Abstract: Muscle glucose uptake during exercise is regulated by a coordinated increase in glucose delivery (via increased blood flow and glucose moving out of the capillaries into the interstitial space), by facilitated glucose transport into the myocytes and by intramyocellular metabolism. The facilitative glucose transporter GLUT4 is translocated to the sarcolemma and the t-tubules, and GLUT4 translocation is essential for glucose transport into the myocytes during exercise. Several molecular mechanisms have been proposed to regulate insulin-independent GLUT4 translocation during in vivo conditions, but the regulation of both exercise-stimulated GLUT4 translocation and the integrative glucose uptake process by exercise remains incompletely understood. GLUT4 intrinsic transporter activity may also be regulated during exercise although there is no firm evidence for this. The multitude of mechanisms involved in muscle glucose uptake stimulation during exercise ensure the delivery of easily combustible fuel to the working muscles.
Publication Year: 2022
Publication Date: 2022-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot