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'different': [16, 115, 132], 'functions': [17], 'brain': [20], 'such': [21], 'as': [22, 37, 39, 87, 89, 180, 223], 'learning': [23], 'and': [24, 41, 83, 99, 136, 139, 150, 163, 200], 'memory.': [25], 'In': [26], 'this': [27, 161], 'study,': [28], 'a': [29, 91, 187, 224, 242], 'combination': [30], 'of': [31, 65, 69, 90, 125, 142, 177, 191, 226, 248], 'molecular': [32, 59, 158], 'biology,': [33], 'X-ray': [34, 63], 'structure': [35, 140], 'determinations,': [36], 'well': [38, 88], 'electrophysiology': [40, 206], 'binding': [42, 116], 'experiments,': [43], 'has': [44, 202], 'been': [45, 102, 203], 'used': [46], 'to': [47, 155, 164], 'increase': [48], 'our': [49], 'knowledge': [50], 'concerning': [51], 'ionotropic': [53], 'glutamate': [54], 'receptor': [55, 134, 220], 'GluR2': [56, 70], 'at': [57], 'level.': [60], 'Five': [61], 'high-resolution': [62], 'structures': [64, 105], 'ligand-binding': [67], 'domain': [68, 178, 192, 198, 227], '(S1S2J)': [71], 'complexed': [72], 'with': [73, 97, 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'explain': [156], 'mechanism': [159], 'behind': [160], 'identify': [165], 'key': [166], 'residues': [167], 'for': [168, 183, 245], 'ligand': [169], 'recognition.': [170], 'induce': [173], 'same': [175], 'degree': [176, 190], 'closure': [179, 199], 'AMPA,': [181], 'except': [182], 'which': [185], 'shows': [186], 'slightly': [188], 'lower': [189], 'closure.': [193, 228], 'An': [194], 'excellent': [195], 'correlation': [196], 'between': [197], 'efficacy': [201], 'obtained': [204], 'from': [205], 'experiments': [207], 'undertaken': [208], 'non-desensitising': [210], 'GluR2i(Q)-L483Y': [211], 'receptors': [212], 'expressed': [213], 'oocytes,': [215], 'providing': [216], 'strong': [217], 'evidence': [218], 'activation': [221], 'occurs': [222], 'result': [225], 'structural': [230], 'results,': [231], 'combined': [232], 'functional': [235], 'studies': [236], 'full-length': [239], 'form': [241], 'powerful': [243], 'platform': [244], 'new': [249], 'selective': [250], 'agonists.': [251]}, 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