Publication Information

{'id': 'https://openalex.org/W2031447127', 'doi': 'https://doi.org/10.1128/mcb.00269-09', 'title': 'Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc', 'display_name': 'Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc', 'publication_year': 2009, 'publication_date': '2009-06-30', 'ids': {'openalex': 'https://openalex.org/W2031447127', 'doi': 'https://doi.org/10.1128/mcb.00269-09', 'mag': '2031447127', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19564413', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2725719'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00269-09', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/mcb.00269-09', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018714307', 'display_name': 'C. Elizabeth Caldon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'C. Elizabeth Caldon', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.', 'institution_ids': ['https://openalex.org/I136750679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049710826', 'display_name': 'C. Marcelo Sergio', 'orcid': 'https://orcid.org/0000-0002-5426-0583'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'C. Marcelo Sergio', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.', 'institution_ids': ['https://openalex.org/I136750679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063484535', 'display_name': 'Judith Schütte', 'orcid': 'https://orcid.org/0000-0002-2705-5920'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Judith Schütte', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.', 'institution_ids': ['https://openalex.org/I136750679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057160141', 'display_name': 'Marijke N. Boersma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Marijke N. Boersma', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010 Australia.', 'institution_ids': ['https://openalex.org/I136750679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110319158', 'display_name': 'Robert L. Sutherland', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210123488', 'display_name': "St Vincent's Clinic", 'ror': 'https://ror.org/02rthxz10', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123488']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Robert L. Sutherland', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia', "St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I4210123488', 'https://openalex.org/I31746571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084427699', 'display_name': 'Jason S. Carroll', 'orcid': 'https://orcid.org/0000-0003-3643-0080'}, 'institutions': [{'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jason S. Carroll', 'raw_affiliation_strings': ['Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom', 'institution_ids': ['https://openalex.org/I2801316944']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067798845', 'display_name': 'Elizabeth A. Musgrove', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210123488', 'display_name': "St Vincent's Clinic", 'ror': 'https://ror.org/02rthxz10', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123488']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth A. Musgrove', 'raw_affiliation_strings': ['Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia', "St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"], 'affiliations': [{'raw_affiliation_string': 'Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia', 'institution_ids': ['https://openalex.org/I136750679']}, {'raw_affiliation_string': "St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia", 'institution_ids': ['https://openalex.org/I4210123488', 'https://openalex.org/I31746571']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.771, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.999943, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '29', 'issue': '17', 'first_page': '4623', 'last_page': '4639'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13437', 'display_name': 'Mechanisms of cancer metastasis', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclin-d', 'display_name': 'Cyclin D', 'score': 0.8418296}, {'id': 'https://openalex.org/keywords/cyclin-a2', 'display_name': 'Cyclin A2', 'score': 0.83566684}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.8227688}, {'id': 'https://openalex.org/keywords/cyclin-e', 'display_name': 'Cyclin E', 'score': 0.79195607}, {'id': 'https://openalex.org/keywords/cyclin-b', 'display_name': 'Cyclin B', 'score': 0.7163552}, {'id': 'https://openalex.org/keywords/cyclin-dependent-kinase-complex', 'display_name': 'Cyclin-dependent kinase complex', 'score': 0.45618218}], 'concepts': [{'id': 'https://openalex.org/C11882975', 'wikidata': 'https://www.wikidata.org/wiki/Q24781041', 'display_name': 'Cyclin D', 'level': 5, 'score': 0.8418296}, {'id': 'https://openalex.org/C28179978', 'wikidata': 'https://www.wikidata.org/wiki/Q5198263', 'display_name': 'Cyclin A2', 'level': 5, 'score': 0.83566684}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.8227688}, {'id': 'https://openalex.org/C94561458', 'wikidata': 'https://www.wikidata.org/wiki/Q24724860', 'display_name': 'Cyclin E', 'level': 5, 'score': 0.79195607}, {'id': 'https://openalex.org/C9743823', 'wikidata': 'https://www.wikidata.org/wiki/Q5198264', 'display_name': 'Cyclin B', 'level': 5, 'score': 0.7163552}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.7021712}, {'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.63079154}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56977594}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5590829}, {'id': 'https://openalex.org/C175738201', 'wikidata': 'https://www.wikidata.org/wiki/Q5198255', 'display_name': 'Cyclin-dependent kinase complex', 'level': 5, 'score': 0.45618218}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.45060065}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44842273}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.30350918}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11331388}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.052220523}], 'mesh': [{'descriptor_ui': 'D019938', 'descriptor_name': 'Cyclin D1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019938', 'descriptor_name': 'Cyclin D1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019938', 'descriptor_name': 'Cyclin D1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019927', 'descriptor_name': 'Cyclin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019927', 'descriptor_name': 'Cyclin E', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019927', 'descriptor_name': 'Cyclin E', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051357', 'descriptor_name': 'Cyclin-Dependent Kinase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051357', 'descriptor_name': 'Cyclin-Dependent Kinase 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051357', 'descriptor_name': 'Cyclin-Dependent Kinase 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050684', 'descriptor_name': 'E2F Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050684', 'descriptor_name': 'E2F Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050684', 'descriptor_name': 'E2F Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00269-09', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2725719', 'pdf_url': 'https://europepmc.org/articles/pmc2725719?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19564413', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00269-09', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.77, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 78, 'referenced_works': ['https://openalex.org/W1555714030', 'https://openalex.org/W1569755992', 'https://openalex.org/W1615606566', 'https://openalex.org/W1762601366', 'https://openalex.org/W1966383348', 'https://openalex.org/W1970068078', 'https://openalex.org/W1970285038', 'https://openalex.org/W1971013160', 'https://openalex.org/W1972295452', 'https://openalex.org/W1980180618', 'https://openalex.org/W1983481592', 'https://openalex.org/W1993507282', 'https://openalex.org/W1994821070', 'https://openalex.org/W1998738134', 'https://openalex.org/W2002550738', 'https://openalex.org/W2008048656', 'https://openalex.org/W2014016589', 'https://openalex.org/W2014735524', 'https://openalex.org/W2018948112', 'https://openalex.org/W2025391956', 'https://openalex.org/W2026039268', 'https://openalex.org/W2030678473', 'https://openalex.org/W2034501906', 'https://openalex.org/W2035416209', 'https://openalex.org/W2036981062', 'https://openalex.org/W2040164071', 'https://openalex.org/W2047816695', 'https://openalex.org/W2050428831', 'https://openalex.org/W2058879820', 'https://openalex.org/W2069755545', 'https://openalex.org/W2072060008', 'https://openalex.org/W2072659475', 'https://openalex.org/W2073689111', 'https://openalex.org/W2074517459', 'https://openalex.org/W2080675426', 'https://openalex.org/W2081736214', 'https://openalex.org/W2083035492', 'https://openalex.org/W2083516264', 'https://openalex.org/W2084602777', 'https://openalex.org/W2086082161', 'https://openalex.org/W2086881399', 'https://openalex.org/W2091327303', 'https://openalex.org/W2093465294', 'https://openalex.org/W2095628944', 'https://openalex.org/W2098953839', 'https://openalex.org/W2101584970', 'https://openalex.org/W2104036704', 'https://openalex.org/W2105988181', 'https://openalex.org/W2107592478', 'https://openalex.org/W2108796882', 'https://openalex.org/W2118413367', 'https://openalex.org/W2119874496', 'https://openalex.org/W2120006551', 'https://openalex.org/W2126889841', 'https://openalex.org/W2127731187', 'https://openalex.org/W2128985829', 'https://openalex.org/W2129036353', 'https://openalex.org/W2129837971', 'https://openalex.org/W2133958387', 'https://openalex.org/W2142095017', 'https://openalex.org/W2150081723', 'https://openalex.org/W2155881657', 'https://openalex.org/W2155953052', 'https://openalex.org/W2156933633', 'https://openalex.org/W2161083747', 'https://openalex.org/W2161888675', 'https://openalex.org/W2162344195', 'https://openalex.org/W2163563958', 'https://openalex.org/W2168870169', 'https://openalex.org/W2169318796', 'https://openalex.org/W2169484696', 'https://openalex.org/W2171693612', 'https://openalex.org/W2322441397', 'https://openalex.org/W2329179976', 'https://openalex.org/W2340617814', 'https://openalex.org/W2442788310', 'https://openalex.org/W4248566171', 'https://openalex.org/W94760739'], 'related_works': ['https://openalex.org/W2401090968', 'https://openalex.org/W2136809856', 'https://openalex.org/W2122500818', 'https://openalex.org/W2099925982', 'https://openalex.org/W2096039018', 'https://openalex.org/W2092104789', 'https://openalex.org/W2072698492', 'https://openalex.org/W2031447127', 'https://openalex.org/W1994160132', 'https://openalex.org/W1991293306'], 'abstract_inverted_index': {'During': [0], 'estrogen-induced': [1], 'proliferation,': [2], 'c-Myc': [3, 104, 191], 'and': [4, 127, 130, 164, 192, 195, 200], 'cyclin': [5, 12, 27, 33, 73, 76, 84, 87, 93, 99, 110, 125, 131, 148, 156, 168, 172, 181, 193], 'D1': [6, 85, 94, 132, 194], 'initiate': [7], 'independent': [8], 'pathways': [9], 'that': [10, 155, 197], 'activate': [11], 'E1-Cdk2': [13, 182], 'by': [14, 115, 119, 159], 'sequestration': [15], 'and/or': [16], 'downregulation': [17], 'of': [18, 48, 51, 71, 83, 92, 103, 121, 141, 167, 171, 180, 189], 'the': [19, 124, 142, 177], 'CDK': [20, 185], 'inhibitor': [21, 186], 'p21Waf1/Cip1,': [22], 'without': [23], 'significant': [24], 'increases': [25], 'in': [26, 39], 'E1': [28, 74, 126, 199], 'protein': [29], 'levels.': [30], 'In': [31], 'contrast,': [32], 'E2': [34, 77, 113, 128, 149, 169, 201], 'undergoes': [35], 'a': [36], 'marked': [37], 'increase': [38], 'expression,': [40], 'which': [41], 'occurs': [42, 161], 'within': [43], '9': [44], 'to': [45, 62, 123], '12': [46], 'h': [47], 'estrogen': [49, 63, 96, 116, 160], 'treatment': [50], 'antiestrogen-pretreated': [52], 'MCF-7': [53], 'breast': [54], 'cancer': [55], 'cells.': [56], 'Both': [57], 'E': [58], 'cyclins': [59, 198], 'are': [60, 202], 'important': [61], 'action,': [64], 'as': [65], 'small': [66], 'interfering': [67], 'RNA': [68], '(siRNA)-mediated': [69], 'knockdown': [70, 91, 140], 'either': [72], 'or': [75], 'attenuated': [78, 95], 'estrogen-mediated': [79], 'proliferation.': [80], 'Inducible': [81], 'expression': [82], 'upregulated': [86], 'E2,': [88], 'while': [89], 'siRNA-mediated': [90, 139], 'effects': [97], 'on': [98], 'E2.': [100, 111], 'However,': [101], 'manipulation': [102], 'levels': [105], 'did': [106], 'not': [107, 203], 'profoundly': [108], 'affect': [109], 'Cyclin': [112], 'induction': [114, 133], 'was': [117, 134], 'accompanied': [118], 'recruitment': [120], 'E2F1': [122, 137], 'promoters,': [129], 'sufficient': [135], 'for': [136], 'recruitment.': [138], 'chromatin': [143], 'remodelling': [144], 'factor': [145], 'CHD8': [146], 'prevented': [147], 'upregulation.': [150], 'Together,': [151], 'these': [152], 'data': [153], 'indicate': [154], 'E2-Cdk2': [157], 'activation': [158], 'via': [162, 184], 'E2F-': [163], 'CHD8-mediated': [165], 'transcription': [166], 'downstream': [170, 188], 'D1.': [173], 'This': [174], 'contrasts': [175], 'with': [176], 'predominant': [178], 'regulation': [179], 'activity': [183], 'association': [187], 'both': [190], 'indicates': [196], 'always': [204], 'coordinately': [205], 'regulated.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031447127', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-24T15:17:00.376831', 'created_date': '2016-06-24'}