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171, 176, 191, 198, 209, 218, 229], 'crystal': [22, 210], 'structure': [23, 41], 'bound': [26], 'to': [27, 65, 114, 127, 161, 178, 217], 'receptor': [29], 'homologue': [30], 'protein': [33], 'from': [34, 112], 'Lymnaea': [35], 'stagnalis.': [36], 'This': [37, 188], 'is': [38, 195], 'first': [40], 'in': [44, 54, 143, 185], 'a': [45, 96, 108], 'pocket': [47], 'containing': [48], 'all': [49, 55], 'five': [50], 'aromatic': [51, 67], 'residues': [52, 72], 'conserved': [53, 192], 'mammalian': [56], 'nAChRs.': [57], 'The': [58, 212], 'ligand-protein': [59], 'interactions': [60, 89], 'characterized': [62], 'by': [63, 71, 181, 208], 'contacts': [64], 'box': [68], 'formed': [69], 'primarily': [70], 'principal': [75, 92], 'side': [76, 106], 'intersubunit': [79], 'interface': [81], '(residues': [82], 'Tyr89,': [83], 'Trp143': [84], 'Tyr185).': [86], 'Besides': [87], 'these': [88, 236], 'side,': [93], 'observe': [95], 'cation-π': [97], 'interaction': [98], 'between': [99], 'Trp53': [102], 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215], 'effects': [199], 'ACh': [201], 'at': [202], 'nAChRs,': [204], 'as': [205], 'also': [206], 'indicated': [207], 'structure.': [211], 'results': [213], 'add': [214], 'understanding': [219], 'how': [221], 'this': [222], 'neurotransmitter': [223], 'exerts': [224], 'its': [225], 'action': [226], 'improves': [228], 'foundation': [230], 'rational': [232], 'drug': [233], 'design': [234], 'targeting': [235], 'receptors.': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2094614783', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-12-15T17:04:15.361952', 'created_date': 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