Publication Information

{'id': 'https://openalex.org/W2095694423', 'doi': 'https://doi.org/10.1128/aac.00707-11', 'title': 'DNA Gyrase Inhibition Assays Are Necessary To Demonstrate Fluoroquinolone Resistance Secondary to <i>gyrB</i> Mutations in Mycobacterium tuberculosis', 'display_name': 'DNA Gyrase Inhibition Assays Are Necessary To Demonstrate Fluoroquinolone Resistance Secondary to <i>gyrB</i> Mutations in Mycobacterium tuberculosis', 'publication_year': 2011, 'publication_date': '2011-07-19', 'ids': {'openalex': 'https://openalex.org/W2095694423', 'doi': 'https://doi.org/10.1128/aac.00707-11', 'mag': '2095694423', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21768507', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3186962'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00707-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3186962?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001797876', 'display_name': 'Alix Pantel', 'orcid': 'https://orcid.org/0000-0002-2317-4199'}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alix Pantel', 'raw_affiliation_strings': ['UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065755441', 'display_name': 'S. Petrella', 'orcid': 'https://orcid.org/0000-0001-6641-5901'}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210133725', 'display_name': 'CNR de la Résistance aux Antibiotiques', 'ror': 'https://ror.org/044yd5h03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133725']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stéphanie Petrella', 'raw_affiliation_strings': ['Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}, {'raw_affiliation_string': 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210133725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066626840', 'display_name': 'Stéphanie Matrat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stéphanie Matrat', 'raw_affiliation_strings': ['UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011342370', 'display_name': 'Florence Brossier', 'orcid': 'https://orcid.org/0000-0003-4078-3380'}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210133725', 'display_name': 'CNR de la Résistance aux Antibiotiques', 'ror': 'https://ror.org/044yd5h03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133725']}, {'id': 'https://openalex.org/I4210121705', 'display_name': 'Pitié-Salpêtrière Hospital', 'ror': 'https://ror.org/02mh9a093', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Florence Brossier', 'raw_affiliation_strings': ['AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I39804081']}, {'raw_affiliation_string': 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210133725']}, {'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008080310', 'display_name': 'Sylvaine Bastian', 'orcid': 'https://orcid.org/0000-0002-9394-8495'}, 'institutions': [{'id': 'https://openalex.org/I4210133725', 'display_name': 'CNR de la Résistance aux Antibiotiques', 'ror': 'https://ror.org/044yd5h03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133725']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sylvaine Bastian', 'raw_affiliation_strings': ['Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210133725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070255886', 'display_name': 'Delphine Reitter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Delphine Reitter', 'raw_affiliation_strings': ['UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055642273', 'display_name': 'Vincent Jarlier', 'orcid': 'https://orcid.org/0000-0003-0957-0002'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210121705', 'display_name': 'Pitié-Salpêtrière Hospital', 'ror': 'https://ror.org/02mh9a093', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}, {'id': 'https://openalex.org/I4210133725', 'display_name': 'CNR de la Résistance aux Antibiotiques', 'ror': 'https://ror.org/044yd5h03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133725']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Jarlier', 'raw_affiliation_strings': ['AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210121705', 'https://openalex.org/I39804081', 'https://openalex.org/I4210097159']}, {'raw_affiliation_string': 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210133725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035143391', 'display_name': 'Claudine Mayer', 'orcid': 'https://orcid.org/0000-0002-6854-5846'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I169173203', 'display_name': 'Délégation Paris 7', 'ror': 'https://ror.org/00bw5n526', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I169173203']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Claudine Mayer', 'raw_affiliation_strings': ['URA 2185, CNRS, Paris, France', 'Unité de Dynamique Structurale des Macromolécules, Département de Biologie Structurale et Chimie, Institut Pasteur, Paris, France', 'Université Paris Diderot Paris 07, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Unité de Dynamique Structurale des Macromolécules, Département de Biologie Structurale et Chimie, Institut Pasteur, Paris, France', 'institution_ids': ['https://openalex.org/I157536573']}, {'raw_affiliation_string': 'Université Paris Diderot Paris 07, Paris, France', 'institution_ids': ['https://openalex.org/I169173203', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'URA 2185, CNRS, Paris, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090449409', 'display_name': 'Alexandra Aubry', 'orcid': 'https://orcid.org/0000-0003-4230-4793'}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I4210121705', 'display_name': 'Pitié-Salpêtrière Hospital', 'ror': 'https://ror.org/02mh9a093', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705']}, {'id': 'https://openalex.org/I4210133725', 'display_name': 'CNR de la Résistance aux Antibiotiques', 'ror': 'https://ror.org/044yd5h03', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210133725']}, {'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Alexandra Aubry', 'raw_affiliation_strings': ['AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'UPMC Université Paris 06, ER5, EA 1541, Laboratoire de Bactériologie-Hygiène, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081']}, {'raw_affiliation_string': 'AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210121705', 'https://openalex.org/I39804081', 'https://openalex.org/I4210097159']}, {'raw_affiliation_string': 'Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, F-75013 Paris, France', 'institution_ids': ['https://openalex.org/I4210133725']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5090449409'], 'corresponding_institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I39804081', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210133725', 'https://openalex.org/I4210097159'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.406, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.817386, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '55', 'issue': '10', 'first_page': '4524', 'last_page': '4529'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gatifloxacin', 'display_name': 'Gatifloxacin', 'score': 0.56010884}, {'id': 'https://openalex.org/keywords/topoisomerase-iv', 'display_name': 'Topoisomerase IV', 'score': 0.52763075}], 'concepts': [{'id': 'https://openalex.org/C167125095', 'wikidata': 'https://www.wikidata.org/wiki/Q70551687', 'display_name': 'DNA gyrase', 'level': 4, 'score': 0.97975063}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.6395558}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.5678933}, {'id': 'https://openalex.org/C2777653605', 'wikidata': 'https://www.wikidata.org/wiki/Q2365016', 'display_name': 'Gatifloxacin', 'level': 4, 'score': 0.56010884}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55990255}, {'id': 'https://openalex.org/C2777112418', 'wikidata': 'https://www.wikidata.org/wiki/Q7824976', 'display_name': 'Topoisomerase IV', 'level': 5, 'score': 0.52763075}, {'id': 'https://openalex.org/C2778049240', 'wikidata': 'https://www.wikidata.org/wiki/Q411447', 'display_name': 'Ofloxacin', 'level': 4, 'score': 0.4746357}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.41775808}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.41103745}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.40724453}, {'id': 'https://openalex.org/C2781276175', 'wikidata': 'https://www.wikidata.org/wiki/Q424193', 'display_name': 'Levofloxacin', 'level': 3, 'score': 0.3233457}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.28108096}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.25802425}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.22269619}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15747845}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15013975}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D024841', 'descriptor_name': 'Fluoroquinolones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024841', 'descriptor_name': 'Fluoroquinolones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D018088', 'descriptor_name': 'Tuberculosis, Multidrug-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018088', 'descriptor_name': 'Tuberculosis, Multidrug-Resistant', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00707-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3186962', 'pdf_url': 'https://europepmc.org/articles/pmc3186962?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186962', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21768507', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3186962', 'pdf_url': 'https://europepmc.org/articles/pmc3186962?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.87, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W144416057', 'https://openalex.org/W1493562191', 'https://openalex.org/W1524720556', 'https://openalex.org/W1942445791', 'https://openalex.org/W1976081360', 'https://openalex.org/W1982168502', 'https://openalex.org/W1991577656', 'https://openalex.org/W1998301640', 'https://openalex.org/W2006433340', 'https://openalex.org/W2009486624', 'https://openalex.org/W2014575289', 'https://openalex.org/W2020661238', 'https://openalex.org/W2026532586', 'https://openalex.org/W2030144417', 'https://openalex.org/W2032342750', 'https://openalex.org/W2039170919', 'https://openalex.org/W2046417607', 'https://openalex.org/W2076536619', 'https://openalex.org/W2099090001', 'https://openalex.org/W2100197432', 'https://openalex.org/W2103017729', 'https://openalex.org/W2103876802', 'https://openalex.org/W2104398522', 'https://openalex.org/W2119282038', 'https://openalex.org/W2119472707', 'https://openalex.org/W2121649640', 'https://openalex.org/W2129759335', 'https://openalex.org/W2135070766', 'https://openalex.org/W2137128333', 'https://openalex.org/W2137575290', 'https://openalex.org/W2140509482', 'https://openalex.org/W2140862820', 'https://openalex.org/W2153599083', 'https://openalex.org/W2170377094', 'https://openalex.org/W2321432077', 'https://openalex.org/W2418210342', 'https://openalex.org/W4248545381', 'https://openalex.org/W4298787543', 'https://openalex.org/W4300919399', 'https://openalex.org/W96877081'], 'related_works': ['https://openalex.org/W4253896316', 'https://openalex.org/W2393261780', 'https://openalex.org/W2387892627', 'https://openalex.org/W2379549916', 'https://openalex.org/W2379388919', 'https://openalex.org/W2167902861', 'https://openalex.org/W2154870920', 'https://openalex.org/W2138130154', 'https://openalex.org/W2113125767', 'https://openalex.org/W2024418453'], 'abstract_inverted_index': {'The': [0], 'main': [1], 'mechanism': [2], 'of': [3, 22, 45, 55, 81, 194, 205, 210, 223, 226], 'fluoroquinolone': [4], '(FQ)': [5], 'resistance': [6, 31], 'in': [7, 12, 17, 25, 29, 49, 60, 75, 84, 104, 138, 151, 157, 162, 167, 199, 207, 228], 'Mycobacterium': [8], 'tuberculosis': [9, 51, 159, 211], 'is': [10, 32, 186], 'mutation': [11, 198], 'DNA': [13, 70, 120, 182, 196], 'gyrase': [14, 71, 116, 121, 183, 197], '(GyrA(2)GyrB(2)),': [15], 'especially': [16], 'gyrA.': [18], 'However,': [19], 'the': [20, 40, 79, 135, 181, 187, 192, 203, 208, 221, 224], 'discovery': [21], 'unknown': [23], 'mutations': [24, 48, 83, 227], 'gyrB': [26, 47, 98], 'whose': [27], 'implication': [28], 'FQ': [30, 43, 66, 85, 168, 178, 200, 206], 'unclear': [33], 'has': [34], 'become': [35], 'more': [36], 'frequent.': [37], 'We': [38, 64, 132], 'investigated': [39], 'impact': [41], 'on': [42, 220], 'susceptibility': [44, 179], 'eight': [46, 136], 'M.': [50, 158], 'clinical': [52, 153], 'strains,': [53], 'three': [54], 'which': [56], 'were': [57, 102, 123], 'previously': [58], 'identified': [59, 150], 'an': [61], 'FQ-resistant': [62, 152], 'strain.': [63], 'measured': [65], 'MICs': [67, 118], 'and': [68, 91, 110, 119, 130, 147], 'also': [69], 'inhibition': [72, 122, 184], 'by': [73, 100], 'FQs': [74], 'order': [76], 'to': [77, 108, 112, 176, 190], 'clarify': [78], 'role': [80, 193], 'these': [82], 'resistance.': [86, 169, 201], 'Wild-type': [87], 'GyrA,': [88], 'wild-type': [89], 'GyrB,': [90], 'mutant': [92], 'GyrB': [93, 139], 'subunits': [94], 'produced': [95], 'from': [96], 'engineered': [97], 'alleles': [99], 'mutagenesis': [101], 'overexpressed': [103], 'Escherichia': [105], 'coli,': [106], 'purified': [107], 'homogeneity,': [109], 'used': [111], 'reconstitute': [113], 'highly': [114], 'active': [115], 'complexes.': [117], 'determined': [124], 'for': [125], 'moxifloxacin,': [126], 'gatifloxacin,': [127], 'ofloxacin,': [128], 'levofloxacin,': [129], 'enoxacin.': [131], 'demonstrated': [133], 'that': [134], 'substitutions': [137], '(D473N,': [140], 'P478A,': [141], 'R485H,': [142], 'S486F,': [143], 'A506G,': [144], 'A547V,': [145], 'G551R,': [146], 'G559A),': [148], 'recently': [149], 'strains': [154, 160], 'or': [155], 'encountered': [156], 'isolated': [161], 'France,': [163], 'are': [164], 'not': [165, 215], 'implicated': [166], 'These': [170], 'results': [171], 'underline': [172], 'that,': [173], 'as': [174], 'opposed': [175], 'phenotypic': [177], 'testing,': [180], 'assay': [185], 'only': [188, 219], 'way': [189], 'prove': [191], 'a': [195], 'Therefore,': [202], 'use': [204], 'treatment': [209], '(TB)': [212], 'patients': [213], 'should': [214], 'be': [216], 'ruled': [217], 'out': [218], 'basis': [222], 'presence': [225], 'gyrB.': [229]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2095694423', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-13T06:54:48.801908', 'created_date': '2016-06-24'}