Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2081541806', 'doi': 'https://doi.org/10.4161/auto.7.3.14780', 'title': 'Autophagy inhibition engages Nrf2-p62 Ub-associated signaling', 'display_name': 'Autophagy inhibition engages Nrf2-p62 Ub-associated signaling', 'publication_year': 2011, 'publication_date': '2011-02-08', 'ids': {'openalex': 'https://openalex.org/W2081541806', 'doi': 'https://doi.org/10.4161/auto.7.3.14780', 'mag': '2081541806', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21252622', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3359479'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4161/auto.7.3.14780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3359479?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113771494', 'display_name': 'Brigit E. Riley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brigit E. Riley', 'raw_affiliation_strings': ['Department of Biology, Stanford University, Stanford, CA USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Stanford University, Stanford, CA USA', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089696102', 'display_name': 'Stephen E. Kaiser', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Stephen E. Kaiser', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058767055', 'display_name': 'Ron R. Kopito', 'orcid': 'https://orcid.org/0000-0001-5027-6935'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ron R. Kopito', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.475, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.855051, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '7', 'issue': '3', 'first_page': '338', 'last_page': '340'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.9783, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bag3', 'display_name': 'BAG3', 'score': 0.42539054}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.92316675}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8761575}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5988617}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.56404054}, {'id': 'https://openalex.org/C99089365', 'wikidata': 'https://www.wikidata.org/wiki/Q18034356', 'display_name': 'BAG3', 'level': 4, 'score': 0.42539054}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.42427805}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23858815}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.18199408}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1541391}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4161/auto.7.3.14780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3359479', 'pdf_url': 'https://europepmc.org/articles/pmc3359479?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359479', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21252622', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3359479', 'pdf_url': 'https://europepmc.org/articles/pmc3359479?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2773258360', 'https://openalex.org/W2517018060', 'https://openalex.org/W2515729632', 'https://openalex.org/W2390710048', 'https://openalex.org/W214686084', 'https://openalex.org/W2127187639', 'https://openalex.org/W2065796363', 'https://openalex.org/W2006544096', 'https://openalex.org/W2001675597', 'https://openalex.org/W1970188754'], 'abstract_inverted_index': {'Genetic': [0], 'inactivation': [1], 'of': [2, 12, 32, 61, 68, 94, 121, 133, 144, 156, 181, 201, 207, 223, 233, 261, 270, 312, 355, 361, 373, 389, 426, 444, 454, 492, 500, 505, 605, 632, 646, 676, 709, 732, 747, 763, 769, 782, 792, 816, 886, 900, 914, 932, 953, 960, 970, 978, 1008, 1030, 1046, 1064, 1080, 1091], 'autophagy': [3, 87, 114, 176, 285, 321, 408, 459, 485, 495, 565, 569, 610, 668, 694, 712, 734, 808, 829, 870, 936, 988, 1002, 1011], 'in': [4, 35, 65, 97, 160, 316, 330, 347, 359, 418, 474, 535, 582, 594, 613, 665, 680, 714, 729, 742, 759, 766, 942, 957, 964, 989, 1010, 1041, 1082], 'liver': [5, 19], 'or': [6, 59, 375, 773, 951, 1095], 'brain': [7], 'leads': [8], 'to': [9, 101, 110, 124, 135, 141, 226, 230, 308, 421, 436, 557, 586, 628, 667, 706, 724, 812, 826, 855, 879, 920, 998, 1014, 1043, 1058, 1087], 'the': [10, 30, 48, 66, 82, 112, 118, 142, 199, 205, 231, 259, 268, 284, 310, 338, 352, 406, 424, 441, 506, 516, 531, 564, 568, 595, 643, 673, 692, 745, 761, 767, 777, 843, 861, 872, 877, 883, 887, 911, 915, 921, 958, 975, 1000, 1005, 1027, 1044, 1059, 1069, 1083], 'appearance': [11, 206, 269], 'ubiquitin-': [13], 'and': [14, 21, 38, 117, 149, 164, 174, 183, 210, 221, 248, 255, 258, 272, 319, 334, 337, 543, 563, 577, 661, 703, 739, 749, 809, 860, 881, 926, 992, 1050], 'p62-positive': [15, 184, 273], 'inclusions': [16, 185, 209], 'coincident': [17], 'with': [18, 169, 239, 267, 371, 469, 478, 655, 776, 848], 'dysfunction': [20], 'neurodegeneration,': [22], 'respectively.': [23], 'In': [24, 151, 1085], 'our': [25, 54, 683, 905, 979, 1023], 'recent': [26], 'study': [27], 'we': [28, 300, 412, 538, 698, 909], 'measured': [29, 910], 'abundance': [31], 'polyubiquitin': [33, 43, 70, 292, 513, 802, 933], 'species': [34, 336], 'autophagy-deficient': [36, 345, 419, 536], 'tissues': [37, 363, 457], 'demonstrated': [39], 'that': [40, 57, 81, 187, 212, 314, 395, 452, 490, 528, 609, 617, 630, 688, 949, 982, 993, 1052], 'a': [41, 62, 215, 327, 470, 479, 482, 498, 614, 710, 727, 783, 821, 837, 898, 954], 'specific': [42, 291], 'chain': [44], 'linkage': [45], 'is': [46, 72, 89, 139, 158, 214, 287, 497, 608, 626, 690, 895, 929, 939, 981], 'not': [47, 108, 128, 414, 477, 691, 787, 996, 1018], 'decisive': [49], 'autophagic': [50, 77, 193, 298, 442, 752, 893], 'substrate-targeting': [51, 115], 'signal.': [52], 'Instead': [53], 'data': [55, 607, 947, 1024], 'suggest': [56, 211, 489, 1051], 'aggregation': [58, 950], 'oligomerization': [60, 203, 952, 983], 'misfolded': [63, 263, 955], 'protein,': [64, 956], 'absence': [67, 762, 959], 'detectable': [69, 961], 'modification,': [71], 'an': [73, 397, 438, 715, 831, 849, 1035], 'important': [74, 627, 1036], 'signal': [75, 116, 410, 519, 728], 'for': [76, 191, 204, 219, 280, 296, 381, 472, 520, 638, 806, 986], 'degradation.': [78, 171, 194, 1021], 'We': [79, 325, 819], 'determined': [80], 'ubiquitin': [83, 153], 'accumulation': [84, 180, 417, 491, 670, 885, 913, 931, 966, 1090], 'observed': [85, 326, 358, 534], 'upon': [86, 423], 'inhibition': [88], 'caused': [90], 'by': [91, 283, 392, 461, 756, 801, 897, 1068], 'p62-mediated': [92], 'activation': [93, 1054], 'Nrf2': [95, 126, 385, 463, 501, 525, 545, 575, 648, 662, 1016, 1081], 'resulting': [96], 'global': [98, 328, 930], 'transcriptional': [99], 'changes': [100, 591], 'ubiquitin-associated': [102], 'genes.': [103], 'Thus,': [104], 'substrate': [105, 130, 403, 517, 695, 713, 770, 799, 1020], 'polyubiquitination': [106, 404, 689, 994], 'does': [107, 786, 995], 'appear': [109, 997], 'be': [111, 125, 437, 558, 999, 1015, 1056], 'major': [113, 407, 693, 976, 1001], 'primary': [119, 1006], 'role': [120, 471, 480, 1007], 'p62': [122, 202, 213, 374, 432, 455, 473, 510, 748, 764, 1009], 'appears': [123, 1013], 'activation,': [127, 1017], 'ubiquitin-dependent': [129], 'degradation.\r\n\r\nSelective': [131], 'targeting': [132, 155, 409, 518, 696, 1003], 'proteins': [134, 157, 236, 264, 277, 805, 985, 1094], 'distinct': [136], 'subcellular': [137], 'machineries': [138], 'fundamental': [140], 'regulation': [143], 'cellular': [145, 162, 1037], 'decisions': [146], 'between': [147, 342], 'catabolism': [148], 'anabolism.': [150], 'particular,': [152], '(Ub)-mediated': [154], 'essential': [159], 'maintaining': [161], 'homeostasis,': [163], 'has': [165, 433, 448, 635, 721], 'been': [166, 434, 449, 636, 722], 'predominantly': [167], 'associated': [168, 238], 'nonlysosomal-mediated': [170], 'However,': [172, 741], 'liver-': [173, 318], 'brain-specific': [175, 320], 'knockout': [177, 322, 597], 'mice': [178, 584, 598], 'exhibit': [179], 'Ub-': [182, 271], 'suggesting': [186], 'Ub-modification': [188, 708], 'targets': [189, 804, 984], 'cargo': [190, 225], 'selective': [192, 216, 281, 297, 521, 711, 733, 807, 817, 828, 912, 965, 987], 'Subsequent': [195], 'reports': [196], 'have': [197], 'established': [198], 'requirement': [200], 'Ub-positive': [208], '‘autophagy': [217], 'adaptor’': [218], 'recognition': [220, 282], 'delivery': [222], 'Ub-modified': [224], 'autophagosomes.': [227], 'Autophagy': [228], 'contributes': [229], 'detoxification': [232, 390, 1038], 'misfolded,': [234, 844, 1092], 'aggregated': [235], 'commonly': [237], 'neurodegenerative': [240, 640, 681], 'disorders': [241], '(Alzheimer': [242], 'disease,': [243, 245, 247], 'Parkinson': [244], 'Huntington': [246], 'Lou': [249], "Gehrig's": [250], 'disease': [251], '[amyotrophic': [252], 'lateral': [253], 'sclerosis]': [254], 'prion': [256], 'encephalophathies)': [257], 'presence': [260, 425], 'these': [262, 590, 606, 743, 946, 973], 'also': [265, 1025], 'correlates': [266], 'inclusions.': [274], 'Revealing': [275], 'how': [276, 647], 'are': [278, 379, 467, 572, 579, 592], '‘marked’': [279], 'machinery': [286], 'essential.\r\n\r\nTo': [288], 'determine': [289], 'whether': [290, 798], 'linkages': [293], 'target': [294, 526], 'substrates': [295], 'degradation': [299, 443], 'used': [301, 539, 699], 'Ub': [302, 313, 332, 356, 416, 493, 532, 720, 750, 774, 790, 1032, 1075], 'absolute': [303], 'quantification': [304], '(AQUA)': [305], 'mass': [306, 701], 'spectrometry': [307, 702], 'measure': [309, 707, 827], 'amount': [311], 'accumulates': [315], 'both': [317, 842], 'mouse': [323, 686], 'models.': [324], 'increase': [329, 941], 'all': [331], 'isopeptide': [333], 'non-isopeptide': [335], 'results': [339, 378, 612, 684, 765, 963], 'were': [340, 364, 555], 'similar': [341], 'two': [343, 348, 382, 888], 'different': [344, 889], 'models': [346], 'separate': [349], 'tissues.': [350], 'Moreover': [351], 'increased': [353], 'levels': [354, 388, 1079], 'conjugates': [357], 'samples': [360], 'Atg7-null': [362], 'suppressed': [365], 'when': [366], 'this': [367, 427], 'mutation': [368], 'was': [369, 405, 754], 'combined': [370], 'deletions': [372], 'Nrf2.': [376], 'These': [377], 'significant': [380], 'reasons.': [383], 'First,': [384], 'controls': [386], 'expression': [387], 'enzymes': [391], 'regulating': [393], 'genes': [394, 527, 562, 634], 'contain': [396], 'antioxidant': [398], 'response': [399, 616, 666, 1086], 'element': [400], '(ARE).': [401], 'If': [402], 'then': [411], 'would': [413], 'expect': [415], 'tissue': [420], 'depend': [422], 'transcription': [428, 552], 'factor.': [429], 'Second,': [430], 'whereas': [431], 'hypothesized': [435], 'adaptor': [439], 'facilitating': [440], 'ubiquitinated': [445], 'substrates,': [446], 'it': [447, 659], 'previously': [450], 'shown': [451, 755], 'loss': [453, 768], 'protects': [456], 'from': [458, 685], 'deficiency': [460, 496, 611, 1012], 'preventing': [462], 'activation.': [464], 'Our': [465, 487, 602, 794], 'observations': [466, 974], 'consistent': [468], 'controlling': [475], 'Nrf2—and': [476], 'as': [481, 515, 726, 736, 1034], 'simple': [483], 'Ub-dependent': [484, 1019], 'adaptor.': [486], 'findings': [488], 'during': [494], 'result': [499], 'stress': [502, 615, 1048], 'signaling': [503, 679, 784, 1033, 1066], 'downstream': [504], 'multifunctional': [507], 'scaffolding': [508], 'protein': [509, 846, 863, 917, 924], 'rather': [511], 'than': [512, 902], 'functioning': [514], 'autophagy.\r\n\r\nTo': [522], 'identify': [523, 813], 'Ub-related': [524, 623], 'might': [529], 'explain': [530], 'dysregulation': [533], 'tissues,': [537], 'bioinformatics,': [540], 'functional': [541], 'genomics': [542], 'RT-PCR.': [544], '(and': [546], 'its': [547], 'heterodimeric': [548], 'binding': [549, 657], 'partner': [550, 658], 'Maf)': [551], 'factor-binding': [553], 'sites': [554], 'found': [556], 'enriched': [559], 'among': [560], 'Ub-associated': [561, 574, 653, 678, 1065], 'network.': [566], 'Within': [567], 'network,': [570], 'there': [571, 928, 938], '35': [573], 'targets,': [576], '22': [578], 'differentially': [580], 'affected': [581], 'Atg7-/-': [583], 'compared': [585, 919], 'wild-type': [587], 'mice.': [588], 'Importantly,': [589], 'reversed': [593], 'Atg7-/Nrf2-double': [596], 'confirming': [599], 'Nrf2-dependent': [600], 'regulation.': [601], 'overall': [603], 'interpretation': [604], 'activates': [618], 'Nrf2,': [619], 'globally': [620], 'affecting': [621], 'numerous': [622, 639], 'proteins.': [624], 'It': [625], 'note': [629], 'upregulation': [631], 'ARE-containing': [633], 'reported': [637], 'disorders.': [641], 'Understanding': [642], 'mechanistic': [644], 'details': [645], 'binds': [649], 'ARE': [650], 'elements': [651], 'within': [652], 'genes,': [654, 1049], 'what': [656], 'binds,': [660], 'nuclear/cytoplasmic': [663], 'trafficking': [664], 'inhibition/p62': [669], 'will': [671], 'reveal': [672], 'physiological': [674], 'relevance': [675], 'Nrf2-p62': [677, 1070], 'disorders.\r\n\r\nSince': [682], 'indicate': [687], 'signal,': [697], 'quantitative': [700], 'flow': [704, 822, 906], 'cytometry': [705, 823, 907], 'autophagy-regulatable': [716, 832], 'stable': [717], 'cell': [718, 833, 874, 1060], 'line.': [719], 'implicated': [723], 'function': [725], 'several': [730], 'forms': [731], 'such': [735], 'pexophagy,': [737], 'mitophagy': [738], 'xenophagy.': [740], 'studies,': [744], 'dependence': [746], 'on': [751, 972], 'clearance': [753], 'immunofluorescence': [757], 'studies': [758], 'which': [760], 'puncta': [771], 'formation': [772], 'colocalization': [775], 'substrate.': [778], 'Colocalization,': [779], 'though': [780], 'indicative': [781], 'role,': [785], 'demonstrate': [788, 948, 1026], 'covalent': [789], 'modification': [791, 800], 'substrates.': [793, 818], 'work': [795], 'addresses': [796], 'directly': [797], 'chains': [803, 934], 'enables': [810], 'us': [811], 'additional': [814, 1096], 'features': [815], 'developed': [820], 'cell-based': [824], 'assay': [825, 908], 'using': [830], 'line': [834], 'stably': [835], 'expressing': [836], 'bicistronic': [838], 'reporter': [839, 873], 'construct': [840], 'containing': [841], 'aggregation-prone': [845, 916, 1093], 'huntingtin': [847], 'expanded': [850], 'polyglutamine': [851], 'tract': [852], '(htt(Q47))': [853], 'fused': [854], 'GFP': [856], '(green': [857], 'fluorescent': [858, 867, 890], 'protein),': [859], 'non-aggregation-prone': [862], 'cherry': [864], 'chFP': [865, 925], '(cherry': [866], 'protein).': [868], 'Following': [869], 'shut-off,': [871], 'lines': [875], 'provide': [876], 'ability': [878], 'quantify': [880], 'compare': [882], 'relative': [884], 'reporters,': [891], 'where': [892], 'selectivity': [894], 'indicated': [896], 'ratio': [899], 'greater': [901], 'one.': [903], 'Using': [904], 'htt(Q47)': [918], 'non-aggregation': [922], 'prone': [923], 'although': [927], 'following': [935, 967], 'shut-off': [937], 'no': [940], 'polyubiquitin-modified': [943], 'htt(Q47).': [944], 'Overall,': [945], 'Ub-modification,': [962], 'genetic': [968], 'ablation': [969], 'autophagy.\r\n\r\nBased': [971], 'conclusion': [977], 'manuscript': [980], 'mammalian': [990], 'cells,': [991], 'signal;': [1004], 'Moreover,': [1022], 'broad': [1028], 'importance': [1029], 'Nrf2-driven': [1031], 'mechanism': [1039], 'acting': [1040], 'addition': [1042], 'arsenal': [1045], 'Nrf2-oxidative': [1047], 'sustained': [1053], 'could': [1055], 'detrimental': [1057], '(Fig.': [1061], '1).\r\n\r\n\r\n\r\nFigure': [1062], '1\r\n\r\nSchematic': [1063], 'regulated': [1067], 'axis.': [1071], 'The': [1072], 'Keap1-Cul3-Rbx1': [1073], 'E3': [1074], 'ligase': [1076], 'maintains': [1077], 'low': [1078], 'cell.': [1084], 'oxidative': [1088], 'insult,': [1089], 'unknown': [1097], '...': [1098]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2081541806', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-10T09:05:53.367348', 'created_date': '2016-06-24'}