Publication Information

{'id': 'https://openalex.org/W1995002689', 'doi': 'https://doi.org/10.1139/y05-061', 'title': 'Stretch-dependent growth and differentiation in vascular smooth muscle: role of the actin cytoskeleton', 'display_name': 'Stretch-dependent growth and differentiation in vascular smooth muscle: role of the actin cytoskeleton', 'publication_year': 2005, 'publication_date': '2005-10-01', 'ids': {'openalex': 'https://openalex.org/W1995002689', 'doi': 'https://doi.org/10.1139/y05-061', 'mag': '1995002689', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16333359'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1139/y05-061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S82722058', 'display_name': 'Canadian Journal of Physiology and Pharmacology', 'issn_l': '0008-4212', 'issn': ['0008-4212', '1205-7541'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313060', 'host_organization_name': 'NRC Research Press', 'host_organization_lineage': ['https://openalex.org/P4310313060'], 'host_organization_lineage_names': ['NRC Research Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056632743', 'display_name': 'Per Hellstrand', 'orcid': 'https://orcid.org/0000-0003-2081-2666'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Per Hellstrand', 'raw_affiliation_strings': ['Vascular Physiology'], 'affiliations': [{'raw_affiliation_string': 'Vascular Physiology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006983556', 'display_name': 'Sebastian Albinsson', 'orcid': 'https://orcid.org/0000-0001-6936-3967'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sebastian Albinsson', 'raw_affiliation_strings': ['Vascular Physiology'], 'affiliations': [{'raw_affiliation_string': 'Vascular Physiology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.492, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.434726, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '83', 'issue': '10', 'first_page': '869', 'last_page': '875'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12793', 'display_name': 'Caveolin-1 and cellular processes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/calponin', 'display_name': 'Calponin', 'score': 0.8937212}, {'id': 'https://openalex.org/keywords/myocardin', 'display_name': 'Myocardin', 'score': 0.6664417}, {'id': 'https://openalex.org/keywords/stress-fiber', 'display_name': 'Stress fiber', 'score': 0.47332343}], 'concepts': [{'id': 'https://openalex.org/C2781122658', 'wikidata': 'https://www.wikidata.org/wiki/Q24744812', 'display_name': 'Calponin', 'level': 3, 'score': 0.8937212}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7026482}, {'id': 'https://openalex.org/C2780286377', 'wikidata': 'https://www.wikidata.org/wiki/Q18048730', 'display_name': 'Myocardin', 'level': 5, 'score': 0.6664417}, {'id': 'https://openalex.org/C69053785', 'wikidata': 'https://www.wikidata.org/wiki/Q907394', 'display_name': 'Serum response factor', 'level': 4, 'score': 0.6222596}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.55377394}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.54145336}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53368914}, {'id': 'https://openalex.org/C2781099445', 'wikidata': 'https://www.wikidata.org/wiki/Q4121060', 'display_name': 'Stress fiber', 'level': 4, 'score': 0.47332343}, {'id': 'https://openalex.org/C167414201', 'wikidata': 'https://www.wikidata.org/wiki/Q1955391', 'display_name': 'Muscle hypertrophy', 'level': 2, 'score': 0.44691497}, {'id': 'https://openalex.org/C6997183', 'wikidata': 'https://www.wikidata.org/wiki/Q271727', 'display_name': 'Myosin', 'level': 2, 'score': 0.4262113}, {'id': 'https://openalex.org/C2777093181', 'wikidata': 'https://www.wikidata.org/wiki/Q15331450', 'display_name': 'RHOA', 'level': 3, 'score': 0.42291865}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.41088232}, {'id': 'https://openalex.org/C151166631', 'wikidata': 'https://www.wikidata.org/wiki/Q904514', 'display_name': 'Focal adhesion', 'level': 3, 'score': 0.3523119}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.32294416}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2460267}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12534198}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.119859606}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020742', 'descriptor_name': 'rhoA GTP-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020742', 'descriptor_name': 'rhoA GTP-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1139/y05-061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S82722058', 'display_name': 'Canadian Journal of Physiology and Pharmacology', 'issn_l': '0008-4212', 'issn': ['0008-4212', '1205-7541'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313060', 'host_organization_name': 'NRC Research Press', 'host_organization_lineage': ['https://openalex.org/P4310313060'], 'host_organization_lineage_names': ['NRC Research Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16333359', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W133296140', 'https://openalex.org/W1921428702', 'https://openalex.org/W1994965373', 'https://openalex.org/W1998621281', 'https://openalex.org/W2000982151', 'https://openalex.org/W2008924522', 'https://openalex.org/W2023687572', 'https://openalex.org/W2058225109', 'https://openalex.org/W2078702741', 'https://openalex.org/W2081383439', 'https://openalex.org/W2087474624', 'https://openalex.org/W2093263274', 'https://openalex.org/W2093723806', 'https://openalex.org/W2096536884', 'https://openalex.org/W2098806594', 'https://openalex.org/W2099583647', 'https://openalex.org/W2099685153', 'https://openalex.org/W2101907071', 'https://openalex.org/W2107744694', 'https://openalex.org/W2110743056', 'https://openalex.org/W2116180227', 'https://openalex.org/W2117822099', 'https://openalex.org/W2120168649', 'https://openalex.org/W2121822802', 'https://openalex.org/W2128443216', 'https://openalex.org/W2130172628', 'https://openalex.org/W2132705463', 'https://openalex.org/W2132997123', 'https://openalex.org/W2137290608', 'https://openalex.org/W2138742704', 'https://openalex.org/W2140424595', 'https://openalex.org/W2142142115', 'https://openalex.org/W2143334331', 'https://openalex.org/W2145009320', 'https://openalex.org/W2153761690', 'https://openalex.org/W2161595178', 'https://openalex.org/W2162035304', 'https://openalex.org/W2162668341', 'https://openalex.org/W2165106797', 'https://openalex.org/W2172082373', 'https://openalex.org/W2322005342'], 'related_works': ['https://openalex.org/W2591171938', 'https://openalex.org/W2335582356', 'https://openalex.org/W2296829780', 'https://openalex.org/W2170650062', 'https://openalex.org/W2163909549', 'https://openalex.org/W2087668326', 'https://openalex.org/W2078819422', 'https://openalex.org/W2006160253', 'https://openalex.org/W1992286016', 'https://openalex.org/W1990002483'], 'abstract_inverted_index': {'The': [0], 'smooth': [1, 36, 51, 104, 125, 209], 'muscle': [2, 37, 52, 105, 126, 210], 'cells': [3, 38], 'in': [4, 20, 42, 72, 78, 100, 109, 138, 161, 178, 207], 'the': [5, 15, 26, 55, 101, 131, 143, 169], 'vascular': [6], 'wall': [7], 'are': [8, 157], 'constantly': [9], 'exposed': [10], 'to': [11, 94, 199], 'distending': [12], 'forces': [13], 'from': [14], 'intraluminal': [16], 'pressure.': [17], 'A': [18, 195], 'rise': [19], 'blood': [21], 'pressure': [22], 'triggers': [23], 'growth': [24, 60, 177, 192], 'of': [25, 35, 49, 63, 67, 97, 103, 122, 145, 147, 168, 187, 202], 'vessel': [27], 'wall,': [28], 'which': [29], 'is': [30, 69, 85, 164, 198], 'characterized': [31], 'primarily': [32], 'by': [33, 184], 'hypertrophy': [34], 'with': [39, 61, 111, 166], 'maintained': [40, 180], 'differentiation': [41, 106, 149, 162], 'a': [43, 95, 179], 'contractile': [44, 181], 'phenotype.': [45], 'Growth': [46], 'factor': [47, 114, 135], 'stimulation': [48], 'dissociated': [50], 'cells,': [53], 'on': [54], 'other': [56], 'hand,': [57], 'causes': [58], 'proliferative': [59], 'loss': [62], 'contractility.': [64], 'This': [65, 159], 'type': [66], 'response': [68, 113], 'also': [70], 'found': [71], 'neointima': [73], 'development': [74], 'following': [75], 'angioplasty': [76], 'and': [77, 116, 129, 155, 193], 'atherosclerotic': [79], 'lesions.': [80], 'An': [81], 'intact': [82, 123, 208], 'tissue': [83], 'environment': [84], 'therefore': [86], 'critical': [87], 'for': [88], 'preserved': [89], 'differentiation.': [90, 194], 'Recent': [91], 'advances': [92], 'point': [93], 'role': [96], 'actin': [98, 132, 140], 'polymerization': [99], 'expression': [102], 'marker': [107], 'genes,': [108], 'concert': [110], 'serum': [112], '(SRF)': [115], 'cofactors,': [117], 'such': [118, 151], 'as': [119, 152], 'myocardin.': [120], 'Stretch': [121], 'venous': [124], 'activates': [127], 'Rho': [128], 'inhibits': [130], 'filament': [133], 'severing': [134], 'cofilin,': [136], 'resulting': [137], 'increased': [139], 'polymerization.': [141], 'Concomitantly,': [142], 'rates': [144], 'synthesis': [146], 'SRF-regulated': [148], 'markers,': [150], 'SM22α,': [153], 'calponin,': [154], 'α-actin,': [156], 'increased.': [158], 'increase': [160], 'signals': [163], 'parallel': [165], 'activation': [167, 186], 'mitogen-activated': [170], 'protein': [171], '(MAP)': [172], 'kinase': [173], 'pathway.': [174], 'Thus': [175], 'stretch-induced': [176], 'phenotype': [182], 'occurs': [183], 'dual': [185], 'signal': [188], 'pathways': [189, 206], 'regulating': [190], 'both': [191], 'current': [196], 'challenge': [197], 'identify': [200], 'sites': [201], 'crosstalk': [203], 'between': [204], 'these': [205], 'tissue.Key': [211], 'words:': [212], 'stretch,': [213], 'hypertension,': [214], 'ERK,': [215], 'Rho,': [216], 'caveolae.': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995002689', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-09T03:46:18.142079', 'created_date': '2016-06-24'}