Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2082019843', 'doi': 'https://doi.org/10.1634/stemcells.2005-0299', 'title': 'Activin A Maintains Self-Renewal and Regulates Fibroblast Growth Factor, Wnt, and Bone Morphogenic Protein Pathways in Human Embryonic Stem Cells', 'display_name': 'Activin A Maintains Self-Renewal and Regulates Fibroblast Growth Factor, Wnt, and Bone Morphogenic Protein Pathways in Human Embryonic Stem Cells', 'publication_year': 2006, 'publication_date': '2006-02-02', 'ids': {'openalex': 'https://openalex.org/W2082019843', 'doi': 'https://doi.org/10.1634/stemcells.2005-0299', 'mag': '2082019843', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16456129'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2005-0299', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/24/6/1476/41880726/stmcls_24_6_1476.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/stmcls/article-pdf/24/6/1476/41880726/stmcls_24_6_1476.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100723974', 'display_name': 'Lei Xiao', 'orcid': 'https://orcid.org/0000-0001-8962-8280'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lei Xiao', 'raw_affiliation_strings': ['Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019273888', 'display_name': 'Xuan Yuan', 'orcid': 'https://orcid.org/0000-0002-7304-9927'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xuan Yuan', 'raw_affiliation_strings': ['Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113553919', 'display_name': 'Saul J. Sharkis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Saul J. Sharkis', 'raw_affiliation_strings': ['Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4140, 'currency': 'USD', 'value_usd': 4140, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.155, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 341, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '24', 'issue': '6', 'first_page': '1476', 'last_page': '1486'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11190', 'display_name': '3D Printing in Biomedical Research', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homeobox-protein-nanog', 'display_name': 'Homeobox protein NANOG', 'score': 0.6008985}, {'id': 'https://openalex.org/keywords/rex1', 'display_name': 'Rex1', 'score': 0.5113947}, {'id': 'https://openalex.org/keywords/nodal-signaling', 'display_name': 'Nodal signaling', 'score': 0.4883363}, {'id': 'https://openalex.org/keywords/fgf8', 'display_name': 'FGF8', 'score': 0.42805338}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8220246}, {'id': 'https://openalex.org/C38643226', 'wikidata': 'https://www.wikidata.org/wiki/Q4677604', 'display_name': 'Activin type 2 receptors', 'level': 4, 'score': 0.7510387}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.73680526}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.6166658}, {'id': 'https://openalex.org/C207701140', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Homeobox protein NANOG', 'level': 5, 'score': 0.6008985}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.57275593}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.56673735}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.56671745}, {'id': 'https://openalex.org/C207168726', 'wikidata': 'https://www.wikidata.org/wiki/Q18050439', 'display_name': 'Rex1', 'level': 5, 'score': 0.5113947}, {'id': 'https://openalex.org/C205583638', 'wikidata': 'https://www.wikidata.org/wiki/Q7046607', 'display_name': 'Nodal signaling', 'level': 5, 'score': 0.4883363}, {'id': 'https://openalex.org/C83330619', 'wikidata': 'https://www.wikidata.org/wiki/Q21124872', 'display_name': 'NODAL', 'level': 2, 'score': 0.4431356}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.4414376}, {'id': 'https://openalex.org/C2776094402', 'wikidata': 'https://www.wikidata.org/wiki/Q17927891', 'display_name': 'FGF8', 'level': 4, 'score': 0.42805338}, {'id': 'https://openalex.org/C2777587049', 'wikidata': 'https://www.wikidata.org/wiki/Q20969945', 'display_name': 'Basic fibroblast growth factor', 'level': 4, 'score': 0.413343}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.337794}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.30098268}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.2797044}, {'id': 'https://openalex.org/C111001777', 'wikidata': 'https://www.wikidata.org/wiki/Q3562192', 'display_name': 'TGF beta signaling pathway', 'level': 3, 'score': 0.26216298}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.21459946}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19521067}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.16004103}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.102900416}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D028322', 'descriptor_name': 'Inhibin-beta Subunits', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000782', 'descriptor_name': 'Aneuploidy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005346', 'descriptor_name': 'Fibroblast Growth Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028322', 'descriptor_name': 'Inhibin-beta Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016688', 'descriptor_name': 'Mice, Inbred NOD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D033581', 'descriptor_name': 'Stem Cell Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033581', 'descriptor_name': 'Stem Cell Transplantation', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013724', 'descriptor_name': 'Teratoma', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D013724', 'descriptor_name': 'Teratoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051153', 'descriptor_name': 'Wnt Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2005-0299', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/24/6/1476/41880726/stmcls_24_6_1476.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16456129', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2005-0299', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/24/6/1476/41880726/stmcls_24_6_1476.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1532405552', 'https://openalex.org/W1551008045', 'https://openalex.org/W1599568627', 'https://openalex.org/W1608762409', 'https://openalex.org/W1953604676', 'https://openalex.org/W1970200774', 'https://openalex.org/W1976962628', 'https://openalex.org/W1978411854', 'https://openalex.org/W1987803647', 'https://openalex.org/W1992160731', 'https://openalex.org/W1992949513', 'https://openalex.org/W2000971601', 'https://openalex.org/W2003589118', 'https://openalex.org/W2014073178', 'https://openalex.org/W2017177010', 'https://openalex.org/W2018855387', 'https://openalex.org/W2025875442', 'https://openalex.org/W2036552662', 'https://openalex.org/W2037479635', 'https://openalex.org/W2045388302', 'https://openalex.org/W2055830220', 'https://openalex.org/W2056089399', 'https://openalex.org/W2060926602', 'https://openalex.org/W2062254572', 'https://openalex.org/W2065546801', 'https://openalex.org/W2066413879', 'https://openalex.org/W2069693786', 'https://openalex.org/W2074742645', 'https://openalex.org/W2085321659', 'https://openalex.org/W2086943348', 'https://openalex.org/W2089426706', 'https://openalex.org/W2095762981', 'https://openalex.org/W2108707301', 'https://openalex.org/W2110301828', 'https://openalex.org/W2111507614', 'https://openalex.org/W2126851387', 'https://openalex.org/W2133501984', 'https://openalex.org/W2138088258', 'https://openalex.org/W2140909735', 'https://openalex.org/W2150163104', 'https://openalex.org/W2151487778', 'https://openalex.org/W2156363980', 'https://openalex.org/W2160266371', 'https://openalex.org/W2161949020', 'https://openalex.org/W2163102268', 'https://openalex.org/W3146189782'], 'related_works': ['https://openalex.org/W3150366320', 'https://openalex.org/W2884438166', 'https://openalex.org/W2205167955', 'https://openalex.org/W2148099781', 'https://openalex.org/W2140780283', 'https://openalex.org/W2128932633', 'https://openalex.org/W2067163479', 'https://openalex.org/W2044911975', 'https://openalex.org/W2031687138', 'https://openalex.org/W1976337831'], 'abstract_inverted_index': {'Abstract': [0], 'Human': [1], 'embryonic': [2], 'stem': [3], 'cells': [4], '(hESCs)': [5], 'self-renew': [6], 'indefinitely': [7], 'while': [8, 61], 'maintaining': [9, 62, 93], 'pluripotency.': [10, 63], 'The': [11], 'molecular': [12], 'mechanism': [13], 'underlying': [14], 'hESCs': [15, 108, 128], 'self-renewal': [16, 59, 124], 'and': [17, 77, 103, 118, 125, 129, 133, 153, 155, 190], 'pluripotency': [18, 126], 'is': [19, 116], 'poorly': [20], 'understood.': [21], 'To': [22], 'identify': [23], 'the': [24, 30, 53, 70, 83, 94, 98, 121, 144, 157, 172, 181, 187], 'signaling': [25, 80, 183], 'pathway': [26], 'molecules': [27, 91], 'that': [28, 113, 140, 185], 'maintain': [29], 'proliferation': [31], 'of': [32, 89, 123, 127, 136, 146, 171], 'hESCs,': [33], 'we': [34, 111], 'performed': [35], 'a': [36, 58, 166], 'microarray': [37], 'analysis': [38], 'comparing': [39], 'an': [40], 'aneuploid': [41], 'H1': [42, 49], 'hESC': [43, 50, 55, 188], 'line': [44, 51, 56], '(named': [45], 'H1T)': [46], 'versus': [47], 'euploid': [48], 'because': [52], 'H1T': [54, 84], 'demonstrates': [57], 'advantage': [60], 'We': [64, 138], 'find': [65, 112], 'differential': [66], 'gene': [67], 'expression': [68, 145], 'for': [69, 120], 'Nodal/Activin,': [71], 'fibroblast': [72], 'growth': [73, 135], 'factor': [74], '(FGF),': [75], 'Wnt,': [76], 'Hedgehog': [78], '(Hh)': [79], 'pathways': [81, 105], 'in': [82, 92, 169, 174], 'line,': [85], 'which': [86], 'implicates': [87], 'each': [88], 'these': [90], 'undifferentiated': [95], 'state,': [96], 'whereas': [97], 'bone': [99], 'morphogenic': [100], 'protein': [101], '(BMP)': [102], 'Notch': [104], 'could': [106], 'promote': [107], 'differentiation.': [109], 'Experimentally,': [110], 'Activin': [114, 141, 163], 'A': [115, 142, 164], 'necessary': [117], 'sufficient': [119], 'maintenance': [122, 170], 'supports': [130], 'long-term': [131], 'feeder': [132], 'serum-free': [134], 'hESCs.': [137, 175], 'show': [139], 'induces': [143], 'Oct4,': [147], 'Nanog,': [148], 'Nodal,': [149], 'Wnt3,': [150], 'basic': [151], 'FGF,': [152], 'FGF8': [154], 'suppresses': [156], 'BMP': [158], 'signal.': [159], 'Our': [160], 'data': [161], 'indicates': [162], 'as': [165], 'key': [167], 'regulator': [168], 'stemness': [173], 'This': [176], 'finding': [177], 'will': [178], 'help': [179], 'elucidate': [180], 'complex': [182], 'network': [184], 'maintains': [186], 'phenotype': [189], 'function.': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2082019843', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 28}, {'year': 2013, 'cited_by_count': 30}, {'year': 2012, 'cited_by_count': 34}], 'updated_date': '2024-12-12T11:57:27.296872', 'created_date': '2016-06-24'}