The Low Density Lipoprotein Receptor Prevents Secretion of Dense ApoB100-containing Lipoproteins from the Liver

Name: Work Video:
Duration: 3 min 30 s
Sofia L. Larsson; Josefin Skogsberg; Johan Björkegren
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4399, 4418, 4437, 4445, 4452, 4531, 4539, 4549, 4566, 4602, 4616, 4687, 4715, 4720, 4732, 4749, 4760, 4804, 4838, 4866, 4878, 4893, 4910, 4936, 4979, 4990, 5052, 5061, 5095, 5113, 5122, 5153, 5160, 5163, 5169, 5173, 5213, 5233, 5241, 5249, 5285, 5310, 5330, 5341, 5351, 5358, 5378, 5398, 5418, 5424, 5431, 5479, 5552, 5579, 5664, 5670, 5685, 5730, 5754, 5770, 5819, 5822, 5867, 5878, 5926, 5932, 5977, 6037, 6045, 6068, 6078, 6095, 6101], 'very': [5, 166, 192, 353, 378, 388, 3772, 4712], 'low': [6, 24, 167, 193, 211, 354, 379, 389, 401, 692, 4713, 5477], 'density': [7, 25, 194, 212, 380, 390, 402, 2317, 2970, 3138, 3180, 3200, 3251, 3290, 4136, 4150], 'lipoproteins': [8, 130, 140, 157, 195, 317, 327, 344, 381, 1587, 1603, 1955, 3022, 3925, 3970, 4005, 4187, 4200, 4257, 4690, 4771, 4982, 5124, 5503, 5555, 5980], '(VLDL)': [9, 196, 382], 'require': [10, 197, 5492], 'microsomal': [11, 198, 396], 'triglyceride': [12, 199, 397, 503, 1931, 3435, 3465, 4271], 'transfer': [13, 200, 398, 504, 2129], 'protein': [14, 201, 461, 475, 505, 2401, 5097], '(MTP).': [15, 202], 'Recent': [16, 203], 'evidence': [17, 204, 715], 'also': [18, 205, 524, 1135, 1865, 3868, 5837, 5872], 'suggests': [19, 206, 4704], 'a': [20, 79, 83, 207, 266, 270, 442, 680, 881, 1028, 1043, 1064, 1109, 1113, 1726, 1872, 1885, 1890, 1969, 2007, 2022, 2140, 2327, 2462, 2508, 2695, 2930, 3067, 3086, 3137, 3159, 3321, 3463, 3637, 3809, 4323, 4344, 4370, 4453, 4502, 4652, 4754, 4787, 5114, 5154, 5210, 5282, 5327, 5369, 5540, 5563, 5898], 'role': [21, 48, 60, 208, 235, 247, 660, 1237], 'for': [22, 158, 180, 209, 345, 367, 512, 1046, 1532, 1841, 2296, 2361, 2396, 2642, 2653, 2663, 2750, 2793, 2796, 2802, 2808, 2839, 2845, 2890, 2926, 2991, 3102, 3212, 3274, 3334, 4728, 4746, 4798, 5119, 5157, 5165, 5392, 5531, 5681, 5800, 5849, 5857, 6080, 6106], 'the': [23, 33, 39, 46, 50, 59, 64, 95, 102, 108, 175, 181, 210, 220, 226, 233, 237, 246, 251, 282, 289, 295, 362, 368, 439, 450, 456, 459, 465, 473, 482, 488, 499, 513, 664, 674, 687, 718, 723, 733, 738, 741, 747, 825, 832, 863, 870, 876, 1023, 1047, 1071, 1123, 1139, 1145, 1156, 1236, 1414, 1452, 1520, 1526, 1533, 1596, 1605, 1615, 1861, 1944, 1953, 2032, 2263, 2313, 2319, 2370, 2409, 2476, 2498, 2527, 2616, 2623, 2636, 2671, 2744, 2790, 2797, 2809, 2818, 2826, 2829, 2860, 2866, 2869, 2914, 2969, 2979, 3015, 3108, 3226, 3229, 3240, 3245, 3250, 3253, 3258, 3280, 3289, 3339, 3349, 3373, 3380, 3412, 3456, 3479, 3668, 3683, 3695, 3698, 3705, 3736, 3752, 3755, 3763, 3766, 3777, 3796, 3801, 3819, 3823, 3838, 3864, 3883, 3972, 3981, 3997, 4000, 4012, 4015, 4036, 4041, 4051, 4080, 4094, 4099, 4112, 4135, 4138, 4142, 4155, 4160, 4185, 4198, 4248, 4267, 4305, 4336, 4363, 4375, 4381, 4396, 4435, 4446, 4449, 4469, 4508, 4521, 4527, 4535, 4546, 4550, 4563, 4598, 4609, 4614, 4619, 4655, 4659, 4685, 4692, 4697, 4729, 4740, 4747, 4750, 4758, 4799, 4836, 4863, 4867, 4879, 4896, 4900, 4933, 4967, 4977, 4988, 4991, 5050, 5059, 5092, 5111, 5120, 5150, 5158, 5166, 5230, 5247, 5311, 5339, 5348, 5356, 5365, 5373, 5393, 5415, 5429, 5449, 5484, 5523, 5550, 5577, 5662, 5668, 5671, 5683, 5728, 5734, 5747, 5752, 5760, 5768, 5776, 5782, 5791, 5801, 5811, 5817, 5827, 5840, 5858, 5868, 5875, 5903, 5924, 5930, 5936, 5971, 5975, 5982, 6034, 6038, 6066, 6072, 6076, 6083, 6092, 6099, 6110], 'lipoprotein': [26, 85, 126, 213, 272, 313, 1039, 4312, 5758], '(LDL)': [27, 214, 1040], 'receptor': [28, 52, 66, 215, 239, 253, 1041, 1045, 1141, 3458, 4017, 4523, 4786, 4969, 4993, 5004, 5673, 5736, 5749, 5784, 5813, 5842, 5860, 5870, 5938, 5973, 6040], 'in': [29, 38, 67, 94, 216, 225, 254, 281, 414, 449, 663, 686, 696, 722, 746, 862, 875, 1022, 1076, 1144, 1240, 1247, 1379, 1451, 1519, 1544, 1730, 1884, 2014, 2133, 2253, 2289, 2308, 2347, 2354, 2389, 2526, 2709, 2918, 2983, 3028, 3053, 3075, 3204, 3360, 3365, 3379, 3398, 3404, 3419, 3424, 3439, 3447, 3636, 3655, 3667, 3717, 3728, 3733, 3780, 3800, 3837, 3875, 3971, 4011, 4035, 4050, 4061, 4079, 4098, 4159, 4247, 4387, 4404, 4408, 4434, 4486, 4504, 4568, 4608, 4618, 4658, 4843, 4895, 5058, 5294, 5408, 5459, 5481, 5487, 5504, 5522, 5556, 5667, 5790, 5826, 5902, 5987, 6000, 6047, 6056, 6104], 'this': [30, 217, 854, 1623, 4044, 4702, 4785, 4851, 4874, 4887, 5003, 5145, 5295, 5807], 'process.': [31, 218], 'However,': [32, 219, 1539, 3993, 4448, 4850, 5558], 'relative': [34, 221, 4564, 5098], 'importance': [35, 222], 'MTP': [37, 62, 170, 224, 249, 357, 607, 662, 688, 721, 753, 829, 1239, 1245, 1370, 1529, 2132, 3647, 3870, 3873, 4721, 4743, 4894, 4929, 4938, 4957, 5063, 5174, 5224, 5242, 5317, 5342, 5359, 5363, 5382, 5406, 5587, 5824], 'two': [40, 227, 415, 2286, 2910, 3734, 4320], 'steps': [41, 228, 418], 'VLDL': [43, 68, 185, 230, 255, 372, 517, 727, 836, 883, 1015, 1030, 1051, 1147, 1154, 1241, 1518, 1537, 3246, 4292, 4733, 4756, 4762, 4945, 5352, 5419, 5488, 5731, 5742, 5835, 6001], 'specific': [47, 234], 'LDL': [51, 65, 133, 149, 238, 252, 320, 336, 1066, 1075, 1119, 1127, 1140, 1619, 3232, 3248, 3457, 3471, 4016, 4249, 4268, 4306, 4522, 4536, 4551, 4599, 4698, 4782, 4968, 4992, 5008, 5217, 5250, 5289, 5517, 5672, 5677, 5716, 5735, 5748, 5783, 5812, 5841, 5859, 5869, 5937, 5972, 6039], 'still': [53, 240, 3986], 'remain': [54, 241], 'unclear.': [55, 242], 'To': [56, 243, 1621, 3793, 4544], 'further': [57, 244, 671, 1018], 'investigate': [58, 245, 4301, 4545], 'assembly,': [69, 256, 728], 'we': [70, 257, 1625, 3867, 4023, 4318, 4500, 4554], 'bred': [71, 258, 1667, 1773], 'mice': [72, 90, 113, 259, 277, 300, 1380, 1512, 1584, 1611, 1637, 1699, 1776, 1805, 1824, 1855, 1859, 1870, 1920, 2539, 2613, 3307, 3331, 3383, 3401, 3407, 3422, 3427, 3445, 3688, 3720, 3740, 3785, 3806, 3847, 3859, 3985, 4195, 4263], 'harboring': [73, 260], '"floxed"': [74, 261], 'Mttp': [75, 262, 1378, 1449, 1609, 1635, 1728, 1735, 1846, 3347, 3643, 3815, 3827, 3834, 4922, 5439, 5460, 5525], 'alleles': [76, 263], '(Mttpflox/flox)': [77, 264], 'Cre': [80, 267, 1862], 'transgene': [81, 268, 1863], 'on': [82, 269, 1968, 2702, 3066, 4907, 6082], 'low-density': [84, 271, 1038], 'receptor-deficient': [86, 273, 5218, 5290, 5717], 'background': [87, 274, 1672, 1875], 'to': [88, 101, 173, 275, 288, 360, 498, 509, 526, 610, 830, 879, 1026, 1070, 1112, 1444, 1515, 1614, 1800, 1844, 2031, 2326, 2748, 2893, 2973, 3094, 3220, 3263, 3270, 3278, 3297, 3517, 3535, 3545, 3559, 3573, 3589, 3603, 3612, 3619, 3774, 3818, 3994, 4058, 4149, 4153, 4426, 4605, 4654, 4725, 4942, 4949, 5002, 5017, 5099, 5105, 5178, 5246, 5413, 5427, 5559, 5575, 5803, 5845, 5883, 5886, 5923, 5993], 'generate': [89, 276, 1801], 'with': [91, 278, 470, 678, 869, 1020, 1103, 1108, 1151, 1525, 1774, 1827, 1867, 1889, 1912, 1935, 2006, 2082, 2262, 2324, 2335, 2380, 2461, 2481, 2507, 2626, 2648, 2658, 2676, 2763, 2789, 2823, 2834, 2873, 2877, 2906, 2960, 2976, 3080, 3266, 3469, 3856, 4111, 4266, 4739, 4840, 4859, 4890, 4962, 5222, 5237, 5302, 5321, 5344, 5386, 5448, 5549, 5773, 6109], 'double': [92, 279], 'deficiency': [93, 280, 1371], 'liver': [96, 283, 1157, 1453, 2251, 2649, 2659, 3431, 3839, 4693, 5802], '(Ldlr–/–': [97, 284, 4638, 4671], 'MttpΔ/Δ).': [98, 285, 1851, 4973], 'In': [99, 160, 286, 347, 455, 818, 853, 1366, 2244, 2611, 2851, 2865, 3410, 3747, 3769, 4092, 4283, 4394, 4424, 4648, 4700, 4735, 4884, 4931, 4953, 5538, 5744, 5762, 5816], 'contrast': [100, 287, 3770, 4425], 'plasma': [103, 109, 290, 296, 697, 1077, 1130, 1627, 1928, 1954, 1961, 2437, 2965, 3350, 3361, 3374, 3392, 3650, 3669, 3684, 3707, 3781, 3802, 3973, 4280, 5888], 'Ldlr+/+': [105, 121, 292, 308, 1807, 1821, 1857, 2534, 3311, 3369, 3405, 3425, 3440, 3518, 3613, 3656, 3659, 3671, 3718, 3738, 3845, 3893, 4083, 4315, 4391, 4409, 4427, 4459, 4495, 4623, 4897], 'MttpΔ/Δ': [106, 112, 118, 122, 293, 299, 305, 309, 1848, 3309, 3315, 3367, 3370, 3382, 3400, 3406, 3421, 3426, 3441, 3444, 3486, 3494, 3657, 3672, 3687, 3739, 3784, 3805, 3843, 3846, 3876, 3891, 3894, 3976, 4066, 4084, 4103, 4194, 4203, 4262, 4286, 4316, 4389, 4392, 4406, 4410, 4428, 4439, 4460, 4463, 4493, 4496, 4624, 4627, 4898, 4902, 4916, 4984], 'mice,': [107, 294, 3371, 3661, 3673, 3977, 5527], 'Ldlr–/–': [111, 117, 298, 304, 1775, 1802, 1817, 1850, 1853, 2531, 3314, 3317, 3366, 3381, 3399, 3420, 3443, 3686, 3729, 3783, 3804, 3842, 3890, 3975, 4065, 4102, 4115, 4193, 4261, 4285, 4388, 4405, 4438, 4462, 4492, 4626, 4901, 4915], 'contained': [114, 301, 3689], 'apoB100.': [115, 302, 1592, 5379, 5399, 5688], 'Accordingly,': [116, 303], 'but': [119, 137, 178, 306, 324, 365, 1590, 3372, 3402], 'not': [120, 307, 477, 1591, 3403, 3808, 3861, 3887, 4289, 4512, 4525, 4723, 4871, 4960, 4995, 5000, 5143, 5176, 5491, 5566], 'hepatocytes': [123, 310, 1253, 1581, 2135, 2584, 2672, 2687, 2759, 2915, 3877, 3895, 4032, 4067, 4085, 4104, 4117, 4146, 4191, 4205, 4259, 4287, 4411, 4440, 4464, 4628, 4917, 5014, 5057, 5219, 5434, 5718, 5725, 5772], 'secreted': [124, 129, 311, 316, 1585, 4139, 4188, 4201], 'apoB100-containing': [125, 156, 312, 343, 1602, 3924, 3969, 3991, 4004, 4140, 4186, 4311, 4689, 4770, 5502, 5554, 5979], 'particles.': [127, 314], 'were': [131, 318, 1513, 1772, 1825, 1864, 1882, 1896, 1908, 1921, 1933, 2004, 2073, 2159, 2248, 2304, 2352, 2367, 2406, 2451, 2459, 2540, 2585, 2614, 2646, 2668, 2673, 2746, 2760, 2787, 2820, 2831, 2856, 2875, 2916, 3051, 3073, 3292, 3319, 3332, 3437, 3653, 3987, 4033, 4483, 4776, 5015], 'HDL': [135, 322, 3018, 3135, 3281, 4164, 4237], 'sizes': [136, 323], 'no': [138, 325, 3851, 4484, 5797], 'VLDL-sized': [139, 326, 5862], 'could': [141, 328, 4499, 5367, 5384, 5402, 5871], 'be': [142, 329, 493, 510, 1017, 1035, 4059, 4235, 4726, 4793, 5179, 5244, 5403, 5423, 5536, 5573, 5994], 'detected.': [143, 330], 'These': [144, 331, 1511, 5891], 'findings': [145, 332], 'indicate': [146, 333, 731, 5780], 'that': [147, 165, 334, 352, 676, 732, 1032, 1121, 1138, 1528, 1579, 1595, 3704, 3795, 3980, 3999, 4184, 4519, 4684, 4705, 4742, 4768, 4772, 4791, 4976, 5229, 5298, 5313, 5338, 5371, 5389, 5404, 5435, 5511, 5519, 5585, 5661, 5675, 5715, 5727, 5781, 5794, 5880, 5970], 'hepatic': [148, 335, 375, 1118, 1146, 1618, 2441, 3434, 3826, 4556, 4706, 4781, 5116, 5516, 5676, 5823, 6043], 'receptors': [150, 337, 1120, 3472, 4783, 5518, 5678], 'function': [151, 338, 4790, 5809, 5866, 6036], 'as': [152, 339, 2034, 2091, 2161, 2547, 2590, 2967, 3119, 3283, 3299, 3674, 4611, 4862, 5319, 5521], '"gatekeepers"': [153, 340], 'targeting': [154, 341, 1447, 4853, 5329], 'dense': [155, 342, 2944, 3021, 4310, 4688, 4769, 5553, 5755, 5978, 5989], 'degradation.': [159, 346, 5010], 'addition,': [161, 348, 3411, 4701, 4954, 5763], 'these': [162, 349, 605, 1547, 1583, 3750, 3984, 4003, 4516, 4569, 5108, 5495, 5512, 5786, 5852], 'results': [163, 350, 4517, 5141], 'suggest': [164, 351, 4518], 'levels': [168, 355, 693, 751, 2525, 3652, 4365, 4615, 4714, 4719, 5172, 5478, 5821], 'are': [171, 358, 5390, 5679, 5838, 5881], 'insufficient': [172, 359, 4941], 'mediate': [174, 361], 'second': [176, 363, 500, 833, 1534], 'step': [177, 183, 364, 370, 436, 515, 725, 834, 1535, 4731, 5168, 5350, 5417, 5486, 5901], 'sufficient': [179, 366, 5412], 'first': [182, 369, 435, 514, 724, 2322, 4730, 5167, 5349, 5416, 5485], 'assembly.': [186, 373, 1538, 4734, 5420], '1The': [383], 'abbreviations': [384], 'used': [385, 1244, 1443, 3333, 5315, 5326, 5574], 'are:': [386], 'VLDL,': [387, 3132, 4161], 'lipoproteins;': [391], 'ER,': [392, 458, 2442, 4610], 'endoplasmic': [393, 452], 'reticulum;': [394], 'MTP,': [395, 5493], 'protein;': [399], 'LDL,': [400, 3133, 4162], 'lipoprotein;': [403], 'pI-pC,': [404], 'polyinosinic-polycytidylic': [405, 1831], 'ribonucleic': [406, 1832], 'acid;': [407], 'PBS,': [408], 'phosphate-buffered': [409, 2764], 'saline.': [410], 'is': [411, 462, 476, 486, 507, 608, 670, 821, 860, 1042, 1060, 1142, 1381, 1523, 1530, 1612, 1736, 4264, 4694, 4744, 4870, 4888, 4994, 5306, 5333, 5445, 5455, 5510, 5796, 5843, 5991], 'usually': [412], 'described': [413, 2092, 2162, 2548, 2591, 3120, 3284, 3300], 'well': [416], 'defined': [417], '(1.Shelness': [419, 754, 838, 1254], 'G.S.': [420, 755, 839, 1255, 1351, 5644], 'Sellers': [421, 756, 840, 1256], 'J.A.': [422, 757, 841, 1257, 1349, 5642], 'Curr.': [423, 621, 702, 758, 842, 1258, 5465], 'Opin.': [424, 622, 703, 759, 843, 1259, 5466], 'Lipidol.': [425, 623, 704, 760, 844, 1260, 5467], '2001;': [426, 761, 845, 1261, 1355, 2568, 5648], '12:': [427, 762, 846, 1262], '151-157Crossref': [428, 763, 847, 1263], 'PubMed': [429, 538, 580, 599, 627, 653, 708, 764, 786, 813, 848, 907, 936, 962, 984, 1008, 1092, 1169, 1189, 1210, 1228, 1264, 1286, 1316, 1343, 1363, 1408, 1437, 1478, 1506, 1573, 1662, 1691, 1720, 1765, 1795, 1995, 2067, 2122, 2177, 2203, 2239, 2430, 2576, 2608, 3005, 3045, 3196, 3963, 4179, 4230, 4593, 4830, 5044, 5086, 5135, 5202, 5275, 5471, 5609, 5636, 5656, 5710, 5918, 5961, 6029], 'Scopus': [430, 539, 581, 600, 628, 654, 709, 765, 814, 849, 908, 937, 963, 985, 1009, 1093, 1170, 1229, 1265, 1287, 1344, 1409, 1438, 1479, 1507, 1574, 1663, 1692, 1721, 1766, 1796, 1996, 2068, 2123, 2204, 2240, 2577, 3006, 4231, 4594, 4831, 5045, 5087, 5136, 5203, 5276, 5472, 5637, 5962, 6030], '(235)': [431, 766, 850, 1266], 'Google': [432, 541, 583, 602, 630, 656, 711, 767, 787, 816, 851, 910, 939, 965, 987, 1011, 1095, 1172, 1190, 1211, 1231, 1267, 1289, 1317, 1346, 1364, 1411, 1440, 1481, 1509, 1576, 1665, 1694, 1723, 1768, 1798, 1998, 2070, 2125, 2178, 2206, 2242, 2431, 2579, 2609, 3008, 3046, 3197, 3964, 4180, 4233, 4596, 4833, 5047, 5089, 5138, 5205, 5278, 5474, 5610, 5639, 5657, 5711, 5919, 5964, 6032], 'Scholar).': [433, 603, 657, 712, 817, 852, 1012, 1096, 1232, 1365, 1412, 1510, 1695, 1999, 2071, 2126, 2243, 2432, 2580, 2610, 3009, 3047, 3198, 3965, 4181, 5090, 5139, 5658, 5920, 5965], 'consists': [437], 'formation': [440, 665, 739], 'small': [443, 1601, 5988], 'pre-VLDL': [444, 742, 4751], 'particle': [445, 491, 743, 859, 873, 884, 1031, 4752], 'takes': [447], 'place': [448], 'rough': [451, 457, 877], 'reticulum': [453], '(ER).': [454], 'apoB': [460, 474, 527, 618, 669, 695, 736, 2457, 2468, 4047, 4158, 5580, 5722], 'translated': [463], 'across': [464], 'membrane': [466], 'becomes': [468], 'enriched': [469, 1019], 'lipids.': [471], 'If': [472, 5483], 'properly': [478], 'folded': [479], 'or': [480, 1251, 1291, 2844, 2955, 4473, 4489, 5396], 'if': [481], 'enrichment': [483], 'lipids': [485, 522, 1021, 1951, 2077], 'insufficient,': [487], 'apoB-containing': [489, 871], 'precursor': [490, 872], 'will': [492, 1016, 1033, 4882], 'degraded': [494], 'instead': [495], 'proceeding': [497], 'step.': [501], 'Microsomal': [502], '(MTP)': [506], 'believed': [508, 609, 5992], 'crucial': [511, 5680], 'because': [519, 1375, 4997, 5309, 5851], 'it': [520], 'transfers': [521], 'binds': [525], '(2.Hussain': [528], 'M.M.': [529, 594, 792, 915, 1393, 1457, 1552, 1641, 1744, 2041, 2096, 2597, 4209, 5023, 6004], 'Bakillah': [530], 'A.': [531, 586, 1197, 1270, 1339, 1404, 1991, 2349, 3035, 3186, 4169, 4580, 4589, 5070, 5186, 5259, 5632, 5697, 5908, 5957, 6012], 'Jamil': [532, 943, 1321, 5127, 5614], 'H.': [533, 944, 1082, 1159, 1322, 1420, 1703, 4813, 5128, 5615], 'Biochemistry.': [534, 595], '1997;': [535, 624], '36:': [536], '13060-13067Crossref': [537], '(53)': [540, 601], 'Scholar,': [542, 584, 631, 768, 788, 911, 940, 966, 988, 1173, 1191, 1212, 1268, 1318, 1347, 1482, 2179, 2207, 5611, 5640], '3.Bradbury': [543], 'P.': [544, 635, 889, 2185, 2599, 6010], 'Mann': [545], 'C.J.': [546], 'Kochl': [547], 'S.': [548, 633, 887, 1272, 1338, 1403, 1674, 1778, 1990, 2211, 4588, 5072, 5188, 5261, 5631, 5956], 'Anderson': [549], 'T.A.': [550], 'Chester': [551], 'S.A.': [552], 'Hancock': [553], 'J.M.': [554, 1296, 3927, 5589], 'Ritchie': [555], 'P.J.': [556], 'Amey': [557], 'J.': [558, 566, 569, 642, 775, 798, 807, 896, 921, 930, 950, 951, 973, 997, 1180, 1193, 1204, 1275, 1304, 1307, 1332, 1352, 1428, 1431, 1463, 1472, 1495, 1558, 1567, 1647, 1656, 1684, 1685, 1711, 1714, 1750, 1759, 1788, 1789, 2049, 2056, 2104, 2111, 2192, 2228, 2421, 2550, 2565, 2602, 2999, 3036, 3187, 3954, 4170, 4215, 4224, 4821, 4824, 5029, 5038, 5075, 5191, 5264, 5597, 5600, 5625, 5645, 5693, 5704, 5909, 6023], 'Harrison': [559], 'G.B.': [560], 'Levitt': [561], 'D.G.': [562], 'Banaszak': [563], 'L.J.': [564], 'Scott': [565, 1303, 5596], 'Shoulders': [567, 1305, 2216, 5598], 'C.C.': [568, 1306, 5599], 'Biol.': [570, 643, 897, 952, 974, 998, 1181, 1224, 1276, 1308, 1496, 2057, 2112, 2193, 2229, 2422, 2566, 5076, 5192, 5265, 5601], 'Chem.': [571, 644, 898, 953, 975, 999, 1182, 1277, 1309, 1497, 2058, 2113, 2194, 2230, 2423, 2567, 5077, 5193, 5266, 5602], '1999;': [572, 778, 810, 933, 976, 1475, 1498, 1570, 1659, 1762, 2195, 4227, 5041], '274:': [573, 977, 1499, 2196], '3159-3164Abstract': [574], 'Full': [575, 577, 648, 650, 781, 783, 902, 904, 957, 959, 979, 981, 1003, 1005, 1087, 1089, 1164, 1166, 1186, 1281, 1283, 1313, 1358, 1360, 1501, 1503, 2062, 2064, 2117, 2119, 2198, 2200, 2234, 2236, 2427, 2571, 2573, 3042, 3193, 3960, 4176, 5081, 5083, 5197, 5199, 5270, 5272, 5606, 5651, 5653, 5915], 'Text': [576, 578, 649, 651, 782, 784, 903, 905, 958, 960, 980, 982, 1004, 1006, 1088, 1090, 1165, 1167, 1187, 1282, 1284, 1314, 1359, 1361, 1502, 1504, 2063, 2065, 2118, 2120, 2199, 2201, 2235, 2237, 2428, 2572, 2574, 3043, 3194, 3961, 4177, 5082, 5084, 5198, 5200, 5271, 5273, 5607, 5652, 5654, 5916], 'PDF': [579, 652, 785, 906, 961, 983, 1007, 1091, 1168, 1188, 1285, 1315, 1362, 1505, 2066, 2121, 2202, 2238, 2429, 2575, 3044, 3195, 3962, 4178, 5085, 5201, 5274, 5608, 5655, 5917], '(85)': [582], '4.Bakillah': [585], 'Nayak': [587], 'N.': [588, 774], 'Saxena': [589], 'U.': [590, 1337, 1402, 1989, 4587, 5630, 5955], 'Medford': [591], 'R.M.': [592], 'Hussain': [593], '2000;': [596, 1207, 2059, 2114, 5132, 5707, 6026], '39:': [597], '4892-4899Crossref': [598], 'Through': [604], 'actions,': [606], 'avoid': [611], 'improper': [612], 'folding': [613, 5375, 5395], 'premature': [615, 1079], 'degradation': [616, 4538, 4601, 4775, 5532, 5684], '(5.Gordon': [619], 'D.A.': [620, 942, 1320, 5126, 5613], '8:': [625], '131-137Crossref': [626], '(81)': [629], '6.Rustaeus': [632], 'Stillemark': [634, 888], 'Lindberg': [636, 890], 'K.': [637, 891, 970, 1418, 1701, 2183, 2998, 3948, 4811], 'Gordon': [638, 892], 'D.': [639, 893, 1324, 1326, 1492, 2215, 3938, 5617, 5619], 'Olofsson': [640, 894, 947, 6064], 'S.O.': [641, 895, 948], '1998;': [645, 899, 1405, 2605], '273:': [646, 900], '5196-5203Abstract': [647, 901], '(110)': [655, 909], 'A': [658, 2255, 2310, 5569, 5864, 5896], 'vital': [659], 'supported': [672], 'by': [673, 684, 1063, 1149, 1738, 1910, 1958, 2078, 2088, 2138, 2285, 2385, 2408, 2453, 2505, 2542, 2690, 3117, 3676, 3701, 3831, 3850, 4008, 4020, 4088, 4108, 4131, 4189, 4202, 4258, 4274, 4328, 4348, 4362, 4613, 4696, 4778, 4983, 5457, 5733, 5810, 5829, 5928], 'fact': [675, 4767, 4975, 5312, 5660], 'patients': [677, 5496, 5513], 'abetalipoproteinemia,': [679, 5453], 'dominant': [681, 5451], 'disorder': [682, 1057, 5452], 'caused': [683, 1062, 4007, 5456], 'mutations': [685, 5458], 'gene': [689, 4869, 4881], '(Mttp),': [690], 'have': [691, 1243, 1372, 5476, 5497, 5514, 5854], '(7.Gregg': [698, 5461], 'R.E.': [699, 946, 1330, 1682, 1786, 2191, 3950, 5462, 5623], 'Wetterau': [700, 1331, 5463, 5624], 'J.R.': [701, 5464], '1994;': [705, 1310, 1340, 3039, 3190, 4173, 5468, 5603, 5633], '5:': [706, 3003, 5469], '81-86Crossref': [707, 5470], '(119)': [710, 5473], 'Although': [713, 5091], 'most': [714, 5307], 'points': [716], 'toward': [717], 'necessity': [719, 826], 'some': [729], 'studies': [730, 1234, 1368, 1542, 1548, 5109], 'translation': [734], 'can': [744, 4709, 5535, 5572], 'occur': [745, 4606, 4710], 'absence': [748, 1597, 3820, 4013, 5357, 5578, 5669], 'normal': [750, 4718, 5171, 5820], '8.Segrest': [769], 'J.P.': [770], 'Jones': [771], 'M.K.': [772, 2053, 2108, 2560, 6016], 'Dashti': [773], 'Lipid': [776, 1353, 1918, 3037, 3188, 3955, 4171, 5646, 5910], 'Res.': [777, 1354, 3038, 3189, 3956, 4172, 5647, 5911], '40:': [779], '1401-1416Abstract': [780], '9.Raabe': [789, 912], 'M.': [790, 913, 990, 1385, 1455, 1490, 1550, 1639, 1742, 2047, 2102, 2172, 2227, 2552, 4207, 5021], 'Veniant': [791, 914, 1392, 1456, 1551, 1640, 1743, 2040, 2095, 2551, 2596, 4208, 5022], 'Sullivan': [793, 916, 1458, 1553, 1642, 1745, 4210, 5024, 6005], 'M.A.': [794, 917, 1459, 1554, 1643, 1746, 4211, 5025, 6006], 'Zlot': [795, 918, 1388, 1460, 1555, 1644, 1747, 2044, 2099, 4212, 5026], 'C.H.': [796, 919, 1389, 1461, 1556, 1645, 1748, 2045, 2100, 4213, 5027], 'Bjorkegren': [797, 920, 1462, 1557, 1646, 1749, 2048, 2103, 4214, 5028], 'Nielsen': [799, 922, 1464, 1559, 1648, 1751, 4216, 5030], 'L.B.': [800, 923, 1465, 1560, 1649, 1752, 4217, 5031], 'Wong': [801, 924, 1390, 1466, 1561, 1650, 1753, 4218, 5032], 'J.S.': [802, 925, 992, 1214, 1391, 1467, 1562, 1651, 1754, 4219, 5033], 'Hamilton': [803, 926, 1394, 1468, 1563, 1652, 1755, 4220, 5034], 'R.L.': [804, 927, 1395, 1469, 1564, 1653, 1756, 4221, 5035, 6020], 'Young': [805, 928, 1396, 1470, 1565, 1654, 1757, 1983, 2054, 2109, 2563, 2600, 4222, 5036, 6021, 6090], 'S.G.': [806, 929, 1397, 1471, 1566, 1655, 1758, 1984, 2055, 2110, 2564, 2601, 4223, 5037, 6022], 'Clin.': [808, 931, 1205, 1432, 1473, 1568, 1657, 1686, 1715, 1760, 1790, 2603, 3000, 4225, 4825, 5039, 5705, 6024], 'Invest.': [809, 932, 1206, 1433, 1474, 1569, 1658, 1687, 1716, 1761, 1791, 2604, 4226, 4826, 5040, 5706, 6025], '103:': [811, 934, 1476, 1571, 1660, 1763, 4228, 5042], '1287-1298Crossref': [812, 935, 1477, 1572, 1661, 1764, 4229, 5043], '(362)': [815, 938, 1480, 1575, 1664, 1767, 4232, 5046], 'contrast,': [819, 4093, 4284, 4395, 4649, 4736, 4932], 'there': [820, 4650, 5795], 'less': [822, 2943, 3020, 3460, 3759, 3812, 3879, 4925, 6057], 'controversy': [823], 'over': [824], 'functional': [828], 'fulfill': [831], 'step,': [855], 'an': [856, 1669, 2035, 2386, 2627, 2984, 3205, 3275, 3395, 3743, 4241, 4794, 5062, 5223, 5303, 5316, 5345, 5381], 'apoB-free': [857], 'lipid': [858, 2128], 'synthesized': [861, 874, 5687], 'smooth': [864], 'ER': [865, 878, 2150, 2155, 2246, 4557, 4620], '(MTP-dependent)': [866], 'fuses': [868], 'form': [880, 1027, 1516, 5368], 'nascent': [882, 1014], '(MTP-independent)': [885], '(6.Rustaeus': [886], '10.Gordon': [941], 'Gregg': [945, 1329, 3949, 5622], 'Boren': [949], '1996;': [954, 1434, 1717, 2174, 4827], '271:': [955], '33047-33053Abstract': [956], '(143)': [964], '11.Wang': [967], 'Y.': [968, 2187], 'Tran': [969], 'Yao': [971, 1327, 5620], 'Z.': [972, 1328, 5621], '27793-27800Abstract': [978], '(117)': [986], '12.Pan': [989], 'Liang': [991], 'Fisher': [993, 1178], 'E.A.': [994, 1179], 'Ginsberg': [995], 'H.N.': [996], '2002;': [1000, 1084, 1161, 1225, 1278, 2231, 4590, 5078, 5194, 5267], '277:': [1001, 1279, 2232, 5079, 5195, 5268], '4413-4421Abstract': [1002], '(49)': [1010], 'Golgi': [1024, 2152, 2157, 2302, 2365, 2444, 4559, 4660], 'apparatus': [1025], 'buoyant': [1029, 1517, 4755, 4761, 5834], 'eventually': [1034], 'secreted.': [1036, 5537], 'key': [1044], 'endocytosis': [1048], 'circulating': [1050, 5498], 'LDL.': [1053], 'dominantly': [1055], 'inherited': [1056], 'familial': [1058, 5544], 'hypercholesterolemia': [1059, 5545], 'primarily': [1061, 1117], 'dysfunctional': [1065], 'receptor,': [1067], 'which': [1068, 1522, 1731, 5170, 5325, 5454], 'leads': [1069, 1111], 'accumulation': [1072, 4010], 'cholesterol-rich': [1074, 1126], 'atherosclerosis': [1080], '(13.Schuster': [1081, 1158], 'Atherosclerosis.': [1083, 1160], '2:': [1085, 1162], '27-30Abstract': [1086, 1163], '(9)': [1094, 1171], 'inhibition': [1098, 5240], 'intracellular': [1100, 4364, 4397, 4780], 'cholesterol': [1101, 1131, 1929, 3353, 3375, 3393, 4269, 5889, 5904, 5927, 5985, 5998, 6046, 6054], 'synthesis': [1102, 4708, 4946], '3-hydroxy-3-methylglutaryl-CoA': [1104], 'reductase': [1105], 'inhibitors': [1106, 1246, 2855, 2925], '(e.g.': [1107], 'statins)': [1110], 'compensatory': [1114], 'up-regulation': [1115], 'increases': [1122], 'uptake': [1124], 'particles,': [1128, 5806], 'lowering': [1129], 'levels.': [1132, 5890], 'It': [1133, 5332, 5421], 'has': [1134, 4855, 5565], 'been': [1136, 1373, 2863, 5567], 'suggested': [1137], 'involved': [1143], 'interfering': [1150], 'from': [1155, 1582, 1604, 1915, 1965, 2075, 2250, 2281, 2306, 2312, 2369, 2741, 2936, 3127, 3239, 3915, 4027, 4192, 4260, 4314, 4458, 4507, 4622, 4691, 4914, 5055, 5216, 5288, 5433, 5582, 5759, 5981], '14.Williams': [1174], 'K.J.': [1175], 'Brocia': [1176], 'R.W.': [1177], '1990;': [1183, 3957], '265:': [1184], '16741-16744Abstract': [1185], '15.Twisk': [1192], 'Gillian-Daniel': [1194, 5694], 'D.L.': [1195, 2181, 4576, 5695], 'Tebon': [1196, 4579, 5696], 'Wang': [1198, 5698], 'L.': [1199, 1488, 1494, 5699], 'Barrett': [1200, 5700], 'P.H.': [1201, 5701], 'Attie': [1202, 4581, 5702], 'A.D.': [1203, 4582, 5703], '105:': [1208, 5708], '521-532Crossref': [1209, 5709], '16.Millar': [1213], 'Maugeais': [1215], 'C.': [1216, 2166, 2217, 2219], 'Fuki': [1217], 'I.V.': [1218], 'Rader': [1219], 'D.J.': [1220, 1302, 5595], 'Arterioscler.': [1221], 'Thromb.': [1222], 'Vasc.': [1223], '22:': [1226], '989-994Crossref': [1227], '(38)': [1230], 'Most': [1233], 'cultures': [1248], 'immortalized': [1250], 'primary': [1252, 1580, 2134, 2477, 4029, 4145, 4190, 4204, 5056, 5771], '17.Kulinski': [1269], 'Rustaeus': [1271, 5071, 5187, 5260], 'Vance': [1273, 5073, 5189, 5262], 'J.E.': [1274, 5074, 5190, 5263], '31516-31525Abstract': [1280, 5080, 5196, 5269], '(127)': [1288, 5088, 5204, 5277], 'Scholar)': [1290, 1441, 1577, 1666, 1724, 1769, 1799, 4834, 5206, 5279, 5712], 'MTP-negative': [1292], 'cells': [1293, 2699, 2745, 2786, 2819, 2830, 2870, 3918], 'lines': [1294, 5584], '(18.Leiper': [1295, 5588], 'Bayliss': [1297, 5590], 'J.D.': [1298, 5591], 'Pease': [1299, 5592], 'R.J.': [1300, 2420, 5593], 'Brett': [1301, 5594], '269:': [1311, 5604], '21951-21954Abstract': [1312, 5605], '19.Gordon': [1319, 5612], 'Sharp': [1323, 5616], 'Mullaney': [1325, 5618], 'Proc.': [1333, 1398, 1985, 4583, 5626, 5951], 'Natl.': [1334, 1399, 1986, 4584, 5627, 5952], 'Acad.': [1335, 1400, 1987, 4585, 5628, 5953], 'Sci.': [1336, 1401, 1988, 4586, 5629, 5954], '91:': [1341, 5634], '7628-7632Crossref': [1342, 5635], '(189)': [1345, 5638], '20.Sellers': [1348, 5641], 'Shelness': [1350, 5643], '42:': [1356, 5649], '1897-1904Abstract': [1357, 5650], 'vivo': [1367], 'hampered': [1374], 'inactivation': [1376], 'embryonically': [1382], 'lethal': [1383], '(21.Raabe': [1384], 'Flynn': [1386, 1979], 'L.M.': [1387, 1980], '95:': [1406], '8686-8691Crossref': [1407], '(223)': [1410], 'Recently,': [1413], 'loxP': [1415, 1739], 'system': [1416, 4809], '(22.Rajewsky': [1417, 1700, 4810], 'Gu': [1419, 1702, 4812], 'Kuhn': [1421, 1704, 4814], 'R.': [1422, 1705, 2189, 4815], 'Betz': [1423, 1706, 4816], 'U.A.': [1424, 1707, 4817], 'Muller': [1425, 1708, 4818], 'W.': [1426, 1486, 1709, 4819], 'Roes': [1427, 1710, 4820], 'Schwenk': [1429, 1712, 4822], 'F.': [1430, 1713, 3033, 3184, 4167, 4823], '98:': [1435, 1718, 4828], '600-603Crossref': [1436, 1719, 4829], '(244)': [1439, 1722, 4832], 'was': [1442, 1956, 2029, 2136, 2321, 2479, 2503, 2620, 2639, 2688, 2700, 2783, 2815, 2902, 2958, 2971, 2981, 3023, 3064, 3115, 3153, 3202, 3261, 3363, 3377, 3415, 3664, 3710, 3742, 3758, 3786, 3807, 3829, 3848, 3878, 4006, 4048, 4086, 4105, 4147, 4432, 4456, 4651, 4764, 4940, 4959, 4970, 5065, 5411], 'create': [1445], 'conditional': [1446, 1727, 4852, 5328], 'specifically': [1450], '(9.Raabe': [1454, 1549, 1638, 1741, 4206, 5020], '23.Chang': [1483], 'B.H.-J.': [1484], 'Liao': [1485], 'Li': [1487], 'Nakamuta': [1489], 'Mack': [1491], 'Chan': [1493], '6051-6055Abstract': [1500], '(118)': [1508], 'unable': [1514], 'liver,': [1521], 'consistent': [1524, 4265, 4738, 4889, 4961], 'idea': [1527], 'necessary': [1531], 'metabolic': [1540], 'labeling': [1541, 2791, 2799, 2813], 'performed': [1543, 4319], 'one': [1545], 'showed': [1578, 3703, 5714], 'HDL-sized': [1586, 2941, 4980, 5501], 'containing': [1588, 1725, 1900, 2720, 2773, 2879, 2900, 2923, 2953, 3017, 3059, 5757], 'apoB48': [1589, 2499, 3112, 3651, 3699, 3767, 4056, 4487, 4998, 5019, 5053, 5096], 'We': [1593, 4182, 4904, 6060], 'hypothesized': [1594], 'livers': [1606, 2528, 2645, 2667, 3454, 3468, 3982, 4985], 'liver-specific': [1608, 1634, 3344, 5012, 5524], 'knockout': [1610, 1636, 5526], 'due': [1613], 'presence': [1616, 3797, 3967, 4001, 4037, 4989, 5060, 5248, 5340, 5551, 5818], 'receptors.': [1620, 4699, 5251], 'test': [1622], 'hypothesis,': [1624], 'conducted': [1626], 'lipid,': [1628], 'lipoprotein,': [1629], 'metabolic-labeling': [1631], 'analyses': [1632], 'onto': [1668, 3155], 'Ldlr-deficient': [1670], '(Ldlr–/–)': [1671], '(24.Ishibashi': [1673, 1777], 'Brown': [1675, 1779, 5949], 'M.S.': [1676, 1780, 3936, 5950], 'Goldstein': [1677, 1781, 5947], 'J.L.': [1678, 1782, 5948], 'Gerard': [1679, 1783], 'R.D.': [1680, 1784], 'Hammer': [1681, 1785], 'Herz': [1683, 1787], '1993;': [1688, 1792], '92:': [1689, 1793, 1993], '883-893Crossref': [1690, 1794], '(1281)': [1693, 1797], 'Mouse': [1696], 'Models—Mx1-Cre': [1697], 'transgenic': [1698], 'allele': [1729], 'exon': [1732], '1': [1733, 2275, 2768, 2919, 3173], 'flanked': [1737], 'sites': [1740], '(Mttpflox/flox': [1770], 'Mx1-Cre)': [1771], 'Mttpflox/flox': [1803, 1808, 1818, 1822, 1854, 1858, 2532, 2535, 2538, 3448, 3482, 3490, 3660, 3719, 3730, 3858, 4116], 'Mx1-Cre': [1804, 1809, 1819, 1823], 'mice.': [1810, 3731, 4903, 6113], 'At': [1811], '21–28': [1812], 'days': [1813, 1843], 'age,': [1815], 'male': [1816], 'injected': [1826, 1866], '500': [1828], 'μl': [1829, 1963, 2775, 3055, 3063], 'acid': [1833, 2027, 3077], '(pI-pC)': [1834], '(1': [1835], 'μg/μl,': [1836], 'Sigma)': [1837, 1940], 'every': [1838], 'other': [1839, 2076, 5387], 'day': [1840], '8': [1842], 'delete': [1845], '(Ldlr+/+': [1847, 3308, 4632, 4665, 4972], 'Littermate': [1852], 'lacking': [1860, 2714, 2837, 3455], 'pI-pC.': [1868], 'had': [1871, 2862, 3462], 'mixed': [1873, 2378, 2959], 'genetic': [1874], '(∼25%': [1876], '129/SvJae': [1877], '∼75%': [1879], 'C57BL/6).': [1880], 'They': [1881], 'housed': [1883], 'pathogen-free': [1886], 'barrier': [1887], 'facility': [1888], '12-h': [1891], 'light/12-h': [1892], 'dark': [1893], 'cycle': [1894], 'fed': [1897, 3320], 'rodent': [1898], 'chow': [1899, 3322], '4.0%': [1901], 'fat': [1902, 4948], '(Lactamin': [1903], 'AB,': [1904, 2011, 2470, 2633, 2885], 'Kimstad,': [1905], 'Sweden).': [1906, 2472, 2521], 'Genotypes': [1907], 'determined': [1909, 1934, 1957, 2407], 'PCR': [1911], 'genomic': [1913], 'DNA': [1914], 'tail': [1916], 'biopsies.': [1917], 'Measurements—The': [1919], 'fasted': [1922], 'overnight': [1923], 'before': [1924, 5533], 'blood': [1925], 'sampling.': [1926], 'Total': [1927], 'concentrations': [1932, 3351], 'colorimetric': [1936], 'assays': [1937], '(INFINITY-triglyceride/cholesterol': [1938], 'kits,': [1939], '2': [1941, 2271, 2362, 2806], 'weeks': [1942, 3337], 'after': [1943, 2859, 3338, 4369, 4374, 5741], 'final': [1945, 2328, 2911, 3340], 'pI-pC': [1946, 3341], 'injection.': [1947], 'distribution': [1949], 'within': [1952, 3288, 4951], 'fractionating': [1959], 'mouse': [1960, 2467, 2583], '(100': [1962, 3384, 4629, 4662], 'pooled': [1964], 'five': [1966], 'mice)': [1967], 'Superose': [1970], '6': [1971], '10/30': [1972], 'column': [1973], '(25.Farese': [1974], 'Jr.,': [1975, 3933], 'R.V.': [1976], 'Ruland': [1977], 'S.L.': [1978], 'Stokowski': [1981], 'R.P.': [1982], '1995;': [1992], '1774-1778Crossref': [1994], '(219)': [1997], 'Liver': [2000, 3304, 3642], 'pieces': [2001], '(∼200': [2002], 'μg)': [2003], 'homogenized': [2005], 'polytron': [2008], '(Techtum': [2009], 'Lab': [2010], 'Umeå,': [2012], 'Sweden)': [2013, 2886], 'chloroform:methanol': [2015], '(2:1,': [2016], 'v/v).': [2017], 'Before': [2018], 'extraction': [2019], 'triglycerides,': [2021], 'known': [2023], 'amount': [2024, 4095], 'tripentadecanoic': [2026], '(Sigma)': [2028], 'added': [2030, 2857], 'mixture': [2033, 2980, 3160], 'internal': [2036], 'standard': [2037], '(26.Leung': [2038, 2093], 'G.K.': [2039, 2094], 'Kim': [2042, 2097, 2553, 6007], 'S.K.': [2043, 2098, 2554, 2556, 6008], 'Raabe': [2046, 2101], 'Neese': [2050, 2105, 2561], 'R.A.': [2051, 2106, 2562], 'Hellerstein': [2052, 2107, 2559, 6015], '275:': [2060, 2115], '7515-7520Abstract': [2061, 2116], '(67)': [2069, 2124, 2241], 'Triglycerides': [2072], 'separated': [2074, 4555], 'thin-layer': [2079], 'chromatography,': [2080], 'transesterified': [2081], 'methanolic': [2083], 'HCl': [2084], '(Aldrich),': [2085], 'quantified': [2087], 'gas': [2089], 'chromatography': [2090, 3390, 4277], 'activity': [2130, 3874, 4877, 4892, 4939, 4958, 5407], 'measured': [2137, 3830, 3869, 4049, 4562], 'using': [2139, 2929], 'commercial': [2141, 2463], 'kit': [2142], '(Calbiochem': [2143], 'Inc.,': [2144], 'San': [2145, 6102], 'Diego,': [2146], 'CA).': [2147], 'Preparation': [2148], 'Sub-cellular': [2153, 4299], 'Fractions—Hepatic': [2154], 'fractions': [2158, 2247, 2303, 2366, 3291, 4165, 4560, 4621, 4661], 'isolated': [2160, 2249, 2305, 2311], '(27.Levy': [2163], 'E.': [2164, 2209, 2213, 2223, 2593], 'Garofalo': [2165, 2218], 'Rouleau': [2167], 'T.': [2168], 'Gavino': [2169], 'V.': [2170], 'Bendayan': [2171, 2226], 'Hepatology.': [2173], '23:': [2175], '848-857Crossref': [2176], '28.Marks': [2180], 'Wu': [2182], 'Paul': [2184], 'Kamisaka': [2186], 'Watanabe': [2188], 'Pagano': [2190], '451-456Abstract': [2197], '(79)': [2205], '29.Levy': [2208], 'Stan': [2210], 'Delvin': [2212], 'Menard': [2214], 'Slight': [2220], 'I.': [2221], 'Seidman': [2222], 'Mayer': [2224], 'G.': [2225, 5942, 6089], '16470-16477Abstract': [2233], 'brief,': [2245, 2612], 'homogenates': [2252, 2320], 'buffer': [2254, 2309, 2348, 3058], '(Tris-HCl,': [2256], 'pH': [2257], '7.4,': [2258], '25': [2259], 'nm': [2260], 'KCl': [2261], 'addition': [2264], 'protease': [2266, 2854, 2907, 2924], 'inhibitors,': [2267], '5': [2268], 'μg/ml': [2269, 2272], 'leupeptin,': [2270], 'aprotinin,': [2273], 'mg/ml': [2276], 'Pefabloc': [2277], 'SC': [2278], 'Plus,': [2279], 'all': [2280, 2404, 2852, 3330], 'Roche': [2282], 'Applied': [2283], 'Science)': [2284], 'consecutive': [2287], 'ultracentrifugations': [2288], 'SW40': [2290, 2390, 2985, 3206], 'Ti': [2291, 2356, 2391, 2986, 3207], 'rotors': [2292, 2357, 2392], 'at': [2293, 2299, 2358, 2393, 2887, 2988, 2994, 3099, 3209, 3213, 3217, 3225, 3236, 4420, 4478, 6065, 6075, 6091, 6098], '14,000': [2294], 'rpm': [2295, 2360, 2395, 2990, 3211], '60': [2297, 2751], 'min': [2298, 2655, 2804, 2843, 2892], '4': [2300, 2888, 3156, 3255, 3910, 4642], '°C.': [2301], 'homogenate': [2307], 'same': [2314, 4934], 'livers.': [2315], 'increased': [2323, 2972, 3262], 'sucrose': [2325, 2346], 'concentration': [2329], '1.07': [2331], 'm': [2332, 2342, 2345, 2376], 'overlaid': [2334], '9': [2336, 2338], '+': [2337, 3911, 4643, 4676], 'ml': [2339, 2678, 2769, 2920, 2947, 2962, 3013, 3143, 3157, 3163, 3168, 3174, 3256], '0.9': [2341, 2373], '0.2': [2344, 2375, 2961], 'gradients': [2351], 'ultracentrifuged': [2353, 2982, 3203], 'SW28': [2355], '16,500': [2359], 'h.': [2363, 2850], 'extracted': [2368], 'interface': [2371], 'between': [2372, 3889, 4491], 'sucrose,': [2377], '1:1': [2379], '20%': [2381], 'glycerol,': [2382], 'pelleted': [2384], 'additional': [2387, 3276, 4796], 'spin': [2388], '28,000': [2394], '90': [2397], 'min.': [2398, 2665, 2752], 'total': [2400, 2449], 'contents': [2402], 'samples': [2405, 2438, 2445], 'method': [2410], 'Lowry': [2412], '(40.Lowry': [2413], 'D.H.': [2414], 'Rosebrough': [2415], 'N.J.': [2416], 'Farr': [2417], 'A.L.': [2418], 'Randall': [2419], '1951;': [2424], '193:': [2425], '265-275Abstract': [2426], 'Western': [2433, 2489, 3677], 'Blot': [2434], 'ApoB—Mouse': [2436], '(2': [2439, 3336], 'μl),': [2440], '(150': [2446], 'μg': [2447], 'protein/well)': [2450], 'fractionated': [2452, 3065], '4%': [2454], 'SDS—PAGE.': [2455], 'proteins': [2458, 3050, 5388], 'detected': [2460, 4433, 5281], 'rabbit': [2464], 'antiserum': [2465], 'against': [2466], '(Biosite': [2469], 'Taby,': [2471], 'binding': [2474], 'antibodies': [2478, 2486], 'assessed': [2480, 2504, 2541, 3116], 'horseradish': [2482], 'peroxidase-labeled': [2483], 'donkey': [2484], 'anti-rabbit': [2485], 'ECL': [2488], 'blotting': [2490], 'detection': [2491], 'reagents': [2492], '(Amersham': [2493, 3082], 'Biosciences).': [2494], 'intensity': [2496, 3106, 3753, 3764], 'apoB100': [2501, 3114, 3663, 3690, 3696, 3744, 3756, 3799, 4025, 4097, 4244, 4339, 4358, 4368, 4384, 4400, 4431, 4455, 4506, 4540, 4567, 4603, 4617, 4707, 4911, 4964, 5100, 5214, 5234, 5286, 5299, 5432, 5480, 5665, 5756], 'bands': [2502, 3700], 'densitometry': [2506, 3118, 3702, 4089], 'Fuji': [2509], 'LAS-1000': [2510], 'CCD': [2511], 'camera': [2512], 'Image': [2514], 'Gauge': [2515], 'version': [2516], '3.45': [2517], 'software': [2518], '(Fuji': [2519], 'Film,': [2520], 'Real-time': [2522], 'PCR—Mttp': [2523], 'mRNA': [2524, 3644, 3828, 3835], 'pI-pC-treated': [2530], 'Mx1-Cre,': [2533, 2536], 'real-time,': [2543], 'quantitative': [2544], 'reverse': [2545], 'transcriptase-PCR,': [2546], '(30.Bjorkegren': [2549], 'Withycombe': [2555], 'Wood': [2557], 'P.A.': [2558], '276:': [2569], '38511-38517Abstract': [2570], '(78)': [2578], 'Primary': [2581, 2756, 2938, 3128, 3916, 4031, 4132], 'Hepatocytes—Primary': [2582], 'prepared': [2586], 'cultured': [2588], 'essentially': [2589], '(31.Kim': [2592], 'Cham': [2594], 'C.M.': [2595], 'Ambroziak': [2598, 6009], '101:': [2606], '1468-1477Crossref': [2607], 'anesthetized,': [2615], 'inferior': [2617], 'vena': [2618], 'cava': [2619], 'cannulated': [2621], 'through': [2622], 'right': [2624], 'atrium': [2625], 'arterial': [2628], 'catheter': [2629], '(Becton-Dickinson': [2630], 'Infusion': [2631], 'Therapy': [2632], 'Sweden),': [2634], 'portal': [2637], 'vein': [2638], 'cut': [2640], 'open': [2641], 'drainage.': [2643], 'perfused': [2647], 'perfusion': [2650], 'medium': [2651, 2661, 2682, 2713, 2731, 2772, 2792, 2836, 2861, 2950, 4081, 4100, 4113, 4143, 4436], '(Invitrogen)': [2652, 2662, 2718], '3': [2654, 2794, 2849, 2946, 4352, 4675], 'then': [2657, 2832], 'digest': [2660], '10': [2664, 2995, 3218], 'harvested,': [2669, 2816], 'washed': [2674, 2761, 2821], 'twice': [2675, 2762, 2822, 2872], '40': [2677, 3898], 'hepatocyte': [2680, 2949, 3165], 'washing': [2681], '(Invitrogen).': [2683], 'number': [2685, 2697], 'calculated': [2689], 'trypan': [2691], 'blue': [2692], 'exclusion,': [2693], 'fixed': [2696, 3074], 'plated': [2701], 'six-well': [2703], 'tissue': [2704], 'culture': [2705], 'plates': [2706], '(BD': [2707], 'Biosciences)': [2708, 2782, 3098], "Dulbecco's": [2710], 'modified': [2711, 6112], "Eagle's": [2712, 2730], 'l-methionine': [2715], 'l-cysteine': [2717], '2.0': [2721], 'mm': [2722, 2725, 3238], 'l-glutamine,': [2723], '2.5': [2724, 3162], 'sodium': [2726], 'pyruvate,': [2727], '1×': [2728], 'minimum': [2729], 'nonessential': [2732], 'amino': [2733], 'acids,': [2734], '6.5%': [2736], 'fetal': [2737], 'bovine': [2738], 'serum': [2739], '(all': [2740], 'Invitrogen),': [2742], 'allowed': [2747], 'attach': [2749], 'Metabolic': [2753], 'Labeling': [2754], 'Hepatocytes—The': [2757], 'attached': [2758], 'saline': [2765], '(PBS),': [2766], 'fresh': [2771, 2835], '50': [2774], '[35S]methionine/cysteine': [2777, 2838], '(Promix,': [2778], '530': [2779], 'Mbq/ml,': [2780], 'Amersham': [2781, 3097], 'added.': [2784], 'incubated': [2788, 2876, 3079, 4034], 'h': [2795, 2807, 2993, 3216, 4353], 'straight': [2798], 'experiments': [2800, 3335, 3866], '15': [2803, 2840, 3062], 'pulse-chase': [2810, 2827, 2867, 3865, 4321, 5765, 6084], 'experiments.': [2811], 'media': [2814], 'PBS.': [2824], 'For': [2825, 3863, 5361], 'experiments,': [2828, 2853, 2868, 5766], 'chased': [2833], '30': [2842, 2891], '1,': [2846, 4349], '2,': [2847, 4350], 'immediately': [2858, 3026, 3293], 'harvested.': [2864], '(washed': [2871], 'PBS)': [2874], 'PBS': [2878, 2899, 2912, 2922, 2952], '100': [2880], 'international': [2881], 'units/ml': [2882], 'Heparin': [2883], '(LeoPharma': [2884], '°C': [2889, 2996, 3101, 3219], 'release': [2894], 'cell': [2895, 2956, 4509, 5583], 'surface-bound': [2896], 'lipoproteins.': [2897, 3992, 5863], 'heparin': [2901, 2954, 5774], 'harvested': [2903], 'supplemented': [2905], 'inhibitors.': [2908], 'After': [2909, 3242], 'washes,': [2913], 'sonicated': [2917], '2–5': [2927], 's': [2928], '550W': [2931], 'sonicator.': [2932], 'Isolation': [2933], 'Lipoproteins': [2935, 4129], 'Labeled': [2937], 'Hepatocytes—To': [2939, 3129, 4133], 'obtain': [2940], 'lipoproteins,': [2945, 4141], 'lysate': [2957], 'human': [2964, 3170], '(used': [2966], 'carrier),': [2968], '1.21': [2974, 3264], 'g/ml': [2975, 3150, 3177, 3265], 'NaBr,': [2977], 'rotor': [2987, 3208], '40,000': [2989, 3210], '>80': [2992], '(32.Carlson': [2997], 'Pathol.': [3001], '1973;': [3002], '32-37Crossref': [3004], '(438)': [3007], 'top': [3011, 3227], '0.5': [3012, 3167], 'tube': [3016, 3273], 'collected': [3024], 'delipidated': [3027, 3049, 3294], 'methanol:diethylether': [3029], '(1:1,': [3030], 'v/v)': [3031], '(33.Karpe': [3032, 3183, 4166], 'Hamsten': [3034, 3185, 4168], '35:': [3040, 3191, 4174], '1311-1317Abstract': [3041, 3192, 4175], 'resolved': [3052], '200': [3054], 'loading': [3057], 'SDS,': [3060], '4–15%': [3068], 'SDS-PAGE': [3069, 3298], 'gradient.': [3070], 'gels': [3072], 'isopropanol:H2O:acetic': [3076], '(5:13:2),': [3078], 'Amplify': [3081], 'Biosciences),': [3083], 'dried': [3084], '(on': [3085], 'Bio-Rad': [3087], 'Model': [3088], '583': [3089], 'gel': [3090], 'dryer),': [3091], 'exposed': [3093], 'film': [3095], '(Hyperfilm,': [3096], '–80': [3100], '4–10': [3103], 'days.': [3104], '35S': [3109], 'incorporated': [3110], 'into': [3111, 4046, 4753], 'above.': [3121, 3285, 3301], 'Density': [3122, 4126], 'Fractionation': [3123], 'ApoB': [3125], 'Secreted': [3126, 4130], 'separately': [3130], 'isolate': [3131, 3279], 'subfractions,': [3136, 3249], 'gradient': [3139, 3201, 3230, 4151], 'consisting': [3140], '3.0': [3142], 'each': [3144, 4421, 4479], '1.065,': [3146], '1.020,': [3147], '1.006': [3149], 'NaCl': [3151], 'solutions': [3152], 'layered': [3154], 'medium,': [3166], 'plasma,': [3171], '1.42': [3176], 'NaBr': [3178, 3267], '(final': [3179], '1.10': [3181], 'g/ml)': [3182], 'This': [3199, 4681], 'least': [3214], '14': [3215], 'float': [3221], 'Svedberg': [3222], 'flotation': [3223, 3234], '>20': [3224], '(Svedberg': [3233], '12–20)': [3235], '29': [3237], 'top.': [3241], 'isolation': [3243], 'remaining': [3254], 'bottom': [3259], 'fraction': [3260, 4250], 'transferred': [3269], 'another': [3271], 'ultracentrifuge': [3272], 'run': [3277], 'subfraction,': [3282], 'All': [3286], 'apolipoproteins': [3287], 'subjected': [3296, 4148], 'Plasma': [3302, 3640], 'Lipids—pI-pC-treated': [3305], 'littermate': [3306], 'versus': [3310, 3316, 3385, 3899, 4071, 4415, 4468, 4634, 4667], 'Mttpflox/flox,': [3312], 'Mttpflox/flox)': [3318], 'diet': [3323], '(4.0%': [3324], 'fat)': [3325], 'until': [3326], 'week': [3327], '7,': [3328], 'when': [3329, 4966, 5833], 'injection).': [3342], 'recombination': [3345, 3816, 4865, 4923], 'reduced': [3348, 3849, 4107, 5068], 'triglycerides': [3355, 3362], '(Table': [3356, 3450], 'I).': [3357, 3451], 'reduction': [3359, 3376, 5051, 5232], 'similar': [3364, 3654, 4386, 4457, 5570], 'greater': [3378], '65': [3386], 'mg/dl).': [3387], 'Fast-performance': [3388], 'liquid': [3389, 4276], 'revealed': [3394], 'LDL-cholesterol': [3396], 'peak': [3397, 3414], '(Fig.': [3408, 3428, 3680, 3691, 4090, 4124, 4251, 4281, 4293, 4379, 4412, 4441, 4465], '1).': [3409, 3429, 4282], 'HDL-cholesterol': [3413], 'about': [3416], '2-fold': [3417], 'higher': [3418, 3438, 5855], 'than': [3423, 3446, 3467, 3760, 3853, 3880, 4019, 4407, 4920, 4926, 5355, 5723, 5861, 5997], 'weight': [3432, 3498, 3508], 'content': [3436, 3466, 4565], 'controls': [3449], 'Of': [3452], 'note,': [3453], 'weighed': [3459], 'lower': [3464, 5887], 'intact': [3470, 5515], 'independent': [3473], 'Mttp.Table': [3475], 'IBasic': [3476], 'characteristics': [3477], 'study': [3480, 4682, 4703, 4837, 5828, 5968], 'miceLdlr+/+': [3481], '(n': [3483, 3487, 3491, 3495, 3714, 3725, 3790, 3908], '=': [3484, 3488, 3492, 3496, 3552, 3562, 3566, 3576, 3582, 3592, 3596, 3606, 3623, 3626, 3629, 3632, 3715, 3726, 3791, 3906, 3909, 4076, 4122, 4641, 4674, 4679], '10)Ldlr+/+': [3485], '10)Ldlr-/-': [3489, 3493], '10)Body': [3497], '(g)26': [3499], '±': [3500, 3502, 3504, 3506, 3510, 3512, 3520, 3522, 3528, 3530, 3538, 3540, 3550, 3554, 3564, 3568, 3580, 3584, 3594, 3598, 3712, 3723, 3788, 3897, 3901, 4069, 4073, 4119, 4630, 4636, 4663, 4669], '224': [3501], '223': [3503], '222': [3505], '2Liver': [3507], '(g)1.21': [3509], '0.121.43': [3511], '0.15ap': [3513], '<': [3514, 3532, 3542, 3556, 3570, 3586, 3600, 3609, 3616, 4646], '0.05': [3515, 3610], 'compared': [3516, 3534, 3544, 3558, 3572, 3588, 3602, 3611, 3618, 3855, 4110, 4858, 5236, 5320], 'Mttpflox/flox.1.13': [3519], '0.081.25': [3521], '0.24Liver': [3523], 'TG': [3524, 3548], '(mg/g': [3525], 'wt': [3526], 'tissue)216': [3527], '82648': [3529], '216bp': [3531], '0.005': [3533, 3543, 3557, 3571, 3587, 3601, 3617], 'Ldlr-/-': [3536, 3546, 3560, 3574, 3590, 3604, 3620], 'Mttpflox/flox.161': [3537], '62318': [3539], '84bp': [3541], 'Mttpflox/flox.Plasma': [3547], '(mg/dl)99': [3549], '26cn': [3551], '13.43': [3553], '15bp': [3555], 'Mttpflox/flox.,dn': [3561, 3591], '19.136': [3563], '24en': [3565], '16.42': [3567], '24bp': [3569], 'Mttpflox/flox.,fn': [3575, 3605], '14.Plasma': [3577], 'chol': [3578], '(mg/dl)119': [3579], '23cn': [3581], '13.54': [3583], '22bp': [3585], '19.174': [3593], '36en': [3595], '16.73': [3597], '25bp': [3599], '14.a': [3607], 'p': [3608, 3615, 3905, 4645, 4678], 'Mttpflox/flox.b': [3614], 'Mttpflox/flox.c': [3621], 'n': [3622, 3625, 3628, 3631, 4075, 4121, 4640, 4673], '13.d': [3624], '19.e': [3627], '16.f': [3630], '14.': [3633], 'Open': [3634], 'table': [3635], 'new': [3638], 'tab': [3639], 'ApoB,': [3641], 'Levels,': [3645], 'Activity—': [3648], 'whereas': [3662, 5292], 'almost': [3665], 'undetectable': [3666, 4087], 'judged': [3675], 'blot': [3678], 'analysis': [3679], '2).': [3681, 3692], 'Surprisingly,': [3682, 4239], 'Assessment': [3693], 'average': [3706, 5304], 'apoB100/B48': [3708, 3778], 'ratio': [3709, 3779], '0.68': [3711], '0.15': [3713], '8)': [3716, 3727], '1.75': [3722], '0.53': [3724], 'Only': [3732], 'eight': [3737], 'examined': [3741], 'band': [3745, 3757, 4245], 'detectable.': [3746], 'both': [3748, 3841, 4062, 4844, 5161, 5438, 5738], 'cases,': [3751], '5%': [3761], 'band.': [3768], 'much': [3773], 'our': [3775, 4885, 5322, 5409, 5560, 5745, 5764], 'surprise,': [3776], '1.40': [3787], '0.39': [3789], '7).': [3792], 'ensure': [3794], 'result': [3810], 'efficient': [3813], 'pI-pC-mediated': [3814], 'related': [3817], 'Ldlr,': [3822], 'level': [3824, 4935], 'real-time': [3832], 'PCR.': [3833], 'expression': [3836], 'more': [3852, 4402, 4919, 5721, 5995, 6049], '95%': [3854, 4921], 'control': [3857], '(data': [3860, 4511], 'shown).': [3862, 4513], 'activity.': [3871, 4930], '3%': [3881, 4927, 4955], 'wild-type': [3884, 5724], 'did': [3886, 4288], 'differ': [3888], '(62': [3896], '47': [3900], '39': [3902], 'pmol/100': [3903], 'μg/hr,': [3904], '0.55': [3907], '4)).': [3912], 'ApoB100': [3913, 4078], 'Secretion': [3914], 'Hepatocytes—Intestinal': [3917], 'secrete': [3919, 4290, 5018, 5719, 5804], 'only': [3920, 4106, 5066, 5209, 5280], 'trace': [3921], 'amounts': [3922], '(34.Hoeg': [3926], 'Sviridov': [3928], 'D.D.': [3929], 'Tennyson': [3930], 'G.E.': [3931], 'Demosky': [3932], 'S.J.': [3934], 'Meng': [3935], 'Bojanovski': [3937], 'Safonova': [3939], 'I.G.': [3940], 'Repin': [3941], 'V.S.': [3942], 'Kuberger': [3943], 'M.B.': [3944], 'Smirnov': [3945], 'V.N.': [3946], 'Higuchi': [3947], 'Brewer': [3951], 'Jr,': [3952], 'H.B.': [3953], '31:': [3958], '1761-1769Abstract': [3959], 'therefore,': [3978], 'indicated': [3979, 4361, 4573, 4612], 'capable': [3988], 'secreting': [3990], 'rule': [3995], 'out': [3996], 'possibility': [3998, 5112], 'their': [4009, 4279, 5505, 5884], 'rather': [4018], 'reemerging': [4021], 'secretion,': [4022, 5235], 'analyzed': [4024], 'labeled': [4028, 4367, 4430, 4454], 'hepatocytes.': [4030, 4393, 4952], '[35S]methionine/cysteine,': [4039], 'incorporation': [4042], 'label': [4045], 'medium.': [4052], 'seemed': [4057, 4401, 4604], 'unaffected': [4060], 'Ldlr+/+MttpΔ/Δ': [4063], '(104': [4068], '7%': [4070], '93': [4072], '4%,': [4074], '3).': [4077, 4091, 4125], '∼30%,': [4109], '(69': [4118], '23%,': [4120], '4)': [4123], 'ApoB100-containing': [4128], 'determine': [4134, 5428], 'ultracentrifugation': [4152], 'examine': [4154], 'suspected': [4183], 'would,': [4196, 5520], 'like': [4197], 'apoB48-containing': [4199, 4981, 5123], 'Scholar),': [4234, 4597, 5048, 5475, 6033], 'size.': [4238], 'however,': [4240], 'equally': [4242], 'intense': [4243], 'appeared': [4246, 4385], '4).': [4252, 4294], 'LDL-sized': [4256], 'peaks': [4272], 'shown': [4273, 5016], 'fast-performance': [4275], 'any': [4291, 4944, 4963], 'Apo100': [4295], 'Synthesis,': [4296], 'Turnover,': [4297], 'Location—To': [4300], 'plausible': [4302], 'mechanisms': [4303], 'underlying': [4304], 'receptor-mediated': [4307, 4537, 4552, 4600, 5009], 'prevention': [4308, 5729], 'hepatocytes,': [4317, 4429, 4497, 5291], 'experiments:': [4322], 'short': [4324], '15-min': [4325, 4371], 'pulse': [4326, 4346, 4372], 'followed': [4327, 4347], '15-': [4329], '30-min': [4331], 'chase': [4332, 4354, 4377], 'periods': [4333, 4355, 4378], '(to': [4334, 4356], 'estimate': [4335, 4357], 'rate': [4337], 'de': [4340, 4528], 'novo': [4341, 4529], 'synthesis),': [4342], '2-h': [4345], 'turnover).': [4359], 'As': [4360, 4572], 'subsequent': [4376], '5A),': [4380], 'biosynthesis': [4382, 4488, 4530], 'turnover': [4398, 4490], 'rapid': [4403], '5B,': [4413, 4442, 4466], 'black': [4414, 4467], 'white': [4416, 4471, 4474], 'sections': [4417], 'bars': [4419], 'time': [4422, 4480], 'point).': [4423, 4481], 'gray': [4443, 4476], 'section': [4444], 'bars).': [4447], 'overall': [4450], 'recovery': [4451], 'entire': [4470], 'bar': [4472, 4477], 'There': [4482], 'differences': [4485], 'nor': [4498], 'detect': [4501], 'difference': [4503], 'heparin-releasable': [4505], 'surface': [4510], 'Taken': [4514], 'together,': [4515], '(i)': [4520], 'does': [4524, 4999, 5490], 'affect': [4526], 'apoB100,': [4532], '(ii)': [4534], 'mainly': [4541, 4607, 4779, 5789], 'occurs': [4542], 'intracellularly.': [4543], 'sub-cellular': [4547, 4570, 5777], 'location': [4548], 'degradation,': [4553, 5107, 5850], 'fractions.': [4571], 'previously': [4574], '(35.Gillian-Daniel': [4575], 'Bates': [4577], 'P.W.': [4578], '99:': [4591], '4337-4342Crossref': [4592], '(61)': [4595], '63%': [4631], 'MttpΔ/Δ)': [4633, 4666], '330': [4635], '123%': [4637], 'MttpΔ/Δ),': [4639, 4672], '4,': [4644], '0.04).': [4647], 'tendency': [4653], 'inverse': [4656], 'relation': [4657], '40%': [4664], '77': [4668], '54%': [4670], '3,': [4677], '0.59).': [4680], 'shows': [4683], 'prevented': [4695], 'despite': [4711, 4918, 4987], 'MTP.': [4716, 5331], 'Thus,': [4717], 'do': [4722, 5142, 5175], 'seem': [4724, 5177], 'essential': [4727, 4745, 5391], 'notion': [4741], 'transformation': [4748], 'particle,': [4757], 'particles': [4763, 5530, 5787, 5836, 5848, 5853, 5990, 6002, 6051], 'abolished.': [4765], 'escape': [4773], 'co-translational': [4774], 'targeted': [4777, 4868, 4880], 'assigns': [4784], 'novel': [4788], '"gatekeeping"': [4789], 'may': [4792, 5101], 'important': [4795, 4841], 'mechanism': [4797], 'cholesterol-lowering': [4800], 'antiatherosclerotic': [4802], 'effects': [4803, 5877], 'statins.': [4805], 'Lox': [4807], 'P': [4808], 'allows': [4835], 'genes': [4839], 'functions': [4842], 'adult': [4845], 'life': [4846], 'embryonic': [4848], 'development.': [4849], 'technology': [4854], 'its': [4856, 5103], 'limitations': [4857], 'conventional': [4860], 'targeting,': [4861], 'Cre-mediated': [4864], 'complete.': [4872], 'Using': [4873], 'system,': [4875, 5324], 'residual': [4876, 4891, 4928, 4937, 4956, 5405], 'remain.': [4883], 'case,': [4886], 'found': [4905], 'that,': [4906], 'average,': [4908], '69%': [4909, 5305], 'remained': [4913], 'maintain': [4943], 'causing': [4947], 'accumulate': [4950], 'present': [4971], 'occurred': [4986, 5737], 'surprising,': [4996], 'bind': [5001], 'and,': [5005], 'hence,': [5006], 'escapes': [5007], 'Previously,': [5011], 'Mttp-deficient': [5013], 'inhibitor': [5064, 5318, 5346, 5366, 5383], 'marginally': [5067], '(17.Kulinski': [5069, 5185, 5258], 'smaller': [5093], 'size': [5094], 'decrease': [5102], 'vulnerability': [5104], 'protease-mediated': [5106], 'evoke': [5110], 'separate': [5115], 'synthetic': [5117], 'pathway': [5118, 5156, 5906], '(36.Gordon': [5125], 'Biochim.': [5129], 'Biophys.': [5130], 'Acta.': [5131], '1486:': [5133], '72-83Crossref': [5134], '(191)': [5137], 'Our': [5140], 'support': [5144, 5149, 5414], 'possibility.': [5146], 'Rather,': [5147], 'they': [5148, 5314, 5534], 'traditional': [5151], 'view': [5152], 'common': [5155], 'species': [5162], 'apoB,': [5164], 'essential.': [5180], 'Interestingly,': [5181], 'Kulinski': [5182, 5255], 'et': [5183, 5256, 5690, 5831], 'al.': [5184, 5257, 5691], 'recently': [5207, 5713], 'reported': [5208], 'minor': [5211], 'reappearance': [5212, 5284], 'upon': [5220, 5239], 'incubation': [5221, 5769], 'inhibitor.': [5225], 'authors': [5227], 'concluded': [5228], 'preferential': [5231], 'apoB48,': [5238], 'cannot': [5243], 'attributed': [5245], 'reason': [5253], 'why': [5254, 5446], 'marginal': [5283], 'we,': [5293], 'study,': [5296], 'show': [5297], 'remains': [5301], 'likely': [5308, 5844], 'model': [5323, 5410], 'possible,': [5334], 'even': [5336], 'likely,': [5337], 'together': [5343], 'affects': [5347], 'differently': [5354], 'alone.': [5360], 'instance,': [5362], 'complex': [5370], 'hinders': [5372], 'proper': [5374, 5394], 'lipidation': [5377, 5397], 'Alternatively,': [5380], 'interact': [5385], 'Another': [5400], 'explanation': [5401], 'would': [5422, 6041], 'great': [5425], 'interest': [5426], 'completely': [5436, 5750], 'lack': [5437, 5586], 'Ldlr.': [5441], 'An': [5442], 'inevitable': [5443], 'question': [5444], 'individuals': [5447], 'rare': [5450], 'plasma.': [5482, 5557], "wouldn't": [5494], 'LDL-': [5499], 'plasma?': [5506], 'obvious': [5508], 'answer': [5509], 'target': [5528], 'those': [5529], 'theory,': [5539], 'combined': [5541], 'abetalipoproteinemia': [5542], 'genotype': [5546], 'should': [5547], 'go': [5548], 'knowledge,': [5561], 'such': [5562], 'patient': [5564], 'reported.': [5568], 'argument': [5571], 'understand': [5576], 'reemerged': [5666], 'indicates': [5674, 5969], 'regulating': [5682], 'newly': [5686], 'Twisk': [5689, 5830], '(15.Twisk': [5692], '3.5-fold': [5720], 'intracellularly': [5739], 'secretion.': [5743], 'model,': [5746], 'blocked': [5751], 'liver.': [5761, 5983], 'including': [5767, 5935], 'subfractionation': [5778], 'studies,': [5779, 6085], 'targets': [5785], 'intracellularly,': [5788], 'ER.': [5792], 'Assuming': [5793], 'biological': [5798], 'incentive': [5799], 'lipid-poor': [5805, 5847], 'gatekeeping': [5808, 5865, 6035], 'makes': [5814], 'sense.': [5815], '(as': [5825], 'al.),': [5832], 'made,': [5839], 'prioritize': [5846], 'affinity': [5856], 'help': [5873], 'explain': [5874], 'anti-atherosclerotic': [5876], 'statins': [5879], 'unrelated': [5882], 'ability': [5885], 'drugs': [5892], 'inhibit': [5893], '3-hydroxy-3-methyl-glutaryl': [5894], 'coenzyme': [5895], 'reductase,': [5897], 'tightly': [5899], 'regulated': [5900], 'biosynthetic': [5905], '(37.Endo': [5907], '1992;': [5912], '33:': [5913], '1569-1582Abstract': [5914], 'Cells': [5921], 'respond': [5922], 'shortage': [5925], 'up-regulating': [5929], 'transcription': [5931], 'cholesterol-regulated': [5933], 'genes,': [5934], '(38.Ma': [5939], 'P.T.': [5940], 'Gil': [5941], 'Sudhof': [5943], 'T.C.': [5944], 'Bilheimer': [5945], 'D.W.': [5946], '1986;': [5958], '83:': [5959], '8370-8374Crossref': [5960], '(285)': [5963], 'current': [5967], 'prevents': [5974], 'Because': [5984], 'carried': [5986, 5999], 'atherogenic': [5996, 6050, 6058], '(39.Veniant': [6003], 'Chu': [6011], 'Wilson': [6013], 'M.D.': [6014], 'Rudel': [6017], 'L.L.': [6018], 'Walzem': [6019], '106:': [6027], '1501-1510Crossref': [6028], '(102)': [6031], 'prevent': [6042], 'potentially': [6048], 'promote': [6053], 'VLDL.': [6059], 'thank': [6061], 'Professor': [6062, 6087], 'Sven-Olof': [6063], 'Department': [6067], 'Medical': [6069], 'Biochemistry': [6070], 'Wallenberg': [6073], 'laboratory': [6074], 'University': [6077, 6100], 'Göteborg': [6079], 'advice': [6081], 'Stephen': [6088], 'Gladstone': [6093], 'Institute': [6094], 'Cardiovascular': [6096], 'Disease': [6097], 'Francisco': [6103], 'California': [6105], 'providing': [6107], 'us': [6108], 'genetically': [6111]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2059471110', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-06T17:10:04.678059', 'created_date': '2016-06-24'}
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