Title: Subproteomic analysis of metal-interacting proteins in human B cells
Abstract: PROTEOMICSVolume 5, Issue 14 p. 3614-3622 Regular Article Subproteomic analysis of metal-interacting proteins in human B cells Kirsten Heiss, Kirsten Heiss Max-Planck Institute for Immunobiology, Freiburg, Germany These authors contributed equallySearch for more papers by this authorChristof Junkes, Christof Junkes Max-Planck Institute for Immunobiology, Freiburg, Germany These authors contributed equallySearch for more papers by this authorNelson Guerreiro, Nelson Guerreiro Novartis Pharma AG, BioMarker Development, Basel, SwitzerlandSearch for more papers by this authorMahima Swamy, Mahima Swamy Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorMargarita M. Camacho-Carvajal, Margarita M. Camacho-Carvajal Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorWolfgang W.A. Schamel, Wolfgang W.A. Schamel Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorIan D. Haidl, Ian D. Haidl Dalhousie University, Department of Pediatrics and Microbiology and Immunology, Halifax, CanadaSearch for more papers by this authorDoris Wild, Doris Wild Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorHans Ulrich Weltzien, Hans Ulrich Weltzien Max-Planck Institute for Immunobiology, Freiburg, GermanySearch for more papers by this authorHermann-Josef Thierse Dr., Corresponding Author Hermann-Josef Thierse Dr. [email protected] Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanyMax-Planck Institute for Immunobiology & University of Freiburg, Research Group "Allergy and Immunoproteomics", Stübeweg 51, D-79108 Freiburg, Germany Fax: +49-761-5108534===Search for more papers by this author Kirsten Heiss, Kirsten Heiss Max-Planck Institute for Immunobiology, Freiburg, Germany These authors contributed equallySearch for more papers by this authorChristof Junkes, Christof Junkes Max-Planck Institute for Immunobiology, Freiburg, Germany These authors contributed equallySearch for more papers by this authorNelson Guerreiro, Nelson Guerreiro Novartis Pharma AG, BioMarker Development, Basel, SwitzerlandSearch for more papers by this authorMahima Swamy, Mahima Swamy Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorMargarita M. Camacho-Carvajal, Margarita M. Camacho-Carvajal Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorWolfgang W.A. Schamel, Wolfgang W.A. Schamel Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorIan D. Haidl, Ian D. Haidl Dalhousie University, Department of Pediatrics and Microbiology and Immunology, Halifax, CanadaSearch for more papers by this authorDoris Wild, Doris Wild Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanySearch for more papers by this authorHans Ulrich Weltzien, Hans Ulrich Weltzien Max-Planck Institute for Immunobiology, Freiburg, GermanySearch for more papers by this authorHermann-Josef Thierse Dr., Corresponding Author Hermann-Josef Thierse Dr. [email protected] Max-Planck Institute for Immunobiology, Freiburg, Germany University of Freiburg, Biology III, Department of Molecular Immunology, GermanyMax-Planck Institute for Immunobiology & University of Freiburg, Research Group "Allergy and Immunoproteomics", Stübeweg 51, D-79108 Freiburg, Germany Fax: +49-761-5108534===Search for more papers by this author First published: 16 September 2005 https://doi.org/10.1002/pmic.200401215Citations: 42 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Metal-protein interactions are vitally important in all living organisms. Metalloproteins, including structural proteins and metabolic enzymes, participate in energy transfer and redox reactions or act as metallochaperones in metal trafficking. Among metal-associated diseases, T cell mediated allergy to nickel (Ni) represents the most common form of human contact hypersensitivity. With the aim to elucidate disease-underlying mechanisms such as Ni-specific T cell activation, we initiated a proteomic approach to identify Ni-interacting proteins in human B cells. As antigen presenting cells, B cells are capable of presenting MHC-associated Ni-epitopes to T cells, a prerequisite for hapten-specific T cell activation. Using metal-affinity enrichment, 2-DE and MS, 22 Ni-interacting proteins were identified. 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Publication Year: 2005
Publication Date: 2005-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 51
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