toriyama': [773], 'Hoshino': [777], 'Differentiation.': [783], '1996;': [784, 2517, 2541, 2713, 2736], '61:': [785], '161-167Crossref': [786], '(28)': [788], 'The': [791, 1018, 1060, 1274, 1360, 1622, 1709, 1753, 1974, 2405, 2893, 3179, 3339, 3418, 3550, 4061, 4333], 'lung-specific': [805], 'homeobox': [806], 'containing': [807, 1773, 2172, 2322, 2990, 3586, 4139, 4155], 'factor,': [809], 'factor-1': [812, 1130], '(TTF-1),': [813], 'recently': [815, 1066], '(8Reynolds': [817, 933, 2001, 2950, 3047], 'Although': [833, 1203, 1511, 3773], 'biological': [835], 'functions': [836], 'are': [839, 971, 1116, 1385, 1514, 3207, 3751, 4178], 'not': [840, 3757, 4206, 4248, 4258], 'fully': [841, 3293, 3348], 'understood,': [842], 'protein': [844, 969, 1169, 1663, 4312, 4336], 'splice': [846], 'variants': [847], 'have': [851, 1064], 'been': [852, 1065], 'several': [855, 1069], 'carcinomas': [856], '11Garver': [871], 'Chan': [873], 'C.S.': [874], 'Milner': [875], 'P.G.': [876], '1993;': [883, 1157, 1701, 4325], '9:': [884], '463-466Crossref': [885], '(117)': [888], 'suggest': [893], 'may': [896, 1004], 'play': [897, 1005, 1328], 'tumorigenesis,': [901], 'perhaps': [902], 'angiogenesis.': [908], 'bimodal': [918], 'manner,': [919], 'with': [920, 958, 1042, 1930, 2039, 2386, 2421, 2453, 3273, 3405, 3423, 3490, 3508, 3613, 3675, 3844, 3979, 4051, 4135, 4173], 'high': [921], 'levels': [922, 4048], 'at': [926, 1655, 1838, 1848, 1870, 2193, 2399, 2410, 2636, 2648, 2671, 2695, 3369, 3660, 3686, 4187, 4228], 'E13-16.5': [927], 'days': [930], '(PN)': [931], '5-12': [932], 'Elevated': [949], 'period': [955, 1369, 1383], 'coincident': [957], 'alveolarization': [959, 1363], 'development': [963, 983, 2071], 'remodeling.': [965], 'absent': [972], 'after': [977, 1689, 2339, 3867, 3954], 'alveolar': [979, 1389, 1684, 3796, 3891], 'stage': [980], '(PN15).': [984], 'potential': [994, 4180], 'vasculogenesis': [997], 'angiogenesis,': [999], 'hypothesized': [1001], 'formation': [1010, 1406, 1534, 1608], 'differentiation': [1012, 1448], 'bed.': [1017], 'vasculature': [1020, 1040, 3801, 3835], 'highly': [1022], 'responsive': [1023], 'changes': [1025], 'ambient': [1027], 'oxygen.': [1028], 'Chronic': [1029], 'initially': [1031, 1172], 'induces': [1032, 4351], 'vasoconstriction': [1033], 'followed': [1034, 1644, 1844, 1865, 2690], 'associated': [1041, 3978], 'hypertension': [1044], '(12Thomas': [1045], 'B.J.': [1046], 'Wanstall': [1047], 'J.C.': [1048], 'Eur.': [1049], 'Pharmacol.': [1051], '477:': [1053], '153-161Crossref': [1054], '(34)': [1057], 'surveyed': [1067], 'strains': [1070], 'mice.': [1072, 1935], 'an': [1075, 1167, 1394, 2220, 2633, 3195, 3274, 3734, 4152, 4168], 'inbred': [1076, 3735], 'strain': [1077], 'chronic': [1082, 1106, 4291], 'caused': [1084], 'arteries.': [1090, 1583], 'develop': [1093, 3737], 'hypertrophy': [1096], 'hypertension,': [1099], 'whereas': [1100, 3748], 'FVB/N': [1101, 3749, 3764], 'unresponsive': [1104], '2W.': [1108], 'Nichols,': [1109], 'unpublished': [1110], 'observations.': [1111], 'Cellular': [1112], 'part': [1119], 'regulator': [1122], 'systemic': [1126], 'oxygen': [1127], 'homeostasis,': [1128], '(HIF-1)': [1131], '(13Semenza': [1132, 1188], 'G.L.': [1133, 1135, 1147, 1149, 1189, 1191, 1307], 'Wang': [1134, 1190, 1461, 2583, 2614, 2776, 2823], 'Cell.': [1137, 1193, 1308, 3108], '1992;': [1139, 1195], '12:': [1140, 1196], '5447-5454Crossref': [1141, 1197], '(2209)': [1144, 1200], 'Scholar,14Wang': [1146], 'Semenza': [1148], 'Proc.': [1150, 1235, 1467, 3245], 'Natl.': [1151, 1236, 1468, 3246], 'Acad.': [1152, 1237, 1469, 3247], 'Sci.': [1153, 1238, 1470, 3248], 'U.': [1154, 1239, 1471, 3249], '90:': [1158], '4304-4308Crossref': [1159], '(1205)': [1162], 'αβ-heterodimeric': [1168], 'identified': [1173, 1801, 1876], 'mediates': [1180, 4339], 'activity': [1182], 'erythropoietin': [1185], 'enhancer': [1187], 'HIF-1β': [1204, 1252], 'constitutively': [1206], 'expressed,': [1207], 'rapidly': [1210, 2262], 'Under': [1214], 'normoxic': [1215, 3787], 'conditions,': [1216, 3788], 'hydroxylation,': [1221], 'subsequent': [1222], 'ubiquitination,': [1223], 'proteasomal': [1225, 1256], 'degradation': [1226], '(15Huang': [1227], 'L.E.': [1228], 'Gu': [1229], 'Schau': [1231], 'Bunn': [1233], 'H.F.': [1234], '1998;': [1242], '95:': [1243], '7987-7992Crossref': [1244], '(1849)': [1247], 'During': [1250, 1381], 'binds': [1253, 1268, 4348], 'HIF-1α,': [1254], 'prohibiting': [1255], 'degradation,': [1257], 'complex': [1260], 'transported': [1262], 'nucleus,': [1265], 'where': [1266], 'it': [1267], '(HREs,': [1272], '5′-RCGTG-3′).': [1273], 'HIF-1α/HIF-1β': [1277], 'HREs': [1279, 2972, 4181, 4214, 4226], 'assists': [1280], 'recruitment': [1283], 'coactivator': [1285], 'molecules': [1286], 'form': [1288], 'initiation': [1290], 'complexes': [1291, 1485], 'enhance': [1293], 'mediate': [1299, 4216], 'physiologic': [1302], '(16Semenza': [1306], '2001;': [1309, 1354], '107:': [1310], '1-3Abstract': [1311], '(790)': [1319], 'Epithelial-mesenchymal': [1322], 'interactions,': [1323], 'autocrine-paracrine': [1326, 1423], 'signals,': [1327], 'critical': [1330, 1518], 'directing': [1333], 'providing': [1336], 'signals': [1337], 'induce': [1339, 4259], 'genetic': [1340], 'programs': [1341], '(17Costa': [1345], 'R.H.': [1346], 'Kalinichenko': [1347], 'V.V.': [1348], 'Lim': [1349], 'L.': [1350, 2532, 2727], 'Physiol.': [1353, 3536], '280:': [1355], 'L823-L838Crossref': [1356], 'process': [1361, 1403], 'occurs': [1364], 'primarily': [1365], 'completed': [1372], '3-4': [1374], 'weeks': [1375, 3814, 3884, 3907, 3971], 'age': [1377], 'mouse.': [1380], 'this': [1382, 1402], 'alveoli': [1384], 'increasingly': [1386], 'septated,': [1387], 'walls': [1390], 'thin': [1391], 'generate': [1393, 1600, 3004], 'efficient': [1395], 'gas': [1396], 'exchange': [1397], 'compartment.': [1398], 'Also': [1399], 'required': [1400], 'vasculature.': [1410, 1612], 'Muscularization': [1411], 'arterioles': [1414], 'develops': [1415], 'late': [1416], 'gestation': [1418], 'signaling,': [1424], 'directs': [1426], 'cell-specific': [1429, 4342], '(18Veyssier-Belot': [1432], 'C.': [1433], 'Cacoub': [1434], 'P.': [1435, 2536, 2731], 'Cardiovasc.': [1436], '1999;': [1438], '44:': [1439], '274-282Crossref': [1440], '(75)': [1443], 'Smooth': [1446], 'directed': [1450], '(SRF)': [1456], 'coactivator,': [1457], '(19Wang': [1459], 'Z.': [1460], 'D.-Z.': [1462], 'Pipes': [1463], 'G.C.T.': [1464], 'Olson': [1465, 2512, 2537, 2585, 2616, 2708, 2732, 2778, 2825], 'E.N.': [1466, 2513, 2538, 2586, 2617, 2709, 2733, 2779, 2826], '100:': [1475], '7129-7134Crossref': [1476], '(432)': [1479], 'forms': [1483], 'protein-DNA': [1484], 'consisting': [1486], 'dimerized': [1488], 'SRF': [1489], 'bound': [1490], 'CArG': [1492], 'box': [1493], 'sequences': [1494], '(20Kumar': [1495], 'M.S.': [1496], 'Owens': [1497, 2587, 2618, 2780, 2827], 'G.K.': [1498, 2588, 2619, 2781, 2828], 'Arterioscler.': [1499], 'Thromb.': [1500], 'Vasc.': [1501], '23:': [1504], '737-747Crossref': [1505], '(158)': [1508], 'epithelial-mesenchymal': [1512], 'interactions': [1513], 'known': [1515, 4116], 'be': [1517], 'molecular': [1523, 2455], 'mechanisms': [1524], 'mesenchymal': [1529], 'communicate': [1531], 'remain': [1540], 'poorly': [1541], 'understood.': [1542], 'present': [1545], 'study': [1546], 'demonstrate': [1548, 3360], 'Furthermore,': [1558], 'myocardin,': [1571], 'markers': [1575], 'mechanism': [1588], 'influences': [1592, 1606], 'midkine,': [1601], 'paracrine': [1603], 'signal,': [1604], 'Mouse': [1613], 'Models': [1614], 'Animal': [1616, 1642, 1650, 3499], 'Husbandry—CAST/eiJ': [1617], 'obtained': [1620], 'from': [1621, 1980, 2349, 2361, 2797, 2900, 2904, 2907, 3185, 4354], 'Jackson': [1623], 'Laboratories': [1624], '(Bar': [1625], 'Harbor,': [1626], 'ME)': [1627], 'housed': [1629, 1956, 3785], 'temperature-controlled': [1632], 'room': [1633, 2400, 3462, 3687], '(22-25': [1634], '°C)': [1635], 'under': [1636, 1988], '12-h': [1638], 'light/12-h': [1639], 'dark': [1640], 'cycle.': [1641], 'husbandry': [1643], 'protocols': [1645], 'approved': [1646], 'Institutional': [1649], 'Care': [1651], 'Use': [1653], 'Committee': [1654], 'Cincinnati': [1656], "Children's": [1657], 'Hospital': [1658], 'Research': [1659], 'Foundation.': [1660], 'Human': [1661], 'surfactant': [1662, 4311, 4335], 'C': [1664, 3817, 4313, 4337], '(SP-C)': [1665], 'selectively': [1667], 'endodermally': [1670], 'derived': [1671], 'subsets': [1682], 'bronchiolar': [1686], 'birth': [1690], '(21Wert': [1691, 4315], 'S.E.': [1692, 1886, 2086, 3140, 3228, 4316], 'Glasser': [1693, 4317], 'S.W.': [1694, 4318], 'Korfhagen': [1695, 3241, 3532, 4319], 'T.R.': [1696, 3242, 3533, 4320], '156:': [1702, 4326], '426-443Crossref': [1703, 4327], '(273)': [1706, 4330], 'SP-C-rtTA+/tg': [1710, 1873, 1927], 'transgene': [1711, 1757, 1810, 1961], 'inserting': [1715, 1761], '3.7': [1716], 'kilobases': [1717, 4141], 'SP-C': [1721], 'upstream': [1723], 'transactivator': [1728], '(rtTA)': [1729], '(22Tichelaar': [1731], 'J.W.': [1732], 'Lu': [1733], 'W.': [1734, 1894, 2094, 3148], '2000;': [1740, 2144, 2562, 2756, 3252], '275:': [1741], '11858-11864Abstract': [1742], '(276)': [1750], '(tetO)7-CMV-MK+/tg': [1754, 1796, 1919, 1931], '-tg/tg': [1756, 1798, 1933], '696-bp': [1763], 'cDNA': [1766, 2438, 2866, 2913], 'downstream': [1767], 'minimal': [1770, 2162, 4361], 'CMV': [1771, 4362], 'seven': [1774], 'concatamerized': [1775], 'receptor': [1777], 'sites.': [1779], 'Transgenic': [1780, 1951], 'pronuclear': [1785], 'injection': [1786], 'using': [1787, 1812, 2032, 2055, 2269, 2356, 2367, 2432, 2439, 2882, 2981, 3039, 4308], 'standard': [1788, 2901, 2910], 'techniques,': [1789], 'genotypes': [1791], 'determined': [1793, 2899], 'PCR.': [1795], 'amplification': [1803, 1879, 2864, 2906], '559-bp': [1806], 'sequence': [1807], 'following': [1814, 2051, 2375, 3615], 'primers:': [1815], 'forward': [1816], '(5′-GCC': [1817, 2467], 'ATC': [1818], 'CAC': [1819, 2501], 'GCT': [1820, 2489, 2854], 'GTT': [1821, 2500], 'TTG': [1822, 2491], 'AC-3′)': [1823], '(5′-GGT': [1826], 'CTT': [1827, 1829, 1831], 'TGA': [1828], 'GGT': [1830], 'GGA': [1832, 2471], 'GG-3′).': [1833], 'PCR': [1834, 1878, 2429, 2462, 2630, 3001], 'parameters': [1835, 2631], 'included': [1836, 2632, 3065], 'heating': [1837, 2635], '95': [1839, 1849, 2637, 2649], '°C': [1840, 1850, 1855, 1861, 2412, 2638, 2650, 2655, 2661, 2673, 2678, 2684, 3662], 'for': [1841, 1851, 1856, 1862, 1994, 2019, 2045, 2213, 2253, 2402, 2413, 2460, 2639, 2651, 2656, 2662, 2674, 2679, 2685, 2809, 3122, 3396, 3464, 3683, 3706, 3812, 3903, 3957, 3982, 4021], '5': [1842, 2640, 3397], 'min': [1843, 3468], '30': [1846, 1852, 1857, 2652, 2657, 2669, 2675, 2680], 'cycles': [1847, 2647, 2670], 's,': [1853, 1858, 2653, 2658, 2676, 2681], '57': [1854], '72': [1860, 1871, 2660, 2683, 2696], '45': [1863, 2663], 's': [1864], '7-min': [1868, 2693], 'extension': [1869, 2694], '°C.': [1872, 2195, 2697], 'previously': [1881, 1999, 2081, 2338, 2948, 3045, 3099, 3135, 3318, 3521, 3561], 'described': [1882, 1958, 1976, 2000, 2082, 2949, 3100, 3136, 3279, 3319, 3522], '(23Mucenski': [1883, 2083, 3137], 'Wert': [1885, 2085, 3139], 'Nation': [1887, 2087, 3141], 'J.M.': [1888, 2088, 2141, 2511, 2534, 2707, 2729, 3142], 'Loudy': [1889, 2089, 3143], 'D.E.': [1890, 2090, 3144], 'Huelsken': [1891, 2091, 3145], 'Birchmeier': [1893, 2093, 3147], 'Morrisey': [1895, 2095, 3149], 'E.E.': [1896, 2096, 3150], '278:': [1903, 2103, 3157], '40231-40238Abstract': [1904, 2104, 3158], '(261)': [1912, 2112, 3166], 'Double': [1915], '(SP-C-rtTA+/tg,': [1918], '-tg/tg)': [1921], 'created': [1923], 'crossing': [1925], 'feeding': [1941], 'animals': [1942], 'doxycycline-containing': [1943], 'food': [1944, 3477], '(625': [1945], 'mg/kg,': [1946], 'Harlan': [1947], 'Teklad,': [1948], 'Madison,': [1949, 2393], 'WI).': [1950], 'control': [1953, 1989, 3079], 'above.': [1959, 2291, 3280], 'verified': [1964, 2944, 3022], '(RT)-PCR': [1968], 'three': [1970, 3710], 'separate': [1971], 'lines.': [1973], 'experiments': [1975], 'here': [1977], 'utilize': [1978], 'single': [1982], 'founder': [1983], 'line': [1984], 'doxycycline.': [1991], 'Immunohistochemistry—Immunohistochemical': [1992], 'performed': [1997, 2031, 2050, 2079, 2420, 2431, 2868, 2979, 3036, 3097, 3358, 3612, 3670, 4223], 'Immunohistochemical': [2017], '(α-SMA)': [2023], '(1:20,000,': [2024], 'Sigma)': [2025, 2029], '(1:500,': [2028], '5-μm': [2033], 'paraffin': [2034, 3226, 3557], 'sections.': [2035], 'Sections': [2036], 'treated': [2038, 2385], '3%': [2040, 2323], 'hydrogen': [2041], 'peroxide': [2042], 'methanol': [2044], '15': [2046, 2403], 'min.': [2047, 2641, 3708], 'Staining': [2048], "manufacturer's": [2053, 2258, 2427], 'instructions': [2054], '"Mouse': [2057], 'Mouse"': [2059], '(M.O.M.)': [2060], 'monoclonal': [2061, 3276], 'antibody': [2062, 3277, 3621, 3630, 3678, 3695], 'kit': [2063, 2275, 2889, 2986], '(Vector': [2064], 'Laboratories,': [2065], 'Burlingame,': [2066], 'CA),': [2067], 'sections': [2069, 3269], '3,3-diamino-benzidine': [2073], 'reagent': [2074, 2358], '(Sigma).': [2075], 'Bromodeoxyuridine': [2076], 'immunostaining': [2077, 3981], 'Vitro': [2116, 2281], 'Exposure': [2117, 3377], 'Hypoxia—Human': [2119], '(JEG-3),': [2122, 4078], '(MFLM-4)': [2127], '(24Akeson': [2128], 'A.L.': [2129], 'Wetzel': [2130], 'Thompson': [2132], 'F.Y.': [2133], 'Brooks': [2134], 'S.K.': [2135], 'Paradis': [2136], 'Gendron': [2138], 'R.L.': [2139], 'Greenberg': [2140], '217:': [2145], '11-23Crossref': [2146], '(63)': [2149], '(H-441)': [2156], 'maintained': [2160, 2288], 'essential': [2163], 'medium,': [2164, 2168], "Dulbecco's": [2165, 2318], 'modified': [2166, 2319], "Eagle's": [2167, 2320], 'RPMI,': [2170], 'respectively,': [2171], '10%': [2173], 'calf': [2175, 2325], 'serum,': [2176], '2': [2177, 3883], 'mm': [2178], 'glutamine,': [2179], 'antibiotics.': [2181], 'Cells': [2182, 2216, 2239, 2329], 'routinely': [2184], 'cultured': [2185], '5%': [2187, 2246, 2251, 3664], 'CO2,': [2188], '95%': [2189], 'air': [2190, 3463], '(normoxic': [2191], 'conditions)': [2192], '37': [2194], 'At': [2196, 2292, 3169], '80-90%': [2197, 2293], 'confluence,': [2198, 2294], 'split': [2201, 2297], 'plated': [2203, 2299], '35-mm': [2205, 2301], 'dishes': [2206], 'allowed': [2208], 'grow': [2210], 'normoxia': [2212], '18': [2214], 'h.': [2215, 2255], 'placed': [2218, 3385], 'into': [2219, 2937], 'incubator': [2221], 'FiO2': [2224, 3393], '(Thermo': [2227], 'Forma': [2228], 'Series': [2229], 'II': [2230], 'Water': [2231], 'Jacketed': [2232], 'CO2': [2233, 2252], 'Incubator,': [2234], '3100,': [2236], 'Marietta,': [2237], 'OH).': [2238], 'exposed': [2241, 3391, 3460, 3806, 4015], 'mixture': [2244], 'O2,': [2247], '90%': [2248], 'N2,': [2249], '4': [2254, 3661, 3813, 3906, 3970, 4027], 'Following': [2256], 'instructions,': [2259], 'lysed,': [2263, 2331], 'total': [2265, 2382, 3084], 'RNA': [2266, 2333, 2346, 2383, 2794, 4032], 'isolated': [2268, 2335, 2348, 2796, 4034], 'Absolutely': [2271, 2369], 'RNA®': [2272, 2370], 'RT-PCR': [2273, 2344, 2371], 'Miniprep': [2274, 2372], '(Stratagene,': [2276], 'La': [2277], 'Jolla,': [2278], 'CA).': [2279, 3644], 'Addition': [2282], 'Protein—MFLM-4': [2285], 'outlined': [2290, 2337, 2705, 3046], 'dishes.': [2302], 'After': [2303, 3689, 3709, 3899], '6': [2304], 'h,': [2305], 'μg/ml': [2307], 'recombinant': [2308], '(rhMK': [2311], '258-MD,': [2312], 'R&D': [2313], 'Systems,': [2314], 'Minneapolis,': [2315], 'MN)': [2316], 'medium': [2321], 'added.': [2328], '24': [2340], 'h': [2341, 3685], 'culture.': [2343], 'Analysis—Total': [2345], 'wild': [2350], 'type': [2351], 'double': [2353, 3364], 'Trizol®': [2357], '(Invitrogen)': [2359, 2398, 2423], 'grown': [2363], 'culture': [2365], 'Kit': [2373], '(Stratagene)': [2374], "manufacturers'": [2377], 'instructions.': [2378], '2-μg': [2379], 'aliquots': [2380, 2434], '1': [2387, 2686, 3684, 3868, 3958], 'μl': [2388], 'each': [2389, 3089, 3282], 'RNasin': [2391], '(Promega,': [2392], 'WI)': [2394], 'DNase': [2396, 2406], 'I': [2397, 2407, 2888], 'temperature': [2401], 'm.': [2404, 2687], 'heat-denatured': [2409], '90': [2411], 'min,': [2415], 'SuperScript™II-RT': [2422], 'according': [2424], 'protocol.': [2428], '2-μl': [2433], 'Taq': [2440], 'polymerase': [2441], '(Roche': [2442, 2890], 'Applied': [2443, 2891], 'Science).': [2444, 2892], 'Products': [2445], 'electrophoresed': [2447], '1.5%': [2450], 'agarose': [2451], 'gel': [2452], 'appropriate': [2454], 'weight': [2456, 3202, 3206], 'standards.': [2457], 'Primers': [2458], 'reactions': [2463], 'include': [2464], '(forward': [2466, 2486], 'TGG': [2468], 'AAA': [2469, 2848], 'GTG': [2470, 2483, 2844], 'CAA': [2472, 2479], 'GAT': [2473], 'G-3′)': [2474, 2859], '(5′-GGA': [2477], 'AGA': [2478], 'AAG': [2480], 'GCA': [2481, 2845, 2853], 'CTG': [2482, 2502], 'G-3′)),': [2484, 2508], '(5′-GTT': [2487], 'TCT': [2488], 'GCC': [2490], 'TAT': [2492], 'AGG': [2493], 'AGC': [2494, 2503], 'AAT': [2495, 2842], 'TA-3′)': [2496], '(5′-AAA': [2499], 'CTA': [2504], 'ATA': [2505], 'GTC': [2506], 'CCA': [2507], 'calponin': [2509], '(25Miano': [2510, 2706], '271:': [2518, 2714], '7095-7103Abstract': [2519, 2715], '(112)': [2527, 2723], '(26Li': [2531], 'Miano': [2533, 2728], 'Cserjesi': [2535, 2730], 'Circ.': [2539, 2589, 2620, 2734, 2782, 2829], '78:': [2542, 2737], '188-195Crossref': [2543, 2738], '(340)': [2546, 2741], 'α-SMA': [2549, 3275, 3983, 3988], '(27Arakawa': [2550], 'Hosegawa': [2552, 2746], 'Yanai': [2554, 2748], 'N.': [2555, 2749], 'Obinata': [2556, 2750], 'Matsuda': [2558, 2752], 'Y.': [2559, 2753], 'FEBS': [2560, 2754], 'Lett.': [2561, 2755], '481:': [2563, 2757], '193-196Crossref': [2564, 2758], '(43)': [2567, 2761], '(28Yoshida': [2571, 2602, 2811], 'Sinha': [2573, 2604, 2766, 2813], 'Dandre': [2575, 2606, 2768, 2815], 'Wamhoff': [2577, 2608, 2770, 2817], 'B.R.': [2578, 2609, 2771, 2818], 'Hoofnagle': [2579, 2610, 2772, 2819], 'M.H.': [2580, 2611, 2773, 2820], 'Kremer': [2581, 2612, 2774, 2821], 'B.E.': [2582, 2613, 2775, 2822], 'D.Z.': [2584, 2615, 2777, 2824], '92:': [2592, 2623, 2785, 2832], '856-864Crossref': [2593, 2624, 2786, 2833], '(310)': [2596, 2627, 2789, 2836], 'glyceraldehyde-3-phosphate': [2600, 4052], 'dehydrogenase': [2601, 4053], 'initial': [2634], 'amplified': [2644, 2667], '35': [2646], '50': [2654], 's.': [2664], '94': [2672], '60': [2677, 3707], 'Both': [2688], 'All': [2698, 3019, 3594], 'other': [2699], 'primer': [2700, 2807], 'pairs': [2701, 2808], 'utilized': [2703], '26Li': [2726], '27Arakawa': [2744], '28Yoshida': [2764], 'Real-time': [2792], 'RT-PCR—Total': [2793], 'reverse-transcribed': [2801, 4036], 'cDNA.': [2803, 4038, 4157], 'Oligonucleotide': [2804], 'SYBR': [2805, 2886], 'green': [2806], 'Scholar)': [2838], 'β-actin': [2840, 2917], '(5′-TGG': [2841], 'CCT': [2843], 'TCC': [2846, 2858], 'ATG': [2847], 'C-3′': [2849], '5′-TAA': [2851], 'AAC': [2852], 'CAG': [2855, 2857], 'TAA': [2856], 'generated.': [2861], 'Quantitative': [2862], 'fluorogenic': [2863], 'Smart': [2871], 'Cycler®': [2872], 'processing': [2873], 'block,': [2874], 'SC1000-1': [2876], '(Cepheid,': [2877], 'Sunnyvale,': [2878], 'CA)': [2879], 'LightCycler-DNA': [2884], 'Master': [2885], 'Green': [2887], 'relative': [2894, 4046], 'abundance': [2895], 'curves': [2902], 'serially': [2908], 'diluted': [2909, 3624, 3637, 3679, 3699], 'pools': [2911], 'normalized': [2915, 3121], 'mRNA.': [2918], 'Plasmid': [2919, 3063], 'Construction': [2920], 'Mutagenesis—The': [2922], 'entire': [2923], '2.5-kilobase': [2924], '(p2.5MK-luc)': [2925, 4150], '5′-truncated': [2928], '1.7-kilobase': [2929], '(p1.7MK-luc)': [2930, 4204], 'directionally': [2935], 'cloned': [2936], 'pGL3-basic': [2939], 'reporter': [2940, 2976, 3032], 'plasmid': [2941, 4138], '(Promega)': [2942], 'sequencing': [2946], 'two': [2970, 4179], 'putative': [2971], 'p2.5MK-luc': [2975, 3071], 'construct': [2977], 'QuikChange™': [2983], 'site-directed': [2984, 4220], '(Stratagene).': [2987], 'Synthetic': [2988], 'oligonucleotides': [2989], 'desired': [2992], 'mutation': [2993], '(RCGTG': [2994], '→': [2995], 'CTTGC)': [2996], 'extended': [2998], 'reaction': [3002], 'promoters': [3005], 'contained': [3007], 'mutant': [3009, 3015], '5′': [3010], 'p2.5MK(Δ5′HRE)-luc,': [3012], 'p2.5MK(Δ3′HRE)-luc.': [3018], 'constructs': [3020, 3034], 'sequencing.': [3024], 'Transfection': [3025], 'Reporter': [3027, 3118], 'Gene': [3028], 'Assays—Functional': [3029], 'assays': [3030, 3095, 3119], 'triplicate': [3038], 'transient': [3040], 'transfection': [3041, 3090, 3123], 'JEG-3': [3043, 4131], 'concentrations': [3064], '500': [3066], 'ng/μl': [3067, 3070, 3075], 'pRSV-βGAL,': [3068], '100': [3069], 'p1.7MK-luc,': [3073], '80-480': [3074], 'pCMV-HIF-1α,': [3076], 'pCDNA': [3078], 'vector': [3080, 4154], 'bring': [3082], 'amount': [3085], '1.08': [3092], 'μg.': [3093], 'β-Galactosidase': [3094], '(29Bohinski': [3101], 'R.J.': [3102], 'DiLauro': [3103], '1994;': [3110], '14:': [3111], '5671-5681Crossref': [3112], '(484)': [3115], 'efficiency': [3124], 'based': [3125], 'β-galactosidase': [3128], 'activity.': [3129], 'Morphometric': [3130], 'Analysis—Mice': [3131], 'killed': [3133], 'time': [3171], 'necropsy,': [3173], 'hearts': [3174], 'removed': [3176], 'dissected.': [3178], 'ventricle': [3181, 3188], '(RV)': [3182], 'separated': [3184, 3650], 'left': [3187, 3551], 'septum': [3190], '(LV+S)': [3191], 'weighed': [3193], 'analytical': [3196], 'balance.': [3197], 'Ratios': [3198], 'RV': [3200, 3204], 'weight/LV+S': [3201], 'weight/body': [3205], 'represented.': [3208], 'Lungs': [3209], 'inflation': [3211], 'fixed,': [3212], 'washed': [3213], 'phosphate-buffered': [3215], 'saline,': [3216], 'dehydrated': [3217], 'series': [3220], 'alcohols,': [3222], 'embedded': [3224, 3555], '(30Wert': [3227], 'Yoshida': [3229], 'LeVine': [3231], 'Ikegami': [3233], 'Jones': [3235], 'Ross': [3237], 'G.F.': [3238], 'Fisher': [3239], 'J.H.': [3240], '97:': [3253], '5972-5977Crossref': [3254], '(362)': [3257], 'peripheral': [3265, 3342, 3826, 3925, 3935], 'vessels,': [3267], 'immunohistochemically': [3271], 'stained': [3272], 'randomized': [3283], '60×': [3284], 'field,': [3285], 'vessels': [3286, 3345, 3591, 3595, 3938], '(15-50-μm': [3287], 'external': [3288], 'diameter)': [3289], 'classified': [3291], 'muscularized': [3294, 3302, 3351], '(actin': [3295, 3303, 3311], '>75%': [3297], 'circumference),': [3300, 3308], 'partially': [3301, 3350], '25-50%': [3305], 'non-muscularized': [3310], '<25%': [3313], 'circumference)': [3316], '(31Zaidi': [3320], 'S.H.': [3321], 'You': [3322], 'X.M.': [3323], 'Ciura': [3324], 'Husain': [3326], 'Rabinovitch': [3328], 'Circulation.': [3330], '2002;': [3331], '105:': [3332], '516-521Crossref': [3333], '(139)': [3336], 'percentage': [3340], 'blood': [3344, 3937], 'calculated,': [3353], 't': [3355], 'tests': [3356], 'significant': [3361], 'differences': [3362], 'between': [3363], 'non-transgenic': [3367, 3382], 'littermates': [3368], 'p': [3371], '≤': [3372], '0.05': [3373], 'level.': [3374], 'Vivo': [3376, 3729], 'Hypoxia—Double': [3379], 'normobaric': [3388], 'chamber': [3389, 3419], '0.10': [3395], 'weeks.': [3398], 'Normobaric': [3399], 'achieved': [3402], 'displacement': [3404], 'N2': [3406], 'Pro-Ox': [3410], 'Model': [3411], '110': [3412], 'unit': [3413], '(Biospherix,': [3414], 'Ltd.,': [3415, 3431], 'Redfield,': [3416], 'NY).': [3417], 'changed': [3421], 'regularly': [3422], 'activated': [3424, 4159], 'carbon': [3425, 3453], '(Fisher),': [3426], 'Drierite': [3427, 3429], '(Hammond': [3428], 'Co,': [3430], 'Xenia,': [3432], 'OH),': [3433], 'Baralyme®': [3435], '(Allied': [3436], 'Healthcare': [3437], 'Products,': [3438], 'Inc.,': [3439], 'St.': [3440], 'Louis,': [3441], 'MO)': [3442], 'prevent': [3444], 'toxic': [3446], 'accumulation': [3447], 'ammonia,': [3449], 'excess': [3450], 'humidity,': [3451], 'dioxide.': [3454], 'Once': [3455], 'week,': [3457, 3959], 'less': [3465], 'than': [3466], '20': [3467], 'obtain': [3470], 'body': [3471], 'weights,': [3472], 'clean': [3473], 'cages,': [3474], 'and/or': [3475, 3589], 'replenish': [3476], 'water.': [3479], 'Pulmonary': [3480, 3542], 'Arteriograms,': [3481], 'Histology,': [3482], 'Arterial': [3484], 'Density': [3485], 'Counts—Adult': [3486], 'sacrificed': [3489], 'sodium': [3492], 'pentobarbital': [3493], '(26%)': [3494], 'euthanasia': [3495], 'solution': [3496, 3511], '(Fort': [3497], 'Dodge': [3498], 'Health,': [3500], 'Fort': [3501], 'Dodge,': [3502], 'IA),': [3503], 'infused': [3507], 'heated': [3510], 'gelatin': [3513], 'barium': [3515], 'through': [3516], 'artery': [3519], '(32Le': [3523], 'Cras': [3524], 'T.D.': [3525], 'Hardie': [3526], 'W.D.': [3527], 'Fagan': [3528], '285:': [3538], 'L1046-L1054PubMed': [3539], 'arterial': [3543, 3565], 'architecture': [3544], 'imaged': [3546], 'x-ray': [3548], 'radiography.': [3549], 'subsequently': [3554], 'sectioned': [3559], 'described.': [3562], 'determine': [3564], 'density,': [3566], 'barium-filled': [3567], 'arteries': [3569], 'counted': [3571, 3603], 'blinded': [3574], 'observer': [3575], 'randomly': [3577], 'selected': [3578], 'high-powered': [3579, 3600], '(60×)': [3580], 'fields': [3581, 3601], 'distal': [3583], 'Fields': [3585], 'large': [3587, 3590], 'airways': [3588, 3926], 'excluded.': [3593], 'counted,': [3597], 'five': [3599], 'per': [3604], 'animal.': [3605], 'Western': [3606], 'Blot': [3607], 'Analysis—Western': [3608], 'blot': [3609], 'analysis': [3610], 'primary': [3616, 3677], 'antibodies:': [3617], 'rabbit': [3619], 'polyclonal': [3620, 3629], 'Tie-2': [3623], '1:2000': [3625, 3638], 'goat': [3628], 'platelet': [3632], 'endothelial': [3633], 'adhesion': [3635], 'molecule': [3636], '(Santa': [3639, 3696], 'Cruz': [3640], 'Biotechnology,': [3641], 'Santa': [3642], 'Cruz,': [3643], 'Lung': [3645], 'homogenates': [3646], '(25': [3647], 'μg)': [3648], 'SDS-PAGE,': [3652], 'transferred': [3653], 'nitrocellulose': [3655], 'membranes,': [3656], 'overnight': [3659], 'nonfat': [3665], 'dried': [3666], 'milk.': [3667], 'Immunodetection': [3668], 'incubating': [3672], 'membranes': [3674], 'blocking': [3681, 3701], 'buffer': [3682, 3702], 'temperature.': [3688], 'washing,': [3690], 'secondary': [3692], 'horseradish': [3693], 'peroxidase-conjugated': [3694], 'Cruz)': [3697], '(1:10,000)': [3703], 'applied': [3705], 'washes,': [3711], 'ECL': [3712], 'Plus': [3713], 'detection': [3714], '(Amersham': [3715], 'Biosciences)': [3716], 'performed,': [3718], 'auto-radiographs': [3720], 'taken.': [3722], 'Hypoxia': [3727], 'Vitro—CAST/eiJ': [3732], 'mice,': [3733], 'strain,': [3736], 'remodeling': [3739], 'cor': [3741], 'pulmonale': [3742], '(FiO2': [3745, 3809, 4018], '0.10),': [3747], 'resistant': [3752], 'adult': [3763, 3782, 3803], '(Fig.': [3768, 3815, 3836, 3851, 3872, 3897, 3939, 3972, 3984, 4105, 4163, 4175, 4210, 4241, 4267, 4364], '1,': [3769, 3816, 3837, 3852, 3873, 3940, 4023], 'A': [3770], 'B).': [3772], 'barely': [3776], 'detectable': [3777], 'intense': [3789], '0.10)': [3811, 4020], 'D).': [3819], 'E': [3838], 'F).': [3840], 'Intensity': [3841], 'exposure': [3848, 3879, 3900, 3956, 3967], 'G': [3853, 3874], 'L).': [3855, 3943], 'lining': [3864], 'proximal': [3865, 4272], 'bronchioles': [3866], 'week': [3869], 'I).': [3876], 'When': [3877], 'hypoxic': [3878, 3955, 3966], 'lengthened': [3881, 3968], 'regions': [3892], 'parenchyma': [3896], '1J).': [3898], '3': [3904], 'throughout': [3912], 'conducting': [3923], 'K': [3941], 'steadily': [3962], '2).': [3973], 'Increasing': [3974], '1F)': [3985], '(not': [3990], 'shown).': [3991], 'Thus,': [3992], 'hypoxemia-susceptible': [4001], 'mice.Fig.': [4003], '2MK': [4004], '0,': [4022], '2,': [4024], '3,': [4025], 'weeks,': [4028], 'whole': [4030], 'RT-PCR,': [4044], 'compared': [4050], '(GAPDH)': [4054], 'mRNA.View': [4055], 'Large': [4056], 'Image': [4057], 'Figure': [4058], 'ViewerDownload': [4059], '(PPT)': [4060], 'effect': [4062], 'assessed': [4069], 'including': [4074], '(MFLM-4),': [4083], '(H-441).': [4088], 'all': [4099], '3).': [4106], 'Regulates': [4108], 'Transcription': [4110], 'Vitro—Because': [4112], 'transcriptional': [4117], 'mediator': [4118], 'assessed.': [4130], 'co-transfected': [4134, 4172], 'luciferase-reporter': [4137], '2.5': [4140], '5′-region': [4144], '4)': [4164], 'acted': [4166], 'additive': [4169], 'manner': [4170], 'when': [4171, 4262], 'TTF-1': [4174], '4B).': [4176], 'There': [4177], '2.5MK-luc': [4184], 'plasmid,': [4185], '-1701': [4188, 4229], '-1697': [4190, 4231], '(5′-HRE)': [4191], '+48': [4193, 4233], '+52': [4195], '(3′-HRE).': [4196], 'Deletion': [4197], '5′-HRE': [4200, 4246], 'did': [4205, 4247, 4257], 'inhibit': [4207, 4250], '4C).': [4211], 'identify': [4213], 'HIF-1α-induced': [4217, 4275], 'transcription,': [4219], '+52,': [4235], 'generating': [4236], 'p2.5MK(Δ5′HRE)-luc': [4237], 'p2.5MK(Δ3′HRE)-luc,': [4239], 'respectively': [4240], '4D).': [4242], 'Mutation': [4243], 'significantly': [4249], 'transactivation': [4251], 'contrast,': [4255], '3′-HRE': [4264], 'mutated': [4266], '4D),': [4268], 'demonstrating': [4269], 'HRE': [4273], 'regulates': [4274], 'MK.': [4278], 'Inducible': [4279], 'Murine': [4285], 'Lung—To': [4286], 'doxycycline': [4349], 'tet-O': [4355], 'sites': [4357], 'activate': [4359], '5A).': [4365], 'trans': [4371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2098840758', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-08T12:25:45.516505', 'created_date': '2016-06-24'}
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