Title: Zn(II), Cd(II) and Hg(II) complexes of sulfadrugs
Abstract: The triple sulfa drugs, sulfadiazine, sulfamerazine and sulfamethazine, form a large number of metal complexes in different solvent media. The present studies show the synthesis and characterization of the Hg(II) complexes of sulfadiazine 1, sulfamerazine 2 and sulfamethazine 3 in dimethylformamide solution in presence of ammonia. The compounds were characterised by spectroscopic methods and crystal structures of the complexes were determined. All the compounds, 1, 2 and 3, crystallise in monoclinic crystal systems with the space groups of C2/c, C2/c and P21/c, respectively. Compounds 1 and 3 have eight coordinate ‘2+6’ geometries, with two tridentate sulfonamide ions and two DMF molecules in the coordination sphere. Complex 2 has a six co-ordinate, ‘2+4’ geometry which contains a short linear N–Hg–N moiety from co-ordinated sulfonamides. The IR spectral data suggest the binding of mercury atom to the sulfonamidic nitrogen atoms in agreement with the crystal structure determination.
Publication Year: 1976
Publication Date: 1976-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 14
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