Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2083906562', 'doi': 'https://doi.org/10.1093/emboj/17.8.2215', 'title': 'IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases', 'display_name': 'IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases', 'publication_year': 1998, 'publication_date': '1998-04-15', 'ids': {'openalex': 'https://openalex.org/W2083906562', 'doi': 'https://doi.org/10.1093/emboj/17.8.2215', 'mag': '2083906562', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9545235', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1170566'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/emboj/17.8.2215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127916151', 'display_name': 'The EMBO Journal', 'issn_l': '0261-4189', 'issn': ['0261-4189', '1460-2075'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170566', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030174900', 'display_name': 'Quinn L. Deveraux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188891513', 'display_name': 'Sanford Burnham Prebys Medical Discovery Institute', 'ror': 'https://ror.org/03m1g2s55', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I188891513']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Q. L. Deveraux', 'raw_affiliation_strings': ['The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA'], 'affiliations': [{'raw_affiliation_string': 'The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA', 'institution_ids': ['https://openalex.org/I188891513']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5030174900'], 'corresponding_institution_ids': ['https://openalex.org/I188891513'], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 32.452, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1394, 'citation_normalized_percentile': {'value': 0.99997, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '17', 'issue': '8', 'first_page': '2215', 'last_page': '2223'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9454, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9339, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/xiap', 'display_name': 'XIAP', 'score': 0.9333845}, {'id': 'https://openalex.org/keywords/inhibitor-of-apoptosis', 'display_name': 'Inhibitor of apoptosis', 'score': 0.62594175}, {'id': 'https://openalex.org/keywords/intrinsic-apoptosis', 'display_name': 'Intrinsic apoptosis', 'score': 0.58831453}, {'id': 'https://openalex.org/keywords/nlrp1', 'display_name': 'NLRP1', 'score': 0.5406205}, {'id': 'https://openalex.org/keywords/caspase-9', 'display_name': 'Caspase-9', 'score': 0.53043437}, {'id': 'https://openalex.org/keywords/apoptosome', 'display_name': 'Apoptosome', 'score': 0.5248004}, {'id': 'https://openalex.org/keywords/caspase-2', 'display_name': 'Caspase 2', 'score': 0.48073816}, {'id': 'https://openalex.org/keywords/caspase-10', 'display_name': 'Caspase 10', 'score': 0.47108114}, {'id': 'https://openalex.org/keywords/caspase-8', 'display_name': 'Caspase 8', 'score': 0.46407038}, {'id': 'https://openalex.org/keywords/caspase-7', 'display_name': 'Caspase 7', 'score': 0.4540076}], 'concepts': [{'id': 'https://openalex.org/C33195913', 'wikidata': 'https://www.wikidata.org/wiki/Q20970121', 'display_name': 'XIAP', 'level': 5, 'score': 0.9333845}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.89437777}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7574557}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7291717}, {'id': 'https://openalex.org/C29311851', 'wikidata': 'https://www.wikidata.org/wiki/Q408223', 'display_name': 'Cytochrome c', 'level': 3, 'score': 0.71252096}, {'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.6583023}, {'id': 'https://openalex.org/C2777408456', 'wikidata': 'https://www.wikidata.org/wiki/Q174299', 'display_name': 'Inhibitor of apoptosis', 'level': 4, 'score': 0.62594175}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.60144883}, {'id': 'https://openalex.org/C163421366', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Intrinsic apoptosis', 'level': 5, 'score': 0.58831453}, {'id': 'https://openalex.org/C170301204', 'wikidata': 'https://www.wikidata.org/wiki/Q24788681', 'display_name': 'Inhibitor of apoptosis domain', 'level': 5, 'score': 0.5498795}, {'id': 'https://openalex.org/C176912530', 'wikidata': 'https://www.wikidata.org/wiki/Q18036542', 'display_name': 'NLRP1', 'level': 5, 'score': 0.5406205}, {'id': 'https://openalex.org/C2775998712', 'wikidata': 'https://www.wikidata.org/wiki/Q14907714', 'display_name': 'Caspase-9', 'level': 5, 'score': 0.53043437}, {'id': 'https://openalex.org/C193349765', 'wikidata': 'https://www.wikidata.org/wiki/Q2061363', 'display_name': 'Apoptosome', 'level': 5, 'score': 0.5248004}, {'id': 'https://openalex.org/C155863897', 'wikidata': 'https://www.wikidata.org/wiki/Q14913269', 'display_name': 'Caspase 2', 'level': 5, 'score': 0.48073816}, {'id': 'https://openalex.org/C1186008', 'wikidata': 'https://www.wikidata.org/wiki/Q17855945', 'display_name': 'Caspase 10', 'level': 5, 'score': 0.47108114}, {'id': 'https://openalex.org/C48297814', 'wikidata': 'https://www.wikidata.org/wiki/Q14911965', 'display_name': 'Caspase 8', 'level': 5, 'score': 0.46407038}, {'id': 'https://openalex.org/C91096171', 'wikidata': 'https://www.wikidata.org/wiki/Q17855901', 'display_name': 'Caspase 7', 'level': 5, 'score': 0.4540076}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.42967498}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.3947814}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2926662}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.20976439}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.08772662}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020169', 'descriptor_name': 'Caspases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003574', 'descriptor_name': 'Cytochrome c Group', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053148', 'descriptor_name': 'Caspase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053453', 'descriptor_name': 'Caspase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002457', 'descriptor_name': 'Cell Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002461', 'descriptor_name': 'Cell Line, Transformed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015853', 'descriptor_name': 'Cysteine Proteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015853', 'descriptor_name': 'Cysteine Proteinase Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003574', 'descriptor_name': 'Cytochrome c Group', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004792', 'descriptor_name': 'Enzyme Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004792', 'descriptor_name': 'Enzyme Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051636', 'descriptor_name': 'X-Linked Inhibitor of Apoptosis Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/emboj/17.8.2215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127916151', 'display_name': 'The EMBO Journal', 'issn_l': '0261-4189', 'issn': ['0261-4189', '1460-2075'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170566', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9545235', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170566', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W12870641', 'https://openalex.org/W1486886656', 'https://openalex.org/W1535874622', 'https://openalex.org/W1543457854', 'https://openalex.org/W1557686543', 'https://openalex.org/W1611610664', 'https://openalex.org/W1644953918', 'https://openalex.org/W1893157084', 'https://openalex.org/W1962843014', 'https://openalex.org/W1964558717', 'https://openalex.org/W1971813119', 'https://openalex.org/W1975449325', 'https://openalex.org/W1975667451', 'https://openalex.org/W1979444649', 'https://openalex.org/W1979842763', 'https://openalex.org/W1979995768', 'https://openalex.org/W1985520226', 'https://openalex.org/W1991865867', 'https://openalex.org/W1992045438', 'https://openalex.org/W2000623989', 'https://openalex.org/W2002154440', 'https://openalex.org/W2013801793', 'https://openalex.org/W2032221839', 'https://openalex.org/W2035523654', 'https://openalex.org/W2040499984', 'https://openalex.org/W2040810776', 'https://openalex.org/W2045114648', 'https://openalex.org/W2051070266', 'https://openalex.org/W2056469110', 'https://openalex.org/W2072692243', 'https://openalex.org/W2072858020', 'https://openalex.org/W2076807689', 'https://openalex.org/W2078001244', 'https://openalex.org/W2078297328', 'https://openalex.org/W2083658751', 'https://openalex.org/W2086493438', 'https://openalex.org/W2087593127', 'https://openalex.org/W2090161008', 'https://openalex.org/W2090202756', 'https://openalex.org/W2093423926', 'https://openalex.org/W2095169267', 'https://openalex.org/W2100783563', 'https://openalex.org/W2119586900', 'https://openalex.org/W2119683782', 'https://openalex.org/W2120492514', 'https://openalex.org/W2122538814', 'https://openalex.org/W2129104604', 'https://openalex.org/W2130866079', 'https://openalex.org/W2143455699', 'https://openalex.org/W2144701362', 'https://openalex.org/W2149967205', 'https://openalex.org/W4230515018'], 'related_works': ['https://openalex.org/W4233449584', 'https://openalex.org/W2157999078', 'https://openalex.org/W2156639711', 'https://openalex.org/W2139617193', 'https://openalex.org/W2108554204', 'https://openalex.org/W2084318835', 'https://openalex.org/W2083522556', 'https://openalex.org/W2080419671', 'https://openalex.org/W2080413964', 'https://openalex.org/W2006544424'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2083906562', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 33}, {'year': 2015, 'cited_by_count': 32}, {'year': 2014, 'cited_by_count': 36}, {'year': 2013, 'cited_by_count': 62}, {'year': 2012, 'cited_by_count': 44}], 'updated_date': '2024-12-09T16:39:40.013573', 'created_date': '2016-06-24'}