Title: Mn<sup>2+</sup> Dopant‐Controlled Synthesis of NaYF<sub>4</sub>:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery
Abstract: Advanced MaterialsVolume 24, Issue 9 p. 1226-1231 Communication Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery Gan Tian, Gan Tian Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Chemistry, Sichuan University, Chengdu, 610064, P. R. ChinaSearch for more papers by this authorZhanjun Gu, Corresponding Author Zhanjun Gu [email protected] Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaKey Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China.Search for more papers by this authorLiangjun Zhou, Liangjun Zhou Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorWenyan Yin, Wenyan Yin Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorXiaoxiao Liu, Xiaoxiao Liu Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorLiang Yan, Liang Yan Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorShan Jin, Shan Jin Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorWenlu Ren, Wenlu Ren Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorGengmei Xing, Gengmei Xing Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorShoujian Li, Shoujian Li College of Chemistry, Sichuan University, Chengdu, 610064, P. R. ChinaSearch for more papers by this authorYuliang Zhao, Corresponding Author Yuliang Zhao [email protected] Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, ChinaKey Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China.Search for more papers by this author Gan Tian, Gan Tian Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Chemistry, Sichuan University, Chengdu, 610064, P. R. ChinaSearch for more papers by this authorZhanjun Gu, Corresponding Author Zhanjun Gu [email protected] Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaKey Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China.Search for more papers by this authorLiangjun Zhou, Liangjun Zhou Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorWenyan Yin, Wenyan Yin Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorXiaoxiao Liu, Xiaoxiao Liu Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorLiang Yan, Liang Yan Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorShan Jin, Shan Jin Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorWenlu Ren, Wenlu Ren Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorGengmei Xing, Gengmei Xing Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. ChinaSearch for more papers by this authorShoujian Li, Shoujian Li College of Chemistry, Sichuan University, Chengdu, 610064, P. R. ChinaSearch for more papers by this authorYuliang Zhao, Corresponding Author Yuliang Zhao [email protected] Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, ChinaKey Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China.Search for more papers by this author First published: 27 January 2012 https://doi.org/10.1002/adma.201104741Citations: 734Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Pure dark red emission (650–670nm) of NaYF4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn2+) doping. In addition, the Mn2+- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description adma_201104741_sm_suppl.pdf15.3 MB suppl Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 a) F. Auzel, Chem. Rev. 2004, 104, 139; b) F. Wang, X Liu, Chem. Soc. Rev. 2009, 38, 976; c) D. K. Chatterjee, M. K. Gnanasammandhan, Y. Zhang, Small 2010, 6, 2781; d) M. Haase, H. Schafer, Angew. Chem. Int. Ed. 2011, 50, 5808. 2 a) D. K. Chatterjee, A. 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