Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1968126027', 'doi': 'https://doi.org/10.1107/s0907444913011839', 'title': 'Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain', 'display_name': 'Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain', 'publication_year': 2013, 'publication_date': '2013-08-15', 'ids': {'openalex': 'https://openalex.org/W1968126027', 'doi': 'https://doi.org/10.1107/s0907444913011839', 'mag': '1968126027', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23999288'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1107/s0907444913011839', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114502960', 'display_name': 'Acta Crystallographica Section D Biological Crystallography', 'issn_l': '0907-4449', 'issn': ['0907-4449', '1399-0047'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051552014', 'display_name': 'Christian Krintel', 'orcid': 'https://orcid.org/0000-0001-5925-5639'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Christian Krintel', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048035528', 'display_name': 'Kasper Harpsøe', 'orcid': 'https://orcid.org/0000-0002-9326-9644'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Kasper Harpsøe', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049696241', 'display_name': 'Linda G. Zachariassen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Linda G. Zachariassen', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084968972', 'display_name': 'Dan Peters', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210118034', 'display_name': 'NeuroSearch (Denmark)', 'ror': 'https://ror.org/027x7jn80', 'country_code': 'DK', 'type': 'company', 'lineage': ['https://openalex.org/I4210118034']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Dan Peters', 'raw_affiliation_strings': ['NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark'], 'affiliations': [{'raw_affiliation_string': 'NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark', 'institution_ids': ['https://openalex.org/I4210118034']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005937010', 'display_name': 'Karla Frydenvang', 'orcid': 'https://orcid.org/0000-0002-5823-3478'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Karla Frydenvang', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088259448', 'display_name': 'Darryl S. Pickering', 'orcid': 'https://orcid.org/0000-0001-8687-6094'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Darryl S. Pickering', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000797815', 'display_name': 'Michael Gajhede', 'orcid': 'https://orcid.org/0000-0001-9864-2287'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Michael Gajhede', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031606835', 'display_name': 'J.S. Kastrup', 'orcid': 'https://orcid.org/0000-0003-2654-1510'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jette S. Kastrup', 'raw_affiliation_strings': ['∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.'], 'affiliations': [{'raw_affiliation_string': '∥Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.546, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.710086, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '69', 'issue': '9', 'first_page': '1645', 'last_page': '1652'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': "Sweeteners' Taste and Impact on Health", 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/allosteric-modulator', 'display_name': 'Allosteric modulator', 'score': 0.60545874}, {'id': 'https://openalex.org/keywords/glutamate-receptors', 'display_name': 'Glutamate Receptors', 'score': 0.531205}, {'id': 'https://openalex.org/keywords/nmda-receptors', 'display_name': 'NMDA Receptors', 'score': 0.501661}, {'id': 'https://openalex.org/keywords/ionotropic-glutamate-receptor', 'display_name': 'Ionotropic glutamate receptor', 'score': 0.4362125}], 'concepts': [{'id': 'https://openalex.org/C160268369', 'wikidata': 'https://www.wikidata.org/wiki/Q295251', 'display_name': 'AMPA receptor', 'level': 4, 'score': 0.9567194}, {'id': 'https://openalex.org/C115955781', 'wikidata': 'https://www.wikidata.org/wiki/Q6063798', 'display_name': 'Ionotropic effect', 'level': 4, 'score': 0.82831556}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6554351}, {'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.6205069}, {'id': 'https://openalex.org/C2776038425', 'wikidata': 'https://www.wikidata.org/wiki/Q2649417', 'display_name': 'Allosteric modulator', 'level': 4, 'score': 0.60545874}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5460425}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.44320336}, {'id': 'https://openalex.org/C2781001490', 'wikidata': 'https://www.wikidata.org/wiki/Q24779507', 'display_name': 'Ionotropic glutamate receptor', 'level': 5, 'score': 0.4362125}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.39192972}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3785659}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34212196}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33729053}, {'id': 'https://openalex.org/C61174792', 'wikidata': 'https://www.wikidata.org/wiki/Q420510', 'display_name': 'Glutamate receptor', 'level': 3, 'score': 0.32566905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22751829}], 'mesh': [{'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018091', 'descriptor_name': 'Receptors, AMPA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010078', 'descriptor_name': 'Oxazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010078', 'descriptor_name': 'Oxazines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010078', 'descriptor_name': 'Oxazines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010880', 'descriptor_name': 'Piperidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025941', 'descriptor_name': 'Protein Interaction Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018091', 'descriptor_name': 'Receptors, AMPA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018091', 'descriptor_name': 'Receptors, AMPA', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D018091', 'descriptor_name': 'Receptors, AMPA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018091', 'descriptor_name': 'Receptors, AMPA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1107/s0907444913011839', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114502960', 'display_name': 'Acta Crystallographica Section D Biological Crystallography', 'issn_l': '0907-4449', 'issn': ['0907-4449', '1399-0047'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23999288', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1636225847', 'https://openalex.org/W1922786159', 'https://openalex.org/W1965270719', 'https://openalex.org/W1969672293', 'https://openalex.org/W1978817835', 'https://openalex.org/W1980970141', 'https://openalex.org/W1981910711', 'https://openalex.org/W2000300989', 'https://openalex.org/W2000372617', 'https://openalex.org/W2006606811', 'https://openalex.org/W2009309964', 'https://openalex.org/W2016288186', 'https://openalex.org/W2023989346', 'https://openalex.org/W2031843068', 'https://openalex.org/W2042678699', 'https://openalex.org/W2063792561', 'https://openalex.org/W2063987809', 'https://openalex.org/W2065521724', 'https://openalex.org/W2069644503', 'https://openalex.org/W2081659500', 'https://openalex.org/W2087262968', 'https://openalex.org/W2088545219', 'https://openalex.org/W2106962648', 'https://openalex.org/W2108921801', 'https://openalex.org/W2116275717', 'https://openalex.org/W2128904157', 'https://openalex.org/W2142706899', 'https://openalex.org/W2144081223', 'https://openalex.org/W2147949826', 'https://openalex.org/W2149868835', 'https://openalex.org/W2153928331', 'https://openalex.org/W2154714625', 'https://openalex.org/W2161452357', 'https://openalex.org/W2163341755', 'https://openalex.org/W2164700170', 'https://openalex.org/W2171021618', 'https://openalex.org/W2171953679', 'https://openalex.org/W2180229411'], 'related_works': ['https://openalex.org/W4282046937', 'https://openalex.org/W4281635707', 'https://openalex.org/W3009802088', 'https://openalex.org/W2772529147', 'https://openalex.org/W2494765976', 'https://openalex.org/W2146230033', 'https://openalex.org/W2109464295', 'https://openalex.org/W2067285410', 'https://openalex.org/W1989793724', 'https://openalex.org/W1846511012'], 'abstract_inverted_index': {'Positive': [0], 'allosteric': [1], 'modulators': [2, 27], 'of': [3, 18, 41, 62, 71, 83, 97, 109, 117, 133, 147], 'the': [4, 16, 39, 63, 68, 81, 94, 106, 130], 'ionotropic': [5], 'glutamate': [6], 'receptor': [7, 26, 58], 'A2': [8], '(GluA2)': [9], 'can': [10], 'serve': [11], 'as': [12, 29], 'lead': [13], 'compounds': [14], 'for': [15, 127], 'development': [17], 'cognitive': [19], 'enhancers.': [20], 'Several': [21], 'benzamide-type': [22], '(S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic': [23], 'acid': [24], '(AMPA)': [25], 'such': [28], 'aniracetam,': [30], 'CX516': [31, 52, 72, 92, 98, 110], 'and': [32, 60, 93, 111, 119, 121, 143], 'CX614': [33, 120], 'have': [34], 'been': [35, 78], 'shown': [36], 'to': [37, 73, 115], 'inhibit': [38], 'deactivation': [40, 146], 'AMPA': [42, 57, 74, 148], 'receptors': [43, 75], 'with': [44, 91], 'a': [45, 84], 'less': [46], 'pronounced': [47], 'effect': [48], 'on': [49], 'desensitization.': [50], 'Despite': [51], 'being': [53], 'an': [54], 'extensively': [55], 'investigated': [56], 'modulator': [59], 'one': [61], 'few': [64], 'clinically': [65], 'evaluated': [66], 'compounds,': [67], 'binding': [69, 107], 'mode': [70], 'has': [76], 'not': [77], 'reported.': [79, 101], 'Here,': [80], 'structures': [82, 103], 'GluA2': [85], 'ligand-binding': [86], 'domain': [87], 'mutant': [88], 'in': [89], 'complex': [90], '3-methylpiperidine': [95], 'analogue': [96], '(Me-CX516)': [99], 'are': [100, 113], 'The': [102, 135], 'show': [104], 'that': [105, 122, 139], 'modes': [108], 'Me-CX516': [112], 'similar': [114], 'those': [116], 'aniracetam': [118, 142], 'there': [123], 'is': [124], 'limited': [125], 'space': [126], 'substitution': [128], 'at': [129], 'piperidine': [131], 'ring': [132], 'CX516.': [134], 'results': [136], 'therefore': [137], 'support': [138], 'CX516,': [140], 'like': [141], 'CX614,': [144], 'modulates': [145], 'receptors.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968126027', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-08-13T04:13:54.448303', 'created_date': '2016-06-24'}