Title: Characterization of the insulin resistance of glucose utilization in adipocytes from patients with hyper- and hypothyroidism
Abstract: Abstract. Insulin action on glucose utilization was characterized in adipocytes from 10 thyrotoxic patients, 6 hypothyroid patients and 10 age- and sex-matched control subjects. In thyrotoxic patients insulin binding at low insulin concentrations was reduced ( P < 0.05) and accompanied by impaired insulin sensitivity of glucose transport ( P < 0.02), glucose oxidation ( P < 0.05) and lipogenesis ( P < 0.05). Glucose transport and glucose oxidation rates also exhibited depressed maximal insulin responsiveness ( P < 0.05). In hypothyroid patients insulin binding was reduced, too, ( P < 0.05) and associated with impaired sensitivity to insulin of glucose transport ( P < 0.05). Both glucose transport and lipogenesis rates showed decreased maximal insulin responsiveness ( P < 0.05). In conclusion: In man, both hyper- and hypothyroidism are characterized by insulin resistance of adipocyte glucose utilization localized to insulin binding as well as to insulin-stimulated glucose transport and metabolism.
Publication Year: 1988
Publication Date: 1988-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 20
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