Publication Information

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'the': [6, 34, 41, 52, 86, 116, 145, 149, 159, 164, 184, 222, 233, 260, 288, 295, 306, 340, 370, 399, 403, 413, 418, 438, 476, 487, 565, 575, 581, 587, 675, 685, 703, 709, 761, 1074, 1091, 1271, 1285, 1339, 1406, 1417, 1423, 1431, 1437, 1456, 1464, 1468, 1491, 1595, 1762, 1812, 1833, 1874, 1897, 1908, 1919, 1945, 1965, 1974, 1985, 1990, 1996, 2031, 2037, 2060, 2064, 2147, 2153, 2330, 2435, 2439, 2455, 2474, 2671, 2733, 2739, 2768, 2844, 2856, 2869, 2880, 2907, 2914, 2927, 2933, 2937, 2943, 2946, 2975, 2979, 2988, 2996, 3009, 3017, 3022, 3025, 3032, 3043, 3055, 3061, 3070, 3089, 3103, 3115, 3124, 3127, 3135, 3140, 3148, 3170, 3197, 3284, 3287, 3294, 3321, 3338, 3348, 3365, 3395, 3398, 3402, 3408, 3411, 3430, 3436, 3458, 3461, 3470, 3487, 3518, 3525, 3546, 3610, 3644, 3649, 3653, 3662, 3720, 3735, 3748, 3757, 3763, 3773, 3776, 3779, 3785, 3792, 3809, 3813, 3819, 3838, 3861, 3866, 3873, 3876, 3879, 3893, 3900, 3903, 3915, 3926, 3940, 3965, 3984, 3987, 4005, 4023, 4040, 4050, 4057, 4071, 4077, 4088, 4097, 4106, 4129, 4132, 4221, 4275, 4288, 4348, 4367, 4376, 4393, 4416, 4422, 4438, 4441, 4461, 4471, 4475, 4478, 4500, 4505, 4508], 'hepatic': [7, 261], 'assembly': [8, 262, 588], 'and': [9, 26, 37, 104, 131, 162, 248, 263, 280, 291, 358, 385, 416, 502, 589, 648, 655, 715, 1049, 1193, 1458, 1472, 1565, 1580, 1588, 1601, 1619, 1623, 1635, 1701, 1806, 1808, 1869, 1871, 1892, 1894, 1899, 1960, 1962, 1989, 1998, 2027, 2058, 2077, 2084, 2128, 2188, 2225, 2248, 2289, 2300, 2326, 2348, 2376, 2406, 2430, 2432, 2452, 2471, 2487, 2491, 2497, 2527, 2556, 2587, 2618, 2669, 2891, 2998, 3081, 3095, 3137, 3302, 3354, 3376, 3378, 3420, 3447, 3472, 3497, 3500, 3520, 3669, 3737, 3746, 3775, 3795, 3868, 3980, 3986, 4046, 4062, 4282], 'secretion': [10, 82, 143, 169, 212, 264, 336, 397, 423, 466, 590, 1082, 2731, 3120, 3952, 3966, 3995, 4103, 4354, 4368, 4398, 4431, 4447], 'of': [11, 24, 46, 75, 91, 106, 111, 120, 133, 179, 190, 236, 241, 265, 278, 300, 329, 345, 360, 365, 374, 387, 433, 444, 490, 495, 569, 591, 677, 684, 687, 705, 1076, 1083, 1093, 1291, 1342, 1352, 1443, 1463, 1489, 1493, 1560, 1563, 1614, 1638, 1708, 1731, 1753, 1815, 1832, 1877, 1902, 1907, 1918, 1968, 1973, 2000, 2152, 2462, 2481, 2621, 2631, 2688, 2695, 2723, 2906, 2926, 2932, 2936, 2978, 3024, 3118, 3123, 3133, 3144, 3150, 3166, 3200, 3261, 3276, 3286, 3314, 3323, 3364, 3391, 3397, 3404, 3413, 3432, 3444, 3464, 3484, 3511, 3552, 3557, 3641, 3671, 3778, 3808, 3812, 3860, 3875, 3899, 3967, 3975, 4001, 4004, 4031, 4059, 4096, 4110, 4277, 4357, 4369, 4392, 4407, 4421, 4440, 4477, 4502, 4507], 'very': [12, 266, 529, 570], 'low': [13, 267, 525, 530, 571, 1690, 3273], 'density': [14, 268, 526, 531, 572, 1707, 1730], 'lipoprotein': [15, 117, 269, 371, 573, 577, 759, 4492], '(VLDL).': [16, 270], 'The': [17, 271, 692, 1095, 1951, 1977, 2137, 2223, 2280, 2661, 2709, 2834, 2894, 3006, 3362, 3841, 4217, 4464], 'LDL': [18, 272, 534, 693, 737, 2534], 'receptor': [19, 273, 694], '(LDLR)': [20, 274, 695], 'promotes': [21, 275], 'post-translational': [22, 276, 656], 'degradation': [23, 45, 56, 105, 227, 237, 277, 299, 310, 359, 481, 491, 657, 1092, 1357, 1451, 1562, 2773, 3143, 3199, 3390, 3555, 3670, 4030, 4409], 'apoB': [25, 55, 76, 107, 142, 168, 180, 206, 211, 225, 242, 279, 309, 330, 361, 396, 422, 434, 460, 465, 479, 496, 583, 644, 688, 714, 1421, 1450, 1471, 1564, 2490, 2526, 2603, 2712, 2730, 2771, 3066, 3110, 3119, 3138, 3154, 3201, 3392, 3465, 3516, 3531, 3541, 3554, 3951, 3968, 4084, 4093, 4102, 4353, 4370, 4408, 4446, 4483, 4513], 'thereby': [27, 281], 'reduces': [28, 282, 3065], 'VLDL': [29, 191, 283, 445, 593, 678, 765, 1084, 1293, 1354, 1444, 1469, 1494, 1577, 4358, 4462], 'particle': [30, 284, 578], 'secretion.': [31, 285, 766, 1578, 4019, 4085, 4484, 4514], 'We': [32, 48, 286, 302, 1446, 1474, 3255, 3346, 3605, 3937, 4344], 'investigated': [33, 287, 3147, 3550], 'trafficking': [35, 289], 'pathways': [36, 290, 1568], 'ligand': [38, 292, 1438, 4472], 'requirements': [39, 293, 1439], 'LDLR': [42, 53, 71, 125, 201, 223, 296, 307, 325, 379, 455, 477, 722, 762, 1077, 1101, 1272, 1286, 1418, 1465, 1480, 1573, 1911, 1922, 1952, 2145, 2710, 2727, 2741, 2769, 2872, 2881, 2896, 2938, 2981, 2997, 3007, 3063, 3105, 3125, 3136, 3277, 3315, 3341, 3366, 3534, 3608, 3612, 3722, 3739, 3749, 3760, 3767, 3787, 3823, 3870, 3895, 3928, 3942, 3989, 4002, 4025, 4042, 4052, 4079, 4099, 4130, 4223, 4284, 4350, 4395, 4424, 4443, 4480, 4510], 'to': [43, 226, 297, 480, 754, 1080, 1087, 1338, 1356, 2006, 2118, 2329, 2454, 2473, 2610, 2679, 2702, 2732, 2772, 2848, 3108, 3293, 3333, 3434, 3750, 3833, 3850, 3856, 3883, 3954, 4014, 4100, 4128, 4136, 4290, 4444, 4458, 4481, 4511], 'promote': [44, 298], 'apoB.': [47, 134, 301, 388, 1094], 'first': [49, 303, 2148], 'tested': [50, 304, 4499], 'whether': [51, 305, 1416, 2868, 3060, 3131, 4487], 'drives': [54, 308], 'in': [57, 128, 140, 170, 181, 204, 213, 228, 311, 382, 394, 424, 435, 458, 467, 482, 721, 726, 733, 736, 757, 768, 1090, 1334, 1422, 1430, 1483, 1603, 1689, 1718, 1736, 1944, 2020, 2030, 2048, 2373, 2389, 2438, 2450, 2469, 2614, 2665, 2782, 2836, 2843, 2945, 2987, 3008, 3016, 3021, 3139, 3203, 3263, 3279, 3320, 3343, 3368, 3371, 3384, 3394, 3410, 3429, 3494, 3517, 3537, 3648, 3652, 3674, 3726, 3728, 3743, 3771, 3931, 3934, 3949, 3957, 3993, 4017, 4028, 4056, 4073, 4082, 4092, 4220, 4260, 4264, 4274, 4428], 'an': [58, 67, 124, 200, 214, 312, 321, 378, 454, 468, 1478, 1571, 2775, 2796, 3425, 3491, 3512, 3607, 4122, 4451], 'endoplasmic': [59, 313, 537], 'reticulum': [60, 314], '(ER)-associated': [61, 315], 'pathway.': [62, 253, 316, 507, 1433, 2777], 'Primary': [63, 317], 'mouse': [64, 318, 2793, 2838, 2870, 3328, 3759], 'hepatocytes': [65, 319, 956, 2016, 2183, 2886, 3076, 3099, 3329, 3745, 3817, 3971, 4281, 4373, 4449], 'harboring': [66, 320], 'ethyl-nitrosourea-induced,': [68, 322], 'ER-retained': [69, 323, 2726, 3062, 3104], 'mutant': [70, 126, 136, 202, 324, 380, 390, 456, 1481, 1574, 2916, 2980, 3045, 3064], 'secreted': [72, 326, 680, 1097, 3071, 3092], 'comparable': [73, 327, 4015], 'levels': [74, 328, 3073, 3443, 3463, 3974, 4000], 'with': [77, 93, 174, 196, 331, 347, 428, 450, 728, 1694, 1745, 1804, 1829, 1867, 1890, 1958, 2051, 2063, 2130, 2142, 2266, 2286, 2292, 2297, 2315, 2338, 2345, 2355, 2393, 2414, 2422, 2425, 2573, 2580, 2589, 2800, 2882, 3003, 3031, 3054, 3317, 3330, 3356, 3439, 3476, 3740, 3756, 3826, 3914, 4039, 4386, 4415, 4450], 'LDLR-null': [78, 332], 'hepatocytes,': [79, 333], 'despite': [80, 334, 4070, 4271], 'reduced': [81, 167, 210, 335, 421, 464, 2729], 'from': [83, 337, 708, 1098, 1455, 1594, 1767, 1799, 1840, 1885, 1956, 2495, 2795, 2840, 2884, 2888, 2942, 3074, 3078, 3085, 3126, 3169, 3457, 3524, 3902, 4371, 4448, 4456], 'cells': [84, 92, 182, 338, 346, 436, 1052, 1686, 1725, 2044, 2263, 2281, 2311, 2386, 2405, 2411, 3011, 3350, 3409, 3474, 3676, 3842, 3891, 4048], 'expressing': [85, 183, 339, 437, 2738, 3259, 3818, 3865, 3892, 3972, 4049, 4375], 'wild-type': [87, 146, 160, 341, 400, 414, 1920, 3339], 'LDLR.': [88, 147, 342, 401, 3399, 4380, 4417], 'Additionally,': [89, 343], 'treatment': [90, 344, 2684, 2707], 'brefeldin': [94, 112, 348, 366, 542], 'A': [95, 349, 719, 1825, 2236, 2443, 3036, 4045], 'inhibited': [96, 350], 'LDLR-dependent': [97, 351, 1449, 3116, 3153, 3492, 3513, 4090], 'degradation.': [98, 352, 691, 1278, 3155, 3532], 'However,': [99, 148, 353, 402, 3482, 3889, 4112, 4266, 4390], 'this': [100, 197, 354, 451, 2780, 2837, 3112, 3318, 3961, 4225, 4363, 4488], 'rescue': [101, 355], 'was': [102, 137, 151, 356, 391, 405, 1765, 1809, 1838, 1883, 2140, 2336, 2448, 2467, 2677, 3106, 3788, 4425], 'reversible,': [103, 357], 'occurred': [108, 362, 3393], 'upon': [109, 363], 'removal': [110, 364, 3483], 'A.': [113, 367, 785, 791, 962, 983, 992, 1034, 1120, 1126, 1213, 1219, 1300, 1363, 1390, 1787, 1852, 1928, 2097, 2199, 2211, 2507, 2540, 2747, 2756, 3212, 3571, 4180], 'To': [114, 368, 2177, 2778, 2866, 2990, 3058, 3129, 3310, 3400, 3717, 3803, 3959, 4020, 4361, 4485], 'characterize': [115, 369], 'reuptake': [118, 189, 234, 372, 443, 488, 1290, 1442, 1492, 3563, 4356], 'pathway': [119, 247, 373, 501], 'degradation,': [121, 375], 'we': [122, 376, 1409, 1414, 1435, 2787, 2877, 2994, 3068, 3146, 3325, 3406, 3733, 3963, 4033, 4365, 4498], 'employed': [123, 377, 3256, 3606], 'defective': [127, 203, 381, 457, 1482, 3725, 3930, 3948], 'constitutive': [129, 245, 383, 499, 1484, 3663, 3932, 4074, 4261], 'endocytosis': [130, 384, 1485, 3565, 3727, 3933, 4139], 'internalization': [132, 240, 386, 494, 1341, 2261, 3668, 3859, 3898, 4276], 'This': [135, 389, 1553, 2765, 3267, 3656], 'as': [138, 144, 157, 392, 398, 411, 724, 1344, 1346, 1649, 2090, 2190, 2500, 2736, 3543, 3545, 4494], 'effective': [139, 393, 4081], 'reducing': [141, 395, 4429], 'effect': [150, 404, 3149, 3403, 3514, 4501], 'dependent': [152, 406], 'on': [153, 407, 1420, 1467, 1557, 1625, 1713, 2275, 3152, 3515, 3831, 4460, 4504], 'apolipoprotein': [154, 408, 516, 519, 716], 'E': [155, 409, 717], '(apoE)': [156, 410], 'only': [158, 412, 3890], 'LDLR,': [161, 415, 533, 3815, 3977, 3979], 'not': [163, 208, 417, 462, 1743, 3029, 3088, 3195, 3467], 'endocytic': [165, 185, 246, 419, 439, 500, 1500, 3664, 3810, 4075, 4262], 'mutant,': [166, 186, 420, 440, 2890, 3609], 'apoE-null': [171, 425], 'cells.': [172, 426], 'Treatment': [173, 427, 3438], 'heparin': [175, 429, 4503], 'rescued': [176, 430], 'a': [177, 229, 244, 251, 431, 483, 498, 505, 682, 697, 734, 1088, 1335, 1348, 1427, 1496, 1626, 1706, 1729, 2131, 2143, 2339, 2459, 2478, 2574, 2581, 2715, 2783, 2789, 2841, 2849, 3047, 3158, 3264, 3272, 3312, 3369, 3379, 3382, 3509, 3639, 3805, 3827, 4035, 4054, 4272, 4405, 4412], 'pool': [178, 432], 'indicating': [187, 441, 3388, 3451], 'that': [188, 221, 442, 475, 689, 1073, 1270, 1284, 1448, 1459, 1477, 2114, 2721, 2767, 2983, 3114, 3161, 3389, 3452, 3522, 3719, 3925, 3939, 4022, 4069, 4105, 4126, 4270, 4347, 4402, 4437, 4468], 'via': [192, 239, 446, 493, 1495, 4359], 'apoE': [193, 209, 249, 447, 463, 503, 4086, 4292, 4453, 4459, 4469], 'still': [194, 448, 1487], 'occurs': [195, 238, 449, 492, 725, 1452, 2939, 4410, 4490], 'mutant.': [198, 452], 'Finally,': [199, 453], 'binding': [205, 459, 3836, 4457], 'but': [207, 461, 3019, 3087], 'apoE-dependent': [215, 469], 'manner.': [216, 470, 3266], 'Together,': [217, 471], 'these': [218, 472], 'data': [219, 473, 2662, 3923, 4067, 4115, 4435], 'suggest': [220, 474, 3521], 'directs': [224, 478, 2770], 'post-ER': [230, 484, 1428], 'compartment.': [231, 485], 'Furthermore,': [232, 486], 'mechanism': [235, 489, 1501], 'through': [243, 250, 497, 504, 653, 711, 1288, 1347, 2714, 2774, 3564, 4355, 4411, 4491], 'ligand-dependent': [252, 506], '3The': [511], 'abbreviations': [512], 'used': [513, 1748, 2227, 2524, 2788], 'are:': [514], 'apoB,': [515, 3145, 4032], 'B;': [517], 'apoE,': [518], 'E;': [520], 'ARH,': [521], 'autosomal': [522], 'hypercholesterolemia;': [523, 546], 'LDL,': [524, 1343], 'lipoprotein;': [527, 532], 'VLDL,': [528], 'receptor;': [535], 'ER,': [536, 2944], 'reticulum;': [538], 'β-Gal,': [539], 'β-galactosidase;': [540], 'BFA,': [541, 3324, 3405], 'A;': [543], 'FH,': [544], 'familial': [545, 729], 'LSD,': [547], 'least': [548, 2696, 3946, 4404], 'significant': [549, 2697, 3897], 'difference;': [550], 'WT,': [551, 2889, 3079, 3086], 'wild': [552], 'type;': [553], 'DMEM,': [554], "Dulbecco's": [555], 'modified': [556], "Eagle's": [557], 'medium;': [558], 'Ad,': [559], 'adenoviral;': [560], 'pfu,': [561], 'plaque-forming': [562], 'unit.': [563], 'major': [566], 'protein': [567, 700, 2179, 2640, 3072], 'component': [568], '(VLDL),': [574], 'triglyceride-enriched': [576], 'produced': [579], 'by': [580, 1569, 1646, 1761, 1864, 1915, 2004, 2181, 2568, 2571, 2578, 2607, 2638, 2691, 3283], 'liver.': [582], 'essential': [585], 'nascent': [592, 1292, 1353], 'particles': [594, 679, 1096, 1276, 1294, 1355], '(1Davis': [595], 'R.A.': [596, 631, 659, 661], 'Biochim.': [597], 'Biophys.': [598], 'Acta.': [599], '1999;': [600, 890], '1440:': [601], '1-31Crossref': [602], 'PubMed': [603, 623, 639, 671, 747, 807, 835, 871, 893, 919, 950, 975, 996, 1018, 1044, 1068, 1142, 1166, 1188, 1235, 1264, 1313, 1331, 1376, 1400, 1524, 1548, 1678, 1791, 1856, 1941, 2110, 2172, 2218, 2520, 2553, 2658, 2760, 2829, 2971, 3187, 3224, 3250, 3584, 3602, 3632, 3696, 3712, 4163, 4184, 4212, 4250, 4315, 4339], 'Scopus': [604, 624, 640, 748, 836, 872, 894, 920, 951, 997, 1019, 1045, 1167, 1189, 1265, 1401, 1525, 1549, 1679, 1792, 1857, 2173, 2219, 2761, 2830, 3188, 3251, 3633, 3697, 3713, 4164, 4185, 4213, 4251, 4316, 4340], '(164)': [605], 'Google': [606, 626, 642, 672, 750, 808, 838, 874, 896, 922, 953, 976, 999, 1021, 1047, 1069, 1143, 1169, 1191, 1236, 1267, 1314, 1332, 1377, 1403, 1527, 1551, 1681, 1794, 1859, 1942, 2111, 2175, 2221, 2521, 2554, 2659, 2763, 2832, 2972, 3190, 3225, 3253, 3585, 3603, 3635, 3699, 3715, 4166, 4187, 4215, 4253, 4318, 4342], 'Scholar,': [607, 627, 809, 839, 897, 923, 977, 1000, 1022, 1144, 1170, 1237, 1315, 1378, 1528, 3226, 3586, 3700, 4167, 4188, 4319], '2Fisher': [608], 'E.A.': [609, 1058, 1321, 3592], 'Ginsberg': [610, 3237], 'H.N.': [611, 3238], 'J.': [612, 662, 797, 798, 819, 824, 887, 905, 908, 939, 958, 969, 1004, 1006, 1007, 1059, 1132, 1133, 1152, 1155, 1174, 1176, 1177, 1225, 1226, 1253, 1296, 1307, 1322, 1359, 1370, 1515, 1518, 1544, 1667, 1924, 1935, 2093, 2104, 2203, 2503, 2514, 2536, 2547, 2649, 2823, 2962, 3173, 3215, 3239, 3567, 3578, 3593, 4152, 4200, 4201, 4239, 4306, 4309, 4335], 'Biol.': [613, 663, 867, 940, 1008, 1060, 1178, 1254, 1323, 1668, 2650, 2963, 3216, 3240, 3594, 4153, 4202, 4240], 'Chem.': [614, 664, 941, 1009, 1061, 1179, 1255, 1324, 1669, 2651, 2964, 3217, 3241, 3595, 4154, 4203, 4241], '2002;': [615, 993, 2757, 4155, 4181, 4242], '277:': [616, 4156, 4243], '17377-17380Abstract': [617], 'Full': [618, 620, 668, 804, 830, 832, 914, 916, 945, 947, 1013, 1015, 1065, 1139, 1161, 1163, 1183, 1185, 1232, 1259, 1261, 1328, 1673, 1675, 2655, 2968, 3184, 3221, 3245, 3247, 3599, 3629, 3693, 3709, 4158, 4160, 4207, 4209, 4245, 4247], 'Text': [619, 621, 669, 805, 831, 833, 915, 917, 946, 948, 1014, 1016, 1066, 1140, 1162, 1164, 1184, 1186, 1233, 1260, 1262, 1329, 1674, 1676, 2656, 2969, 3185, 3222, 3246, 3248, 3600, 3630, 3694, 3710, 4159, 4161, 4208, 4210, 4246, 4248], 'PDF': [622, 670, 806, 834, 918, 949, 1017, 1067, 1141, 1165, 1187, 1234, 1263, 1330, 1677, 2657, 2970, 3186, 3223, 3249, 3601, 3631, 3695, 3711, 4162, 4211, 4249], '(379)': [625], '3Blasiole': [628], 'D.A.': [629, 2196], 'Davis': [630, 660], 'Attie': [632, 967, 984, 1305, 1368, 1933, 2102, 2164, 2208, 2512, 2545, 2748, 3576], 'A.D.': [633, 968, 985, 1306, 1369, 1934, 2103, 2165, 2209, 2513, 2546, 2749, 3577], 'Mol.': [634], 'Biosyst.': [635], '2007;': [636, 1521, 1545, 2215, 2826, 4312, 4336], '3:': [637], '608-619Crossref': [638], '(90)': [641], 'Scholar).': [643, 673, 751, 1404, 1552, 1682, 2176, 2222, 2522, 2660, 2764, 2833, 2973, 3191, 3254, 3604, 3716, 4216, 4343], 'constitutively': [646], 'expressed,': [647], 'its': [649, 712, 755, 3000, 3752, 3955, 4138, 4258], 'stability': [650], 'regulated': [652], 'co-': [654], '(4Borchardt': [658], '1987;': [665], '262:': [666], '16394-16402Abstract': [667], 'Therefore,': [674, 2974], 'number': [676], 'function': [683], 'proportion': [686], 'escapes': [690], 'ubiquitously': [698], 'expressed': [699, 2633, 2664, 3734, 3765], 'responsible': [701, 3666, 4473], 'clearance': [704, 738], 'cholesterol-rich': [706], 'lipoproteins': [707, 3673], 'bloodstream': [710], 'ligands,': [713], '(apoE).': [718], 'loss': [720, 1075, 4259], 'activity,': [723, 4076], 'humans': [727, 769], 'hypercholesterolemia': [730, 2835], '(FH),': [731], 'results': [732, 2839, 3507, 3911, 4455], 'defect': [735, 3956, 4072, 4273], '(5Brown': [739], 'M.S.': [740, 884, 2959, 3622, 3686, 3702], 'Goldstein': [741, 885, 2960, 3623, 3687, 3703], 'J.L.': [742, 886, 2961, 3624, 3688, 3704], 'Science.': [743], '1986;': [744, 3626, 3690], '232:': [745], '34-47Crossref': [746], '(4383)': [749], 'In': [752, 1405, 2597, 2627, 3041, 3783], 'addition': [753], 'role': [756], 'mediating': [758, 1490], 'clearance,': [760], 'also': [763, 1475, 3020, 3724], 'regulates': [764], 'Studies': [767], '(6James': [770, 1105, 1198], 'R.W.': [771, 1056, 1106, 1199, 1319, 3590], 'Martin': [772, 1107, 1200], 'B.': [773, 813, 925, 1108, 1201, 1239, 1653, 2814], 'Pometta': [774, 1109, 1202], 'D.': [775, 1110, 1203], 'Fruchart': [776, 1111, 1204], 'J.C.': [777, 817, 859, 1112, 1205, 1513, 1542, 4151, 4196, 4238, 4304, 4333], 'Duriez': [778, 1113, 1206], 'P.': [779, 781, 823, 1114, 1116, 1207, 1209, 1507, 1530, 4147, 4234, 4298, 4321], 'Puchois': [780, 1115, 1208], 'Farriaux': [782, 1117, 1210], 'J.P.': [783, 1118, 1211], 'Tacquet': [784, 1119, 1212], 'Demant': [786, 1121, 1214], 'T.': [787, 1122, 1215, 3210, 3214], 'Clegg': [788, 1123, 1216], 'R.J.': [789, 1124, 1217, 2648], 'Munro': [790, 1125, 1218], 'Oliver': [792, 1127, 1220], 'M.F.': [793, 1128, 1221], 'Packard': [794, 1129, 1222], 'C.J.': [795, 1130, 1223], 'Shepherd': [796, 1131, 1224], 'Lipid': [799, 825, 909, 1134, 1156, 1227], 'Res.': [800, 826, 910, 1135, 1157, 1228], '1989;': [801, 1136, 1229, 3181], '30:': [802, 1137, 1230], '159-169Abstract': [803, 1138, 1231], '7Tremblay': [810], 'A.J.': [811], 'Lamarche': [812], 'Ruel': [814], 'I.L.': [815], 'Hogue': [816], 'Bergeron': [818], 'Gagne': [820], 'C.': [821, 843, 1028, 1384, 1503, 4190, 4294], 'Couture': [822], '2004;': [827, 911, 1010, 1158, 1180], '45:': [828, 912, 1159, 3627, 3691], '866-872Abstract': [829], '(48)': [837], '8Millar': [840], 'J.S.': [841, 3177], 'Maugeais': [842], 'Ikewaki': [844], 'K.': [845, 1030, 1386], 'Kolansky': [846], 'D.M.': [847], 'Barrett': [848, 965, 1303, 1366, 1931, 2100, 2510, 2543, 3574], 'P.H.': [849, 966, 1304, 1367, 1932, 2101, 2511, 2544, 3575], 'Budreck': [850], 'E.C.': [851], 'Boston': [852], 'R.C.': [853], 'Tada': [854], 'N.': [855, 1511, 2194, 3230, 4302], 'Mochizuki': [856], 'S.': [857, 991, 1026, 1382, 1770, 1786, 1851, 2201, 2755, 2951, 4143, 4179, 4230], 'Defesche': [858], 'Wilson': [860], 'J.M.': [861], 'Rader': [862], 'D.J.': [863, 2161], 'Arterioscler.': [864], 'Thromb.': [865], 'Vasc.': [866], '2005;': [868], '25:': [869], '560-565Crossref': [870], '(76)': [873], 'Scholar),': [875, 954, 1048, 1268, 3636, 4254], 'mice': [876, 1591], '(9Horton': [877], 'J.D.': [878], 'Shimano': [879], 'H.': [880, 931, 1245, 1659, 1778, 1845, 2957, 3236], 'Hamilton': [881], 'R.L.': [882], 'Brown': [883, 2958, 3621, 3685], 'Clin.': [888, 970, 1308, 1371, 1519, 1936, 2105, 2515, 2548, 3579, 4310], 'Investig.': [889, 971, 1309, 1372, 1520, 1937, 2106, 2516, 2549, 3580, 4311], '103:': [891], '1067-1076Crossref': [892], '(158)': [895], '10Nassir': [898, 1145], 'F.': [899, 933, 1146, 1247, 1661], 'Xie': [900, 1147], 'Y.': [901, 1148], 'Patterson': [902, 1149], 'B.W.': [903, 1150], 'Luo': [904, 1151], 'Davidson': [906, 1153], 'N.O.': [907, 1154], '1649-1659Abstract': [913, 1160], '(19)': [921, 952, 1168, 1266, 1680], '11Teusink': [924, 1238], 'Mensenkamp': [926, 1240, 1654], 'A.R.': [927, 1038, 1241, 1394, 1655], 'van': [928, 934, 1242, 1248, 1656, 1662], 'der': [929, 1243, 1657], 'Boom': [930, 1244, 1658], 'Kuipers': [932, 1246, 1660], 'Dijk': [935, 1249, 1663], 'K.W.': [936, 1250, 1664], 'Havekes': [937, 1251, 1665], 'L.M.': [938, 1252, 1666, 4173], '2001;': [942, 1041, 1256, 1397, 1670], '276:': [943, 1257, 1671], '40693-40697Abstract': [944, 1258, 1672], 'primary': [955, 2885, 3075, 3730, 3935], '(12Twisk': [957, 1295, 1358, 1923, 2092, 2502, 2535, 3566], 'Gillian-Daniel': [959, 1297, 1360, 1925, 2094, 2504, 2537, 3568], 'D.L.': [960, 979, 1298, 1361, 1926, 2095, 2505, 2538, 2743, 3569], 'Tebon': [961, 982, 1299, 1362, 1927, 2096, 2197, 2506, 2539, 2746, 3570], 'Wang': [963, 1301, 1364, 1929, 2098, 2508, 2541, 3572], 'L.': [964, 1302, 1365, 1930, 2099, 2509, 2542, 3573], '2000;': [972, 1310, 1373, 1788, 1938, 2107, 2517, 2550, 3581], '105:': [973, 1311, 1374, 1939, 2108, 2518, 2551, 3582], '521-532Crossref': [974, 1312, 1375, 1940, 2109, 2519, 2552, 3583], '13Gillian-Daniel': [978], 'Bates': [980, 2744], 'P.W.': [981, 2745], 'Proc.': [986, 1781, 1846, 2750, 4174], 'Natl.': [987, 1782, 1847, 2751, 4175], 'Acad.': [988, 1783, 1848, 2752, 4176], 'Sci.': [989, 1784, 1849, 2753, 4177], 'U.': [990, 1772, 1785, 1850, 2754, 4178], '99:': [994, 2758, 4182], '4337-4342Crossref': [995, 2759], '(61)': [998, 2762], '14Larsson': [1001, 1171], 'S.L.': [1002, 1172, 2163], 'Skogsberg': [1003, 1173], 'Bjorkegren': [1005, 1175], '279:': [1011, 1181], '831-836Abstract': [1012, 1182], '(53)': [1020, 1190], '15Jiang': [1023, 1379], 'X.C.': [1024, 1380], 'Qin': [1025, 1381], 'Qiao': [1027, 1383], 'Kawano': [1029, 1385], 'Lin': [1031, 1387], 'M.': [1032, 1388, 1774, 1843, 3234, 4145, 4232], 'Skold': [1033, 1389], 'Xiao': [1035, 1391], 'X.': [1036, 1392, 3228], 'Tall': [1037, 1393], 'Nat.': [1039, 1395], 'Med.': [1040, 1396], '7:': [1042, 1398], '847-852Crossref': [1043, 1399], '(231)': [1046, 1402], 'human': [1050, 3340], 'hepatoma': [1051], '(16Williams': [1053], 'K.J.': [1054, 1317, 3588], 'Brocia': [1055, 1318, 3589], 'Fisher': [1057, 1320, 3591], '1990;': [1062, 1325, 3218, 3596], '265:': [1063, 1326, 3219, 3597], '16741-16744Abstract': [1064, 1327, 3598], 'Scholar)': [1070, 1192, 1333, 1795, 1860, 1943, 2112, 2555], 'have': [1071, 1194, 1282], 'revealed': [1072, 3490], 'activity': [1078, 1102, 2620, 3316, 3665, 3811, 4263], 'leads': [1079], 'increased': [1081, 2976, 3441], 'particles,': [1085], 'due': [1086, 3953], 'decrease': [1089, 3109, 3493], 'livers': [1099], 'lacking': [1100], 'are': [1103], 'small': [1104], 'decreased': [1195], 'triglyceride': [1196], 'content': [1197], 'suggesting': [1269, 4401], 'preferentially': [1273], 'targets': [1274], 'underlipidated': [1275], 'Initial': [1279], 'mechanistic': [1280], 'studies': [1281, 4268], 'suggested': [1283, 2766], 'operates': [1287], 'rapid': [1289], '16Williams': [1316, 3587], 'process': [1336, 4107], 'similar': [1337, 3999], 'LDLR-mediated': [1340, 1441, 1561, 3530, 3553], 'well': [1345], 'direct': [1349, 4413], 'intracellular': [1350, 3799], 'targeting': [1351], 'current': [1407], 'study,': [1408], 'addressed': [1410], 'two': [1411, 2683], 'questions.': [1412], 'First,': [1413], 'asked': [1415], 'acts': [1419], 'ER': [1424, 1457, 2875, 2992, 3033, 3056, 3141, 3171, 3519, 3526, 3558], 'or': [1425, 2295, 3337, 3821, 3848, 4378], 'at': [1426, 1611, 1705, 1728, 2036, 2302, 2458, 2477, 2898, 2918, 3791, 3837, 3878, 3945, 4131, 4403], 'step': [1429], 'secretory': [1432, 3167], 'Second,': [1434], 'studied': [1436], 'particles.': [1445], 'show': [1447, 1476, 2670, 3924, 4269], 'after': [1453, 2014, 2075, 2080, 2940, 3418], 'exit': [1454, 2941, 3122, 3523], 'it': [1460, 2984], 'involves': [1461], 'both': [1462, 3134, 3772, 3871, 3983, 4286], 'ligands': [1466], 'particle,': [1470], 'apoE.': [1473, 4360], 'FH': [1479, 1572], 'capable': [1488], 'recently': [1497, 4113], 'described,': [1498], 'non-canonical': [1499], '(17Jones': [1502, 4293], 'Garuti': [1504, 1535, 4295, 4326], 'R.': [1505, 1536, 2808, 2818, 3208, 4296, 4327], 'Michaely': [1506, 4146, 4233, 4297], 'Li': [1508, 1533, 2817, 4193, 4299, 4324], 'W.P.': [1509, 1534, 4194, 4300, 4325], 'Maeda': [1510, 4301], 'Cohen': [1512, 1541, 4150, 4195, 4237, 4303, 4332], 'Herz': [1514, 4199, 4305], 'Hobbs': [1516, 1539, 4148, 4197, 4235, 4307, 4330], 'H.H.': [1517, 1540, 4149, 4198, 4236, 4308, 4331], '117:': [1522, 4313], '165-174Crossref': [1523, 4314], '(57)': [1526, 4317], '18Michaely': [1529, 4320], 'Zhao': [1531, 4322], 'Z.': [1532, 4323], 'Huang': [1537, 4328], 'L.J.': [1538, 4329], 'EMBO': [1543, 4334], '26:': [1546, 4337], '3273-3282Crossref': [1547, 4338], '(27)': [1550, 4341], 'study': [1554], 'sheds': [1555], 'light': [1556], 'general': [1558], 'mechanisms': [1559, 3551], 'specifically': [1566, 3560], 'predicts': [1567], 'which': [1570, 2903, 2923, 3027, 3051, 3637, 4255], 'may': [1575, 4351], 'regulate': [1576, 4101, 4352, 4482, 4512], 'Mice': [1579, 1608, 1630], 'Hepatocyte': [1581], 'Isolation—Wild-type': [1582], '(C57BL/6J),': [1583], 'C678Y': [1584, 2850, 2871, 2915, 3044, 3090], '(HLB301),': [1585], 'Ldlr-/-': [1586, 2892, 3082, 3098, 3327, 3744, 3816, 3970], '(Ldlrtm1Her),': [1587], 'apoE-/-': [1589, 4372], '(apoEtm1Unc)': [1590], 'were': [1592, 1609, 1631, 1644, 1687, 1726, 1747, 1913, 1954, 2002, 2017, 2045, 2071, 2088, 2116, 2184, 2228, 2264, 2282, 2312, 2353, 2368, 2387, 2412, 2485, 2493, 2530, 2566, 2605, 2636, 2663, 2700, 3824, 3843, 3912, 4384], 'obtained': [1593, 2794], 'Jackson': [1596, 2254, 2321, 2861], 'Laboratory': [1597, 2862], '(Bar': [1598], 'Harbor,': [1599, 2257, 2324], 'ME)': [1600, 2325], 'bred': [1602], 'our': [1604, 3729, 4495], 'animal': [1605], 'care': [1606], 'facility.': [1607], 'weaned': [1610], '3–4': [1612], 'weeks': [1613, 1637], 'age,': [1615], 'fed': [1616], 'standard': [1617, 2331, 2672], 'chow': [1618], 'water': [1620, 2451, 2470], 'ad': [1621], 'libitum,': [1622], 'housed': [1624], '12-h': [1627], 'dark/light': [1628], 'cycle.': [1629], 'sacrificed': [1632], 'between': [1633, 2682, 3469], '8': [1634], '18': [1636], 'age': [1639], 'hepatocyte': [1641, 2615, 3731], 'isolation.': [1642], 'Hepatocytes': [1643, 3084], 'isolated': [1645, 3077], 'liver': [1647], 'perfusion': [1648], 'described': [1650, 2091, 2191, 2501], 'previously': [1651, 2192, 2719], '(11Teusink': [1652], 'For': [1683, 1721, 2259, 2382, 2408], 'confocal': [1684, 3004], 'microscopy,': [1685], 'plated': [1688, 1727], 'glucose': [1691], 'DMEM': [1692, 2022, 2050, 2269, 2378, 2423], 'supplemented': [1693, 2021, 2049, 2268, 2374, 2392, 2424], '10%': [1695, 2052], 'fetal': [1696, 2024, 2054], 'bovine': [1697, 2025, 2055], 'serum,': [1698], 'penicillin-streptomycin,': [1699], 'l-glutamine,': [1700], 'sodium': [1702], 'pyruvate': [1703], '(Invitrogen)': [1704, 2379], '3.6': [1709], '×': [1710, 1733], '105': [1711], 'cells/well': [1712], 'collagen-coated': [1714, 1737], 'coverslips': [1715], '(BD': [1716, 1740], 'Biosciences)': [1717], '6-well': [1719], 'plates.': [1720], 'all': [1722], 'other': [1723], 'applications,': [1724], '0.8': [1732], '106': [1734], 'cells/dish': [1735], '60-mm': [1738], 'dishes': [1739], 'Biosciences).': [1741], 'Cells': [1742, 2484, 3864], 'infected': [1744, 2029, 3326, 3349], 'virus': [1746, 2035], 'within': [1749], '16': [1750], 'h.': [1751, 2042, 2279, 3361], 'Generation': [1752], 'Tetracycline-inducible': [1754], 'Adenoviral': [1755, 2011], 'Vectors—A': [1756], 'reverse': [1757, 1986, 3435], 'tetracycline-controlled': [1758, 1987], 'transactivator': [1759, 1988], 'driven': [1760], 'cytomegalovirus': [1763, 1827], 'promoter': [1764, 1828], 'cut': [1766, 1839, 1884, 1955], 'pWHE146': [1768], '(19Urlinger': [1769], 'Baron': [1771], 'Thellmann': [1773], 'Hasan': [1775], 'M.T.': [1776], 'Bujard': [1777, 1844], 'Hillen': [1779], 'W.': [1780], '97:': [1789], '7963-7968Crossref': [1790], '(755)': [1793], '(a': [1796], 'generous': [1797], 'gift': [1798], 'Wolfgang': [1800, 1865], 'Hillen,': [1801], 'Universitat': [1802], 'Erlangen)': [1803], 'MluI': [1805], 'BamHI': [1807, 1870], 'inserted': [1810, 1872, 1895, 1963], 'into': [1811, 1873, 1896, 1964], 'XbaI': [1813, 1820, 1961, 1966, 1982], 'site': [1814, 1876, 1901, 1967], 'pVQ': [1816, 1878, 1886, 1903, 1969, 1978, 1991], 'E3': [1817, 1979], '3.1': [1818, 1980], 'Δ': [1819, 1981], '(ViraQuest,': [1821], 'North': [1822], 'Liberty,': [1823], 'IA).': [1824], 'minimal': [1826], 'seven': [1830], 'repeats': [1831], 'tetracycline': [1834], 'operator': [1835], '(tet-on': [1836], 'promoter)': [1837], 'pUHC13-3': [1841], '(20Gossen': [1842], '1992;': [1853], '89:': [1854], '5547-5551Crossref': [1855], '(4268)': [1858], '(also': [1861], 'kindly': [1862], 'supplied': [1863], 'Hillen)': [1866], 'XhoI': [1868], 'XhoI/BamHI': [1875], 'Ad5': [1879, 1904, 1970, 1992], 'K-NpA': [1880, 1905, 1971, 1993], '(ViraQuest).': [1881], 'LacZ': [1882], 'AdRSV': [1887], 'ntLacZ': [1888], '(ViraQuest)': [1889], 'HindIII': [1891, 1898], 'SpeI': [1893, 1900], 'downstream': [1906, 1972, 3556], 'tet-on': [1909, 1975], 'promoter.': [1910, 1976], 'mutants': [1912, 2728], 'created': [1914], 'site-directed': [1916], 'mutagenesis': [1917, 2798], '(WT)': [1921], 'pCI': [1946, 1957], 'vector': [1947], '(Promega,': [1948], 'Madison,': [1949, 2446], 'WI).': [1950], 'cDNAs': [1953, 2724], 'NheI': [1959], 'shuttle': [1983], 'containing': [1984, 1995, 2034, 2146, 2270], 'shuttles': [1994], 'operators': [1997], 'genes': [1999, 3260], 'interest': [2001, 3262], 'combined': [2003], 'Viraquest': [2005], 'generate': [2007], 'tetracycline-inducible': [2008, 3265], 'adenoviral': [2009, 3257, 3331, 3741], 'vectors.': [2010], 'Infection—Four': [2012], 'hours': [2013], 'isolation,': [2015], 'washed': [2018, 2284, 2421], 'once': [2019, 2285], 'without': [2023, 2380], 'serum': [2026, 2056], 'then': [2028, 2313, 3421, 3844], 'same': [2032, 2065, 2440, 2734], 'medium': [2033, 2288, 2299, 2391, 2457, 2476, 3358], 'indicated': [2038, 2436, 3282], 'concentrations': [2039], '2': [2041, 3360, 3416], 'Infected': [2043], 'incubated': [2046, 2265, 2301, 2388, 2413, 3825], 'overnight': [2047], 'tetracycline-free': [2053], '(Clontech)': [2057], 're-fed': [2059, 2296], 'following': [2061], 'day': [2062], 'medium.': [2066, 2441], 'All': [2067, 2310], 'viral': [2068, 3268], 'expression': [2069, 3278, 4003, 4391, 4420], 'experiments': [2070, 2598, 2628], 'performed': [2072, 2089, 2337, 2494, 2678, 2701, 4034], '∼40': [2073], 'h': [2074, 2079, 2372, 2402, 3353, 3417, 3428], 'isolation': [2076, 2616], '36': [2078], 'infection.': [2081], 'Western': [2082], 'Blots': [2083], 'Confocal': [2085, 2334], 'Microscopy—Western': [2086], 'blots': [2087], 'except': [2113], 'proteins': [2115, 2565], 'transferred': [2117], 'Westran': [2119], 'S': [2120], 'polyvinylidene': [2121], 'difluoride': [2122], 'membrane': [2123], '(Whatman,': [2124], 'Florham': [2125], 'Park,': [2126], 'NJ)': [2127], 'probed': [2129], 'polyclonal': [2132, 2229, 2271, 2531, 2557, 3828], 'rabbit': [2133, 2532, 2558], 'anti-LDLR': [2134, 2138, 2230, 2272, 3829, 3918], 'antibody': [2135, 2139, 2260, 2273, 3830, 3877, 3901, 3919], '(1:500).': [2136], 'generated': [2141, 2791], 'truncated': [2144], '354': [2149], 'amino': [2150, 2851], 'acids': [2151], 'N': [2154], 'terminus': [2155], '(21Dirlam': [2156], 'K.A.': [2157], 'Gretch': [2158], 'D.G.': [2159], 'LaCount': [2160], 'Sturley': [2162], 'Protein': [2166, 2365], 'Expression': [2167], 'Purif.': [2168], '1996;': [2169], '8:': [2170, 2216], '489-500Crossref': [2171], '(21)': [2174], 'detect': [2178], 'localization': [2180, 3002, 3770, 3800], 'immunofluorescence,': [2182], 'fixed,': [2185], 'permeabilized,': [2186], 'stained,': [2187], 'mounted': [2189, 2327], '(22Nassoury': [2193], 'Blasiole': [2195], 'Oler': [2198], 'Benjannet': [2200], 'Hamelin': [2202], 'Poupon': [2204], 'V.': [2205], 'McPherson': [2206], 'P.S.': [2207], 'Prat': [2210], 'Seidah': [2212], 'N.G.': [2213], 'Traffic.': [2214], '718-732Crossref': [2217], '(205)': [2220], 'antibodies': [2224], 'stains': [2226], '(1:300),': [2231], 'Alexa': [2232], 'Fluor': [2233], '488-conjugated': [2234], 'concanavalin': [2235, 3035], '(50': [2237], 'μg/ml,': [2238], 'Molecular': [2239], 'Probes,': [2240], 'Carlsbad,': [2241], 'CA),': [2242, 2247], '4′,6-diamidino-2-phenylindole': [2243], '(Vector': [2244], 'Laboratories,': [2245], 'Burlingame,': [2246], 'donkey': [2249, 2316], 'anti-rabbit': [2250, 2317], 'IgG-Rhodamine': [2251], 'Red-X': [2252], '(1:200,': [2253, 2320], 'Immuno-Research,': [2255, 2322], 'Bar': [2256, 2323], 'ME).': [2258], 'experiments,': [2262, 2385, 2410], 'cold': [2267, 2287, 3357], '(1:300)': [2274], 'ice': [2276, 3832], '1': [2278, 2371, 2419, 3352], 'either': [2283, 3845], 'fixed': [2290, 3847], 'immediately': [2291, 3846], '2%': [2293], 'paraformaldehyde': [2294], 'warm': [2298], '37': [2303, 3851], '°C': [2304, 3852], '10': [2306, 2426, 2463, 3854, 3908], 'min': [2307, 3855], 'before': [2308, 2403], 'fixation.': [2309], 'stained': [2314, 3747], 'IgG-fluorescein': [2318], 'isothiocyanate': [2319], 'according': [2328], 'protocol': [2332], '(above).': [2333], 'microscopy': [2335], 'Nikon': [2340], 'Eclipse': [2341], 'TE2000-U': [2342], 'laser-scanning': [2343], 'microscope': [2344], '408-,': [2346], '488-,': [2347], '543-nm': [2349], 'laser': [2350], 'lines.': [2351], 'Images': [2352], 'processed': [2354], 'Adobe': [2356], 'PhotoShop': [2357], 'CS2,': [2358], 'version': [2359], '9.0': [2360], '(Adobe,': [2361], 'San': [2362], 'Jose,': [2363], 'CA).': [2364], 'Secretion': [2366, 2713, 3542], 'Assays—Hepatocytes': [2367], 'starved': [2369], 'methionine': [2375], 'cysteine-free': [2377], 'serum.': [2381], 'continuous': [2383], 'labeling': [2384, 2475, 3419], 'starve': [2390], 'l-[35S]methionine/cysteine': [2394], '(100': [2395], 'μCi/dish,': [2396], 'PerkinElmer': [2397], 'Life': [2398], 'Sciences)': [2399], '4': [2401], 'harvesting': [2404], 'media.': [2407], 'pulse-chase': [2409, 4036], '200': [2415], 'μCi/dish': [2416], '[35S]methionine/cysteine': [2417], 'h,': [2420], 'mm': [2427], 'unlabeled': [2428], 'cysteine': [2429, 3642], 'methionine,': [2431], 'chased': [2433, 3355, 3407, 3423], 'times': [2437], 'Brefeldin': [2442], '(BFA,': [2444], 'Epicenter,': [2445], 'WI)': [2447], 'dissolved': [2449, 2468], 'added': [2453, 2472], 'chase': [2456, 3489], 'final': [2460, 2479], 'concentration': [2461, 2480], 'μg/ml.': [2464], 'Heparin': [2465, 4515], '(Sigma)': [2466], '6': [2482], 'mg/ml.': [2483], 'lysed,': [2486], 'immunoprecipitations': [2488, 2529], 'albumin': [2492, 2528, 2560, 2608, 3448], 'media': [2496], 'cell': [2498, 2625, 2639, 3205, 3780, 3793, 3839, 3880, 3904], 'lysates': [2499, 2883], 'Antibodies': [2523], 'anti-pig': [2533], 'anti-human': [2559], '(Sigma),': [2561], 'respectively.': [2562], 'Immunoprecipitated,': [2563], 'radiolabeled': [2564, 3347], 'resolved': [2567], 'SDS-PAGE,': [2569], 'detected': [2570], 'autoradiography': [2572], 'PhosphorImager': [2575], 'screen': [2576, 2799], 'followed': [2577, 2690], 'scanning': [2579], 'Typhoon': [2582], '9410': [2583], 'variable': [2584], 'mode': [2585], 'imager,': [2586], 'quantitated': [2588], 'ImageQuant': [2590], 'TL': [2591], 'v2002.01': [2592], '(GE': [2593], 'Healthcare,': [2594], 'Uppsala,': [2595], 'Sweden).': [2596], 'testing': [2599, 2629], 'endogenous': [2600, 3758], 'genetic': [2601], 'effects,': [2602], 'values': [2604, 2609, 2635], 'normalized': [2606, 2637], 'correct': [2611], 'differences': [2613, 2681, 2704], 'efficiencies': [2617], 'specific': [2619], 'incorporated': [2622], '35S': [2623], 'among': [2624, 2705, 3969], 'types.': [2626], 'effects': [2630, 4383], 'virally': [2632, 3764], 'proteins,': [2634], '(23Lowry': [2641], 'O.H.': [2642], 'Rosebrough': [2643], 'N.J.': [2644], 'Farr': [2645], 'A.L.': [2646], 'Randall': [2647], '1951;': [2652], '193:': [2653], '265-275Abstract': [2654], 'mean': [2666], 'arbitrary': [2667], 'units': [2668], 'error.': [2673], "Student's": [2674], 't': [2675], 'test': [2676, 2694, 2779, 3960, 4362], 'determine': [2680, 2703, 2867, 3130, 3401, 3751, 4486], 'conditions.': [2685, 2708, 3345], 'One-way': [2686], 'analysis': [2687], 'variance': [2689], "Fisher's": [2692], 'protected': [2693], 'difference': [2698], '(LSD)': [2699], 'multiple': [2706], 'Regulates': [2711], 'Post-ER': [2716], 'Mechanism—Our': [2717], 'laboratory': [2718], 'reported': [2720], 'transfection': [2722], 'encoding': [2725], 'extent': [2735], 'those': [2737, 3561], 'WT': [2740, 2895, 3010, 3736, 3766, 3820, 3867, 3894, 3976, 3985, 4010, 4041, 4377, 4394], '(13Gillian-Daniel': [2742], 'ER-associated': [2776, 3198], 'result': [2781], 'more': [2784], 'physiological': [2785], 'system,': [2786, 3732], 'newly': [2790, 2928], 'hypercholesterolemic': [2792], 'ethyl-nitrosourea': [2797], 'high': [2801], 'throughput': [2802], 'phenotyping': [2803], '(24Svenson': [2804], 'K.L.': [2805], 'Von': [2806], 'Smith': [2807], 'Magnani': [2809], 'P.A.': [2810], 'Suetin': [2811], 'H.R.': [2812], 'Paigen': [2813], 'Naggert': [2815], 'J.K.': [2816], 'Churchill': [2819], 'G.A.': [2820], 'Peters': [2821], 'L.L.': [2822], 'Appl.': [2824], 'Physiol.': [2825], '102:': [2827], '2369-2378Crossref': [2828], '(137)': [2831], 'mutation': [2842, 2873], 'Ldlr': [2845], 'gene': [2846, 4454], 'leading': [2847], 'acid': [2852], 'substitution': [2853, 3640, 4219], '(numbering': [2854], 'excludes': [2855], '21-amino-acid': [2857], 'signal': [2858, 3658], 'peptide).': [2859], '4The': [2860], 'Stock': [2863], 'Number': [2864], '005061.': [2865], 'confers': [2874], 'retention,': [2876, 2993], 'blotted': [2878], 'derived': [2887], 'mice.': [2893, 3083], 'migrated': [2897, 2917], '∼150': [2899], 'kDa': [2900, 2920], '(Fig.': [2901, 2921, 3039, 3100, 3386, 3478, 3502, 3761, 3781, 3801, 3885, 3906, 3996, 4007, 4043, 4064, 4399, 4432], '1A),': [2902, 2922], 'characteristic': [2905, 2925], 'mature,': [2908], 'fully': [2909], 'glycosylated': [2910], 'receptor.': [2911, 2934], 'By': [2912, 4418], 'contrast,': [2913, 3042, 3784, 4419], '∼100': [2919], 'synthesized,': [2929], 'immature': [2930], 'form': [2931], 'Glycosylation': [2935], 'Golgi': [2947], '(26Cummings': [2948], 'R.D.': [2949, 3179], 'Kornfeld': [2950], 'Schneider': [2952], 'W.J.': [2953], 'Hobgood': [2954], 'K.K.': [2955], 'Tolleshaug': [2956], '1983;': [2965], '258:': [2966], '15261-15273Abstract': [2967], 'mobility': [2977], 'suggests': [2982, 3113, 4104, 4467], 'retained': [2986], 'ER.': [2989, 3128, 3459], 'verify': [2991, 3718, 4021], 'immunostained': [2995], 'determined': [2999, 3069], 'subcellular': [3001], 'microscopy.': [3005], 'showed': [3012, 3046, 3768, 3796, 3872, 3896, 4053], 'punctate': [3013, 3769], 'staining,': [3014], 'largely': [3015], 'periphery': [3018, 3774], 'interior': [3023, 3777], 'cells,': [3026], 'did': [3028, 3466], 'overlap': [3030], 'marker,': [3034], '(Con': [3037], 'A)': [3038], '1B).': [3040], 'reticular': [3048], 'staining': [3049], 'pattern,': [3050], 'completely': [3052, 4426], 'overlapped': [3053], 'marker.': [3057], 'assess': [3059], 'secretion,': [3067, 3111], 'C678Y,': [3080], 'mice,': [3091], 'less': [3093], 'apoB-100': [3094, 3374, 3499, 3994, 4061, 4397, 4430], 'apoB-48': [3096, 3385, 3501, 4063, 4387], 'than': [3097], '1C).': [3101], 'Since': [3102], 'unable': [3107], 'regulation': [3117, 4489], 'requires': [3121], 'retention': [3132], 'affects': [3142], 'BFA': [3151, 3156, 3193, 3414, 3433, 3440, 3453, 3477, 3485], 'fungal': [3159], 'metabolite': [3160], 'reversibly': [3162], 'blocks': [3163], 'anterograde': [3164], 'transport': [3165, 3456], 'cargo': [3168], '(27Lippincott-Schwartz': [3172], 'Yuan': [3174], 'L.C.': [3175], 'Bonifacino': [3176], 'Klausner': [3178], 'Cell.': [3180, 3625, 3689, 3705], '56:': [3182], '801-813Abstract': [3183], '(1315)': [3189], 'Notably,': [3192], 'does': [3194], 'inhibit': [3196], 'observed': [3202, 3913, 4385], 'some': [3204], 'types': [3206], '(28Sato': [3207], 'Imanaka': [3209], 'Takatsuki': [3211], 'Takano': [3213], '11880-11884Abstract': [3220], '29Wu': [3227], 'Sakata': [3229], 'Lele': [3231], 'K.M.': [3232], 'Zhou': [3233], 'Jiang': [3235], '1997;': [3242], '272:': [3243], '11575-11580Abstract': [3244], '(69)': [3252], 'vectors': [3258, 3332, 3742], 'system': [3269, 3319], 'allowed': [3270], 'basal': [3274], 'level': [3275], 'uninduced': [3280, 3344], 'conditions,': [3281], 'ratio': [3285], '100-kDa': [3288], 'band': [3289, 3296], '(ER': [3290], 'pool)': [3291], 'relative': [3292], '150-kDa': [3295], '(post-ER': [3297], 'pool,': [3298], 'supplemental': [3299], 'Fig.': [3300, 3308], 'S1A),': [3301], 'enabled': [3303], '90–95%': [3304], 'infection': [3305], 'efficiency': [3306], '(supplemental': [3307], 'S1B).': [3309], 'establish': [3311], 'baseline': [3313], 'absence': [3322, 3431], 'express': [3334], 'β-galactosidase': [3335], '(Ad-β-Gal)': [3336], '(Ad-LDLR-WT)': [3342], 'presence': [3363, 3396, 3412, 3874], 'resulted': [3367], 'reduction': [3370, 3383, 4055], 'total': [3372, 3495, 4060], 'recovered': [3373], '(cellular': [3375, 3496], 'secreted)': [3377, 3498], 'trend': [3380], 'toward': [3381], '2A),': [3387], 'further': [3422], 'additional': [3426], '3': [3427], 'effects.': [3437], 'cellular': [3442, 3462], 'apoB-100,': [3445], 'apoB-48,': [3446], '(not': [3449, 3920, 4388], 'shown),': [3450], 'indeed': [3454], 'blocked': [3455], 'Importantly,': [3460, 3998], 'differ': [3468], 'β-Gal-': [3471], 'LDLR-expressing': [3473], 'treated': [3475], '2B,': [3479, 3503], 'left': [3480], 'panels).': [3481, 3505], 'during': [3486], 'second': [3488], 'right': [3504], 'These': [3506, 3922, 4066, 4434], 'support': [3508], 'lack': [3510], 'An': [3533], 'Mutant': [3535], 'Defective': [3536], 'Constitutive': [3538], 'Endocytosis': [3539], 'Reduces': [3540], 'Effectively': [3544], 'Wild': [3547], 'Type—We': [3548], 'next': [3549], 'exit,': [3559], 'involving': [3562], '“JD”': [3611], '(30Davis': [3613, 3677], 'C.G.': [3614, 3678], 'Lehrman': [3615, 3679], 'M.A.': [3616, 3680], 'Russell': [3617, 3681], 'D.W.': [3618, 3682], 'Anderson': [3619, 3683], 'R.G.': [3620, 3684], '15-24Abstract': [3628, 3692], '(242)': [3634, 3698], 'has': [3638], 'critical': [3645], 'tyrosine': [3646], '(Tyr-807)': [3647], 'FDNPVY': [3650, 4133], 'sequence': [3651, 4135], 'C-terminal': [3654], 'tail.': [3655], 'peptide': [3657, 4134], 'apoB-containing': [3672, 4278], 'immortalized': [3675], '31Brown': [3701], '1976;': [3706], '9:': [3707], '663-674Abstract': [3708], '(132)': [3714], 'JD': [3721, 3738, 3786, 3814, 3822, 3869, 3927, 3941, 3978, 3988, 4024, 4051, 4078, 4089, 4098, 4222, 4283, 4349, 4379, 4423, 4442, 4479, 4509], 'steady-state': [3753], 'localization.': [3754], 'As': [3755, 4038], '1B),': [3762], '3A).': [3782, 3802], 'highly': [3789], 'enriched': [3790], 'surface': [3794, 3881, 3905], 'relatively': [3797], 'little': [3798], 'obtain': [3804], 'functional': [3806, 4027], 'readout': [3807], 'allow': [3834, 3857], 'surface.': [3840], 'warmed': [3849], 'bound': [3862], 'antibody.': [3863], 'prior': [3882], 'warming': [3884], '3B,': [3886, 3907], '0': [3887], 'min).': [3888, 3909], 'Identical': [3910], 'C7': [3916], 'monoclonal': [3917], 'shown).': [3921, 4389], 'hepatocytes.': [3936, 4265], 'hypothesized': [3938, 4346], 'would': [3943], 'be': [3944], 'partially': [3947], 'regulating': [3950, 4083], 'endocytosis.': [3958, 4111], 'hypothesis,': [3962, 4364], 'compared': [3964, 4366], 'various': [3973], 'β-Gal.': [3981], 'Surprisingly,': [3982], 'induced': [3990], 'dose-dependent': [3991], 'reductions': [3992, 4016], '4A).': [3997], 'variants': [4006], '4A,': [4008], 'inset,': [4009], 'versus': [4011], 'JD+)': [4012], 'led': [4013], 'apoB100': [4018], 'promoting': [4029], 'analysis.': [4037], '2,': [4044], 'B),': [4047], 'recovery': [4058], '4B).': [4065], 'reveal': [4068], 'Mediates': [4087], 'Reduction': [4091], 'Secretion—The': [4094], 'ability': [4095, 4289, 4439, 4476, 4506], 'independent': [4109], 'published': [4114], 'provide': [4116], 'another': [4117], 'potential': [4118], 'explanation.': [4119], 'ARH': [4120], 'LDLR-specific': [4123], 'clathrin': [4124], 'adaptor': [4125], 'binds': [4127], 'mediate': [4137], '(32He': [4140, 4227], 'G.': [4141, 4228], 'Gupta': [4142, 4229], 'Yi': [4144, 4231], '44044-44049Abstract': [4157, 4244], '(174)': [4165, 4252], '33Mishra': [4168], 'S.K.': [4169], 'Watkins': [4170], 'S.C.': [4171], 'Traub': [4172], '16099-16104Crossref': [4183], '(148)': [4186], '34Jones': [4189], 'Hammer': [4191], 'R.E.': [4192], '2003;': [4204], '278:': [4205], '29024-29030Abstract': [4206], '(78)': [4214], 'Y807C': [4218], 'disrupts': [4224], 'interaction': [4226, 4414], 'accounts': [4256], 'recent': [4267], 'lipoproteins,': [4279], 'Arh-/-': [4280], 'fibroblasts': [4285], 'maintain': [4287], 'internalize': [4291], 'therefore': [4345], 'ectopically': [4374], 'No': [4381], 'receptor-dependent': [4382], 'lowered': [4396], '5A),': [4400], 'portion': [4406], 'ineffective': [4427], '5A).': [4433], 'indicate': [4436], 'reduce': [4445], 'intact': [4452], 'particle.': [4463], 'previous': [4465], 'experiment': [4466], 'reuptake,': [4493], 'hypothesis': [4496], 'predicts,': [4497], 'b': [4516]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2085418023', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T14:43:22.771467', 'created_date': '2016-06-24'}