Title: GPER:a novel target in treatment of estrogen-related diseases
Abstract:G protein-coupled estrogen receptor 1(GPER) is a novel receptor,which belongs to the family of G protein-coupled receptors,to many of the rapid biological responses to estrogen.Different from the two ...G protein-coupled estrogen receptor 1(GPER) is a novel receptor,which belongs to the family of G protein-coupled receptors,to many of the rapid biological responses to estrogen.Different from the two classical nuclear estrogen receptors,ERα and ERβ,GPER modulates both rapid non-genomic reaction and genomic transcriptional events of estrogen.In this regard,GPER may be considered as a valuable target toward novel therapeutic strategy for many estrogen-related diseases.The intrinsic appearance of GPER,including structure,subcellular localization,ligands,signal transduction pathway and relationship with diseases is reviewed in this paper.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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