p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

Name: Work Video:
Duration: 3 min 30 s
Seetharaman Balasenthil; Ayşegül A. Şahin; Christopher J. Barnes; Rui‐An Wang; Richard G. Pestell; Ratna K. Vadlamudi; Rakesh Kumar
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'has': [4, 243, 839, 1236, 1317, 1425, 1529, 1740, 1811, 2042, 2696, 3075, 4544], 'been': [5, 244, 486, 840, 1238, 1318, 1426, 1530, 1741, 1812, 2044, 2697, 3076, 4545], 'shown': [6, 245, 1033, 1319, 1427, 1742, 3461, 4181, 4546], 'recently': [7, 246, 3029], 'to': [8, 74, 247, 313, 908, 990, 1070, 1320, 1428, 1437, 1696, 1743, 1802, 1814, 2295, 2451, 2491, 2499, 2613, 2647, 2741, 2878, 2903, 3018, 3045, 3078, 3286, 3870, 3873, 3881, 3924, 4313, 4547, 4611, 4756, 4760, 4764, 4811, 5020, 5031], 'induce': [9, 248], 'hyperplasia': [10, 209, 249, 448, 1471, 3048, 3080, 3303, 5047], 'in': [11, 40, 56, 93, 110, 210, 222, 235, 250, 279, 295, 332, 349, 449, 461, 474, 488, 988, 997, 1040, 1058, 1080, 1122, 1228, 1240, 1323, 1467, 1472, 1532, 1634, 1638, 1692, 1790, 1825, 1910, 2046, 2139, 2152, 2160, 2172, 2187, 2205, 2226, 2243, 2310, 2320, 2389, 2426, 2511, 2655, 2779, 2796, 2799, 2870, 2890, 2916, 2935, 2951, 2977, 3012, 3024, 3039, 3071, 3220, 3233, 3253, 3278, 3292, 3304, 3315, 3327, 3335, 3346, 3359, 3372, 3379, 3401, 3409, 3422, 3441, 3455, 3462, 3559, 3610, 3619, 3637, 3660, 3730, 3749, 3774, 3808, 3842, 3859, 3888, 3961, 3992, 4026, 4152, 4177, 4182, 4196, 4205, 4224, 4230, 4242, 4258, 4297, 4621, 4630, 4652, 4699, 4831, 4836, 4840, 4893, 4935, 4969, 4982, 4991, 5013, 5048], 'the': [12, 28, 34, 37, 41, 151, 211, 225, 251, 267, 273, 276, 280, 390, 450, 464, 489, 531, 594, 647, 662, 665, 803, 807, 848, 1041, 1059, 1111, 1123, 1177, 1473, 1623, 1642, 1750, 1786, 1791, 2146, 2153, 2181, 2188, 2264, 2321, 2358, 2456, 2493, 2496, 2502, 2609, 2649, 2727, 2733, 2742, 2792, 3001, 3020, 3025, 3040, 3072, 3146, 3213, 3221, 3227, 3318, 3331, 3341, 3390, 3436, 3456, 3473, 3484, 3496, 3503, 3569, 3576, 3591, 3634, 3638, 3661, 3682, 3736, 3775, 3790, 3802, 3836, 3843, 3907, 4047, 4149, 4197, 4216, 4225, 4237, 4243, 4254, 4265, 4292, 4308, 4376, 4424, 4433, 4455, 4613, 4700, 4719, 4732, 4767, 4774, 4894, 4912, 4921, 4930, 4979, 4992, 4995, 5026, 5035, 5045, 5079], 'mammary': [13, 57, 63, 212, 252, 296, 302, 451, 1468, 1474, 1688, 1693, 2048, 2140, 2206, 3026, 3042, 3073, 3234, 3255, 3259, 3295, 3305, 3562, 5049], 'epithelium,': [14, 253], 'a': [15, 24, 72, 157, 160, 193, 254, 263, 311, 396, 399, 432, 602, 717, 857, 1034, 1054, 1494, 2137, 2163, 2311, 2447, 2840, 2846, 2930, 2947, 3013, 3034, 3046, 3246, 3596, 3631, 3654, 3670, 3892, 4087, 4164, 4193, 4349, 4359, 4436, 4693, 4837], 'phenotype': [16, 255, 1495], 'also': [17, 98, 256, 337, 913, 995, 1237, 2043, 3205, 3432, 3753, 4191, 4602, 4711], 'manifested': [18, 257, 1496], 'by': [19, 135, 145, 183, 258, 374, 384, 422, 599, 646, 659, 716, 1049, 1114, 1497, 1727, 1819, 1900, 1905, 1958, 1963, 2009, 2471, 2731, 2830, 2838, 2999, 3225, 3579, 3755, 3814, 4263, 4339, 4343, 4348, 4389, 4427, 4957, 5007, 5033], 'overexpression': [20, 259, 1619, 1685, 2012, 3032, 3070], 'of': [21, 27, 36, 43, 78, 108, 121, 129, 153, 159, 167, 185, 198, 214, 227, 260, 266, 275, 282, 317, 347, 360, 368, 392, 398, 406, 424, 437, 453, 466, 491, 533, 596, 601, 604, 642, 649, 661, 664, 719, 732, 738, 793, 797, 806, 847, 1045, 1053, 1072, 1110, 1117, 1179, 1462, 1526, 1535, 1539, 1626, 1641, 1686, 1722, 1737, 1749, 1821, 1897, 1965, 2038, 2132, 2149, 2155, 2166, 2168, 2183, 2190, 2305, 2325, 2377, 2441, 2495, 2520, 2606, 2687, 2810, 2852, 2949, 3022, 3033, 3153, 3215, 3217, 3223, 3229, 3249, 3276, 3289, 3307, 3321, 3325, 3333, 3343, 3354, 3368, 3385, 3444, 3448, 3450, 3477, 3486, 3499, 3554, 3587, 3633, 3640, 3644, 3663, 3684, 3727, 3746, 3759, 3777, 3793, 3797, 3805, 3822, 3838, 3848, 3851, 3866, 3884, 3909, 3920, 3929, 3988, 4017, 4023, 4049, 4072, 4148, 4172, 4200, 4227, 4239, 4246, 4294, 4310, 4352, 4362, 4369, 4379, 4435, 4616, 4624, 4641, 4643, 4657, 4687, 4696, 4703, 4708, 4721, 4773, 4821, 4826, 4846, 4914, 4932, 4945, 4959, 4978, 4994, 4997, 5004, 5028, 5038], 'cyclin': [22, 44, 79, 103, 115, 122, 130, 154, 168, 180, 199, 228, 261, 283, 318, 342, 354, 361, 369, 393, 407, 419, 438, 467, 1502, 1527, 1723, 1751, 1792, 1798, 1816, 1898, 1960, 2010, 2039, 2124, 2150, 2191, 2481, 2522, 2811, 2817, 2853, 3068, 3156, 3207, 3218, 3230, 3250, 3269, 3290, 3322, 3357, 3377, 3438, 3453, 3478, 3500, 3504, 3510, 3570, 3592, 3606, 3641, 3664, 3737, 3760, 3766, 3798, 3806, 3828, 3839, 3852, 3867, 3875, 3886, 3910, 3925, 3933, 3973, 3989, 4018, 4024, 4052, 4157, 4201, 4228, 4247, 4353, 4370, 4383, 4410, 4442, 4459, 4604, 4625, 4649, 4688, 4704, 4734, 4747, 4776, 4822, 4833, 4896, 4901, 4915, 4933, 4946, 4954, 5005, 5039], 'D1,': [23, 155, 229, 262, 394, 468, 3799, 4248], 'known': [25, 264, 607], 'indicator': [26, 265], 'proliferative': [29, 268, 1908, 2051], 'stage.': [30, 269], 'Here': [31, 270, 2178], 'we': [32, 271, 2179, 3028, 3200, 3211, 3338, 3481, 3667, 3800, 4055, 4190, 4249, 4609, 4807], 'investigated': [33, 272, 2180], 'role': [35, 274, 1036, 2138, 2148, 2182, 3021, 3632, 3656, 4223, 4361], 'Pak1': [38, 55, 68, 89, 109, 133, 143, 162, 178, 196, 232, 277, 294, 307, 328, 348, 372, 382, 401, 417, 435, 471, 643, 713, 733, 794, 835, 861, 912, 993, 1038, 1056, 1112, 1121, 1172, 1224, 1233, 1315, 1424, 1465, 2161, 2184, 2204, 2292, 2484, 2695, 2725, 2746, 2815, 2856, 2957, 3007, 3023, 3037, 3203, 3224, 3263, 3326, 3334, 3344, 3355, 3369, 3386, 3396, 3420, 3430, 3451, 3466, 3475, 3489, 3494, 3558, 3588, 3603, 3635, 3647, 3658, 3680, 3748, 3813, 3826, 3855, 3894, 3904, 3914, 3930, 3945, 4040, 4050, 4073, 4089, 4150, 4173, 4217, 4240, 4256, 4300, 4337, 4364, 4380, 4403, 4406, 4417, 4428, 4438, 4445, 4542, 4601, 4622, 4701, 4710, 4744, 4819, 4910, 4928, 4939, 4952, 4965, 4980, 5008, 5053], 'pathway': [39, 163, 206, 278, 402, 445, 1113, 1824, 3636, 3895, 4151, 4218, 4365, 4439, 4698, 4981], 'expression': [42, 77, 107, 152, 166, 201, 281, 316, 346, 391, 405, 440, 1052, 1116, 1461, 1721, 2041, 2189, 3232, 3288, 3345, 3431, 3440, 3639, 3726, 3745, 3796, 3831, 3877, 3908, 4171, 4204, 4245, 4257, 4338, 4355, 4368, 4385, 4750, 4931, 4948], 'D1': [45, 80, 104, 116, 123, 181, 200, 284, 319, 343, 355, 362, 420, 439, 1503, 1528, 1618, 1691, 1724, 1752, 1793, 1799, 1817, 1899, 1961, 1967, 2011, 2040, 2125, 2151, 2192, 2272, 2482, 2506, 2523, 2812, 2818, 2854, 2932, 3010, 3069, 3157, 3208, 3219, 3231, 3251, 3270, 3291, 3358, 3378, 3439, 3454, 3469, 3479, 3501, 3511, 3571, 3593, 3607, 3650, 3665, 3738, 3761, 3767, 3782, 3807, 3829, 3840, 3853, 3868, 3876, 3887, 3911, 3926, 3934, 3974, 3990, 4019, 4025, 4044, 4053, 4158, 4202, 4229, 4354, 4384, 4411, 4443, 4448, 4460, 4605, 4626, 4650, 4689, 4705, 4735, 4748, 4777, 4897, 4902, 4916, 4934, 4947, 4955, 5006, 5040], 'using': [46, 285, 2193, 2369, 2459, 2608, 2635, 2732, 2839, 2864, 3502, 4264, 4301, 4400, 4728], 'tissue': [47, 286], 'culture': [48, 287, 2197, 2781], 'models': [49, 288, 2198], 'and': [50, 97, 126, 173, 207, 230, 289, 336, 365, 412, 446, 469, 483, 495, 526, 528, 537, 652, 724, 735, 918, 923, 1067, 1078, 1133, 1184, 1278, 1362, 1419, 1436, 1636, 2007, 2050, 2143, 2199, 2210, 2220, 2254, 2280, 2298, 2367, 2387, 2412, 2453, 2483, 2498, 2603, 2630, 2723, 2771, 2783, 2813, 2819, 2845, 2855, 2862, 2873, 2895, 2944, 2955, 2961, 2964, 2989, 3145, 3239, 3356, 3376, 3415, 3418, 3452, 3618, 3765, 3827, 3912, 3936, 3963, 3971, 3978, 4008, 4063, 4083, 4208, 4304, 4307, 4405, 4471, 4599, 4738, 4751, 4762, 4789, 4828, 4949, 4963, 5009, 5022, 5041], 'transgenic': [51, 69, 290, 308, 2200, 2688, 3238, 3264, 3281, 3294, 5054], 'mice': [52, 70, 216, 291, 309, 455, 2201, 2689, 3265, 3309, 5055], 'expressing': [53, 292, 2202, 2290, 2690, 3678, 3811, 3942], 'activated': [54, 293, 715, 2203, 4746], 'glands.': [58, 297, 2207, 3256], 'We': [59, 298, 3350, 4144, 4289, 5074], 'found': [60, 299, 1621, 1813, 2045], 'that': [61, 177, 208, 231, 300, 416, 447, 470, 1223, 2123, 3031, 3148, 3202, 3302, 3903, 3913, 4077, 4146, 4215, 4458, 4743, 4752, 4909, 4926, 4976], 'hyperplastic': [62, 301, 2047], 'glands': [64, 213, 303, 452, 1469, 1694, 2049, 3235, 3296, 3306], 'from': [65, 171, 304, 410, 2263, 2268, 2273, 2278, 2282, 3236, 3261, 3568, 3735, 4163, 4454, 5051], 'catalytically': [66, 305, 1118, 3491], 'active': [67, 306, 859, 1119, 2291, 2567, 2693, 3492, 3944, 4005], 'exhibit': [71, 310], '5-': [73, 312], '7-fold': [75, 314], 'increased': [76, 102, 315, 341, 1042, 1171, 1907, 3744, 3795, 3874, 3882, 4021], 'as': [81, 320, 523, 608, 656, 658, 845, 1631, 1951, 3573, 3599, 3771, 3773, 3878, 3880, 4086, 4681, 4683], 'compared': [82, 321, 3574], 'with': [83, 101, 224, 322, 340, 463, 842, 1176, 1785, 2136, 2234, 2249, 2302, 2349, 2357, 2384, 2455, 2479, 2517, 2626, 2785, 2832, 2860, 2911, 2929, 2956, 2974, 2983, 2987, 2992, 3004, 3317, 3435, 3575, 3835, 3891, 3948, 4000, 4013, 4029, 4081, 4187], 'stage-matched': [84, 323, 3240], 'wild-type': [85, 324, 3241, 3254, 3487], 'mice.': [86, 325, 3242], 'In': [87, 326, 906, 1894, 3257, 4919], 'addition,': [88, 327, 1895], 'levels': [90, 120, 329, 359, 3758, 3776, 3883], 'were': [91, 330, 2224, 2241, 2261, 2293, 2299, 2355, 2381, 2424, 2443, 2477, 2514, 2624, 2749, 2774, 2794, 2858, 2868, 2884, 2909, 2927, 2970, 2997, 3832, 3946, 3958, 3998, 4011, 4398, 4726, 4816], 'elevated': [92, 119, 331, 358, 3756], 'human': [94, 236, 333, 475, 1180, 1229, 1536, 2052, 2214, 4733, 4775], 'breast': [95, 111, 237, 334, 350, 476, 739, 998, 1046, 1062, 1125, 1181, 1279, 1363, 1537, 1627, 1697, 1911, 2053, 2156, 2173, 2194, 2215, 2952, 3336, 3347, 3364, 3424, 3612, 3674, 4231, 4260, 4970, 4983, 4998, 5014], 'tumors': [96, 335, 1185, 1325, 1538, 3374, 3381, 3403, 3411], 'correlated': [99, 338, 3433], 'well': [100, 339, 657, 1175, 3434, 3620, 3772, 3879, 4682], 'expression.': [105, 344, 3209, 4444], 'Increased': [106, 345], 'cancer': [112, 351, 740, 999, 1047, 1063, 1126, 1182, 1364, 1628, 1698, 1912, 2174, 2195, 2216, 3365, 3613, 3616, 3675, 4232, 4261, 4984, 4999, 5015], 'cells': [113, 352, 741, 1048, 1183, 1739, 1828, 1913, 2223, 2240, 2288, 2380, 2509, 2623, 2793, 3565, 3624, 3732, 3751, 3810, 3890, 3940, 3997, 4010, 4027, 4154, 4262, 4986, 5017, 5030], 'stimulated': [114, 353, 3566, 3605, 3733, 4603], 'promoter': [117, 356, 1753, 1794, 3572, 3594, 3608, 3688, 4690, 4768, 4778, 4814, 4841, 4903], 'activity,': [118, 357, 4691], 'mRNA,': [124, 363], 'protein,': [125, 364], 'nuclear': [127, 366, 623, 926, 3271, 3407, 3417, 3864, 3981], 'accumulation': [128, 367, 3865], 'D1.': [131, 169, 370, 408, 3323, 3642, 4371, 4823], 'Conversely,': [132, 371, 1108], 'inhibition': [134, 373, 4147], 'an': [136, 186, 204, 375, 425, 443, 1822, 1906, 2128, 2427, 2460, 3016, 3150, 3267, 3284, 3394, 3685, 3917, 4068, 4221, 4390, 4451, 4942, 4960], 'auto-inhibitory': [137, 376, 804, 4069], 'peptide': [138, 377, 4070], '(amino': [139, 378, 4074], 'acids': [140, 379, 4075], '83-149)': [141, 380, 4076], 'or': [142, 381, 1962, 2323, 2360, 2786, 2816, 3490, 3556, 3601, 3949, 4003, 4638, 4645], 'knockdown': [144, 383], 'short': [146, 385, 629], 'interference': [147, 386, 630], 'RNA': [148, 387, 2466, 2497, 2503, 2720], 'markedly': [149, 388], 'reduced': [150, 389], 'suggesting': [156, 395, 4358, 4692, 4908], 'requirement': [158, 397, 4434], 'functional': [161, 400, 3791, 4363, 4437, 4989], 'for': [164, 403, 1037, 1797, 2307, 2417, 2433, 2501, 2803, 2807, 2875, 2887, 2897, 2922, 2979, 3657, 3954, 3966, 3980, 4366, 4440, 4818, 5078], 'optimal': [165, 404, 4244, 4367, 4441], 'Results': [170, 409], 'deletion': [172, 411, 4825], 'mutant': [174, 413, 1057, 4416], 'analysis': [175, 414, 3244, 4772], 'indicate': [176, 415], 'regulates': [179, 418, 3155, 3906, 4911, 4929, 4953], 'transcription': [182, 421, 1818, 3158, 3567, 3577, 3734, 4159, 4162, 4461, 4606, 4651, 4913, 4956], 'means': [184, 423, 600, 1820, 4958], 'NF-κB-dependent': [187, 205, 426, 444, 1823, 4961], 'pathway.': [188, 427], 'Together,': [189, 428, 2119, 3627], 'these': [190, 429, 2120, 3628, 3900, 4617], 'findings': [191, 430, 4213], 'suggest': [192, 431, 1222, 2122, 3301, 3902, 4457], 'model': [194, 433], 'wherein': [195, 434], 'regulation': [197, 436, 490, 1748, 3476, 3498, 3662, 4623, 4702, 4754, 4820], 'might': [202, 441, 3204, 4219, 5042], 'involve': [203, 442], 'Pak1-TG': [215, 454, 3308], 'may': [217, 456, 1225, 2126, 3310, 3915, 4987], 'be': [218, 457, 1226, 1321, 1744, 1955, 3311, 3871, 3916, 4387, 4463], 'associated,': [219, 458, 3312], 'at': [220, 459, 837, 853, 1434, 1622, 2430, 2900, 2946, 2958, 2965, 3313, 4785, 4851], 'least': [221, 460, 3314], 'part,': [223, 462, 3316], 'up-regulation': [226, 465, 1896, 3320, 4977, 5003], 'is': [233, 472, 521, 644, 714, 994, 1620, 1725, 1795, 1903, 3857, 4180, 4941, 4966, 5018], 'up-regulated': [234, 473, 1322, 4464], 'tumors.': [238, 477, 3445, 4971], 'The': [478, 590, 1720, 1806, 2422, 2745, 2826, 2882, 2907, 2925, 2968, 3584, 3743, 3862, 4170, 4740], 'small': [479, 591, 1807], 'GTPases,': [480], 'including': [481, 722, 800, 1501, 4469], 'Cdc42': [482, 529], 'Rac1,': [484], 'have': [485, 985, 1032, 4220, 4988], 'implicated': [487], 'mammalian': [492], 'cell': [493, 736, 991, 1043, 1064, 1076, 1127, 1131, 1803, 2196, 2378, 3676], 'morphology': [494], 'motility': [496, 737], '(1.Narumiya': [497], 'S.': [498, 558, 929, 953, 1281, 1285, 1408, 4279, 4556], 'Ishizaki': [499], 'T.': [500, 678, 701, 1253, 1337, 1567, 1757, 2064, 2090, 3090, 3116, 4476, 4792], 'Watanabe': [501], 'N.': [502, 2058, 2335, 3084], 'FEBS': [503], 'Lett.': [504], '1997;': [505, 707, 895, 1305, 1925], '410:': [506], '68-72Crossref': [507], 'PubMed': [508, 550, 569, 585, 687, 710, 761, 787, 829, 883, 901, 947, 977, 1027, 1103, 1165, 1215, 1273, 1308, 1357, 1394, 1455, 1489, 1520, 1559, 1587, 1612, 1679, 1715, 1777, 1849, 1889, 1946, 1985, 2002, 2032, 2101, 2114, 2344, 2562, 2598, 2680, 2713, 2765, 3062, 3127, 3140, 3195, 3548, 3718, 4109, 4139, 4284, 4330, 4496, 4536, 4574, 4594, 4674, 4801, 4888, 5069], 'Scopus': [509, 551, 570, 586, 762, 788, 830, 884, 902, 948, 978, 1028, 1104, 1166, 1216, 1274, 1309, 1358, 1395, 1415, 1456, 1490, 1521, 1560, 1588, 1613, 1680, 1716, 1778, 1850, 1890, 1947, 1986, 2003, 2033, 2102, 2115, 2563, 2599, 2681, 2714, 2766, 3063, 3128, 3141, 3196, 3549, 3719, 4110, 4140, 4285, 4331, 4497, 4537, 4575, 4595, 4802, 4889, 5070], '(332)': [510, 2682], 'Google': [511, 553, 572, 588, 688, 711, 764, 790, 832, 886, 904, 950, 980, 1030, 1106, 1168, 1218, 1276, 1311, 1360, 1397, 1417, 1458, 1492, 1523, 1562, 1590, 1615, 1682, 1718, 1780, 1852, 1892, 1928, 1949, 1988, 2005, 2035, 2104, 2117, 2345, 2565, 2601, 2683, 2716, 2768, 3065, 3130, 3143, 3198, 3551, 3721, 4112, 4142, 4287, 4333, 4499, 4539, 4577, 4597, 4675, 4804, 4891, 5072], 'Scholar).': [512, 589, 712, 791, 833, 905, 981, 1107, 1169, 1219, 1459, 1524, 1616, 1683, 1719, 1781, 1893, 2036, 2118, 2346, 2684, 2717, 2769, 3066, 3552, 3722, 4143, 4288, 4334, 4540, 5073], 'More': [513, 1422], 'specifically,': [514], 'Rac1': [515, 1809], 'induces': [516, 530, 1470], 'cortical': [517], 'actin': [518, 535], 'polymerization,': [519], 'which': [520, 728, 4065, 4813], 'seen': [522], 'membrane': [524], 'ruffling': [525], 'lamellipodia,': [527], 'formation': [532, 595], 'peripheral': [534], 'microspikes': [536], 'filopodia': [538], '(2.Ridley': [539], 'A.J.': [540], 'Hall': [541, 576], 'A.': [542, 560, 577, 1147, 1197, 1249, 1333, 1376, 1402, 1445, 1479, 1511, 1513, 1550, 1552, 1706, 1708, 2337, 2580, 2659, 2703, 2755, 3052, 3700, 4280, 4320, 4580, 4794, 5059], 'Cell.': [543, 564, 578, 682, 705, 824, 878, 1607, 1844, 1941, 1980, 1997, 2096, 2339, 2675, 3122, 4669], '1992;': [544], '70:': [545], '389-399Abstract': [546], 'Full': [547, 582, 758, 782, 784, 898, 942, 944, 972, 974, 1022, 1024, 1098, 1100, 1160, 1162, 1210, 1212, 1268, 1270, 1352, 1354, 1389, 1391, 1674, 1676, 1884, 1886, 2027, 2029, 2557, 2559, 2593, 2595, 3190, 3192, 3543, 3545, 3713, 3715, 4106, 4134, 4136, 4531, 4533, 4569, 4571, 4589, 4591, 4883, 4885], 'Text': [548, 583, 759, 783, 785, 899, 943, 945, 973, 975, 1023, 1025, 1099, 1101, 1161, 1163, 1211, 1213, 1269, 1271, 1353, 1355, 1390, 1392, 1675, 1677, 1885, 1887, 2028, 2030, 2558, 2560, 2594, 2596, 3191, 3193, 3544, 3546, 3714, 3716, 4107, 4135, 4137, 4532, 4534, 4570, 4572, 4590, 4592, 4884, 4886], 'PDF': [549, 584, 760, 786, 900, 946, 976, 1026, 1102, 1164, 1214, 1272, 1356, 1393, 1678, 1888, 2031, 2561, 2597, 3194, 3547, 3717, 4108, 4138, 4535, 4573, 4593, 4887], '(3867)': [552], 'Scholar,': [554, 573, 689, 765, 887, 951, 1398, 1418, 1563, 1591, 1853, 1929, 1989, 2105, 3131, 4113, 4500, 4578], '3.Kozma': [555], 'R.': [556, 767, 775, 822, 876, 1015, 1091, 1153, 1203, 1382, 1404, 1449, 1483, 2329, 2586, 2667, 2673, 2707, 2759, 3056, 3706, 4115, 4127, 4324, 4560, 5063], 'Ahmed': [557], 'Best': [559], 'Lim': [561, 679, 702], 'L.': [562, 680, 703, 814, 868, 1005, 1083, 1139, 1189, 1368, 1509, 1548, 1704, 2572, 2665, 3692, 4665], 'Mol.': [563, 681, 704, 1606, 1843, 1940, 1979, 1996, 2095, 3121, 4668], 'Biol.': [565, 683, 706, 753, 777, 894, 937, 967, 1017, 1093, 1155, 1205, 1384, 1608, 1669, 1845, 1879, 1942, 1981, 1998, 2022, 2097, 2552, 2588, 3123, 3185, 3538, 3708, 4101, 4129, 4526, 4564, 4584, 4670, 4878], '1995;': [566, 579, 939, 969], '15:': [567], '1942-1952Crossref': [568], '(885)': [571], '4.Nobes': [574], 'C.D.': [575], '81:': [580], '53-62Abstract': [581], '(3771)': [587], 'GTPases': [592, 4082], 'regulate': [593, 3206], 'cytoskeletal': [597], 'structures': [598], 'family': [603], 'serine/threonine': [605], 'kinases': [606, 610], '(Paks).': [611], '1The': [612], 'abbreviations': [613], 'used': [614, 2490, 2646, 3669, 4057], 'are:': [615], 'Pak1,': [616, 3154, 4007], 'kinase;': [618], 'ER,': [619], 'estrogen': [620, 1431], 'receptor-α;': [621], 'NF-κB,': [622], 'factor': [624, 2170, 2257], 'κB;': [625], 'Dox,': [626], 'doxycycline;': [627], 'siRNA,': [628, 2726], 'RNA;': [631], 'PBS,': [632, 2797], 'phosphate-buffered': [633, 2385], 'saline;': [634], 'WT,': [635], 'wild': [636], 'type;': [637], 'GST,': [638], 'glutathione': [639], 'S-transferase.': [640], 'Activation': [641, 792], 'accompanied': [645, 1904, 3754, 4347], 'disassembly': [648], 'stress': [650, 1073], 'fibers': [651], 'focal': [653], 'adhesion': [654], 'complexes,': [655], 'maintenance': [660], 'integrity': [663, 2494], 'motile': [666], 'leading': [667, 1801, 3923], 'edge': [668], '(5.Zhao': [669], 'Z.S.': [670], 'Manser': [671], 'E.': [672, 691], 'Chen': [673, 696], 'X.Q.': [674, 697], 'Chong': [675], 'C.': [676, 1297, 1575, 1651, 1765, 1861, 2056, 2066, 2534, 3082, 3092, 3167, 3520, 4484, 4508, 4860], 'Leung': [677, 700], '1998;': [684, 1019, 1943, 1982], '18:': [685, 1585, 1775, 1944, 1983, 4494], '2153-2163Crossref': [686], '6.Manser': [690], 'Huang': [692], 'H.Y.': [693], 'Loo': [694], 'T.H.': [695, 820, 874], 'Dong': [698], 'J.M.': [699], '17:': [708], '1129-1143Crossref': [709], 'number': [718], 'extracellular': [720, 919], 'signals,': [721, 2135], 'heregulin-β1': [723], 'epidermal': [725, 2255], 'growth': [726, 1135, 1733, 1735, 2169, 2256], 'factor,': [727], 'are': [729, 3460], 'potent': [730], 'inducers': [731], 'activity': [734, 1173, 2644, 3159, 3609, 4904], '(7.Galiesteo': [742, 4090], 'M.L.': [743, 4091], 'Chernoff': [744, 890, 958, 1010, 1088, 1148, 1198, 1377, 2581, 3701, 4092], 'J.': [745, 751, 752, 773, 776, 891, 936, 955, 959, 966, 1011, 1013, 1016, 1089, 1092, 1149, 1154, 1199, 1204, 1263, 1283, 1287, 1347, 1378, 1383, 1410, 1451, 1485, 1577, 1583, 1655, 1668, 1767, 1773, 1865, 1878, 1991, 1993, 1995, 2021, 2072, 2338, 2538, 2551, 2582, 2587, 2709, 2761, 3058, 3098, 3171, 3184, 3524, 3537, 3702, 3707, 4093, 4099, 4100, 4128, 4326, 4486, 4492, 4512, 4525, 4563, 4583, 4864, 4877, 5065], 'Su': [746, 4094], 'Y.C.': [747, 4095], 'Skolnik': [748, 4096], 'E.Y.': [749, 4097], 'Schlessinger': [750, 4098], 'Chem.': [754, 778, 938, 968, 1018, 1094, 1156, 1206, 1385, 1670, 1880, 2023, 2553, 2589, 3186, 3539, 3709, 4102, 4130, 4527, 4565, 4585, 4879], '1996;': [755, 1999, 2341, 4103, 4671], '271:': [756, 4104], '20997-21000Abstract': [757, 4105], '(237)': [763, 4111], '8.Bagheri-Yarmand': [766], 'Vadlamudi': [768, 1006, 1084, 1446, 1480, 2670, 2704, 2756, 3053, 4122, 4321, 5060], 'R.K.': [769, 810, 864, 1007, 1085, 1137, 1187, 1366, 1447, 1481, 2570, 2671, 2705, 2757, 3054, 3690, 4123, 4322, 5061], 'Wang': [770, 1140, 1190, 1369, 2573, 2660, 3693, 4120], 'R.A.': [771, 935, 1141, 1191, 1370, 1443, 1477, 2574, 2661, 2701, 2753, 3050, 3694, 4121, 4318, 5057], 'Mendelsohn': [772, 1012], 'Kumar': [774, 821, 875, 1014, 1090, 1152, 1202, 1381, 1448, 1482, 2585, 2672, 2706, 2758, 3055, 3705, 4126, 4323, 5062], '2000;': [779, 1095, 1157, 1207, 1386, 1609, 1846, 2024, 2590, 3710, 4566, 4586], '275:': [780, 1096, 1158, 1208, 1387, 2025, 2591, 3711, 4567, 4587], '39451-39457Abstract': [781], '(117)': [789], 'involves': [795], 'autophosphorylation': [796], 'several': [798, 1498], 'sites,': [799], 'Thr-423': [801, 838], 'within': [802, 4766], 'loop': [805], '(9.Vadlamudi': [809, 863], 'Li': [811, 865, 2067, 3093], 'F.': [812, 866, 1247, 1289, 1331], 'Adam': [813, 867, 1001, 1138, 1188, 1367, 2571, 2664, 3691], 'Nguyen': [815, 869, 1144, 1194, 1373, 2577, 3697], 'D.': [816, 870, 1145, 1195, 1251, 1291, 1299, 1335, 1374, 1645, 1855, 2528, 2578, 3161, 3514, 3698, 4502, 4854], 'Ohta': [817, 871], 'Y.': [818, 872, 1581, 1771, 4490], 'Stossel': [819, 873], 'Nat.': [823, 877, 2674], 'Bio.': [825, 879, 2676], '2002;': [826, 880, 1412, 1452, 1486, 2710, 2762, 3059, 4281, 4327, 5066], '4:': [827, 881], '681-690Crossref': [828, 882], '(266)': [831, 885, 903], 'Accordingly,': [834, 1684, 4824], 'phosphorylation': [836, 4022], 'linked': [841], 'its': [843, 909, 1439, 2158, 5010], 'activation,': [844], 'substitution': [846], 'acidic': [849], 'residue': [850], 'glutamic': [851], 'acid': [852, 2352], 'this': [854, 1420, 4188, 4722, 4753], 'site': [855, 4850], 'yields': [856], 'constitutively': [858, 2289, 2691, 3943, 4004], 'T423E': [860, 1120, 1464, 2694, 3036, 3237, 3262, 3493, 3557, 3602, 3646, 4006, 4030], 'enzyme': [862], '10.Sells': [888], 'M.A.': [889, 957, 1605, 1842], 'Trends': [892], 'Cell': [893, 1303, 2208, 2269, 2371, 2436], '7:': [896, 4799], '162-167Abstract': [897], 'addition': [907, 989], 'cytoskeleton': [910], 'effects,': [911], 'activates': [914], 'c-Jun': [915], 'NH2-terminal': [916], 'signal-regulated': [920], 'kinases,': [922], 'thus': [924, 4084], 'influences': [925], 'signaling': [927, 1729, 1810, 1902, 2171, 2185, 3589, 3659, 3856, 3905, 4241, 4467, 4543, 4619, 4940], '(11.Bagrodia': [928], 'Derijard': [930], 'B.': [931, 1400, 1647, 1857, 2530, 3163, 3516, 4504, 4856], 'Davis': [932], 'R.J.': [933, 963, 1659, 1869, 2542, 3175, 3528, 4516, 4868], 'Cerione': [934], '270:': [940, 970], '27995-27998Abstract': [941], '(598)': [949], '12.Zhang': [952], 'Han': [954], 'Sells': [956], 'Knaus': [960], 'U.G.': [961], 'Ulevitch': [962], 'Bokoch': [964], 'G.M.': [965], '23934-23936Abstract': [971], '(653)': [979], 'Several': [982], 'recent': [983], 'studies': [984, 4397, 4725], 'suggested': [986, 4214], 'that,': [987], 'motility,': [992], 'involved': [996], 'progression.': [1000, 1805], 'et': [1002], 'al.': [1003], '(13.Adam': [1004], 'Kondapaka': [1008], 'S.B.': [1009, 4663], '273:': [1020], '28238-28246Abstract': [1021], '(272)': [1029], 'Scholar)': [1031, 1277, 1312, 1361, 2006, 3144, 4676, 4892], 'mechanistic': [1035, 4694], 'activation': [1039, 3931, 4550], 'invasion': [1044], 'heregulin.': [1050], 'Furthermore,': [1051, 1170, 1314], 'kinase-dead': [1055], 'highly': [1060, 4967], 'invasive': [1061, 3611], 'lines': [1065, 3282], 'MDA-MB-435': [1066], 'MDA-MB-231': [1068, 2213], 'led': [1069], 'stabilization': [1071], 'fibers,': [1074], 'enhanced': [1075], 'spreading,': [1077], 'reduction': [1079, 4195, 4351, 4839], 'invasiveness': [1081, 1178], '(14.Adam': [1082], 'Mandal': [1086, 1142, 1192, 1371, 2330, 2575, 2668, 3695, 4116], 'M.': [1087, 1143, 1193, 1372, 1406, 1599, 1649, 1653, 1836, 1859, 1863, 2062, 2078, 2331, 2532, 2536, 2576, 2669, 3088, 3104, 3165, 3169, 3518, 3522, 3696, 4117, 4506, 4510, 4582, 4858, 4862], '12041-12050Abstract': [1097], '(158)': [1105], 'hyperactivation': [1109], 'conditional': [1115], 'non-invasive': [1124], 'line': [1128], 'MCF-7': [1129, 3673, 3731, 3750, 3809, 3889, 3939, 3996, 4060, 4153, 4259], 'promotes': [1130], 'migration': [1132], 'anchorage-independent': [1134], '(15.Vadlamudi': [1136, 1186, 1365, 2569, 3689], 'Sahin': [1146, 1196, 1375, 2579, 3699], 'Hung': [1150, 1200, 1379, 2583, 3703], 'M.C.': [1151, 1201, 1380, 2584, 3704], '36238-36244Abstract': [1159, 1209, 1388, 2592, 3712], '(225)': [1167, 1217, 1396, 2600, 3720], 'correlates': [1174], 'Emerging': [1220], 'data': [1221, 4973], 'overexpressed': [1227], 'cancers.': [1230, 1313], 'For': [1231, 1731], 'example,': [1232, 1732], 'gene': [1234, 4749], 'amplification': [1235], 'reported': [1239, 3077], 'ovarian': [1241, 1324], '(16.Schraml': [1242, 1326], 'P.': [1243, 1301, 1327, 2074, 2109, 3100, 3135], 'Schwerdtfeger': [1244, 1328], 'G.': [1245, 1329], 'Burkhalter': [1246, 1330], 'Raggi': [1248, 1332], 'Schmidt': [1250, 1334, 1514, 1553, 1709], 'Ruffalo': [1252, 1336], 'King': [1254, 1338], 'W.': [1255, 1339], 'Wilber': [1256, 1340], 'K.': [1257, 1341, 1573, 1763, 2070, 3096, 4482], 'Mihatsch': [1258, 1342], 'M.J.': [1259, 1295, 1343, 4558], 'Moch': [1260, 1344], 'H.': [1261, 1345, 1569, 1571, 1759, 1761, 4478, 4480], 'Am.': [1262, 1346], 'Pathol.': [1264, 1348], '2003;': [1265, 1349, 2098, 3124], '163:': [1266, 1350], '985-992Abstract': [1267, 1351], '(146)': [1275, 1359], '(17.Bekri': [1280], 'Adelaide': [1282], 'Merscher': [1284], 'Grosgeorge': [1286], 'Caroli-Bosc': [1288], 'Perucca-Lostanlen': [1290], 'Kelley': [1292], 'P.M.': [1293, 2076, 3102], 'Pebusque': [1294], 'Theillet': [1296], 'Birnbaum': [1298], 'Gaudray': [1300], 'Cytogenet.': [1302], 'Genet.': [1304], '79:': [1306], '125-131Crossref': [1307], '(132)': [1310], 'protein': [1316, 2442, 3768, 3830, 4203], '18.Salh': [1399], 'Marotta': [1401], 'Wagey': [1403], 'Sayed': [1405], 'Pelech': [1407], 'Int.': [1409], 'Cancer.': [1411, 4797], '98:': [1413], '145-154Crossref': [1414], '(66)': [1416], 'study).': [1421], 'recently,': [1423], 'directly': [1429], 'phosphorylate': [1430], 'receptor-α': [1432], '(ER)': [1433], 'Ser-305': [1435], 'promote': [1438, 5025], 'transactivation': [1440], 'functions': [1441, 5037], '(19.Wang': [1442, 1476, 2700, 2752, 3049, 4317, 5056], 'Mazumdar': [1444, 1478, 2702, 2754, 3051, 4319, 5058], 'EMBO': [1450, 1484, 1582, 1772, 2708, 2760, 3057, 4325, 4491, 5064], '21:': [1453, 1487, 2711, 2763, 3060, 4328, 5067], '5437-5447Crossref': [1454, 1488, 2712, 2764, 3061, 4329, 5068], '(157)': [1457, 1491, 2715, 2767, 3064, 4332, 5071], 'Additionally,': [1460], 'kinase-active': [1463, 3035, 3747, 3812, 4684, 5052], 'transgene': [1466, 3038], 'epithelium': [1475, 3260, 5050], 'Scholar),': [1493, 1950, 2566, 2602, 3199, 4598, 4805], 'other': [1499], 'oncogenes': [1500], '(20.Wang': [1504, 1543, 1699], 'T.C.': [1505, 1544, 1700], 'Cardiff': [1506, 1545, 1701], 'R.D.': [1507, 1546, 1702], 'Zukerberg': [1508, 1547, 1703], 'Lees': [1510, 1549, 1705], 'Arnold': [1512, 1551, 1707, 4793], 'E.V.': [1515, 1554, 1710], 'Nature.': [1516, 1555, 1711], '1994;': [1517, 1556, 1712], '369:': [1518, 1557, 1713], '669-671Crossref': [1519, 1558, 1714], '(899)': [1522, 1561, 1717], 'Overexpression': [1525, 3324, 3367], 'noted': [1531], 'over': [1533], '50%': [1534, 2296], 'all': [1540, 1639], 'histological': [1541], 'types': [1542], '21.Matsumura': [1564], 'I.': [1565, 1755, 4474], 'Kitamura': [1566, 1756, 4475], 'Wakao': [1568, 1758, 4477], 'Tanaka': [1570, 1760, 4479], 'Hashimoto': [1572, 1762, 4481], 'Albanese': [1574, 1650, 1764, 1860, 2065, 2533, 3091, 3166, 3519, 4483, 4507, 4859], 'Downward': [1576, 1766, 4485], 'Pestell': [1578, 1600, 1666, 1768, 1837, 1876, 2093, 2549, 3119, 3182, 3535, 4487, 4523, 4875], 'R.G.': [1579, 1601, 1667, 1769, 1838, 1877, 2094, 2550, 3120, 3183, 3536, 4488, 4524, 4876], 'Kanakura': [1580, 1770, 4489], '1999;': [1584, 1671, 1774, 1881, 2554, 3187, 3540, 4493, 4528, 4880], '1367-1377Crossref': [1586, 1776, 4495], '(295)': [1589, 1779, 4498], '22.Henry': [1592], 'D.O.': [1593, 1830], 'Moskalenko': [1594, 1831], 'S.A.': [1595, 1832], 'Kaur': [1596, 1833], 'K.J.': [1597, 1834], 'Fu': [1598, 1648, 1835, 1858, 2061, 2531, 3087, 3164, 3517, 4505, 4857], 'Camonis': [1602, 1839], 'J.H.': [1603, 1840], 'White': [1604, 1841], '20:': [1610, 1847, 2112, 3138], '8084-8092Crossref': [1611, 1848], '(87)': [1614, 1851], 'Cyclin': [1617, 2505, 3009, 3468, 3649, 4043, 4447], 'earliest': [1624], 'stages': [1625, 1640], 'progression': [1629], 'such': [1630], 'ductal': [1632], 'carcinoma': [1633], 'situ': [1635], 'maintained': [1637, 2225, 2242], 'metastasis': [1643], '(23.Joyce': [1644, 2527, 3160, 3513, 4853], 'Bouzahzah': [1646, 1856, 2529, 3162, 3515, 4503, 4855], "D'Amico": [1652, 1862, 2535, 3168, 3521, 4509, 4861], 'Steer': [1654, 1864, 2537, 3170, 3523, 4511, 4863], 'Klein': [1656, 1866, 2539, 3172, 3525, 4513, 4865], 'J.U.': [1657, 1867, 2540, 3173, 3526, 4514, 4866], 'Lee': [1658, 1868, 2541, 3174, 3527, 4515, 4867], 'Segall': [1660, 1870, 2543, 3176, 3529, 4517, 4869], 'J.E.': [1661, 1871, 2544, 3177, 3530, 4518, 4870], 'Westwick': [1662, 1872, 2545, 3178, 3531, 4519, 4871], 'J.K.': [1663, 1873, 2546, 3179, 3532, 4520, 4872], 'Der': [1664, 1874, 2547, 3180, 3533, 4521, 4873], 'C.J.': [1665, 1875, 2548, 3181, 3534, 4522, 4874], '274:': [1672, 1882, 2555, 3188, 3541, 4529, 4881], '25245-25249Abstract': [1673, 1883, 2556, 3189, 3542, 4530, 4882], '(263)': [1681, 1891, 2564, 3197, 3550, 4538, 4890], 'murine': [1687, 1826, 3041, 3560], 'tumor': [1689, 2953, 3348, 3360, 3425, 3458, 5029], 'virus-cyclin': [1690], 'leads': [1695, 3044], 'regulated': [1726], 'diverse': [1728, 2133, 4936], 'cascades.': [1730], 'factor-dependent': [1734], 'stimulation': [1736, 4686], 'hematopoietic': [1738], 'dependent': [1745], 'on': [1746, 2364, 2420, 2446, 2776, 3495, 3590, 3648, 3932, 4051, 4382, 4409, 4648], 'STAT5': [1747], '(21.Matsumura': [1754, 4473], 'Also,': [1782, 4843], 'NF-κB': [1783, 1787, 4472, 4549, 4697, 4782, 4848], 'interaction': [1784], 'binding': [1788, 4783, 4849], 'sites': [1789, 4784, 4830], 'required': [1796], 'expression,': [1800, 3480, 3666, 4054], 'cycle': [1804], 'GTPase': [1808], 'activate': [1815], 'NIH3T3': [1827], '(22.Henry': [1829], '23.Joyce': [1854, 4501], 'ERα': [1901], 'response': [1909], '(24.Wilcken': [1914], 'N.R.': [1915], 'Prall': [1916, 2015], 'O.W.': [1917, 1931, 1970, 2016], 'Musgrove': [1918, 1934, 1973, 2017], 'E.A.': [1919, 1935, 1974, 2018], 'Sutherland': [1920, 1938, 1977, 2019], 'R.L.': [1921, 1939, 1978, 2020], 'Clin.': [1922], 'Cancer': [1923], 'Res.': [1924], '3:': [1926, 2678], '849-854PubMed': [1927], '25.Prall': [1930], 'Rogan': [1932, 1971], 'E.M.': [1933, 1972], 'Watts': [1936, 1975], 'C.K.': [1937, 1976], '4499-4508Crossref': [1945, 1984], '(217)': [1948, 1987], 'ERα-stimulated': [1952], 'proliferation': [1953], 'could': [1954, 4462], 'effectively': [1956], 'blocked': [1957], 'antisense': [1959], 'microinjection': [1964], 'anti-cyclin': [1966, 2271], 'antibodies': [1968, 2458], '(25.Prall': [1969], '26.Lukas': [1990], 'Bartkova': [1992], 'Bartek': [1994], '16:': [2000, 4672], '6917-6925Crossref': [2001], '(298)': [2004], 'reversed': [2008], '(27.Carroll': [2013], 'J.S.': [2014, 2107, 3133], '38221-38229Abstract': [2026], '(122)': [2034], 'Up-regulation': [2037], 'disease': [2054], '(28.Wang': [2055, 3081], 'Pattabiraman': [2057, 3083], 'Zhou': [2059, 3085], 'J.N.': [2060, 3086], 'Sakamaki': [2063, 3089], 'Z.': [2068, 3094], 'Wu': [2069, 3095], 'Hulit': [2071, 3097], 'Neumeister': [2073, 3099], 'Novikoff': [2075, 3101], 'Brownlee': [2077, 3103], 'Scherer': [2079, 3105], 'P.E.': [2080, 3106], 'Jones': [2081, 3107], 'J.G.': [2082, 3108], 'Whitney': [2083, 3109], 'K.D.': [2084, 3110], 'Donehower': [2085, 3111], 'L.A.': [2086, 3112], 'Harris': [2087, 3113], 'E.L.': [2088, 3114], 'Rohan': [2089, 3115], 'Johns': [2091, 3117], 'D.C.': [2092, 3118], '23:': [2099, 3125], '6159-6173Crossref': [2100, 3126], '(178)': [2103, 3129], '29.Michaelson': [2106, 3132], 'Leder': [2108, 3134], 'Oncogene.': [2110, 3136], '2001;': [2111, 2677, 3137, 4131], '5093-5099Crossref': [2113, 3139], '(151)': [2116, 3142], 'observations': [2121], 'constitute': [2127], 'important': [2129, 3918, 4222, 4943], 'downstream': [2130], 'target': [2131], 'upstream': [2134, 3151, 3921, 5011], 'gland': [2141, 3043], 'development': [2142], 'tumorigenesis.': [2144], 'Despite': [2145], 'widespread': [2147, 3047], 'biology': [2154, 4226], 'cancer,': [2157, 3337], 'involvement': [2159, 3216, 4695], 'signaling,': [2162], 'common': [2164], 'point': [2165, 4392, 4415], 'convergence': [2167], 'cells,': [2175, 2212, 2217, 2219], 'remains': [2176], 'unknown.': [2177], 'pathways': [2186, 4316], 'Cultures': [2209], 'Reagents—MCF-7': [2211], 'HeLa': [2218], 'endometrial': [2221, 3622], 'Ishikawa': [2222, 3623], "Dulbecco's": [2227, 2244], 'modified': [2228, 2245], "Eagle's": [2229, 2246], 'medium': [2230, 2247, 2313], 'F12': [2231], '(1:1)': [2232], 'supplemented': [2233, 2248], '10%': [2235, 2250, 2448], 'fetal': [2236, 2251, 2317], 'calf': [2237, 2252], 'serum.': [2238], 'HC11': [2239, 3564, 4653], 'serum': [2253, 2319, 2915, 2919, 2942], '(10': [2258], 'ng/ml).': [2259], 'Antibodies': [2260], 'purchased': [2262], 'following': [2265], 'companies:': [2266], 'anti-Pak1': [2267], 'Signaling,': [2270], 'Santa': [2274], 'Cruz': [2275], 'Biotechnology,': [2276], 'anti-vinculin': [2277], 'Sigma,': [2279], 'anti-HA': [2281], 'Roche': [2283], 'Applied': [2284, 2617], 'Science.': [2285], 'Metabolic': [2286], 'Labeling—MCF-7': [2287], 'grown': [2294], 'confluency': [2297], 'metabolically': [2300], 'labeled': [2301, 4012], '20': [2303, 2604], 'μCi/ml': [2304], '[35S]methionine': [2306], '24': [2308, 2790, 3820, 3955], 'h': [2309, 3821], 'methionine-free': [2312], 'containing': [2314, 2438, 3362, 4402, 4731], '2%': [2315, 2912, 2936], 'dialyzed': [2316], 'bovine': [2318, 2918, 2941], 'absence': [2322], 'presence': [2324], 'doxycycline': [2326], '(Dox)': [2327], '(30.Kumar': [2328], 'Ratzkin': [2332], 'B.J.': [2333], 'Liu': [2334], 'Lipton': [2336], 'Biochem.': [2340], '62:': [2342], '102-112Crossref': [2343], 'Conditioned': [2347], 'media': [2348], 'equal': [2350, 2439], 'trichloroacetic': [2351], 'precipitable': [2353], 'counts': [2354], 'immunoprecipitated': [2356], 'desired': [2359], 'control': [2361, 2500, 3580, 3683, 4165, 4344], 'antibody,': [2362, 2985], 'resolved': [2363, 2445], 'PAGE': [2365], 'gels,': [2366], 'analyzed': [2368, 2470], 'autoradiography.': [2370], 'Extracts,': [2372], 'Immunoprecipitation,': [2373], 'Immunoblotting': [2374], 'Assays—For': [2375], 'preparation': [2376], 'extracts,': [2379], 'washed': [2382, 2971], '3×': [2383], 'saline': [2386], 'lysed': [2388, 2625], 'buffer': [2390, 2894], '(50': [2391], 'mm': [2392, 2397, 2403, 2406, 2409], 'Tris-HCl,': [2393], 'pH': [2394], '7.5,': [2395], '120': [2396], 'NaCl,': [2398], '1%': [2399, 2917, 2940], 'Triton': [2400], 'X-100,': [2401], '100': [2402], 'NaF,': [2404], '200': [2405], 'NaVO5,': [2407], 'phenylmethylsulfonyl': [2410], 'fluoride,': [2411], 'protease': [2413], 'inhibitor': [2414], 'mixture': [2415], '(GIBCO)': [2416], '15': [2418, 2434], 'min': [2419, 2877, 2889, 2899], 'ice.': [2421], 'lysates': [2423, 2437], 'centrifuged': [2425], 'Eppendorf': [2428], 'centrifuge': [2429], '4': [2431], '°C': [2432], 'min.': [2435, 2924], 'amounts': [2440], 'immunoprecipitated,': [2444], 'SDS-PAGE,': [2449], 'transferred': [2450], 'nitrocellulose,': [2452], 'probed': [2454, 2478], 'appropriate': [2457], 'ECL': [2461], 'method.': [2462], 'Northern': [2463, 2472, 2475], 'Blotting—Total': [2464], 'cytoplasmic': [2465, 3397, 3419], '(20': [2467], 'μg)': [2468], 'was': [2469, 2489, 2633, 2645, 2653, 2729, 2828, 2836, 3370, 3387, 3399, 3595, 3752, 4346, 4634], 'blot': [2473], 'analysis.': [2474], 'blots': [2476], '32P-labeled': [2480], 'cDNA': [2485], 'probe.': [2486], 'Actin': [2487], 'mRNA': [2488, 3762], 'assess': [2492, 3330], 'loading.': [2504], 'Promoter-Reporter': [2507], 'Assays—Subconfluent': [2508], 'cultured': [2510], '6-well': [2512, 2780], 'plates': [2513, 2782], 'transiently': [2515], 'cotransfected': [2516, 3999], 'μg': [2519], 'full-length': [2521], 'promoter-luciferase': [2524, 3739], 'reporter': [2525, 2637, 3507, 3740, 4167, 4729], 'construct': [2526], 'pak1': [2568], 'ng': [2605], 'β-galactosidase': [2607, 2643], 'Fugene-6': [2610], 'reagent': [2611], 'according': [2612, 2740], 'manufacturers': [2614], 'protocol': [2615], '(Roche': [2616], 'Science).': [2618], 'Twenty-four': [2619], 'hours': [2620], 'after': [2621], 'transfection,': [2622], 'passive': [2627], 'lysis': [2628], 'buffer,': [2629], 'luciferase': [2631, 2636, 3506, 4166, 4899], 'assay': [2632, 2638], 'performed': [2634, 2654, 2998, 3351, 4399, 4727], 'kit': [2639, 2737], '(Promega,': [2640], 'Madison,': [2641], 'WI).': [2642], 'normalize': [2648], 'transfection.': [2650], 'Each': [2651], 'transfection': [2652, 4396], 'triplicate': [2656], 'wells': [2657], '(31.Mazumdar': [2658], 'Mishra': [2662], 'S.K.': [2663], 'Bagheri-Yarmand': [2666], '30-37Crossref': [2679], 'Transgenic': [2685, 3014], 'Studies—Generation': [2686], 'described': [2698, 2750], 'previously': [2699, 3671, 4058, 4291], 'Short': [2718], 'Interference': [2719], '(siRNA)': [2721], 'Design': [2722], 'Treatment—For': [2724], 'siRNA': [2728, 2735, 4266, 4296, 4312, 4345], 'synthesized': [2730, 3779], 'silencer': [2734], 'construction': [2736], '(Ambion,': [2738], 'Texas)': [2739], "manufacturer's": [2743], 'instructions.': [2744], 'targeted': [2747], 'sequences': [2748], 'earlier': [2751], 'Immunofluorescence': [2770], 'Confocal': [2772], 'Imaging—Cells': [2773], 'plated': [2775], 'glass': [2777], 'coverslips': [2778], 'treated': [2784, 3947], 'without': [2787, 3950], 'Dox.': [2788], 'After': [2789, 3819], 'h,': [2791], 'rinsed': [2795], 'fixed': [2798, 3960], 'cold': [2800], '100%': [2801], 'methanol': [2802, 2874, 3962], '10': [2804, 2888, 2980, 3423, 4062, 4207], 'min,': [2805, 2981], 'processed': [2806], 'immunofluorescent': [2808], 'localization': [2809, 3384, 3850, 3935, 3991], 'HA-tagged': [2814, 3728], 'F-actin': [2820], '(using': [2821], 'Alexa-568-labeled': [2822], 'phalloidin,': [2823], 'Molecular': [2824], 'Probes).': [2825], 'DNA': [2827, 3982], 'visualized': [2829, 2837], 'counter-staining': [2831], 'ToPro3.': [2833], 'Fluorescent': [2834], 'labeling': [2835], 'Zeiss': [2841], 'LSM': [2842], '510': [2843], 'microscope': [2844], '63×': [2847], 'objective.': [2848], 'Immunohistochemistry—For': [2849], 'immunohistochemical': [2850, 3352], 'detection': [2851], 'sections': [2857, 2883, 2908, 2926, 2969], 'deparaffinized': [2859], 'xylene': [2861], 'rehydrated': [2863], 'graded': [2865], 'ethanol.': [2866], 'Sections': [2867], 'incubated': [2869, 2910, 2928, 2962, 2982], '0.3%': [2871], 'H2O2': [2872], '30': [2876, 2898, 2923], 'inactivate': [2879], 'endogenous': [2880, 3972, 4255, 4299], 'peroxidase.': [2881], 'then': [2885, 2990, 3959, 4009], 'boiled': [2886], '0.01': [2891], 'm': [2892], 'citrate': [2893], 'cooled': [2896], 'room': [2901, 2966], 'temperature': [2902], 'expose': [2904], 'antigenic': [2905], 'epitopes.': [2906], 'normal': [2913, 2937, 3561], 'goat': [2914, 2938], 'albumin,': [2920, 2943], 'PBS': [2921, 2978], 'mouse-cyclin': [2931], '(1:25': [2933], 'diluted': [2934], 'serum,': [2939], 'PBS)': [2945], 'dilution': [2948, 2960], '1:50': [2950], 'arrays,': [2954], '1:25': [2959], 'overnight': [2963], 'temperature.': [2967], 'three': [2972, 3279, 4780], 'times': [2973], '0.05%': [2975], 'Tween': [2976], 'secondary': [2984], 'developed': [2986], 'DAB-H2O2,': [2988], 'counter-stained': [2991], "Mayer's": [2993], 'hematoxylin.': [2994], 'Negative': [2995], 'controls': [2996], 'replacing': [3000], 'primary': [3002], 'antibody': [3003], 'corresponding': [3005], 'IgG.': [3006], 'Regulates': [3008, 4446], 'Expression': [3011], 'Model—In': [3015], 'attempt': [3017], 'define': [3019], 'gland,': [3027], 'demonstrated': [3030, 4290], 'Because': [3067, 4541], 'tissues': [3074], 'cause': [3079], 'finding': [3147], 'Rac,': [3149], 'effector': [3152], 'hypothesized': [3201], 'Therefore,': [3210], 'explored': [3212], 'possibility': [3214], 'action': [3222], 'examining': [3226], 'status': [3228, 3342], 'Immunohistochemical': [3243], 'revealed': [3245], 'background': [3247], 'level': [3248, 3783, 4199], 'staining': [3252, 3272, 3353, 3398, 3408], 'contrast,': [3258], 'exhibited': [3266], 'intense': [3268, 3395], '(Fig.': [3273, 3297, 3405, 3413, 3428, 3582, 3625, 3741, 3763, 3769, 3784, 3845, 3896, 4168, 4210, 4356, 4430, 4715, 4769, 4905], '1A).': [3274], 'Quantitation': [3275, 3847], 'signals': [3277, 3922], 'independent': [3280], 'indicated': [3283], '∼5-': [3285], '7-fold-increased': [3287], 'T423E-Pak1': [3293, 3729], '1B).': [3298], 'These': [3299, 4212, 4972], 'results': [3300, 3629, 3901, 4714, 4741, 4922], 'potential': [3319, 3474, 4360, 4614, 4781, 5002], 'Breast': [3328], 'Tumors—To': [3329], 'significance': [3332, 4238, 4615], 'next': [3339, 3482, 3668, 4056, 4250], 'determined': [3340, 3801], 'specimens.': [3349], 'arrays': [3361], '60': [3363], 'sections.': [3366], 'observed': [3371, 3400, 3863, 4145, 4192], '34': [3373, 3391], '(55%)': [3375], '42': [3380], '(70%).': [3382], 'Subcellular': [3383], 'variable.': [3388], 'Of': [3389], 'Pak1-positive': [3392], 'tumors,': [3393], '19': [3402], '(56%)': [3404], '2A),': [3406], '5': [3410], '(15%)': [3412], '2B),': [3414], 'both': [3416, 3825, 4679], 'immunoreactivity': [3421], 'specimens': [3426], '(29%)': [3427], '2C).': [3429], 'overall': [3437], 'about': [3442, 3789], '40%': [3443], 'Representative': [3446], 'examples': [3447], 'co-expression': [3449, 4642, 4656], 'same': [3457], 'specimen': [3459], 'Fig.': [3463, 3860, 4183, 4631], '2': [3464], '(I-L).': [3465], 'Stimulates': [3467], 'Promoter': [3470], 'Activity—To': [3471], 'investigate': [3472, 4612, 4718], 'examined': [3483], 'effects': [3485, 4640], '(WT)': [3488], 'transcriptional': [3497], 'D1-promoter': [3505], 'system': [3508], '(-1745': [3509], 'luciferase)': [3512], 'Cotransfection': [3553, 4707], 'WTPak1': [3555], 'epithelial': [3563, 4985, 5016], 'driven': [3578], 'vector': [3581, 4002], '3).': [3583, 3626], 'stimulatory': [3585, 4637], 'effect': [3586, 4048, 4378], 'wide-spread': [3597], 'phenomenon,': [3598], 'WT-Pak1': [3600], 'efficiently': [3604], 'MDA-MB-231,': [3614], 'cervical': [3615], 'HeLa,': [3617], 'differentiated': [3621], 'implied': [3630], 'Effect': [3643], 'Kinase-Active': [3645], 'Expression—To': [3651, 4045], 'further': [3652, 4235, 4374, 5024], 'implicate': [3653], 'regulatory': [3655], 'characterized': [3672, 4059], 'clone': [3677], 'HA-tagged-T423E': [3679], 'under': [3681], 'inducible': [3686], 'tetracycline': [3687], 'As': [3723, 4628], 'expected,': [3724], 'induced': [3725, 4426], '4A).': [3742], 'steady-state': [3757], '4B)': [3764], '4C),': [3770], 'newly': [3778], 'metabolic-labeled': [3780], '35S-cyclin': [3781], '4D).': [3785], 'To': [3786, 4234, 4372, 4717], 'gain': [3787], 'clues': [3788], 'consequence': [3792], 'Pak1-mediated': [3794], 'subcellular': [3803], 'distribution': [3804], 'quantitative': [3815], 'confocal': [3816, 4305], 'scanning': [3817], 'microscopy.': [3818], 'Dox': [3823, 3951], 'treatment,': [3824], 'greatly': [3833], 'induced,': [3834], 'majority': [3837], 'accumulating': [3841], 'nucleus.': [3844], '5A).': [3846], 'cellular': [3849], 'upon': [3854], 'presented': [3858, 4923], '5B.': [3861], 'seems': [3869], 'due': [3872], 'phosphorylated': [3885], 'hyperactivated': [3893], '5C).': [3897], 'Taken': [3898], 'together,': [3899], 'mediator': [3919], 'expression.Fig.': [3927], '5Effect': [3928], 'phosphorylation.': [3937], 'A,': [3938], 'stably': [3941], '(1.0': [3952], 'μg/ml)': [3953], 'h.': [3956], 'Cells': [3957], 'immunofluorescently': [3964], 'stained': [3965], 'HA-Pak1': [3967], '(green,': [3968, 3975], 'left': [3969], 'panels)': [3970, 3977], 'right': [3976], 'counterstained': [3979], '(blue)': [3983], '(×65': [3984], 'magnification).': [3985], 'B,': [3986], 'quantitation': [3987], 'Pak1-activated': [3993], 'cells.': [3994, 4233, 4654, 5000], 'C,': [3995], 'either': [4001], '[32P]orthophosphoric': [4014], 'acid.': [4015], 'Immunoprecipitation': [4016], 'showed': [4020, 4742], 'transfected': [4028], 'Pak1.View': [4031], 'Large': [4032], 'Image': [4033], 'Figure': [4034], 'ViewerDownload': [4035], 'Hi-res': [4036], 'image': [4037], 'Download': [4038], '(PPT)': [4039], 'Status': [4041], 'Modulates': [4042], 'validate': [4046], 'clones': [4061, 4179, 4206], '17,': [4064], 'ectopically': [4066], 'express': [4067], 'fragment': [4071], 'does': [4078], 'not': [4079, 4161, 4342], 'interact': [4080], 'acts': [4085], 'dominant-negative': [4088, 4646, 4658], '32.Bagheri-Yarmand': [4114], 'Talukder': [4118], 'A.H.': [4119], 'Kung': [4124], 'H.J.': [4125], '276:': [4132], '29403-29409Abstract': [4133], '(106)': [4141], 'substantially': [4155, 4677], 'suppressed': [4156], 'but': [4160, 4341, 4421], '6A).': [4169], 'inhibitory': [4174, 4377, 4639], 'domain': [4175], '83-149': [4176], 'stable': [4178], '6A,': [4184], 'inset.': [4185], 'Consistent': [4186], 'finding,': [4189], 'marked': [4194], 'baseline': [4198], '17': [4209], '6B).': [4211], 'confirm': [4236], 'selectively': [4251], 'knocked': [4252], 'down': [4253], 'methodology': [4267], '(33.Yu': [4268], 'J.Y.': [4269], 'DeRuiter': [4270], 'S.L.': [4271], 'Turner': [4272], 'D.L.': [4273], 'Proc.': [4274], 'Natl.': [4275], 'Acad.': [4276], 'Sci.': [4277], 'U.': [4278], '99:': [4282], '6047-6052Crossref': [4283], '(964)': [4286], 'efficacy': [4293], 'Pak1-specific': [4295, 4311], 'down-regulating': [4298], 'Western': [4302], 'blotting': [4303], 'microscopy': [4306], 'ability': [4309, 5027], 'suppress': [4314], 'Pak1-driven': [4315], 'Interestingly,': [4335, 4413, 4655], 'reducing': [4336], 'Pak1-siRNA': [4340], 'significant': [4350, 4636, 4838], '6C),': [4357], 'study': [4373, 4810], 'whether': [4375], '(83-149)': [4381, 4404, 4407, 4418, 4429], 'can': [4386], 'relieved': [4388, 4423], 'activating': [4391, 4414], 'mutation': [4393], '(Pak1': [4394], 'L107F),': [4395], 'plasmids': [4401, 4730], 'L107F': [4408, 4419], 'promoter.': [4412], 'partially': [4420], 'significantly': [4422], 'repression': [4425], '6D),': [4431], 'validating': [4432], 'Transcription': [4449], 'via': [4450], 'NF-κB-Dependent': [4452], 'Pathway—Data': [4453], 'literature': [4456], 'through': [4465, 4917], 'multiple': [4466], 'pathways,': [4468], 'Stat5a': [4470, 4647], 'modulate': [4548], '(34.Frost': [4551], 'J.A.': [4552], 'Swantek': [4553], 'J.L.': [4554], 'Stippec': [4555], 'Yin': [4557], 'Gaynor': [4559], 'Cobb': [4561], 'M.H.': [4562], '19693-19699Abstract': [4568], '(166)': [4576], '35.Foryst-Ludwig': [4579], 'Naumann': [4581], '39779-39785Abstract': [4588], '(98)': [4596], 'because': [4600], '(this': [4607], 'study),': [4608], 'wished': [4610], 'mediatory': [4618], 'molecules': [4620], 'transcription.': [4627, 4706], 'illustrated': [4629], '7A,': [4632], 'there': [4633], 'no': [4635], 'WT': [4644, 4709], 'IκB': [4659], '(36.Harhaj': [4660], 'E.W.': [4661], 'Maggirwar': [4662], 'Good': [4664], 'Sun': [4666], 'S.C.': [4667], '6736-6743Crossref': [4673], 'inhibited': [4678], 'basal': [4680], 'Pak1-induced': [4685], 'yielded': [4712], 'similar': [4713], '7B).': [4716], 'mechanism': [4720], 'regulation,': [4723], 'cotransfection': [4724], 'promoter-deletion': [4736], 'constructs': [4737], 'T423E-Pak1.': [4739], 'strongly': [4745, 4907], 'mapped': [4755], 'regions': [4757, 4815], 'between': [4758], '-1745': [4759], '-630': [4761, 4832], '-261': [4763], '-66': [4765, 4895], '7C).': [4770], 'Sequence': [4771], 'identified': [4779], 'positions': [4786], '-858,': [4787], '-749,': [4788], '-39': [4790, 4852], '(37.Motokura': [4791], 'Genes': [4795], 'Chromosomes': [4796], '1993;': [4798], '89-95Crossref': [4800], '(145)': [4803], 'so': [4806], 'extended': [4808], 'our': [4809], 'examine': [4812], 'critical': [4817], '-858': [4827], '-749': [4829], 'D1-luciferase': [4834], 'resulted': [4835], 'activity.': [4842], 'site-directed': [4844], 'mutagenesis': [4845], 'one': [4847], 'IκBMT': [4898], 'abolished': [4900], '7D),': [4906], 'NF-κB.': [4918], 'summary,': [4920], 'here': [4924], 'demonstrate': [4925], '(i)': [4927], 'cell-types;': [4937], '(ii)': [4938], 'regulator': [4944], 'functions;': [4950], '(iii)': [4951], 'pathway;': [4962], '(iv)': [4964], 'expressed': [4968], 'provide': [4974], 'evidence': [4975], 'implications': [4990], 'enhancement': [4993], 'growth-rate': [4996], 'Any': [5001], 'activators': [5012], 'likely': [5019], 'sustain': [5021], 'perhaps': [5023], 'grow': [5032], 'supporting': [5034], 'putative': [5036], 'contribute': [5043], 'toward': [5044], 'noticed': [5046], 'thank': [5075], 'Bruce': [5076], 'Mayer': [5077], 'pEBG-GST': [5080], 'vector.': [5081]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090342862', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-10T04:19:06.796660', 'created_date': '2016-06-24'}
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