Title: The Use of Sulfonamides in the Control of Pullorum Disease
Abstract: STUDIES on the use of sulfonamides in reducing mortality from pullorum disease were reported by Severens, Roberts and Card (1945). They found that sulfadiazine and sulfamerazine-treated birds showed a reduction in mortality from 70% to 96% in comparison to untreated control birds. Sulfamerazine was as effective in 0.5% level in the feed as a 2.0% level of sulfadiazine. Hens that had been infected at 1 day of age and treated with sulfadiazine and sulfamerazine did not react to the pullorum agglutination test at 9 months of age. Mullen (1946) reported a difference of 14% in mortality with turkeys treated wifh 0.5% sulfamerazine in comparison to untreated controls in eleven flocks totaling 22,965 turkey poults. The results of these investigators showed that those sulfonamides which produced a relatively high blood level without toxicity gave promise of being effective chemotherapeutic agents for the treatment and control of pullorum disease. Three experiments were . . .