Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2093577878', 'doi': 'https://doi.org/10.1084/jem.191.10.1745', 'title': "Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement", 'display_name': "Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement", 'publication_year': 2000, 'publication_date': '2000-05-15', 'ids': {'openalex': 'https://openalex.org/W2093577878', 'doi': 'https://doi.org/10.1084/jem.191.10.1745', 'mag': '2093577878', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10811867', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2193161'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.191.10.1745', 'pdf_url': 'https://rupress.org/jem/article-pdf/191/10/1745/1695717/992276.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jem/article-pdf/191/10/1745/1695717/992276.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031495729', 'display_name': 'James B. Petro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James B. Petro', 'raw_affiliation_strings': ['aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146'], 'affiliations': [{'raw_affiliation_string': 'aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072072818', 'display_name': 'S.M. Jamshedur Rahman', 'orcid': 'https://orcid.org/0000-0002-6811-5133'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S.M. Jamshedur Rahman', 'raw_affiliation_strings': ['aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146'], 'affiliations': [{'raw_affiliation_string': 'aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103537792', 'display_name': 'Dean W. Ballard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dean W. Ballard', 'raw_affiliation_strings': ['aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146'], 'affiliations': [{'raw_affiliation_string': 'aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076315131', 'display_name': 'Wasif N. Khan', 'orcid': 'https://orcid.org/0000-0002-7354-8312'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wasif N. Khan', 'raw_affiliation_strings': ['aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146'], 'affiliations': [{'raw_affiliation_string': 'aDepartment of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.753, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 297, 'citation_normalized_percentile': {'value': 0.999861, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '191', 'issue': '10', 'first_page': '1745', 'last_page': '1754'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11725', 'display_name': 'Genetic Basis of Primary Immunodeficiency Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11725', 'display_name': 'Genetic Basis of Primary Immunodeficiency Disorders', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Genomic Aberrations and Treatment of Chronic Lymphocytic Leukemia', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-?B Signaling in Inflammation and Cancer', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/btk-inhibitors', 'display_name': 'BTK Inhibitors', 'score': 0.534422}, {'id': 'https://openalex.org/keywords/b-cell-abnormalities', 'display_name': 'B Cell Abnormalities', 'score': 0.528807}, {'id': 'https://openalex.org/keywords/transcription-factors', 'display_name': 'Transcription Factors', 'score': 0.506289}, {'id': 'https://openalex.org/keywords/ror1', 'display_name': 'ROR1', 'score': 0.431096}], 'concepts': [{'id': 'https://openalex.org/C90059517', 'wikidata': 'https://www.wikidata.org/wiki/Q423572', 'display_name': "Bruton's tyrosine kinase", 'level': 4, 'score': 0.7779056}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5307754}, {'id': 'https://openalex.org/C23440912', 'wikidata': 'https://www.wikidata.org/wiki/Q18030230', 'display_name': 'ROR1', 'level': 5, 'score': 0.431096}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.41897687}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41253918}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4011917}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3817961}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.36251575}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34951714}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33173615}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.3262899}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.30430007}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21218243}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.06584999}], 'mesh': [{'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011947', 'descriptor_name': 'Receptors, Antigen, B-Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000077329', 'descriptor_name': 'Agammaglobulinaemia Tyrosine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000361', 'descriptor_name': 'Agammaglobulinemia', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000361', 'descriptor_name': 'Agammaglobulinemia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000361', 'descriptor_name': 'Agammaglobulinemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000361', 'descriptor_name': 'Agammaglobulinemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051550', 'descriptor_name': 'I-kappa B Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007153', 'descriptor_name': 'Immunologic Deficiency Syndromes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007153', 'descriptor_name': 'Immunologic Deficiency Syndromes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007153', 'descriptor_name': 'Immunologic Deficiency Syndromes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007153', 'descriptor_name': 'Immunologic Deficiency Syndromes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011947', 'descriptor_name': 'Receptors, Antigen, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.191.10.1745', 'pdf_url': 'https://rupress.org/jem/article-pdf/191/10/1745/1695717/992276.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2193161', 'pdf_url': 'https://europepmc.org/articles/pmc2193161?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193161', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10811867', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.191.10.1745', 'pdf_url': 'https://rupress.org/jem/article-pdf/191/10/1745/1695717/992276.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1505967628', 'https://openalex.org/W1529773650', 'https://openalex.org/W1586623480', 'https://openalex.org/W1592440579', 'https://openalex.org/W1606809499', 'https://openalex.org/W1617532721', 'https://openalex.org/W1915074145', 'https://openalex.org/W1927267735', 'https://openalex.org/W1964553344', 'https://openalex.org/W1966408108', 'https://openalex.org/W1969790491', 'https://openalex.org/W1975225711', 'https://openalex.org/W1980166477', 'https://openalex.org/W1981070246', 'https://openalex.org/W1981150156', 'https://openalex.org/W1993216157', 'https://openalex.org/W1995073073', 'https://openalex.org/W2004533847', 'https://openalex.org/W2009014327', 'https://openalex.org/W2015788325', 'https://openalex.org/W2016591994', 'https://openalex.org/W2017508812', 'https://openalex.org/W2025200482', 'https://openalex.org/W2025755006', 'https://openalex.org/W2029381336', 'https://openalex.org/W2031208947', 'https://openalex.org/W2035277099', 'https://openalex.org/W2039392072', 'https://openalex.org/W2051774115', 'https://openalex.org/W2054526083', 'https://openalex.org/W2058751432', 'https://openalex.org/W2061235611', 'https://openalex.org/W2078427707', 'https://openalex.org/W2080251738', 'https://openalex.org/W2086015876', 'https://openalex.org/W2086730768', 'https://openalex.org/W2091695331', 'https://openalex.org/W2094466581', 'https://openalex.org/W2096589599', 'https://openalex.org/W2111202304', 'https://openalex.org/W2125941855', 'https://openalex.org/W2139459601', 'https://openalex.org/W2149902181', 'https://openalex.org/W2150033965', 'https://openalex.org/W2152676014', 'https://openalex.org/W2152901500', 'https://openalex.org/W2159219386', 'https://openalex.org/W2159403435', 'https://openalex.org/W2160991051', 'https://openalex.org/W2162741904', 'https://openalex.org/W2166781237', 'https://openalex.org/W4237429324'], 'related_works': ['https://openalex.org/W56039399', 'https://openalex.org/W3029761319', 'https://openalex.org/W284991352', 'https://openalex.org/W2160930114', 'https://openalex.org/W2150814991', 'https://openalex.org/W2029323837', 'https://openalex.org/W2027911638', 'https://openalex.org/W2023447434', 'https://openalex.org/W1977408386', 'https://openalex.org/W1963500867'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 18, 24, 29, 48, 70, 85, 155], 'the': [2, 10, 34, 61, 90, 122, 140, 150], 'gene': [3], 'encoding': [4], "Bruton's": [5], 'tyrosine': [6], 'kinase': [7, 117], '(btk)': [8], 'cause': [9, 89], 'B': [11, 40, 51, 75, 151], 'cell': [12, 41, 43, 52, 76, 152], 'deficiency': [13], 'diseases': [14], 'X-linked': [15, 21], 'agammaglobulinemia': [16], '(XLA)': [17], 'humans': [19], 'and': [20, 28, 46, 137, 157], 'immunodeficiency': [22], '(xid)': [23], 'mice.': [25], 'In': [26], 'vivo': [27], 'vitro': [30], 'studies': [31], 'indicate': [32, 132], 'that': [33, 81, 133], 'BTK': [35, 134], 'protein': [36], 'is': [37], 'essential': [38], 'for': [39, 126], 'survival,': [42], 'cycle': [44], 'progression,': [45], 'proliferation': [47], 'response': [49], 'to': [50, 60, 88, 139, 149], 'antigen': [53], 'receptor': [54], '(BCR)': [55], 'stimulation.': [56], 'BCR': [57], 'stimulation': [58], 'leads': [59], 'activation': [62, 95, 114], 'of': [63, 96, 115], 'transcription': [64], 'factor': [65, 67], 'nuclear': [66], '(NF)-κB,': [68], 'which': [69, 119], 'turn': [71], 'regulates': [72], 'genes': [73], 'controlling': [74], 'growth.': [77], 'We': [78], 'now': [79], 'demonstrate': [80], 'a': [82], 'null': [83], 'mutation': [84, 109], 'btk': [86], 'known': [87], 'xid': [91], 'phenotype': [92], 'prevents': [93], 'BCR-induced': [94], 'NF-κB.': [97], 'This': [98, 108], 'defect': [99], 'can': [100], 'be': [101], 'rescued': [102], 'by': [103], 'reconstitution': [104], 'with': [105, 112, 143], 'wild-type': [106], 'BTK.': [107], 'also': [110], 'interferes': [111], 'BCR-directed': [113], 'IκB': [116], '(IKK),': [118], 'normally': [120], 'targets': [121], 'NF-κB': [123, 138], 'inhibitor': [124], 'IκBα': [125], 'degradation.': [127], 'Taken': [128], 'together,': [129], 'these': [130], 'findings': [131], 'couples': [135], 'IKK': [136], 'BCR.': [141], 'Interference': [142], 'this': [144], 'coupling': [145], 'mechanism': [146], 'may': [147], 'contribute': [148], 'deficiencies': [153], 'observed': [154], 'XLA': [156], 'xid.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2093577878', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-09T21:57:03.827884', 'created_date': '2016-06-24'}