Publication Information

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1785, 1965, 1989, 1996, 2216, 2257, 2341, 2371, 2382, 2493, 2710, 2755, 2845, 2892, 2945, 2979, 2984, 3051, 3094, 3104, 3166, 3295, 3348, 3374, 3471, 3509, 3555, 3564, 3643, 3759, 3785, 3808, 3866, 3904, 4018, 4047, 4136, 4260, 4326, 4370, 4444, 4540, 4551, 4568, 4609], 'neutral,': [5, 319], 'magnesium-dependent': [6, 320], 'sphingomyelinase': [7, 321, 1011, 1646, 2132], '(SMase)': [8, 322], 'was': [9, 49, 84, 107, 171, 240, 323, 363, 398, 421, 485, 554, 1392, 1783, 2010, 2017, 2022, 2040, 2075, 2133, 2180, 2212, 2231, 2339, 2356, 2379, 2393, 2419, 2435, 2461, 2491, 2525, 2559, 2579, 2607, 2620, 2648, 2673, 2733, 2762, 2781, 2824, 2829, 2989, 3005, 3032, 3157, 3182, 3221, 3245, 3273, 3284, 3346, 3388, 3398, 3406, 3442, 3486, 3491, 3514, 3552, 3569, 3633, 3648, 3718, 4134, 4176, 4317, 4332, 4406, 4432], 'performed.': [10, 324], 'One': [11, 325, 1648, 3340, 3625], 'inhibitor': [12, 22, 326, 336, 1820, 2844], 'discovered': [13, 327], 'in': [14, 26, 66, 129, 133, 153, 168, 242, 328, 340, 380, 443, 447, 467, 482, 556, 666, 688, 720, 859, 1400, 1419, 1491, 1520, 1718, 1725, 1767, 1813, 1823, 1860, 1974, 2172, 2183, 2270, 2307, 2330, 2358, 2499, 2511, 2562, 2581, 2588, 2622, 2629, 2695, 2704, 2722, 2774, 2797, 2883, 2905, 2926, 3024, 3078, 3100, 3128, 3212, 3250, 3370, 3400, 3438, 3444, 3521, 3590, 3683, 3709, 3713, 3762, 3772, 3779, 3959, 3973, 4089, 4103, 4123, 4165, 4209, 4239, 4295, 4299, 4319, 4334, 4355, 4367, 4435, 4439, 4451, 4472, 4487], 'the': [15, 24, 82, 88, 99, 120, 159, 166, 178, 304, 308, 329, 338, 396, 402, 413, 434, 473, 480, 492, 618, 622, 650, 667, 689, 706, 711, 721, 845, 861, 912, 915, 939, 954, 1049, 1197, 1374, 1379, 1383, 1576, 1584, 1633, 1644, 1719, 1763, 1809, 1816, 1837, 1871, 1877, 1880, 1966, 1970, 1975, 1987, 1997, 2001, 2160, 2226, 2229, 2271, 2287, 2331, 2336, 2353, 2391, 2458, 2472, 2475, 2487, 2495, 2512, 2552, 2563, 2571, 2582, 2623, 2679, 2682, 2685, 2731, 2751, 2779, 2784, 2811, 2814, 2819, 2822, 2843, 2864, 2867, 2887, 2893, 2915, 2935, 2949, 2977, 2996, 3000, 3008, 3047, 3069, 3072, 3074, 3135, 3176, 3219, 3240, 3248, 3254, 3271, 3276, 3287, 3309, 3316, 3322, 3343, 3382, 3489, 3517, 3581, 3651, 3710, 3714, 3945, 3960, 4022, 4026, 4068, 4075, 4132, 4141, 4179, 4187, 4195, 4210, 4230, 4233, 4343, 4378, 4403, 4410, 4424, 4440, 4445, 4459, 4473, 4477, 4591, 4625], 'screen,': [16, 330], 'GW4869,': [17, 200, 331, 514, 3243], 'functioned': [18, 332], 'as': [19, 252, 333, 566, 656, 685, 687, 775, 1834, 1992, 2137, 2437, 2527, 2650, 2768, 3107, 3408, 3720, 4223], 'a': [20, 134, 188, 243, 300, 334, 448, 502, 557, 614, 632, 1660, 1791, 1868, 1993, 2177, 2184, 2368, 2396, 2423, 2589, 2769, 3258, 3401, 3678, 3741, 3769, 3789, 3796, 3812, 3822, 3836, 3871, 3878, 3887, 3910, 3989, 4083, 4151, 4161, 4224, 4296, 4416, 4622], 'noncompetitive': [21, 335], 'of': [23, 31, 62, 81, 90, 94, 102, 123, 139, 161, 165, 177, 180, 198, 213, 273, 288, 307, 337, 345, 376, 395, 404, 408, 416, 437, 453, 475, 479, 491, 494, 512, 527, 587, 602, 621, 641, 652, 669, 691, 703, 710, 716, 730, 756, 848, 914, 941, 944, 956, 1009, 1048, 1120, 1196, 1220, 1376, 1387, 1444, 1466, 1518, 1545, 1575, 1586, 1722, 1758, 1765, 1777, 1808, 1811, 1818, 1836, 1841, 1846, 1858, 1870, 1873, 1879, 1911, 1950, 1969, 1972, 2000, 2047, 2154, 2188, 2236, 2245, 2253, 2262, 2277, 2281, 2323, 2333, 2474, 2486, 2497, 2516, 2586, 2605, 2627, 2684, 2725, 2738, 2786, 2794, 2806, 2813, 2821, 2873, 2878, 2889, 2908, 2929, 2942, 2957, 2962, 3016, 3027, 3039, 3071, 3081, 3089, 3137, 3226, 3242, 3253, 3261, 3267, 3324, 3342, 3353, 3376, 3447, 3482, 3524, 3612, 3616, 3621, 3627, 3653, 3656, 3672, 3703, 3716, 3743, 3976, 4014, 4030, 4037, 4067, 4082, 4097, 4111, 4117, 4232, 4250, 4279, 4285, 4302, 4322, 4339, 4349, 4380, 4383, 4402, 4426, 4525, 4596, 4611], 'enzyme': [25, 339, 1381], 'vitro': [27, 130, 341, 444], 'with': [28, 233, 342, 547, 850, 923, 1018, 1329, 1397, 1417, 1773, 1829, 2151, 2233, 2259, 2401, 2422, 2678, 2735, 2842, 2851, 2857, 2919, 2939, 2954, 2987, 3013, 3034, 3046, 3223, 3269, 3281, 3286, 3311, 3315, 3392, 3788, 3811, 3839, 3870, 3883, 3909, 3957, 3968, 4154, 4178, 4207, 4218, 4254, 4277, 4415, 4448, 4467, 4533, 4629], 'an': [29, 343, 638, 854, 3035, 3393, 3923, 4271], 'IC50': [30, 344], '1': [32, 346, 2316, 2342, 2372, 2410, 2413, 2637, 2981, 3251, 3262, 3463, 3537, 3540, 3543, 3603, 3610, 3614, 3809, 4261, 4512, 4516, 4569], 'μm.': [33, 46, 347, 360], 'It': [34, 348, 1849], 'did': [35, 147, 219, 349, 461, 533], 'not': [36, 127, 148, 220, 231, 350, 441, 462, 534, 545, 2560, 2569], 'inhibit': [37, 56, 351, 370], 'acid': [38, 352, 792, 1010, 1399, 2169, 2790, 4393], 'SMase': [39, 64, 353, 378, 1187], 'at': [40, 43, 110, 141, 201, 354, 357, 424, 455, 515, 961, 2222, 2344, 2347, 2374, 2384, 2610, 2701, 2715, 2765, 2818, 2834, 2899, 3054, 3065, 3208, 3291, 3298, 3505, 3560, 3573, 3640, 3688, 3740, 3860, 3940, 3985, 4062, 4143, 4226, 4263, 4364, 4412, 4547, 4564, 4578], 'up': [41, 355, 2833, 3495], 'to': [42, 55, 155, 174, 226, 246, 356, 369, 469, 488, 540, 560, 647, 649, 674, 751, 771, 843, 864, 910, 929, 1642, 1655, 1715, 1727, 1754, 1761, 1909, 1943, 1979, 2214, 2283, 2395, 2759, 2803, 2849, 2863, 2885, 3190, 3247, 3257, 3301, 3380, 3478, 3635, 4034, 4050, 4079, 4171, 4186, 4244, 4359, 4397, 4428, 4554, 4571, 4621], 'least': [44, 358], '150': [45, 359, 2220, 2260, 4495], 'The': [47, 92, 137, 361, 406, 451, 745, 950, 1366, 1573, 2210, 2350, 2377, 2416, 2477, 2827, 3060, 3153, 3385, 3404, 3440, 3512, 3550, 3567, 3646, 3701, 3801, 3848, 3863, 3901, 3980, 4266, 4400], 'compound': [48, 83, 362, 397], 'then': [50, 364, 1416, 2380, 2420, 3804, 4056, 4330, 4545], 'evaluated': [51, 365, 3174], 'its': [53, 367, 1953], 'ability': [54, 368], 'tumor': [57, 371, 782], 'necrosis': [58, 372, 783], 'factor': [59, 373, 784, 830, 1730], '(TNF)-induced': [60, 374], 'activation': [61, 179, 286, 298, 375, 493, 600, 612, 1189, 1857, 1866, 1878, 1907, 1946, 1991, 3705], 'neutral': [63, 377, 789, 967, 1645, 2131], '(N-SMase)': [65, 379, 1188], 'MCF7': [67, 381, 1824, 1951, 2687], 'cells.': [68, 382, 3304], 'GW4869': [69, 124, 140, 162, 218, 229, 239, 383, 438, 454, 476, 532, 543, 553, 1793, 1812, 2498, 2517, 2587, 2628, 2672, 2761, 2807, 2815, 2868, 2874, 2890, 2988, 4316], '(10': [70, 384, 3450, 3586], 'μm)': [71, 385], 'partially': [72, 108, 386, 422], 'inhibited': [73, 98, 387, 412], 'TNF-induced': [74, 223, 388, 537], 'sphingomyelin': [75, 389, 945], '(SM)': [76, 390], 'hydrolysis,': [77, 391], 'and': [78, 144, 261, 279, 392, 458, 575, 593, 637, 658, 682, 694, 728, 743, 764, 833, 837, 920, 946, 969, 1046, 1091, 1222, 1273, 1302, 1349, 1415, 1421, 1542, 1613, 1710, 1760, 1769, 1787, 1799, 1845, 1863, 1883, 1952, 1958, 1983, 2031, 2053, 2081, 2096, 2106, 2112, 2127, 2135, 2205, 2219, 2274, 2319, 2327, 2335, 2365, 2390, 2457, 2506, 2518, 2522, 2603, 2642, 2645, 2654, 2675, 2744, 2750, 2831, 2959, 2967, 2991, 3007, 3029, 3042, 3049, 3086, 3097, 3130, 3139, 3163, 3168, 3188, 3232, 3275, 3289, 3313, 3326, 3367, 3396, 3434, 3469, 3488, 3496, 3516, 3558, 3571, 3618, 3638, 3665, 3686, 3699, 3712, 3765, 3775, 3783, 3806, 3855, 3955, 3971, 4025, 4043, 4058, 4114, 4131, 4167, 4205, 4221, 4242, 4247, 4283, 4307, 4324, 4329, 4362, 4470, 4475, 4521, 4529, 4558, 4560, 4586, 4606, 4613, 4616, 4656], '20': [79, 145, 196, 205, 393, 459, 510, 519, 2402, 2600, 3480, 3522, 3644, 4508], 'μm': [80, 146, 394, 460, 2640, 2671, 4256], 'protected': [85, 399, 3857], 'completely': [86, 97, 400, 411], 'from': [87, 249, 277, 401, 563, 591, 1583, 2011, 2018, 2023, 2035, 2056, 2069, 2076, 2084, 2091, 2102, 2117, 2616, 3002, 3858, 3992, 4074, 4160, 4476, 4583], 'loss': [89, 403], 'SM.': [91, 405], 'addition': [93, 138, 407, 452, 2683, 2785, 3241, 3652, 4379], '10–20': [95, 409], 'μmGW4869': [96, 410], 'initial': [100, 414], 'accumulation': [101, 415], 'ceramide,': [103, 417, 849], 'whereas': [104, 183, 418, 497], 'this': [105, 211, 419, 525, 642, 676, 1819, 1865, 1906, 1936], 'effect': [106, 209, 420, 523, 2496], 'lost': [109, 423], 'later': [111, 425], 'time': [112, 426, 1968, 2820, 2998, 3947, 4197, 4345, 4461], 'points': [113, 427], '(24': [114, 428], 'h).': [115, 429], 'These': [116, 265, 430, 579], 'data': [117, 431], 'therefore': [118, 283, 432, 597], 'support': [119, 433], 'inhibitory': [121, 435, 1657, 1801], 'action': [122, 160, 436, 474, 955, 1375], 'on': [125, 210, 439, 524, 705, 1803, 1955, 2367, 3022, 3474, 3677, 3852, 3877, 4045, 4538], 'N-SMase': [126, 285, 297, 440, 599, 611, 1661, 1717, 1759, 1766, 1859, 1945, 1973, 1990, 2433, 2505, 2556], 'only': [128, 442], 'but': [131, 445, 1297], 'also': [132, 186, 446, 500, 645, 840, 1192, 1298, 2483], 'cellular': [135, 150, 449, 464, 753], 'model.': [136, 450], 'both': [142, 456], '10': [143, 203, 457, 517, 2670, 2723, 2927, 2940, 3455, 3472, 3510, 3619, 4048, 4335, 4498, 4504, 4522, 4541, 4552], 'modify': [149, 463], 'glutathione': [151, 465, 1874, 4070, 4112, 4156], 'levels': [152, 466, 847, 3172], 'response': [154, 468, 863, 1726], 'TNF,': [156, 470, 776, 781, 1830, 3270], 'suggesting': [157, 471, 853], 'that': [158, 296, 472, 610, 672, 696, 927, 1796, 1854, 1864, 1875, 1977, 3283, 3749, 4423, 4575], 'occurred': [163, 477], 'downstream': [164, 478], 'drop': [167, 481, 1872], 'glutathione,': [169, 483], 'which': [170, 484, 959, 1831], 'shown': [172, 486, 750, 1394, 1853], 'previously': [173, 487, 1653, 1852, 2438, 2528, 3409, 3721], 'occur': [175, 489], 'upstream': [176, 287, 490, 601], 'N-SMase.': [181, 495, 1804], 'Further,': [182, 496], 'TNF': [184, 498, 1089, 1223, 1855, 1948, 2021, 2992, 3707, 4331, 4427], 'treatment': [185, 499, 1017, 1328, 1396, 1465, 1544, 1949, 2850, 2993, 3268], 'caused': [187, 501], '75%': [189, 503], 'increase': [190, 504, 844], 'ofde': [191, 505], 'novo': [192, 506, 948, 1368, 1578], 'synthesized': [193, 507], 'ceramide': [194, 214, 508, 528, 747, 858, 919, 1388, 1593, 1847, 3167, 3349, 3383, 3386], 'after': [195, 509, 1016, 1194, 1218, 1274, 1395, 2728, 3429, 3936], 'h': [197, 511, 2343, 2373, 2757, 3266, 3787, 3810, 4262, 4570], 'incubation,': [199, 513], 'either': [202, 516], 'or': [204, 518, 966, 2156, 2208, 2514, 2584, 2625, 3795, 3821, 4646], 'μm,': [206, 520], 'had': [207, 521], 'no': [208, 522], 'pathway': [212, 526, 916, 1369, 1579], 'generation.': [215, 529], 'In': [216, 291, 530, 605, 2551, 2667], 'addition,': [217, 531], 'significantly': [221, 247, 535, 561, 4433], 'impair': [222, 536], 'NF-κB': [224, 538, 2088, 3704, 3792, 3867], 'translocation': [225, 539], 'nuclei.': [227, 541], 'Therefore,': [228, 542], 'does': [230, 544, 2568], 'interfere': [232, 546], 'other': [234, 548, 924, 1634, 1774, 4456], 'key': [235, 549, 1775], 'TNF-mediated': [236, 550], 'signaling': [237, 551], 'effects.': [238, 552], 'able,': [241, 555], 'dose-dependent': [244, 558], 'manner,': [245, 559], 'protect': [248, 562], 'cell': [250, 564, 629, 758, 930, 1843, 1959, 3061, 3090, 4235], 'death': [251, 565, 630, 759, 1844, 1881], 'measured': [253, 567, 2436, 2649], 'by': [254, 270, 312, 568, 584, 626, 918, 953, 1373, 2005, 2042, 2242, 2463, 2489, 2652, 2783, 3084, 3109, 3134, 3184, 3321, 3351, 3390, 3436, 3493, 3503, 3650, 3835, 3953, 4139, 4203, 4377, 4408, 4481, 4603], 'nuclear': [255, 569, 765], 'condensation,': [256, 570], 'caspase': [257, 280, 571, 594, 726, 1884, 2098, 4639], 'activation,': [258, 282, 572, 596, 727], 'PARP': [259, 573, 4612], 'degradation,': [260, 574], 'trypan': [262, 576], 'blue': [263, 577, 3664], 'uptake.': [264, 578], 'protective': [266, 580], 'effects': [267, 581, 1817, 1954], 'were': [268, 582, 1821, 1941, 2034, 2055, 2068, 2083, 2090, 2101, 2116, 2255, 2269, 2305, 2431, 2509, 2692, 2713, 2753, 2801, 2840, 2855, 2875, 2881, 2897, 2917, 2937, 2951, 2973, 3010, 3020, 3044, 3063, 3076, 3092, 3102, 3126, 3132, 3173, 3206, 3278, 3306, 3319, 3372, 3432, 3501, 3519, 3578, 3588, 3675, 3692, 3738, 3757, 3803, 3833, 3850, 3868, 3907, 3934, 3951, 3965, 3983, 4016, 4032, 4055, 4060, 4077, 4129, 4148, 4169, 4201, 4215, 4237, 4252, 4268, 4293, 4357, 4375, 4464, 4479, 4485, 4536, 4544, 4562, 4576, 4588, 4601, 4627], 'accompanied': [269, 583], 'significant': [271, 585, 1798], 'inhibition': [272, 586], 'cytochrome': [274, 588, 724, 1980, 3905], 'c': [275, 589, 1981, 2095, 3906], 'release': [276, 590, 1982], 'mitochondria': [278, 592], '9': [281, 595, 4648], 'localizing': [284, 598], 'mitochondrial': [289, 603, 713, 722, 762, 1984], 'dysfunction.': [290, 604], 'conclusion,': [292, 606], 'our': [293, 607], 'results': [294, 608], 'indicate': [295, 609], 'is': [299, 613, 631, 644, 909, 1370, 1867], 'necessary': [301, 615, 633, 1994], 'step': [302, 616, 1995], 'full': [305, 619], 'development': [306, 620, 1999], 'cytotoxic': [309, 623, 2002], 'program': [310, 624, 2003], 'induced': [311, 625, 2004], 'TNF.': [313, 627, 2006, 2852], 'Programmed': [628], 'requirement': [634, 1988], 'during': [635, 3768], 'development,': [636], 'altered': [639], 'regulation': [640], 'process': [643, 677, 1721], 'thought': [646], 'contribute': [648, 673], 'occurrence': [651], 'serious': [653], 'illnesses': [654], 'such': [655], 'cancer': [657, 1826, 2690], 'neurodegenerative': [659], 'diseases.': [660], 'Significant': [661], 'progress': [662], 'has': [663, 748, 1013, 1190, 1580, 1651, 1712, 1832, 1850], 'been': [664, 749, 841, 936, 1014, 1125, 1191, 1640, 1652, 1713, 1851], 'made': [665], 'identification': [668, 690], 'crucial': [670], 'events': [671, 701], 'defining': [675], '(mitochondrial': [678], 'dysfunction,': [679, 763, 1985], 'chromatin': [680], 'fragmentation,': [681], 'membrane': [683], 'blebbing)': [684], 'well': [686, 4361], 'molecular': [692, 925], 'mechanisms': [693, 926], 'effectors': [695], 'regulate': [697], 'and/or': [698], 'execute': [699], 'these': [700, 865, 1121, 1861], '(exposure': [702], 'phosphatidylserine': [704], 'plasma': [707], 'membrane,': [708, 714, 723, 4624], 'depolarization': [709], 'outer': [712], 'formation': [715], 'permeability': [717], 'transition': [718], 'pores': [719], 'crelease,': [725], 'alteration': [729], 'calcium': [731], 'homeostasis,': [732], 'Bcl2': [733], 'family': [734], 'members,': [735], 'apoptosis-inducing': [736], 'factor,': [737], 'apoptosis': [738, 773, 1768], 'activating': [739], 'factor-1,': [740], 'Smac/Diablo,': [741], 'IAPs,': [742], 'others).': [744], 'sphingolipid': [746], 'induce': [752, 4429], 'features': [754], 'characteristic': [755], 'programmed': [757], '(membrane': [760], 'blebbing,': [761], 'fragmentation).': [766], 'Moreover,': [767], 'many': [768], 'agents': [769, 866], 'known': [770, 4155], 'cause': [772], '(such': [774], '1The': [777], 'abbreviations': [778], 'used': [779, 1714, 2492, 2891, 3093, 3103, 3347, 3373, 3379, 4017], 'are:': [780], 'α;': [785], 'SMase,': [786], 'sphingomyelinase;': [787, 790], 'N-SMase,': [788, 1786], 'A-SMase,': [791], 'sphigomyelinase;': [793], 'PARP,': [794], 'poly(ADP-ribose)': [795], 'polymerase;': [796], 'PS,': [797], 'phosphatidylserine;': [798], 'SM,': [799], 'sphingomyelin;': [800], 'PAF,': [801], 'platelet-activating': [802], 'factor;': [803], 'PLC,': [804], 'phospholipase': [805], 'C;': [806], 'FBS,': [807], 'fetal': [808], 'bovine': [809, 1546, 2014, 2238, 2617, 3622], 'serum;': [810], 'MSA,': [811, 2861], 'methane': [812, 2788], 'sulfonic': [813, 2789], 'acid;': [814], 'PBS,': [815, 2958, 3028, 3780, 4469], 'phosphate-buffered': [816], 'saline;': [817], 'TRITC,': [818], 'tetramethylrhodamine': [819], 'isothiocyanate;': [820], 'MTT,': [821], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [822], 'bromide.': [823], 'CD95': [824, 1092, 1221], 'cross-linking,': [825], 'daunorubicin,': [826], 'heat': [827, 1300], 'stress,': [828], 'growth': [829, 1729, 2910, 2930, 3214], 'withdrawal,': [831], 'UV-B': [832], 'γ-radiation,': [834], 'bacterial': [835, 2572], 'infections,': [836], 'others)': [838], 'have': [839, 935, 970, 1124, 1639, 4421], 'found': [842], 'intracellular': [846], 'emerging': [851], 'evidence': [852, 1807, 1964], 'important': [855], 'role': [856, 913, 1764], 'regulating/mediating': [860], 'apoptotic': [862], '(for': [867], 'reviews,': [868], 'see': [869], 'Refs.': [870], '1Hannun': [871], 'Y.': [872, 1022, 1736], 'Luberto': [873, 1499], 'C.': [874, 1129, 1161, 1500, 3412], 'Trends': [875], 'Cell': [876], 'Biol.': [877, 1040, 1112, 1212, 1267, 1322, 1343, 1458, 1482, 1511, 1567, 1704, 1899, 2299, 2451, 2661, 3422, 3728], '2000;': [878, 1114, 1182, 1484, 1628, 1706, 2147, 3201, 3424], '10:': [879], '73-80Google': [880], 'Scholar,': [881, 892, 986, 1157, 1253, 1678, 4002], '2Levade': [882], 'T.': [883, 977, 988, 1075, 1151, 1179, 1246, 1259, 1333, 1623, 1667, 1671, 1891, 3118], 'Jaffrezou': [884, 978, 997, 1148, 1176], 'J.P.': [885, 979, 998, 1149, 1177], 'Biochim.': [886, 980, 1408], 'Biophys.': [887, 981, 1409], 'Acta.': [888, 982, 1410], '1999;': [889, 983, 1004, 1460, 1675, 1747, 2301], '1438:': [890, 984], '1-17Google': [891, 985], '3Mathias': [893], 'S.': [894, 1077, 1094, 1143, 1230, 1234, 1236, 1238, 1306, 1536, 1625, 1740], 'Pena': [895], 'L.A.': [896], 'Kolesnick': [897, 1107, 1288, 1434], 'R.N.': [898, 1289], 'Biochem.': [899, 1626, 3119, 3147, 3334, 3998, 4006], 'J.': [900, 1039, 1059, 1082, 1111, 1153, 1181, 1211, 1240, 1247, 1266, 1290, 1321, 1342, 1457, 1472, 1481, 1510, 1551, 1566, 1672, 1703, 1745, 1898, 1928, 2298, 2450, 2544, 2660, 3120, 3146, 3333, 3421, 3727], '1998;': [901, 1269, 1538, 1569, 1901, 2453], '335:': [902], '465-480Google': [903], 'Scholar).': [904, 1007, 1185, 1365, 1572, 1631, 1750, 1904, 1934, 2550, 2666, 3124, 3152, 3204, 3339, 3427, 3733, 4010], 'major': [906], 'current': [907], 'challenge': [908], 'define': [911], 'promoted': [917], 'integrate': [921], 'it': [922, 1711, 1771, 2567], 'lead': [928, 1978], 'death.': [931, 1960], 'Two': [932], 'main': [933], 'routes': [934], 'defined': [937], 'generation': [940], 'ceramide:': [942], 'hydrolysis': [943, 2524], 'de': [947, 1367, 1390, 1505, 1577], 'biosynthesis.': [949], 'first': [951, 1380, 1967, 4315], 'occurs': [952], 'sphingomyelinases': [957], '(SMases),': [958], 'operate': [960], 'different': [962, 971, 2871], 'pH': [963, 2405, 2596, 2635, 2748, 2971, 3236, 3453, 3595, 4310, 4395, 4493], 'optima': [964], '(acid': [965], 'SMase)': [968], 'metal': [972], 'requirements': [973], '(magnesium': [974], 'dependence)': [975], '(2Levade': [976], '4Levade': [987], 'Andrieu-Abadie': [989, 1140, 1166, 1256, 1888], 'N.': [990, 994, 1141, 1167, 1169, 1257, 1337, 1889, 2293, 2295, 3114], 'Segui': [991, 1130], 'B.': [992, 1131, 1159, 1226, 1255, 1308, 1355, 1498, 1887, 2441, 2575], 'Auge': [993, 1168], 'Chatelut': [995], 'M.': [996, 1081, 1098, 1204, 1210, 1244, 1285, 1316, 1427, 1450, 1454, 1502, 1524, 1528, 1621, 1665, 1688, 1702, 1742], 'Salvayre': [999, 1146, 1174, 1241, 3115], 'R.': [1000, 1108, 1147, 1175, 1242, 1425, 1435, 1690, 1734, 1921, 2537, 3116], 'Chem.': [1001, 1041, 1113, 1213, 1268, 1323, 1344, 1459, 1483, 1512, 1568, 1705, 1900, 2300, 2452, 2662, 3423, 3729], 'Phys.': [1002], 'Lipids.': [1003], '102:': [1005], '167-178Google': [1006], 'Activation': [1008], '(A-SMase)': [1012], 'observed': [1015, 1193, 3908], 'UV-A': [1019], 'radiation': [1020], '(5Zhang': [1021], 'Mattjus': [1023], 'P.': [1024, 1261, 1893], 'Schmid': [1025, 1037], 'P.C.': [1026], 'Dong': [1027], 'Z.': [1028, 1106, 1287, 1433], 'Zhong': [1029], 'S.,': [1030, 1555], 'Ma,': [1031], 'W.Y.': [1032], 'Brown': [1033], 'R.E.': [1034], 'Bode': [1035], 'A.M.': [1036], 'H.H.': [1038], '2001;': [1042, 1061, 1154, 1250, 1513, 1609], '276:': [1043, 1514], '11775-11782Google': [1044], 'Scholar)': [1045, 1296, 1414, 1612, 2150], 'stimulation': [1047, 1195, 1443, 3708], 'p75': [1050, 1198], 'neurotropin': [1051, 1199], 'receptor': [1052, 1200, 1224, 1489, 1882], '(6Bilderback': [1053], 'T.R.': [1054], 'Gazula': [1055], 'V.R.': [1056], 'Dobrowsky': [1057], 'R.T.': [1058, 1605], 'Neurochem.': [1060], '76:': [1062], '1540-1551Google': [1063], 'Scholar),': [1064, 1088, 1117, 1217, 1272, 1327, 1348, 1440, 1463, 1487, 1516, 1541, 1709, 2304, 2456], 'CD28': [1065], '(7Boucher': [1066], 'L.M.': [1067, 1263, 1318, 1561, 1895, 1925, 2541], 'Wiegmann': [1068, 1683], 'K.': [1069, 1073, 1102, 1431, 1619, 1669, 1680, 1684, 1700, 2447], 'Futterer': [1070], 'A.': [1071, 1104, 1171, 1277, 1335, 1403, 1429, 1537, 1692, 3196], 'Pfeffer': [1072], 'Machleidt': [1074], 'Schutze': [1076], 'Mak': [1078], 'T.W.': [1079], 'Kronke': [1080, 1243, 1701], 'Exp.': [1083, 1291, 1929, 2545], 'Med.': [1084, 1292, 1930, 2546], '1995;': [1085, 1324, 1437], '181:': [1086], '2059-2068Google': [1087], 'receptor,': [1090], '(8Kirschnek': [1093], 'Paris': [1095], 'F.': [1096, 1314, 1357, 1476, 1663, 3996], 'Weller': [1097], 'Grassme': [1099], 'H.': [1100, 1504, 2291], 'Ferlinz': [1101], 'Riehle': [1103], 'Fuks': [1105, 1286, 1432], 'Gulbins': [1109, 1358], 'E.': [1110, 1137, 1163, 1359, 1601], '275:': [1115, 1485, 1707, 3425], '27316-27323Google': [1116], 'although': [1118], 'some': [1119], 'latter': [1122], 'conclusions': [1123], 'recently': [1126], 'questioned': [1127], '(9Bezombes': [1128], 'Cuvillier': [1132, 1227], 'O.': [1133, 1228, 1682], 'Bruno': [1134], 'A.P.': [1135], 'Uro-Coste': [1136, 1162], 'Gouaze': [1138], 'V.': [1139, 1232, 3690], 'Carpentier': [1142], 'Laurent': [1144, 1172], 'G.': [1145, 1173], 'Levade': [1150, 1178, 1245, 1258, 1890, 3117], 'FASEB': [1152, 1180], '15:': [1155], '297-299Google': [1156], '10Segui': [1158], 'Bezombes': [1160], 'Medin': [1164], 'J.A.': [1165, 2657, 3724], 'Brouchet': [1170], '14:': [1183], '36-47Google': [1184], 'Neutral': [1186], '(11Brann': [1201], 'A.B.': [1202, 1732], 'Tcherpakov': [1203], 'Williams': [1205], 'I.M.': [1206], 'Futerman': [1207, 1743], 'A.H.': [1208, 1597, 1744], 'Fainzilber': [1209, 1741], '2002;': [1214, 2663, 3730], '277:': [1215, 2664, 3731], '9812-9818Google': [1216], 'ligation': [1219, 1351], '(12Segui': [1225], 'Adam-Klages': [1229], 'Garcia': [1231], 'Malagarie-Cazenave': [1233], 'Leveque': [1235], 'Caspar-Bauguil': [1237], 'Coudert': [1239], 'Clin.': [1248], 'Invest.': [1249], '108:': [1251], '143-151Google': [1252], '13Liu': [1254], 'Zhang': [1260, 1892], 'Obeid': [1262, 1317, 1894, 1924, 2540], 'Hannun': [1264, 1319, 1340, 1479, 1508, 1896, 1926, 2296, 2448, 2542, 2655, 2658, 3197, 3419, 3725], 'Y.A.': [1265, 1320, 1341, 1480, 1509, 1897, 1927, 2297, 2449, 2543, 2659, 3198, 3420, 3726], '273:': [1270, 1570, 1902, 2454], '11313-11320Google': [1271, 1903], 'irradiation': [1275], '(14Haimovitz-Friedman': [1276], 'Kan': [1278], 'C.C.': [1279], 'Ehleiter': [1280], 'D.': [1281, 1686, 1738], 'Persaud': [1282], 'R.S.': [1283], 'McLoughlin': [1284], '1994;': [1293, 1345, 3121], '180:': [1294], '525-535Google': [1295], 'upon': [1299, 1947, 3706], 'stress': [1301], 'serum': [1303, 2015, 2239, 3623], 'starvation': [1304], '(15Jayadev': [1305], 'Liu': [1307], 'Bielawska': [1309, 1334, 2044, 3195], 'A.E.': [1310], 'Lee': [1311], 'J.Y.': [1312, 1448], 'Nazaire': [1313], 'Pushkareva': [1315], '270:': [1325], '2047-2052Google': [1326], 'vitamin': [1330], 'D': [1331], '(16Okazaki': [1332], 'Domae': [1336, 2292], 'Bell': [1338, 1406], 'R.M.': [1339, 1407, 2142], '269:': [1346], '4070-4077Google': [1347], 'CD40': [1350], '(17Koppenhoefer': [1352], 'U.': [1353, 1535], 'Brenner': [1354], 'Lang': [1356], 'FEBS': [1360], 'Lett.': [1361], '1997;': [1362, 1931, 2547], '414:': [1363], '444-448Google': [1364], 'regulated': [1371], 'primarily': [1372], 'serine': [1377, 1616], 'palmitoyltransferase,': [1378], 'along': [1382], 'biosynthetic': [1384], 'pathway.': [1385, 1647], 'Accumulation': [1386], 'via': [1389, 2162], 'novobiosynthesis': [1391], 'originally': [1393], 'retinoic': [1398], 'GH4C1': [1401], '(18Kalen': [1402], 'Borchardt': [1404], 'R.A.': [1405], '1992;': [1411], '1125:': [1412], '90-96Google': [1413], 'daunorubicin': [1418], 'P388': [1420], 'U937': [1422], 'cells': [1423, 1446, 1468, 1494, 1522, 1549, 1827, 1862, 2175, 2691, 2712, 2752, 2854, 2916, 2936, 2950, 2978, 3009, 3249, 3431, 3737, 3756, 3864, 3902, 3950, 3964, 4200, 4214, 4374, 4484, 4535, 4557], '(19Bose': [1424], 'Verheij': [1426], 'Haimovitz-Friedman': [1428], 'Scotto': [1430], 'Cell.': [1436], '82:': [1438], '405-414Google': [1439], 'angiotensin': [1441], 'II': [1442], 'PC12W': [1445], '(20Lehtonen': [1447], 'Horiuchi': [1449], 'Daviet': [1451], 'L.': [1452, 1507, 1557], 'Akishita': [1453], 'Dzau': [1455], 'V.J.': [1456], '274:': [1461, 2302], '16901-16906Google': [1462], 'etoposide': [1464], 'Molt-4': [1467], '(21Perry': [1469], 'D.K.': [1470, 1917, 2533, 3194], 'Carton': [1471], 'Shah': [1473], 'A.K.': [1474], 'Meredith': [1475], 'Uhlinger': [1477], 'D.J.': [1478], '9078-9084Google': [1486], 'IgM-induced': [1488], 'cross-linking': [1490], 'Ramos': [1492], 'B': [1493], '(22Kroesen': [1495], 'B.J.': [1496], 'Pettus': [1497], 'Busman': [1501], 'Sietsma': [1503], 'Leij': [1506], '13606-13614Google': [1515], 'loading': [1517], 'palmitate': [1519], 'beta': [1521], '(23Shimabukuro': [1523], 'Zhou': [1525], 'Y.T.': [1526], 'Levi': [1527], 'Unger': [1529], 'R.H.': [1530], 'Proc.': [1531], 'Natl.': [1532], 'Acad.': [1533], 'Sci.': [1534], '95:': [1539], '2498-2502Google': [1540], 'TNF/cycloheximide': [1543], 'cerebral': [1547], 'endothelial': [1548], '(24Xu': [1550], 'Yeh': [1552], 'C.H.': [1553], 'Chen': [1554], 'He,': [1556], 'Sensi': [1558], 'S.L.': [1559], 'Canzoniero': [1560], 'Choi': [1562], 'D.W.': [1563], 'Hsu': [1564], 'C.Y.': [1565], '16521-16526Google': [1571], 'study': [1574], 'benefited': [1581], 'tremendously': [1582], 'availability': [1585], 'highly': [1587], 'specific': [1588, 1756, 1800], 'inhibitors:': [1589], 'fumonisin': [1590], 'B1': [1591], 'synthase': [1594], '(25Merrill': [1595], 'Jr.,': [1596], 'Sullards': [1598], 'M.C.': [1599], 'Wang': [1600], 'Voss': [1602], 'K.A.': [1603], 'Riley': [1604], 'Environ.': [1606], 'Health': [1607], 'Perspect.': [1608], '109:': [1610], '283-289Google': [1611], 'myriocin/ISP1': [1614], 'palmitoyltransferase': [1617], '(26Hanada': [1618], 'Nishijima': [1620], 'Fujita': [1622], 'Kobayashi': [1624], 'Pharmacol.': [1627], '59:': [1629], '1211-1216Google': [1630], 'On': [1632, 3068, 4229], 'hand,': [1635], 'very': [1636], 'few': [1637], 'tools': [1638], 'available': [1641], 'dissect': [1643], 'molecule,': [1649, 1792], 'scyphostatin,': [1650], 'described': [1654, 2138, 2529, 2651, 3108, 3410, 3722], 'exert': [1656], 'activity': [1658, 1802, 2434, 2481, 2647, 3260, 4175], 'versus': [1659], '(27Nara': [1662], 'Tanaka': [1664], 'Hosoya': [1666], 'Suzuki-Konagai': [1668], 'Ogita': [1670], 'Antibiot.': [1673], '(Tokyo).': [1674], '52:': [1676], '525-530Google': [1677], '28Bernardo': [1679], 'Krut': [1681], 'Kreder': [1685], 'Micheli': [1687], 'Schafer': [1689], 'Sickman': [1691], 'Schmidt': [1693], 'W.E.': [1694], 'Schroder': [1695], 'J.M.': [1696], 'Meyer': [1697], 'H.E.': [1698], 'Sandhoff': [1699], '7641-7647Google': [1708], 'implicate': [1716], 'outgrowth': [1720], 'hippocampal': [1723], 'neurons': [1724], 'nerve': [1728], '(29Brann': [1731], 'Scott': [1733], 'Neuberger': [1735], 'Abulafia': [1737], 'Boldin': [1739], 'Neurosci.': [1746], '19:': [1748], '8199-8206Google': [1749], 'We': [1751, 1805, 4420], 'set': [1752], 'out': [1753, 4438], 'develop': [1755], 'inhibitors': [1757], 'determine': [1762], 'how': [1770], 'interacts': [1772], 'regulators': [1776], 'apoptosis.': [1778], 'assay': [1782, 2161, 3405, 4183, 4274], 'developed': [1784], 'we': [1788, 1940, 1962], 'successfully': [1789], 'identified': [1790, 3389], '(Fig.': [1794], '1),': [1795], 'exhibited': [1797], 'provide': [1806, 1963], 'specificity': [1810, 3702], 'vitro.': [1814, 2500], 'Next,': [1815], 'determined': [1822, 2462, 2526, 3579, 4589], 'breast': [1825, 2689], 'treated': [1828, 2856, 3784], 'emerged': [1833], 'one': [1835], 'best': [1838], 'characterized': [1839, 1938], 'models': [1840], 'cytokine-induced': [1842], 'function.': [1848], 'induces': [1856], 'consequence': [1869], 'follows': [1876], '8': [1885, 2906], '(13Liu': [1886], 'Also,': [1905], 'couples': [1908], 'processing': [1910], 'effector': [1912, 1956], 'caspases': [1913, 1957, 4614], '(30Dbaibo': [1914, 2530], 'G.S.': [1915, 2531], 'Perry': [1916, 2532], 'Gamard': [1918, 2534], 'C.J.': [1919, 2535], 'Platt': [1920, 2536], 'Poirier': [1922, 2538], 'G.G.': [1923, 2539], '185:': [1932, 2548], '481-490Google': [1933, 2549], 'Using': [1935], 'newly': [1937], 'inhibitor,': [1939], 'able': [1942], 'confirm': [1944], 'Second,': [1961], 'participation': [1971], 'processes': [1976], 'indicating': [1986], 'complete': [1998, 2726, 2909, 2943, 3213], 'RPMI': [2007, 2696, 2739, 3227, 4303], '1640': [2008, 2697, 2740, 3228], 'medium': [2009, 2732, 2944, 2963, 3001, 3048, 3220, 3256, 3272, 3288, 4474], 'Invitrogen.': [2012], 'Fetal': [2013], '(FBS)': [2016], 'Summit': [2019], 'Technology.': [2020], 'Peprotech': [2024], '(Rocky': [2025], 'Hill,': [2026], 'NJ).': [2027], '[γ-32P]ATP,': [2028], '[methyl-3H]choline': [2029, 2920], 'chloride,': [2030], 'EN3HANCETM': [2032], 'spray': [2033], 'PerkinElmer': [2036, 3916], 'Life': [2037], 'Sciences.': [2038], '[choline-methyl-14C]SM': [2039], 'provided': [2041], 'Alicja': [2043], '(Medical': [2045], 'University': [2046], 'South': [2048], 'Carolina,': [2049], 'Charleston,': [2050], 'SC).': [2051], 'SM': [2052, 2155, 2523, 3105], 'PS': [2054, 2157, 2207, 2519, 2558], 'Avanti': [2057], 'Polar': [2058], 'Lipids,': [2059], 'Inc.': [2060, 2121], 'Silica': [2061], 'Gel': [2062], '60': [2063], 'thin': [2064, 3356], 'layer': [2065, 3357], 'chromatography': [2066, 3358], 'plates': [2067, 3277, 4442, 4463], 'Whatman.': [2070], 'Scintillation': [2071], 'mixture': [2072, 2591, 3674], 'Safety': [2073], 'Solve': [2074], 'Research': [2077], 'Products': [2078], 'International.': [2079], 'Poly(dI-dC)': [2080], 'poly(dN6)': [2082], 'AmershamBiosciences.': [2085], 'Rabbit': [2086], 'anti-p65': [2087, 3791], 'antibodies': [2089, 2100, 2470], 'Rockland;': [2092], 'monoclonal': [2093, 2469, 4641], 'anti-cytochrome': [2094], 'anti-human': [2097, 4638], '6': [2099, 3224, 3654, 4615, 4640], 'Becton': [2103], 'Dickinson': [2104], 'Co.;': [2105], 'rabbit': [2107, 3790, 4631, 4649], 'anti-PARP,': [2108], 'anti-mouse': [2109, 3826], 'IgG-horseradish': [2110, 2114], 'peroxidase,': [2111], 'anti-rabbit': [2113, 3816], 'peroxidase': [2115], 'Santa': [2118, 4635, 4653], 'Cruz': [2119, 4636, 4654], 'Biotechnology,': [2120], '(Santa': [2122], 'Cruz,': [2123], 'CA).': [2124, 4193], 'Partially': [2125, 2501], 'purified': [2126, 2502], 'delipidated': [2128], 'rat': [2129, 2503], 'brain': [2130, 2504], 'prepared': [2134, 4102, 4122, 4164], 'assayed': [2136, 2182, 3719], '(31Hassler': [2139], 'D.F.': [2140, 2443], 'Laethem': [2141], 'Smith': [2143, 2444], 'G.K.': [2144, 2445], 'Methods': [2145, 3199], 'Enzymol.': [2146, 3200], '311:': [2148], '176-184Google': [2149], 'variable': [2152], 'amounts': [2153, 2877, 3669, 4249, 4595], 'incorporated': [2158], 'into': [2159, 2164, 3159], 'solubilization': [2163], 'Triton': [2165, 2203, 2363, 2408, 3777], 'X-100': [2166, 2204, 2364, 3778], 'micelles.': [2167], 'Human': [2168], 'sphingomyelinase,': [2170], 'overexpressed': [2171], 'SF-9': [2173], 'insect': [2174], 'using': [2176, 2467, 3175, 3185, 3580, 3886, 3922, 3988, 4021, 4150, 4270, 4590], 'baculoviral': [2178], 'system,': [2179], 'similarly': [2181, 2862], 'final': [2185, 2924, 3259], 'reaction': [2186, 2211, 2230, 2564, 2590, 3637, 3647, 3673, 4133], 'volume': [2187, 2888, 4338], '50': [2189, 2632, 2804, 3597, 4115, 4255], 'μl': [2190, 2235, 2244, 2252, 2261, 2793, 2805, 3080, 3099, 3446, 3481, 3523, 3626, 3655, 4036, 4073, 4081, 4096, 4116, 4301, 4321, 4348, 4382], 'containing': [2191, 2352, 2361, 2479, 2592, 2631, 2698, 2741, 2859, 2964, 3229, 3609, 3660, 4085, 4304], '100': [2192, 2251, 2593, 2639, 3873, 4340, 4381], 'mm': [2193, 2199, 2309, 2314, 2403, 2411, 2414, 2594, 2601, 2633, 2746, 2771, 2969, 3234, 3451, 3456, 3459, 3464, 3528, 3538, 3541, 3544, 3547, 3598, 3604, 3607, 4087, 4099, 4491, 4496, 4499, 4502, 4505, 4509, 4513], 'sodium': [2194, 4506, 4510], 'acetate': [2195], '(pH': [2196, 2311, 3530], '5),': [2197], '0.1': [2198, 2900, 3458, 3461, 4012], 'zinc': [2200], 'acetate,': [2201], '0.13%': [2202], 'lacking': [2206], 'dithiothreitol.': [2209], 'allowed': [2213], 'proceed': [2215], '10,': [2217], '30,': [2218], 'min': [2221, 2847, 2986, 3053, 3297, 3473, 3557, 3761, 4049, 4138, 4328, 4553], 'room': [2223, 3641], 'temperature.': [2224], 'At': [2225, 2995, 3944, 4194, 4342, 4458], 'appropriate': [2227, 2997], 'time,': [2228], 'quenched': [2232], '75': [2234, 2243, 4035, 4300], '5%': [2237, 2705, 2787, 2795, 2860, 3600, 3679, 4368], 'albumin': [2240], 'followed': [2241, 4135], '8%': [2246], 'trichloroacetic': [2247], 'acid.': [2248], 'After': [2249, 2912, 2932, 2975, 3216, 3264, 3962, 4212, 4312, 4531, 4619], 'centrifugation,': [2250, 3479, 3963, 4213], 'supernatant': [2254, 2392, 3513, 3568], 'counted': [2256], '14C': [2258], 'Optiphase': [2263], 'Supermix.': [2264], 'All': [2265], 'rate': [2266], 'measurements': [2267], 'obtained': [2268, 4149], 'linear': [2272, 2424], 'range': [2273], 'represented': [2275], 'conversion': [2276], 'less': [2278], 'than': [2279], '20%': [2280, 2643], 'substrate': [2282], 'product.': [2284], 'HEK293,': [2285], 'expressing': [2286], 'lyso-PAF': [2288, 2417, 2507], 'PLC': [2289, 2418, 2508], '(32Sawai': [2290], 'Nagan': [2294], '38131-38139Google': [2303], 'lysed': [2306], '25': [2308, 2745, 2968, 3233, 4308, 4347], 'Tris': [2310], '7.4),': [2312], '5': [2313, 2955, 3052, 3296, 3606, 4072, 4137, 4289], 'EDTA,': [2315, 3460, 3539, 3605, 4503], 'mmphenylmethylsulfonyl': [2317, 3467], 'fluoride,': [2318, 4511, 4515], '2': [2320, 2756, 3014, 3025, 3037, 4127, 4501], 'μg/ml': [2321, 3843, 4523], 'each': [2322, 3003, 3030, 3636, 4360, 4398, 4524], 'chymostatin,': [2324], 'leupeptin,': [2325, 4527], 'antipain,': [2326], 'pepstatin': [2328], 'absence': [2332, 2513, 2585, 2626, 3711], 'detergents,': [2334], 'postnuclear': [2337, 4584], 'extract': [2338], 'centrifuged': [2340, 2381, 3050, 3290, 4243, 4546, 4563], '100,000': [2345, 2385, 4565], '×g': [2346], '4': [2348, 2375, 2388, 3299, 3786, 3986], '°C.': [2349, 2376, 3067, 3575, 3862, 4064, 4228, 4265, 4580], 'pellet,': [2351], 'total': [2354, 4069], 'membranes,': [2355], 'resuspended': [2357, 3077, 3443, 3520, 3972], 'lysis': [2359, 3448, 4240, 4384, 4488], 'buffer': [2360, 2630, 3449, 3526, 3592, 4084, 4241, 4385, 4489], '0.1%': [2362, 2407], 'incubated': [2366, 2510, 2580, 2621, 3470, 3589, 3639, 3807, 4044, 4253, 4325, 4363, 4537, 4628], 'rotating': [2369], 'platform': [2370], 'suspension': [2378, 2773, 2780, 2828, 3490, 3551], '1h': [2383], '×': [2386, 2717, 2901, 3056, 3210, 3293, 3507, 3562, 3745, 4290, 4549, 4566], 'gat': [2387], '°C,': [2389], 'applied': [2394], 'HiTrap': [2397], 'Q': [2398], 'column': [2399], 'equilibrated': [2400], 'Tris-HCl,': [2404], '7.4,': [2406, 2636, 4494], 'X-100,': [2409], 'EGTA,': [2412, 3542, 4500], 'EDTA.': [2415], 'eluted': [2421], 'salt': [2425], 'gradient': [2426], '(1.5': [2427], 'm': [2428], 'NaCl).': [2429], 'Fractions': [2430], 'collected,': [2432, 3006, 3274], 'indicated': [2439, 3946, 4196, 4344, 4460], '(33Liu': [2440], 'Hassler': [2442], 'Weaver': [2446], '34472-34479Google': [2455], 'protein': [2459, 2488, 3095, 4019, 4052, 4172, 4251], 'level': [2460], 'Western': [2464], 'blot': [2465], 'analysis': [2466, 4610], 'anti-His6': [2468], 'against': [2471], 'histidine-FLAG': [2473], 'protein.': [2476], 'fraction': [2478], 'peak': [2480], '(which': [2482], 'showed': [2484], 'most': [2485], 'western)': [2490], 'determining': [2494], 'presence': [2515, 2583, 2624, 3715], '(100': [2520], 'μm),': [2521], 'case': [2553], 'ofBacillus': [2554], 'cereus': [2555, 2576], '(Sigma),': [2557], 'included': [2561], 'mixture,': [2565], 'since': [2566], 'affect': [2570], 'enzymatic': [2573], 'activity.': [2574], 'phosphatidylcholine-PLC': [2577], '(Sigma)': [2578], 'Tris,': [2595, 2634, 4492], '7.2,': [2597], '25%': [2598, 3534], 'glycerol,': [2599, 2644, 3536, 3602], 'p-nitrophenyl/phosphorylcholine,': [2602], 'production': [2604, 4401], 'p-nitrophenol': [2606], 'quantified': [2608, 3399], 'spectrophotometrically': [2609], '410': [2611], 'nm.': [2612, 4145], 'Protein': [2613, 3576, 4581], 'phosphatase': [2614, 2646], '2A': [2615], 'kidney': [2618], '(Calbiochem)': [2619], 'mmdithiothreitol,': [2638, 4517], 'MnCl2,': [2641], 'Jones': [2653], '(34Jones': [2656, 3723], '15530-15538Google': [2665, 3732], 'all': [2668], 'assays,': [2669], 'used,': [2674], '30-min': [2676], 'preincubation': [2677, 2983], 'enzymes': [2680], 'preceded': [2681], 'substrate.': [2686], 'human': [2688], 'routinely': [2693, 2763], 'cultured': [2694], '10%': [2699, 3483, 4038], 'FBS': [2700, 2743, 2966, 3231, 4306], '37': [2702, 2835, 4264, 4365], '°C': [2703, 2767, 2836, 3300, 3987, 4366], 'CO2.': [2706], 'Unless': [2707], 'otherwise': [2708], 'indicated,': [2709], 'treatment,': [2711, 3755], 'seeded': [2714, 2898, 3207, 4294], '1.7': [2716, 3209, 3744], '106': [2718, 2902, 3746], 'cells/10-cm': [2719, 2903], 'culture': [2720], 'dish': [2721, 2904], 'ml': [2724, 2737, 2907, 2928, 2941, 2956, 2961, 3015, 3026, 3038, 3225, 3252, 3341, 3369, 3975, 4013, 4029], 'medium;': [2727], '24': [2729, 3217, 4313], 'h,': [2730, 2914, 2934, 2982, 3218, 4314], 'replaced': [2734, 3222], '7': [2736, 2960], '2%': [2742, 2965, 3230, 4305], 'Hepes,': [2747, 2970, 3235, 3452], '7.5,': [2749, 2972], 'rested': [2754], 'prior': [2758, 2848, 3477], 'treatment.': [2760], 'stored': [2764, 3064, 3572, 3856, 4061, 4222, 4577], '−80': [2766, 3066, 3574, 4063, 4227, 4579], '1.5': [2770], 'stock': [2772, 2808, 2816, 4162, 4351], 'Me2SO.': [2775], 'Right': [2776, 3238], 'before': [2777, 3239], 'use,': [2778], 'solubilized': [2782, 4238, 4376], '(MSA)': [2791], '(2.5': [2792], 'MSA': [2796], 'sterile': [2798], 'double-distilled': [2799, 3082, 3978], 'H2O': [2800, 3083], 'added': [2802, 2882, 3246, 3634, 4033, 4078, 4318, 4333, 4358], 'suspension;': [2809], 'therefore,': [2810], 'concentration': [2812, 2925], 'solution': [2817, 2880, 3659, 4101, 4121, 4163, 4352], 'experiments': [2823, 4436], '1.43': [2825], 'mm).': [2826], 'mixed': [2830, 3492, 3553], 'warmed': [2832], 'until': [2837], 'clear.': [2838], 'Cells': [2839, 2896, 3019, 3041, 3125, 3205, 3305], 'preincubated': [2841], '30': [2846, 2985, 3556, 4327], 'Control': [2853], 'Me2SO': [2858], 'samples': [2865, 4267], 'receiving': [2866], 'solution.': [2869], 'When': [2870], 'doses': [2872], 'tested,': [2876], 'vehicle': [2879], 'order': [2884], 'equal': [2886, 4248], 'highest': [2894], 'dose.': [2895], 'medium.': [2911, 3215, 3961, 4211], '48': [2913], 'labeled': [2918], 'chloride': [2921], '(1': [2922], 'μCi/ml': [2923], 'medium/plate).': [2931], '∼60': [2933], 'chased': [2938], '90': [2946], 'min.': [2947, 3511, 3566, 3645, 4542], 'Then': [2948, 4094], 'washed': [2952, 3011, 3033, 3279, 3433, 3805, 3966, 4216, 4465], 'once': [2953, 3012, 3280, 4466], 'added.': [2974], 'resting': [2976], 'approximately': [2980], 'started,': [2990], 'followed.': [2994], 'points,': [2999, 3948, 4198, 4346, 4462], 'plate': [3004, 3031, 3310, 3748, 4275, 4298, 4418], 'ice-cold': [3017, 3969, 3977, 4219, 4468], 'PBS.': [3018, 3040, 3439], 'scraped': [3021, 3307, 4486], 'ice': [3023, 4046, 4539], 'additional': [3036], 'washes': [3043, 4478], 'pooled': [3045], '2000': [3055, 3292], 'g': [3057, 3294, 3508, 3563, 4550, 4567], '(4': [3058], '°C).': [3059], 'pellets': [3062, 3075, 4236], 'day': [3070, 4231], 'measurement,': [3073], '600': [3079], 'vortexing': [3085], 'sonication.': [3087], 'Aliquots': [3088], 'lysates': [3091, 4585], 'determination,': [3096], '250': [3098], 'duplicate': [3101], 'determination': [3106, 3350, 3375, 4020, 4066], 'Andrieu': [3110], 'et': [3111], 'al.': [3112], '(35Andrieu': [3113], '303:': [3122], '341-345Google': [3123], 'harvested': [3127, 3435], 'methanol,': [3129, 3360], 'lipids': [3131, 3354], 'extracted': [3133, 3320], 'method': [3136, 3323], 'Bligh': [3138, 3325], 'Dyer': [3140, 3143, 3327, 3330], '(36Bligh': [3141, 3328], 'E.G.': [3142, 3329], 'W.J.': [3144, 3331], 'Can.': [3145, 3332], 'Physiol.': [3148, 3335], '1959;': [3149, 3336], '37:': [3150, 3337], '911-917Google': [3151, 3338], 'chloroform': [3154], 'organic': [3155, 3344], 'phase': [3156, 3345], 'divided': [3158], 'aliquots': [3160], '(in': [3161], 'duplicates)': [3162], 'dried': [3164], 'down': [3165, 3497], 'phosphate': [3169, 3191, 3378, 4092], 'measurements.': [3170], 'Ceramide': [3171, 3181], 'Escherichia': [3177], 'colidiacylglycerol': [3178], 'kinase': [3179], 'assay.': [3180, 3583, 4593], 'quantitated': [3183, 4407], 'external': [3186], 'standards': [3187], 'normalized': [3189, 4170], 'content': [3192], '(37Perry': [3193], '312:': [3202], '22-31Google': [3203], '106cells/plate': [3211], '7.5.': [3237, 4311], '[3H]palmitate': [3244], 'same': [3255], 'μCi/ml.': [3263], '∼21': [3265], 'PBS': [3282, 3970, 4220], 'combined': [3285, 3314, 3956, 4206], 'collect': [3302], 'floating': [3303], 'off': [3308], 'methanol': [3312], 'floaters.': [3317], 'Lipids': [3318], 'separation': [3352], 'through': [3355, 3898], '(chloroform,': [3359], '4.2': [3361], 'n': [3362], 'ammonium': [3363], 'hydroxide;': [3364], '4:1:0.1;': [3365], 'v/v/v),': [3366], '0.35': [3368], 'duplicates': [3371], 'inorganic': [3377], 'normalize': [3381], 'values.': [3384], 'band': [3387], 'comparison': [3391], 'authentic': [3394], 'standard,': [3395], 'radioactivity': [3397], 'scintillation': [3402], 'counter.': [3403], 'performed': [3407, 3984, 4450], '(38Luberto': [3411], 'Yoo': [3413], 'D.S.': [3414], 'Suidan': [3415], 'H.S.': [3416], 'Bartoli': [3417], 'G.M.': [3418], '14760-14766Google': [3426], 'Briefly,': [3428, 4011], 'treatments,': [3430], 'scraping': [3437], 'pellet': [3441, 4225], '400': [3445], '7.9,': [3454, 3596], 'KCl,': [3457, 3599], 'mmEGTA,': [3462], 'dithiothreitol,': [3465, 3545], '0.5': [3466, 3546], 'fluoride)': [3468], 'ice.': [3475], 'Just': [3476], 'Nonidet': [3484, 4519], 'P-40': [3485], 'added,': [3487, 4130], 'pipetting': [3494], 'three': [3498], 'times.': [3499], 'Nuclei': [3500, 3832], 'pelleted': [3502, 3559], 'microcentrifugation': [3504], '1300': [3506], 'removed,': [3515], 'nuclei': [3518], 'extraction': [3525], '(20': [3527, 3593, 3670, 4490], 'Hepes': [3529], '7.9),': [3531], '0.4m': [3532], 'NaCl,': [3533, 4497], '(v/v)': [3535, 3601, 4039], 'phenylmethylsulfonyl': [3548, 4514], 'fluoride).': [3549], 'gently': [3554], '13,000': [3561], '15': [3565, 3760, 4320], 'flash-frozen': [3570], 'concentrations': [3577, 4582], 'Bio-Rad': [3582, 4023, 4592], 'Nuclear': [3584], 'extracts': [3585], 'μg)': [3587], 'HDKE': [3591], 'mmHepes,': [3594, 4309], 'dithiothreitol)': [3608], 'μg': [3611, 3615, 3620], 'poly(dI-dC),': [3613], 'poly(dN6),': [3617], 'albumin.': [3624], 'radiolabeled': [3628], 'oligonucleotide': [3629], 'probe': [3630], '(60,000–100,000': [3631], 'cpm)': [3632], 'temperature': [3642], 'terminated': [3649], '15%': [3657, 4607], 'Ficoll': [3658], 'indicator': [3661], 'dyes': [3662], '(bromphenol': [3663], 'xylene': [3666], 'cyanol).': [3667], 'Equal': [3668, 4594], 'μl)': [3671], 'loaded': [3676], 'nondenaturing': [3680], 'polyacrylamide': [3681], 'gel': [3682], '1×': [3684], 'TBE': [3685], 'run': [3687], '200': [3689, 4095], 'Gels': [3691], 'placed': [3693], 'onto': [3694], 'Whatman': [3695], 'filter': [3696], 'paper,': [3697], 'dried,': [3698], 'autoradiographed.': [3700], 'GW6948': [3717], 'For': [3734, 4065], 'immunocytochemical': [3735], 'analysis,': [3736, 4234], 'plated': [3739], 'density': [3742], 'cells/100-mm': [3747], 'contained': [3750], '22-mm': [3751], 'glass': [3752], 'coverslips.': [3753], 'Following': [3754], 'fixed': [3758], '4%': [3763, 3773], 'paraformaldehyde': [3764, 3774], 'subsequently': [3766], 'permeabilized': [3767], '15-min': [3770], 'incubation': [3771, 3838], '0.2%': [3776], 'washed,': [3781], 'blocked': [3782], 'antibody': [3793, 3799], '(1:200)': [3794], 'mouse': [3797], 'anti-cytochromec': [3798], '(1:200).': [3800], 'coverslips': [3802, 3849], 'fluorescein': [3813], 'isothiocyanate-conjugated': [3814], 'donkey': [3815], 'IgG': [3817, 3827, 4633, 4642, 4651], '(1:100;': [3818], 'Jackson': [3819, 3829], 'ImmunoResearch)': [3820], 'rhodamine': [3823], '(TRITC)-conjugated': [3824], 'goat': [3825], '(1:200;': [3828], 'ImmunoResearch),': [3830], 'respectively.': [3831, 4618], 'visualized': [3834], '5-min': [3837], 'Hoechst': [3840], 'dye': [3841, 4405], '(5': [3842, 4353], 'bisbenzimide;': [3844], 'Roche': [3845], 'Molecular': [3846], 'Biochemicals).': [3847], 'mounted': [3851, 3876], 'microscope': [3853, 3881, 3912], 'slides': [3854], 'light': [3859], '−20': [3861], 'stained': [3865, 3903], 'photographed': [3869], 'Dage-MTI': [3872], 'video': [3874, 3888], 'camera': [3875], 'Zeiss': [3879], 'Axiovert': [3880], 'equipped': [3882], 'fluorescence': [3884], 'optics,': [3885], 'digitizer': [3889], '(Snappy': [3890], 'Video': [3891], 'Snapshot,': [3892], 'Play': [3893], 'Inc.,': [3894], 'Rancho': [3895], 'Cordova)': [3896], 'operated': [3897], 'Adobe': [3899], 'Photoshop.': [3900], 'confocal': [3911], '(Olympus': [3913], 'IX': [3914], '70),': [3915], 'Biosciences': [3917], 'Ultraview': [3918], 'software,': [3919], 'spinning': [3920], 'disk,': [3921], 'Olympus': [3924], '×40,': [3925], '1.4': [3926], 'numerical': [3927], 'aperture,': [3928], 'oil': [3929], 'immersion': [3930], 'lens.': [3931], 'Fluorescence': [3932], 'signals': [3933], 'collected': [3935, 3952, 4202, 4480], 'single': [3937], 'line': [3938], 'excitation': [3939, 4278], '543': [3941], 'nm': [3942, 4414], '(red).': [3943], 'adherent': [3949, 4199], 'trypsinization': [3954, 4204], 'floaters': [3958, 4208, 4471], 'twice': [3967, 4217], '0.4': [3974], 'H2O.': [3979], 'following': [3981], 'steps': [3982], 'modified': [3990], 'procedure': [3991], 'Tietze': [3993], 'F': [3994], '(39Tietze': [3995], 'Anal.': [3997, 4005], '1969;': [3999], '27:': [4000], '502-522Google': [4001], '40Griffith': [4003], 'O.W.': [4004], '1980;': [4007], '106:': [4008], '207-212Google': [4009], 'lysate': [4015, 4031], 'assay,': [4024], 'remaining': [4027], '0.3': [4028], '5-sulfosalicylic': [4040], 'acid,': [4041], 'mixed,': [4042], 'allow': [4051], 'precipitation.': [4053], 'Samples': [4054], 'centrifuged,': [4057], 'supernatants': [4059, 4076, 4561], 'content,': [4071], '35': [4080], '6.3': [4086], 'EDTA': [4088], '125': [4090], 'mmsodium': [4091], '(GAB).': [4093], '0.315': [4098], 'NADPH': [4100], 'GAB': [4104, 4124], '(final': [4105, 4125], 'concentration,': [4106, 4126], '0.21': [4107], 'mm),': [4108], '0.55': [4109], 'units': [4110], 'reductase,': [4113], '12': [4118], 'mm5,5′-dithiobis-(2-nitrobenzoic': [4119], 'acid)': [4120], 'mm)': [4128], 'reading': [4140], 'OD': [4142, 4411], '412': [4144], 'Concentration': [4146], 'values': [4147, 4157], 'standard': [4152], 'curve': [4153], '(0.1–100': [4158], 'nm)': [4159], 'GAB,': [4166], 'they': [4168], 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'polyclonal': [4632, 4650], '(1:2500;': [4634], 'Biotechnology),': [4637], '(2': [4643], 'μg/ml;': [4644], 'Pharmingen),': [4645], 'anti-caspase': [4647], '(1:500;': [4652], 'Biotechnology)': [4655], 'secondary': [4657], 'anti-rabbi': [4658]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093805100', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2025-01-04T00:34:21.521793', 'created_date': '2016-06-24'}