TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

Name: Work Video:
Duration: 3 min 30 s
Michael A. Mandell; Ashish Jain; John Arko‐Mensah; Santosh Chauhan; Tomonori Kimura; Christina Dinkins; Guido Silvestri; Jan Münch; Frank Kirchhoff; Anne Simonsen; Yongjie Wei; Beth Levine; Terje Johansen; Vojo Deretić
{'id': 'https://openalex.org/W2127187639', 'doi': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'title': 'TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition', 'display_name': 'TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition', 'publication_year': 2014, 'publication_date': '2014-08-01', 'ids': {'openalex': 'https://openalex.org/W2127187639', 'doi': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'mag': '2127187639', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25127057', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4146662'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089870197', 'display_name': 'Michael A. Mandell', 'orcid': 'https://orcid.org/0000-0002-5773-2806'}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael\xa0A. Mandell', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014466375', 'display_name': 'Ashish Jain', 'orcid': 'https://orcid.org/0000-0001-6549-2788'}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Ashish Jain', 'raw_affiliation_strings': ['Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway'], 'affiliations': [{'raw_affiliation_string': 'Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway', 'institution_ids': ['https://openalex.org/I78037679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020332018', 'display_name': 'John Arko‐Mensah', 'orcid': 'https://orcid.org/0000-0001-8709-9311'}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John Arko-Mensah', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043096559', 'display_name': 'Santosh Chauhan', 'orcid': 'https://orcid.org/0000-0001-9167-5107'}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Santosh Chauhan', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086090210', 'display_name': 'Tomonori Kimura', 'orcid': 'https://orcid.org/0000-0001-8186-094X'}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tomonori Kimura', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026169513', 'display_name': 'Christina Dinkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christina Dinkins', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010618682', 'display_name': 'Guido Silvestri', 'orcid': 'https://orcid.org/0000-0001-6602-2470'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guido Silvestri', 'raw_affiliation_strings': ['Yerkes National Primate Research Center, Emory University, 3014 Yerkes, 954 Gatewood Road NE, Atlanta, GA 30329, USA.'], 'affiliations': [{'raw_affiliation_string': 'Yerkes National Primate Research Center, Emory University, 3014 Yerkes, 954 Gatewood Road NE, Atlanta, GA 30329, USA.', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072303851', 'display_name': 'Jan Münch', 'orcid': 'https://orcid.org/0000-0001-7316-7141'}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jan Münch', 'raw_affiliation_strings': ['Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081\xa0Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081\xa0Ulm, Germany', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075006919', 'display_name': 'Frank Kirchhoff', 'orcid': 'https://orcid.org/0000-0002-7052-2360'}, 'institutions': [{'id': 'https://openalex.org/I196349391', 'display_name': 'Universität Ulm', 'ror': 'https://ror.org/032000t02', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I196349391']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank Kirchhoff', 'raw_affiliation_strings': ['Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081\xa0Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081\xa0Ulm, Germany', 'institution_ids': ['https://openalex.org/I196349391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073036493', 'display_name': 'Anne Simonsen', 'orcid': 'https://orcid.org/0000-0003-4711-7057'}, 'institutions': [{'id': 'https://openalex.org/I184942183', 'display_name': 'University of Oslo', 'ror': 'https://ror.org/01xtthb56', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I184942183']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Anne Simonsen', 'raw_affiliation_strings': ['Dept of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway'], 'affiliations': [{'raw_affiliation_string': 'Dept of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway', 'institution_ids': ['https://openalex.org/I184942183']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108468626', 'display_name': 'Yongjie Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I4388891891', 'display_name': 'Southwestern Medical Center', 'ror': 'https://ror.org/05d80e146', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4388891891']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yongjie Wei', 'raw_affiliation_strings': ['Center for Autophagy Research and Howard Hughes Medical Institute, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Autophagy Research and Howard Hughes Medical Institute, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I4388891891']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015807309', 'display_name': 'Beth Levine', 'orcid': 'https://orcid.org/0000-0002-1460-1638'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I4388891891', 'display_name': 'Southwestern Medical Center', 'ror': 'https://ror.org/05d80e146', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4388891891']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beth Levine', 'raw_affiliation_strings': ['Center for Autophagy Research and Howard Hughes Medical Institute, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.'], 'affiliations': [{'raw_affiliation_string': 'Center for Autophagy Research and Howard Hughes Medical Institute, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I4388891891']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035924475', 'display_name': 'Terje Johansen', 'orcid': 'https://orcid.org/0000-0003-1451-9578'}, 'institutions': [{'id': 'https://openalex.org/I78037679', 'display_name': 'UiT The Arctic University of Norway', 'ror': 'https://ror.org/00wge5k78', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I78037679']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Terje Johansen', 'raw_affiliation_strings': ['Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway'], 'affiliations': [{'raw_affiliation_string': 'Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway', 'institution_ids': ['https://openalex.org/I78037679']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091612802', 'display_name': 'Vojo Deretić', 'orcid': 'https://orcid.org/0000-0002-3624-5208'}, 'institutions': [{'id': 'https://openalex.org/I169521973', 'display_name': 'University of New Mexico', 'ror': 'https://ror.org/05fs6jp91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I169521973']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vojo Deretic', 'raw_affiliation_strings': ['Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA.', 'institution_ids': ['https://openalex.org/I169521973']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 19.291, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 288, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '30', 'issue': '4', 'first_page': '394', 'last_page': '409'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bag3', 'display_name': 'BAG3', 'score': 0.6261188}, {'id': 'https://openalex.org/keywords/ulk1', 'display_name': 'ULK1', 'score': 0.52383214}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.9826815}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8140694}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.812243}, {'id': 'https://openalex.org/C99089365', 'wikidata': 'https://www.wikidata.org/wiki/Q18034356', 'display_name': 'BAG3', 'level': 4, 'score': 0.6261188}, {'id': 'https://openalex.org/C71680706', 'wikidata': 'https://www.wikidata.org/wiki/Q18032908', 'display_name': 'ULK1', 'level': 5, 'score': 0.52383214}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.48194027}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.45204926}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.42211145}, {'id': 'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.41377324}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2082459}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.12055048}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11681652}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.07033023}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071189', 'descriptor_name': 'Autophagy-Related Protein-1 Homolog', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071186', 'descriptor_name': 'Beclin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000070584', 'descriptor_name': 'Tripartite Motif Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4146662', 'pdf_url': 'https://europepmc.org/articles/pmc4146662?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146662', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25127057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2014.06.013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S83804233', 'display_name': 'Developmental Cell', 'issn_l': '1534-5807', 'issn': ['1534-5807', '1878-1551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1784425676', 'https://openalex.org/W1851347272', 'https://openalex.org/W1968444524', 'https://openalex.org/W1969971911', 'https://openalex.org/W1970637701', 'https://openalex.org/W1973472942', 'https://openalex.org/W1974067508', 'https://openalex.org/W1977767269', 'https://openalex.org/W1982328089', 'https://openalex.org/W1989966286', 'https://openalex.org/W1992496728', 'https://openalex.org/W1992532731', 'https://openalex.org/W1997112179', 'https://openalex.org/W1998019811', 'https://openalex.org/W1998170956', 'https://openalex.org/W1998631287', 'https://openalex.org/W1999211990', 'https://openalex.org/W2001160077', 'https://openalex.org/W2002288000', 'https://openalex.org/W2005485591', 'https://openalex.org/W2006379278', 'https://openalex.org/W2006840724', 'https://openalex.org/W2009225398', 'https://openalex.org/W2015771752', 'https://openalex.org/W2016962320', 'https://openalex.org/W2018636808', 'https://openalex.org/W2024173579', 'https://openalex.org/W2025665129', 'https://openalex.org/W2025843509', 'https://openalex.org/W2030755802', 'https://openalex.org/W2032684576', 'https://openalex.org/W2040742944', 'https://openalex.org/W2045373134', 'https://openalex.org/W2047144539', 'https://openalex.org/W2048494900', 'https://openalex.org/W2050207498', 'https://openalex.org/W2052107105', 'https://openalex.org/W2056663185', 'https://openalex.org/W2057040546', 'https://openalex.org/W2066697766', 'https://openalex.org/W2066803060', 'https://openalex.org/W2069615171', 'https://openalex.org/W2071519991', 'https://openalex.org/W2073062041', 'https://openalex.org/W2073963703', 'https://openalex.org/W2082314789', 'https://openalex.org/W2082429447', 'https://openalex.org/W2086096948', 'https://openalex.org/W2087652476', 'https://openalex.org/W2088895400', 'https://openalex.org/W2088947549', 'https://openalex.org/W2090282670', 'https://openalex.org/W2096831872', 'https://openalex.org/W2103659405', 'https://openalex.org/W2110950722', 'https://openalex.org/W2114847797', 'https://openalex.org/W2116773729', 'https://openalex.org/W2120782274', 'https://openalex.org/W2121429373', 'https://openalex.org/W2135140747', 'https://openalex.org/W2140915719', 'https://openalex.org/W2143070952', 'https://openalex.org/W2143238979', 'https://openalex.org/W2145266709', 'https://openalex.org/W2146124002', 'https://openalex.org/W2148281700', 'https://openalex.org/W2150168624', 'https://openalex.org/W2154993563', 'https://openalex.org/W2156829363', 'https://openalex.org/W2158926973', 'https://openalex.org/W2164626497', 'https://openalex.org/W2167033587'], 'related_works': ['https://openalex.org/W4386775318', 'https://openalex.org/W4378172260', 'https://openalex.org/W4307919969', 'https://openalex.org/W3030000616', 'https://openalex.org/W2993674672', 'https://openalex.org/W2773258360', 'https://openalex.org/W2751742604', 'https://openalex.org/W2130010919', 'https://openalex.org/W2054536403', 'https://openalex.org/W1970188754'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127187639', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 29}, {'year': 2021, 'cited_by_count': 37}, {'year': 2020, 'cited_by_count': 32}, {'year': 2019, 'cited_by_count': 33}, {'year': 2018, 'cited_by_count': 34}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 32}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 3}], 'updated_date': '2024-12-29T20:09:19.641269', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
