Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl-d-aspartate Receptor

Name: Work Video:
Duration: 3 min 30 s
Stefan Strack; Roger Colbran
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2328, 2349, 2506, 2632, 2758, 2821, 2873, 2983, 3093], 'NR2A': [39, 98, 187, 246, 816, 1953, 1967, 2231, 2536, 2960, 2969, 3463, 3523], 'or': [40, 92, 188, 240, 1053, 1111, 1115, 1334, 1348, 1387, 1425, 1539, 1691, 1798, 1870, 2006], 'NR1,': [41, 189, 2059, 2184, 2999], 'subunits': [42, 190, 819, 1615, 1907, 2037, 2143], 'NMDA': [44, 55, 109, 130, 192, 203, 257, 278, 507, 822, 1613, 1647, 1683, 1992, 2035, 2103, 2141, 2181, 2840, 2857, 2876, 3029, 3083, 3090, 3178, 3189, 3231, 3309, 3325, 3334, 3531], 'are': [46, 194, 337, 773, 1970, 2539, 2550, 2609, 2719, 3234], 'responsible': [47, 195], 'autophosphorylation-dependent': [49, 197], 'targeting': [50, 198, 3185], 'CaMKII.': [52, 200, 2834, 3109], 'CaMKII': [53, 79, 106, 124, 201, 227, 254, 272, 296, 422, 466, 503, 607, 742, 766, 890, 1158, 1383, 1481, 1989, 2022, 2033, 2044, 2064, 2101, 2286, 2310, 2323, 2457, 2502, 2521, 2584, 2613, 2634, 2664, 2712, 2732, 2750, 2848, 2956, 3187, 3215, 3242, 3302, 3332, 3376, 3519, 3579], 'colocalize': [57, 205], 'in': [58, 86, 111, 206, 234, 259, 340, 344, 427, 432, 835, 891, 984, 990, 1092, 1106, 1168, 1187, 1195, 1243, 1431, 1458, 1484, 1588, 1671, 1770, 1795, 1806, 1850, 1885, 1994, 2023, 2093, 2108, 2127, 2243, 2399, 2440, 2445, 2458, 2464, 2607, 2618, 2676, 2721, 2823, 2849, 2878, 2932, 2976, 3006, 3008, 3191, 3197, 3205, 3225, 3243, 3414, 3468], 'neuronal': [59, 207], 'dendritic': [60, 208, 1998, 2024, 3207], 'spines,': [61, 209], 'CaMKII·NMDA': [64, 212, 964], 'receptor': [65, 116, 131, 213, 264, 279, 823, 965, 1614, 1684, 2036, 2142, 2167, 2182, 2841, 2858, 2944, 3055, 3310, 3326, 3532], 'complex': [66, 214, 2031, 2078, 3096], 'can': [67, 215, 2038, 2437, 3535], 'be': [68, 216, 1155, 1976, 2039], 'isolated': [69, 217, 2752], 'from': [70, 218, 1087, 1319, 1507, 1579, 2041, 2741], 'brain': [71, 219, 341, 1545, 2742], 'extracts.': [72, 220, 2744], 'Autophosphorylation': [73, 221], 'induces': [74, 222], 'direct': [75, 223, 877], 'high-affinity': [76, 224, 2449, 2612], 'binding': [77, 94, 225, 242, 1159, 1500, 1509, 1516, 1915, 2197, 2287, 2321, 2369, 2500, 2522, 2585, 2659, 2717, 2957, 3221], 'to': [80, 97, 228, 245, 467, 769, 790, 1154, 1267, 1371, 1382, 1465, 1467, 1501, 1510, 1835, 1843, 1899, 1909, 2088, 2289, 2297, 2319, 2324, 2338, 2350, 2503, 2542, 2586, 2833, 2844, 2889, 2972, 3027, 3076, 3104, 3171, 3188, 3222, 3315, 3338, 3344], '50': [82, 230, 997, 1442, 1490, 1689], 'amino': [83, 231], 'acid': [84, 232, 758, 1687], 'domain': [85, 233, 430, 2206, 2268, 2302, 2361, 2444], 'the': [87, 129, 235, 277, 428, 456, 468, 791, 821, 1088, 1107, 1372, 1468, 1682, 1771, 1883, 1910, 2004, 2076, 2098, 2114, 2120, 2128, 2131, 2162, 2166, 2174, 2178, 2214, 2244, 2258, 2290, 2394, 2435, 2499, 2513, 2547, 2655, 2670, 2674, 2677, 2715, 2722, 2824, 2839, 2943, 2952, 2968, 3009, 3058, 3080, 3118, 3226, 3230, 3235, 3244, 3305, 3308, 3378, 3415, 3469, 3475, 3478, 3590], 'NR2B': [88, 236, 818, 884, 888, 1309, 1315, 1421, 1955, 1969, 2053, 2204, 2233, 2256, 2282, 2325, 2342, 2446, 2734, 2836, 2995, 3183, 3227, 3467, 3521], 'cytoplasmic': [89, 101, 237, 249, 1285, 2175, 2205, 2292], 'tail;': [90, 238], 'little': [91, 239], 'no': [93, 241], 'observed': [96, 244, 1518, 3001], 'NR1': [100, 248, 1296, 1785, 2066, 2220, 2870, 2929, 3018, 3561], 'tails.': [102, 250], 'Specific': [103, 251], 'colocalization': [104, 252, 1856, 2934, 3007, 3174], 'with': [107, 128, 255, 276, 827, 976, 1028, 1102, 1164, 1262, 1389, 1417, 1530, 1540, 1566, 1572, 1592, 1612, 1944, 1952, 1958, 1991, 2034, 2065, 2083, 2102, 2149, 2230, 2262, 2308, 2375, 2625, 2636, 2724, 2733, 2755, 2780, 2855, 2942, 2996, 3015, 3035, 3067, 3111, 3175, 3333, 3408, 3474, 3520, 3604], 'NR2B-containing': [108, 256], 'transfected': [112, 260, 1591, 1766], 'cells': [113, 261, 1583, 1746, 1757, 1808, 1884, 2993], 'depends': [114, 262], 'on': [115, 263, 1276, 1586, 1839, 2508, 2646], 'activation,': [117, 265, 2665], 'Ca2+influx,': [118, 266], 'Thr286': [120, 268, 499, 1114, 2650, 2667, 2846, 3218], 'autophosphorylation.': [121, 269], 'Translocation': [122, 270], 'because': [125, 273, 1979, 2061], 'interaction': [127, 275, 880, 1974, 2099, 2261, 2307, 2315, 2374, 2436, 2635, 2641, 2723, 3330], 'Ca2+channel': [132, 280], 'may': [133, 281, 1975, 3410, 3524], 'potentiate': [134, 282], 'activity': [136, 284, 1916, 1950, 2958, 3213], 'provide': [138, 286, 3526], 'exquisite': [139, 287], 'spatial': [140, 288], 'temporal': [142, 290], 'control': [143, 291, 1502, 1963], 'postsynaptic': [145, 293, 345, 502, 733, 771, 2019], 'substrate': [146, 294, 2510, 2516, 2716], 'phosphorylation.': [147, 295], 'multifunctional,': [299], 'calcium-activated': [300], '(1Braun': [302, 2681], 'A.P.': [303, 2682], 'Schulman': [304, 2683, 3149], 'H.': [305, 639, 2684, 3150, 3493], 'Annu.': [306, 2685], 'Rev.': [307, 2686], 'Physiol.': [308, 2687], '1995;': [309, 324, 561, 802, 1040, 1127, 1208, 1639, 1721, 1924, 2408, 2688, 2703], '57:': [310, 2689], '417-445Crossref': [311, 2690], 'PubMed': [312, 327, 395, 411, 451, 489, 522, 537, 564, 594, 631, 650, 676, 700, 728, 810, 868, 929, 958, 1048, 1075, 1135, 1216, 1233, 1729, 1826, 1932, 2416, 2430, 2487, 2579, 2691, 2706, 2807, 2920, 3138, 3158, 3265, 3281, 3293, 3368, 3400, 3435, 3454, 3499, 3513], 'Scopus': [313, 328, 396, 412, 490, 523, 538, 565, 595, 632, 651, 677, 701, 729, 811, 869, 930, 959, 1049, 1076, 1136, 1217, 1234, 1730, 1827, 1933, 2417, 2488, 2580, 2692, 2707, 2808, 2921, 3159, 3266, 3294, 3369, 3401, 3436, 3455], '(738)': [314, 2693], 'Google': [315, 330, 398, 414, 452, 492, 525, 540, 567, 580, 597, 634, 653, 679, 703, 731, 813, 871, 932, 961, 1051, 1078, 1138, 1219, 1236, 1642, 1732, 1829, 1935, 2419, 2431, 2490, 2582, 2694, 2709, 2810, 2923, 3139, 3161, 3268, 3282, 3296, 3371, 3403, 3438, 3457, 3500, 3514], 'Scholar,': [316, 399, 526, 541, 568, 581, 635, 654, 680, 2420, 2695, 3140, 3269, 3283, 3439, 3501], '2Soderling': [317, 2696], 'T.R.': [318, 549, 645, 723, 2697, 3128, 3363], 'Adv.': [319, 2698], 'Second': [320, 2699], 'Messenger': [321, 2700], 'Phosphoprotein': [322, 2701], 'Res.': [323, 2702, 3431], '30:': [325, 2704], '175-189Crossref': [326, 2705], '(39)': [329, 2708], 'Scholar),': [331, 453, 598, 704, 1220, 1237, 1733, 1936, 2432, 2583, 2811, 3162, 3404], 'whose': [332], 'α': [333, 2745], 'β': [335, 2747], 'isoforms': [336, 2748], 'particularly': [338], 'abundant': [339, 2124], 'cytosol': [342], 'densities': [346], '(PSDs),': [347], '1The': [348], 'abbreviations': [349], 'used': [350], 'are:': [351], 'PSDpostsynaptic': [352], 'densityCaMKIIcalcium/calmodulin-dependent': [353], 'protein': [354, 736, 941, 1378, 1423, 1471, 2135, 2344, 2622], 'IICaMKIIα/βα/β': [356], 'isoform': [357, 740], 'CaMKII[P-T286]CaMKIIαCaMKIIα': [359], 'autophosphorylated': [360, 364, 744, 749, 1101, 2847], 'at': [361, 365, 423, 745, 750, 1113, 1616, 1751, 2248, 2355, 2524, 2649, 3164, 3217, 3300], 'threonine': [362, 366, 369, 425, 746, 751, 754], '286[P-T306]CaMKIIαCaMKIIα': [363], '305': [367, 752], 'and/or': [368, 753, 1968], '306NMDAN-methyl-d-aspartateAPV2-amino-5-phosphonovaleric': [370], 'acidGSTglutathioneS-transferaseLTPlong': [371], 'potentiation.': [373, 762], 'submembranous': [374], 'scaffolds': [375], 'receptors,': [377, 3030], 'ion': [378], 'channels,': [379], 'signal': [381], 'transducers': [382], '(3Kennedy': [383], 'M.B.': [384, 664, 2424, 2475, 2567], 'Trends': [385], 'Neurosci.': [386, 576, 2426, 3277, 3495, 3509], '1997;': [387, 403, 481, 623, 692, 725, 921, 955, 1072, 2912, 3262, 3365, 3392, 3496, 3510], '20:': [388], '264-268Abstract': [389], 'Full': [390, 392, 406, 408, 448, 484, 486, 626, 628, 671, 673, 695, 697, 805, 807, 924, 926, 1043, 1045, 1130, 1132, 1211, 1213, 1724, 1726, 1821, 1823, 1927, 1929, 2411, 2413, 2482, 2484, 2574, 2576, 2802, 2804, 2915, 2917, 3135, 3155, 3395, 3397], 'Text': [391, 393, 407, 409, 449, 485, 487, 627, 629, 672, 674, 696, 698, 806, 808, 925, 927, 1044, 1046, 1131, 1133, 1212, 1214, 1725, 1727, 1822, 1824, 1928, 1930, 2412, 2414, 2483, 2485, 2575, 2577, 2803, 2805, 2916, 2918, 3136, 3156, 3396, 3398], 'PDF': [394, 410, 450, 488, 630, 675, 699, 809, 928, 1047, 1134, 1215, 1728, 1825, 1931, 2415, 2486, 2578, 2806, 2919, 3137, 3157, 3399], '(408)': [397], '4Ziff': [400], 'E.B.': [401], 'Neuron.': [402, 1817, 3151], '19:': [404], '1163-1174Abstract': [405], '(334)': [413], 'Scholar).': [415, 493, 732, 814, 872, 962, 1079, 1139, 1643, 1830, 2491, 2710, 2924, 3297, 3372, 3458, 3515], 'Postsynaptic': [416], 'calcium': [417, 2891, 3066, 3099, 3208, 3311], 'triggers': [419, 3214], 'autophosphorylation': [420, 500, 2648, 2668, 2771, 3107, 3216], 'residue': [426, 2356], 'autoinhibitory': [429], '(Thr286': [431], 'CaMKIIα)': [433], '(5Fukunaga': [434], 'K.': [435, 684], 'Stoppini': [436], 'L.': [437, 1658, 3427, 3541, 3594, 3615], 'Miyamoto': [438], 'E.': [439, 637, 1810], 'Muller': [440, 716, 3356, 3442], 'D.': [441, 717, 1661, 3357, 3443, 3566, 3599, 3619], 'J.': [442, 478, 575, 620, 665, 689, 799, 850, 857, 918, 953, 1037, 1070, 1124, 1205, 1227, 1635, 1718, 1921, 2405, 2425, 2476, 2568, 2796, 2909, 3129, 3260, 3276, 3288, 3389, 3494, 3503, 3508, 3613, 3617], 'Biol.': [443, 479, 621, 666, 690, 800, 919, 1038, 1125, 1206, 1719, 1922, 2406, 2477, 2569, 2797, 2910, 3130, 3390], 'Chem.': [444, 480, 622, 667, 691, 801, 920, 1039, 1126, 1207, 1720, 1923, 2407, 2478, 2570, 2798, 2911, 3131, 3391], '1993;': [445, 647, 3290], '268:': [446], '7863-7867Abstract': [447], 'which': [454, 765, 2160, 2453, 2619, 2981, 3069, 3206, 3530], 'renders': [455], 'persistently': [458], 'active': [459, 2238, 2671], 'causes': [461], 'translocation': [463], 'soluble': [465, 1418], 'PSD': [469, 894, 903, 2091, 2125, 3245, 3379], '(6Strack': [470, 612, 910, 3381], 'S.': [471, 473, 515, 530, 547, 559, 613, 615, 911, 913, 946, 1065, 1069, 3253, 3382, 3384, 3449, 3596], 'Choi': [472, 614, 912, 3383], 'Lovinger': [474, 616, 914, 3385, 3600], 'D.M.': [475, 617, 915, 1634, 3386], 'Colbran': [476, 618, 797, 916, 951, 1035, 1122, 1203, 1716, 1919, 2403, 3258, 3387], 'R.J.': [477, 619, 798, 917, 952, 1036, 1057, 1123, 1204, 1717, 1920, 2404, 3259, 3388], '272:': [482, 624, 693, 922, 2913, 3393], '13467-13470Abstract': [483, 625, 923, 3394], '(252)': [491, 633, 931, 3402], 'Multiple': [494], 'lines': [495, 2494], 'evidence': [497, 2496, 2727], 'indicate': [498, 2497], 'necessary': [505], 'receptor-dependent': [508], 'LTP': [509, 713, 3423], '(7Silva': [510], 'A.J.': [511, 589, 660, 2471, 2563], 'Stevens': [512], 'C.F.': [513], 'Tonegawa': [514], 'Wang': [516], 'Y.': [517, 3425], 'Science.': [518, 533, 590, 724, 3364], '1992;': [519], '257:': [520], '201-206Crossref': [521], '(1183)': [524], '8Pettit': [527], 'D.L.': [528], 'Perlman': [529], 'Malinow': [531], 'R.': [532, 845, 849, 3609], '1994;': [534, 865], '266:': [535], '1881-1885Crossref': [536], '(268)': [539], '9Lledo': [542], 'P.-M.': [543], 'Hjelmstad': [544], 'G.O.': [545], 'Mukherji': [546], 'Soderling': [548, 644, 722, 3127, 3362, 3575], 'Malenka': [550], 'R.C.': [551], 'Nicoll': [552], 'R.A.': [553], 'Proc.': [554, 3444], 'Natl.': [555, 3445], 'Acad.': [556, 3446], 'Sci.': [557, 3447], 'U.': [558, 3448], 'A.': [560, 715, 1814, 3285, 3355, 3450], '92:': [562], '11175-11179Crossref': [563], '(360)': [566], '10Otmakhov': [569], 'N.': [570], 'Griffith': [571, 720, 3360], 'L.C.': [572, 721, 3361], 'Lisman': [573], 'J.E.': [574], '1996;': [577, 668, 1230, 1818, 2479, 2571, 3451], '17:': [578, 1819, 3497, 3511], '5357-5365Crossref': [579], '11Giese': [582], 'K.P.': [583], 'Fedorov': [584], 'N.B.': [585], 'Filipkowski': [586], 'R.K.': [587], 'Silva': [588], '1998;': [591, 2799], '279:': [592], '870-873Crossref': [593], '(884)': [596, 730, 3370], 'PSD-associated': [606, 783, 3249], 'phosphorylates': [608], 'ionotropic': [609], '12McGlade-McCulloh': [636], 'Yamamoto': [638], 'Tan': [640], 'S.E.': [641], 'Brickey': [642], 'D.A.': [643], 'Nature.': [646, 864], '362:': [648], '640-642Crossref': [649], '(337)': [652], '13Omkumar': [655], 'R.V.': [656, 2467, 2559], 'Kiely': [657, 2468, 2560], 'M.J.': [658, 2469, 2561, 2902], 'Rosenstein': [659, 2470, 2562], 'Min': [661, 2472, 2564], 'K.T.': [662, 2473, 2565], 'Kennedy': [663, 2423, 2474, 2566], '271:': [669, 2480, 2572], '31670-31678Abstract': [670, 2481, 2573], '(263)': [678, 2489, 2581], '14Mammen': [681], 'A.L.': [682], 'Kameyama': [683], 'Roche': [685], 'K.W.': [686], 'Huganir': [687], 'R.L.': [688], '32528-32533Abstract': [694], '(358)': [702], 'providing': [705], 'mechanism': [707, 3528], 'increased': [709, 2985], 'synaptic': [710, 3212, 3352], 'strength': [711], 'during': [712, 3320], '(15Barria': [714, 3354], 'Derkach': [718, 3358], 'V.': [719, 1224, 3359, 3552], '276:': [726, 3366], '2042-2045Crossref': [727, 3367], 'density': [734], 'calcium/calmodulin-dependent': [735, 3106], 'α/β': [739], 'CaMKIIα': [743, 748, 1099, 1533, 1776, 2241, 2398, 2647, 2762, 2852, 2927, 2977, 2997, 3016, 3043, 3169], '286': [747], '306': [755], 'N-methyl-d-aspartate': [756], '2-amino-5-phosphonovaleric': [757, 1686], 'glutathioneS-transferase': [759], 'Mechanisms': [763], 'by': [764, 982, 1090, 1322, 1335, 1403, 1476, 1495, 1651, 1858, 1941, 2003, 2119, 2198, 2269, 2456, 2737, 2866, 2939, 2986, 3211, 3248, 3529], 'targeted': [768], 'its': [770, 2266], 'substrates': [772], 'poorly': [774, 3075], 'understood.': [775], 'Previous': [776], 'gel': [777, 1942, 2332], 'overlay': [778, 1384, 1914, 1943, 2199, 2333, 2593], 'analyses': [779], 'revealed': [780, 2016], 'candidate': [782], 'CaMKII-anchoring': [784], 'protein,': [785, 1551], 'p190,': [786], 'binds': [788, 2831, 3073], 'selectively': [789, 2832], 'Thr286-autophosphorylated': [792], '([P-T286]CaMKIIα)': [794], '(16McNeill': [795, 1033, 1120, 1201, 1714, 1917, 2401], 'R.B.': [796, 1034, 1061, 1121, 1202, 1715, 1918, 2402], '270:': [803, 1041, 1128, 1209, 1722, 1925, 2409], '10043-10049Abstract': [804, 1042, 1129, 1210, 1723, 1926, 2410], '(90)': [812, 1050, 1137, 1218, 1731, 1934, 2418], 'The': [815, 1017, 1080, 1283, 2111, 2203, 2442, 2835, 3459], 'share': [824], 'several': [825], 'properties': [826], 'this': [828, 2301, 2360, 3112, 3239], 'CaMKII-binding': [829, 1949, 1971, 2267, 2443], 'activity,': [830, 3342], 'including': [831, 2130], 'apparent': [832], 'size,': [833], 'enrichment': [834], 'PSDs,': [836], 'regional': [838], 'developmental': [840, 3460, 3537], 'expression': [841, 1400, 1604, 1645, 1777, 2966, 3572, 3580, 3592], 'profiles': [842], '2S.': [843], 'Strack,': [844], 'B.': [846, 3622], 'McNeill,': [847], 'Colbran,': [851], 'unpublished': [852], 'data.': [853], '(17Sheng': [854], 'M.': [855, 1063, 1662, 1816, 2791, 3507, 3546, 3557], 'Cummings': [856], 'Roldan': [858], 'L.A.': [859], 'Jan': [860, 862], 'Y.N.': [861], 'L.Y.': [863], '368:': [866, 1231], '144-147Crossref': [867], '(1110)': [870], 'demonstrate': [875], 'specific': [879, 1512, 1515, 2235, 2729], 'between': [881, 1142], '[P-T286]CaMKIIα': [882], 'targets': [889], 'intact': [892, 3198], 'cells.': [893, 2851, 3199], 'isolation': [895], 'immunoprecipitation': [897], 'sodium': [899], 'dodecyl': [900], 'sulfate': [901], '(SDS)-solubilized': [902], 'proteins': [904, 1085, 1523, 2126, 2192, 2225], 'were': [905, 970, 1160, 1185, 1260, 1317, 1339, 1361, 1366, 1380, 1412, 1524, 1578, 1584, 1667, 1699, 1747, 1768, 1832, 1853, 2193, 2234, 2751, 2820, 2864, 2937], 'carried': [906], 'out': [907], 'as': [908, 1311, 1313, 1631, 1803, 2001, 2188, 2240, 2812, 2814], 'described': [909, 1632], 'Scholar)': [933, 1052], 'using': [934, 1326, 1519, 1707, 2043], '2': [935, 1002, 1005, 1415, 1473, 1535, 1558, 1606, 1677, 1742, 1869, 2201, 2363, 2385, 2601, 2652], 'μg/ml': [936, 1030, 1553], 'NR2A/B': [937, 1624, 1787, 1940, 1959], 'antibodies': [938, 944, 1265, 1393, 1398, 1577, 3562], '(Chemicon)': [939], 'phosphatase': [942, 2136], '1': [943, 1008, 1011, 1014, 2012, 2027, 2051, 2137, 2139], '(18Strack': [945, 3252], 'Barban': [947, 3254], 'M.A.': [948, 1059, 3255], 'Wadzinski': [949, 1066, 3256, 3623], 'B.E.': [950, 1067, 3257], 'Neurochem.': [954, 1071, 3261, 3289], '68:': [956, 3263], '2119-2128Crossref': [957, 3264], '(262)': [960, 3267], 'For': [963, 1881], 'coimmunoprecipitation,': [966], 'PSDs': [967, 2042, 2082], '(1': [968, 1526, 1599], 'mg/ml)': [969, 1430], 'cross-linked': [971], '(45': [972], 'min,': [973, 1022], '4': [974, 1528], '°C)': [975, 1529], '0.25': [977], 'mm': [978, 995, 998, 1003, 1006, 1012, 1249, 1254, 1440, 1443, 1451, 1491, 1678], 'dithiobis(succinimidyl': [979], 'suberate),': [980], 'dissolved': [981], 'sonication': [983], '2%': [985, 2094], 'SDS,': [986, 1486, 2095], 'diluted': [988, 1457], '15-fold': [989], '1%': [991, 1244, 1485], 'Nonidet': [992], 'P-40,': [993], '200': [994, 1439], 'NaCl,': [996, 1255, 1441], 'Tris,': [999, 1250, 1444], 'pH': [1000, 1251, 1445], '7.5,': [1001, 1252, 1446], 'EDTA,': [1004, 1492], 'EGTA,': [1007], 'mmphenylmethylsulfonyl': [1009], 'fluoride,': [1010], 'benzamidine,': [1013], 'μm': [1015, 1559], 'microcystin-LR.': [1016], 'supernatant': [1018], 'after': [1019, 1291], 'ultracentrifugation': [1020], '(30': [1021], '100,000': [1023], '×': [1024], 'g)': [1025], 'was': [1026, 1082, 1100, 1463, 1482, 1505, 1517, 1649, 1778, 1956, 2054, 2117, 2317, 2623, 2642, 2735, 2842, 2853, 2982], 'immunoprecipitated': [1027, 1939, 1957, 2040], '3': [1029, 1172, 1596, 1887, 1896, 2948, 2990, 3085], 'goat': [1031, 1199, 1712], 'anti-CaMKII': [1032, 1200, 1713], 'preimmune': [1054, 2048], 'IgG': [1055, 2049], '(19Colbran': [1056], 'Bass': [1058, 3547], 'McNeill': [1060], 'Bollen': [1062], 'Zhao': [1064], 'Strack': [1068], '69:': [1073], '920-929Crossref': [1074], '(46)': [1077], 'cross-linker': [1081, 2086], 'cleaved': [1083], 'eluted': [1086, 1571], 'beads': [1089], 'boiling': [1091], 'reducing': [1093], 'SDS': [1094, 1573], 'sample': [1095, 1574], 'buffer.': [1096, 1575], 'Purified': [1097], 'recombinant': [1098], '[γ-32P]ATP': [1103], '(8,000–40,000': [1104], 'cpm/pmol)': [1105], 'presence': [1108, 2008], 'calcium/calmodulin': [1110, 2247, 2629, 2658, 2680], 'EGTA': [1112], 'Thr305/306,': [1116], 'respectively,': [1117], 'desalted': [1119], 'Stoichiometries': [1140], 'ranged': [1141], '0.17': [1143], '0.39': [1145], '(Thr286)': [1146], '0.24': [1148], '0.47': [1150], '(Thr305/306).': [1151], 'Protein': [1152], 'blots': [1153], 'analyzed': [1156, 1938], 'blocked': [1161, 3079], 'incubated': [1163, 1192, 1525, 1670], '100–200': [1165], 'nm': [1166], '[32P]CaMKII': [1167], '5%': [1169, 1744], 'milk': [1170], 'h,': [1173, 1474, 1527], 'washed': [1174, 1568, 1668], 'extensively,': [1175, 1569], 'autoradiographed.': [1177], '18-Day-old': [1178], 'cultures': [1179], 'dissociated': [1181], 'neonatal': [1182], 'rat': [1183, 1544], 'cortex': [1184], 'fixed': [1186, 1700], 'acetone:methanol': [1188], '(1:1),': [1189], 'blocked,': [1190], '10–14': [1193], 'h': [1194, 1416, 1630], '1:500': [1196, 1708], 'dilutions': [1197, 1710], 'rabbit': [1221, 1738], 'anti-NR1': [1222, 1735], '(20Rema': [1223], 'Ebner': [1225], 'F.F.': [1226], 'Comp.': [1228], 'Neurol.': [1229], '165-184Crossref': [1232], '(36)': [1235], 'mouse': [1239, 1734], 'anti-synaptophysin': [1240], '(Boehringer': [1241], 'Mannheim)': [1242], 'normal': [1245], 'donkey': [1246, 1264], 'serum,': [1247], '10': [1248, 1552], '150': [1253], '0.1%': [1256, 1447], 'Triton': [1257, 1563], 'X-100.': [1258], 'Cultures': [1259, 1698, 1831], 'treated': [1261], 'species-specific': [1263], 'conjugated': [1266], 'Cy3,': [1268], 'Cy2,': [1269], 'Cy5': [1271], '(Jackson': [1272], 'Laboratories)': [1273], 'imaged': [1275], 'Zeiss': [1278], 'laser': [1279], 'scanning': [1280], 'confocal': [1281, 1841], 'microscope.': [1282], 'entire': [1284], 'domains': [1286, 2176], '(C': [1287], 'terminus': [1288], 'starting': [1289], 'immediately': [1290], 'transmembrane': [1292, 2147], 'region': [1293, 2216], 'IV)': [1294], '(splice': [1297], 'variant': [1298], 'A': [1299, 1948, 2313], 'containing': [1300, 1331, 1557, 1676, 2281, 2345, 3177], 'both': [1301, 2883], 'C1': [1302], 'C2': [1304], 'exon': [1305], 'cassettes),': [1306], 'NR2A,': [1307, 2185, 2556], 'subunits,': [1310, 2183], 'well': [1312, 2813], 'shorter': [1314], 'constructs,': [1316], 'subcloned': [1318], 'full-length': [1320, 2291], 'cDNAs': [1321], 'polymerase': [1323, 1328], 'chain': [1324], 'reaction': [1325], 'Pfu': [1327], 'primers': [1330], 'restrictions': [1332], 'sites': [1333], 'restriction': [1336], 'digests.': [1337], 'Fragments': [1338], 'sequenced': [1340], 'ligated': [1342], 'into': [1343, 3044, 3377], 'pRSET-A': [1344], 'His6': [1345, 1358, 1375, 1391, 1419, 2189, 2340], 'tag': [1346, 1359, 1376, 1392, 1420, 2190, 2341], '(Qiagen)': [1347], 'pGEX-2T': [1349], 'glutathione': [1350], 'S-transferase': [1351], '(GST)': [1352], '(Amersham': [1353], 'Pharmacia': [1354], 'Biotech)': [1355], 'fusion': [1356, 1377, 1422, 1470, 1522, 1555, 2191, 2343, 2621], 'vectors.': [1357], 'fusions': [1360, 1365], 'expressed,': [1362], 'GST': [1364, 1521, 1554, 2298, 2759], 'expressed': [1367, 3163], 'purified': [1369, 1532, 2624], 'according': [1370], "manufacturers'": [1373], 'instructions.': [1374], 'lysates': [1379, 2172], 'subjected': [1381], '(see': [1385, 1705], 'above)': [1386, 1706], 'immunoblotted': [1388], 'anti': [1390], '(CLONTECH)': [1394], '125I-labeled': [1396], 'secondary': [1397], 'levels,': [1401], 'followed': [1402, 1475], 'PhosphorImager': [1404], 'quantification.': [1405], 'Ni2+-coated': [1406], '96-well': [1407], 'plates': [1408], '(HisSorb': [1409], 'strips,': [1410], 'Qiagen)': [1411], 'adsorbed': [1413], 'expressing': [1424, 1758, 2173, 2994], 'nonexpressing': [1426], 'bacterial': [1427, 1503, 2224], 'extracts': [1428, 1504], '(0.25': [1429], 'blocking': [1432, 1459], 'buffer': [1433, 1460], '(5': [1434], 'mg/ml': [1435, 1549], 'bovine': [1436], 'serum': [1437], 'albumin,': [1438], 'Tween': [1448], '20,': [1449], '5': [1450], 'β-mercaptoethanol).': [1452], 'After': [1453], 'extensive': [1454], 'washes,': [1455], '[32P-T286]CaMKIIα': [1456, 1945, 2212, 2335], '(200': [1461], 'μl)': [1462], 'allowed': [1464], 'bind': [1466], 'tethered': [1469], '10–12': [1477], 'more': [1478, 2055, 2211], 'washes.': [1479], 'Bound': [1480], 'solubilized': [1483], '0.2': [1487], 'n': [1488], 'NaOH,': [1489], 'quantified': [1494], 'liquid': [1496], 'scintillation': [1497], 'counting.': [1498], 'Nonspecific': [1499], 'subtracted': [1506], 'total': [1508, 1594], 'obtain': [1511], 'binding.': [1513, 2228, 2614], 'No': [1514], '[32P-T306]CaMKIIα.': [1520], 'either': [1531, 1681], '(Fig.': [1534, 2011, 2026, 2050, 2138, 2200, 2362, 2384, 2651, 2947, 2961, 2989, 3020, 3047, 3084], 'D,': [1536], 'see': [1537, 1793, 2072], 'caption)': [1538], 'freshly': [1542], 'prepared': [1543], 'cytosolic': [1546, 2743], 'extract': [1547, 1550], '(∼3': [1548], 'protein)': [1556], 'microcystin-LR': [1560], '0.5%': [1562], 'X-100,': [1564], 'precipitated': [1565, 2825], 'glutathione-agarose,': [1567, 2626], 'CaMKIV': [1576], 'Transduction': [1580], 'Laboratories.': [1581], 'HEK293': [1582, 2850, 2879], 'seeded': [1585], 'coverslips': [1587], '35-mm': [1589], 'dishes,': [1590], 'μg/dish': [1597], 'DNA': [1598], 'μg': [1600, 1607], 'SRα': [1602], 'promotor-CaMKIIα': [1603], 'plasmid,': [1605], 'cytomegalovirus': [1609], 'promotor': [1610], 'plasmids': [1611], 'mass': [1618], 'ratio': [1619], '1:3': [1621], 'NR1a': [1622], 'subunits),': [1625], 'grown': [1627], '48': [1629], '(21Lovinger': [1633], 'Pharmacol.': [1636], 'Exp.': [1637], 'Ther.': [1638], '274:': [1640], '164-172PubMed': [1641], 'Robust': [1644], 'currents': [1648], 'verified': [1650], 'patch-clamp': [1652], 'recording': [1653], 'parallel': [1655], 'cultures.': [1656], '3R.': [1657], 'Popp': [1659], 'Lovinger,': [1663, 3620], 'personal': [1664], 'communication.': [1665], 'Cells': [1666], 'Mg2+-free': [1672], "Hanks'": [1673], 'balanced': [1674], 'saline': [1675], 'CaCl2': [1679], 'antagonist': [1685], '(APV,': [1688], 'μm)': [1690, 1694], 'NMDA/glycine': [1692, 2946, 2987, 3036], '(100/10': [1693], '15': [1696], 'min.': [1697], 'processed': [1702], 'immunofluorescence': [1704, 2867], 'antibody': [1709], '(PharMingen),': [1736], 'anti-NR2A/B': [1739], '(Chemicon).': [1740], 'Between': [1741], 'strongly': [1748, 2827, 3052], 'positive': [1749], 'least': [1752], 'one': [1753], 'label;': [1754], 'only': [1755, 2252, 2518, 3074], 'those': [1756], 'high': [1759], 'levels': [1760, 3166], 'each': [1762], 'antigen': [1763], '(>50%': [1764], 'cells)': [1767], 'included': [1769], 'analyses.': [1772], 'Under': [1773], 'basal': [1774], 'conditions,': [1775], 'diffusely': [1779], 'cytoplasmic.': [1780], 'Irrespective': [1781], 'agonist': [1783, 3012], 'treatment,': [1784], 'strictly': [1788, 2644], 'colocalized': [1789], '(mean': [1790], 'scores': [1791, 2935], '>3.4,': [1792], 'below)': [1794], 'patchy': [1797], 'reticular,': [1799], 'often': [1800], 'perinuclear': [1801], 'pattern': [1802], 'seen': [1804], 'previously': [1805, 1911], 'heterologous': [1807], '(22Kim': [1809], 'Cho': [1811], 'K.O.': [1812], 'Rothschild': [1813], 'Sheng': [1815], '103-113Abstract': [1820], '(476)': [1828], 'randomized': [1833], 'prior': [1834, 2087], 'sampling': [1836], 'digital': [1837], 'images': [1838, 1848], 'microscope': [1842], 'prevent': [1844], 'operator': [1845], 'bias.': [1846], 'Coded': [1847], '(as': [1849], 'Fig.': [1851, 1886, 2600], '3)': [1852, 2383], 'assigned': [1854], 'score': [1857], 'second,': [1860], 'naive': [1861], 'observer:': [1862], '0,': [1863, 1890], 'mutual': [1864], 'exclusion;': [1865], '1,': [1866, 1891], 'coincidental': [1867], 'overlap;': [1868], '3,': [1871, 2599, 3021, 3048], 'increasing': [1872], 'degrees': [1873], 'colocalization,': [1875, 2980], '4,': [1876], 'complete': [1877, 2090], 'overlap': [1878], 'labels.': [1880], 'reference,': [1882], 'scored': [1888], '2,': [1892, 1893], '(from': [1897], 'left': [1898], 'right,': [1900], 'top': [1901], 'tobottom).': [1902], 'To': [1903], 'determine': [1904], 'whether': [1905], 'NR2': [1906], 'contribute': [1908], 'characterized': [1912], '“p190”': [1913], '(Fig.1': [1946], 'A).': [1947, 2202, 2949], 'comigrating': [1951], 'antibodies,': [1960, 1964, 2045], 'indicating': [1965, 2096, 2828], 'proteins.': [1972], 'This': [1973], 'physiologically': [1977], 'relevant,': [1978], 'triple': [1980], 'immunofluorescent': [1981], 'labeling': [1982], 'cultured': [1984], 'cortical': [1985, 3564], 'neurons': [1986], 'demonstrated': [1987, 2118, 2299], 'colocalizes': [1990], 'many': [1995], 'punctae': [1996], 'along': [1997], 'shafts,': [1999], 'identified': [2000], 'synapses': [2002, 3420], 'adjacent': [2005], 'overlapping': [2007], 'synaptophysin': [2010], 'B).': [2013, 2312, 2991], 'Higher': [2014], 'magnification': [2015], 'mostly': [2018], 'localization': [2020], 'spines': [2025], 'C).': [2028, 2364], 'Moreover,': [2029], 'D).': [2052, 2140, 2653, 3024, 3086, 3181], 'efficiently': [2056], 'coprecipitated': [2057], 'than': [2058, 2213, 2393], 'likely': [2060, 3314], 'association': [2062, 2730, 3407, 3517], 'indirect': [2068], '(i.e.': [2069], 'via': [2070, 3406], 'below).': [2073], 'Recovery': [2074], 'receptor-kinase': [2077], 'required': [2079], 'pretreatment': [2080], 'reversible': [2085], 'essentially': [2089], 'solubilization': [2092], 'stable': [2107], 'harsh': [2109], 'detergents.': [2110], 'specificity': [2112], 'cross-linking': [2115], 'procedure': [2116], 'absence': [2121, 2245, 2678, 3010], 'other': [2123, 2656, 2815], 'immunoprecipitate,': [2129], 'catalytic': [2132], 'subunit': [2133, 2837, 2859, 2970, 3228, 3533], 'have': [2144], 'common': [2146], 'topology': [2148], 'three': [2150, 2493], 'membrane-spanning': [2151], 'regions': [2152], 'C-terminal': [2155, 2358], 'tail': [2156], 'variable': [2158], 'length,': [2159], 'forms': [2161], 'intracellular': [2163], 'portion': [2164], '(Fig.2': [2168, 2311, 2772], 'A,': [2169], 'diagram).': [2170], 'Bacterial': [2171], 'predominant': [2179], 'forebrain': [2180, 2400], 'screened': [2194], '[32P]CaMKIIα': [2196], 'bound': [2207, 2251, 2336], 'about': [2208], 'six': [2209], 'times': [2210, 2391], 'corresponding': [2215], 'NR2A;': [2218], 'neither': [2219], 'nor': [2221], 'any': [2222], 'endogenous': [2223], 'showed': [2226, 2285, 2627], 'detectable': [2227, 2955], 'Interactions': [2229], 'autonomously': [2237], 'CaMKII,': [2239, 2263], 'phosphorylated': [2242, 2455, 2463], 'Thr305/306': [2249], '([P-T306]CaMKIIα)': [2250], 'weakly': [2253, 2519], '(<5%).': [2254], 'Because': [2255], 'displayed': [2257, 2763], 'most': [2259], 'robust': [2260], 'mapped': [2265], 'creating': [2270], 'series': [2272], 'truncation': [2274], 'internal': [2276], 'deletion': [2277], 'constructs.': [2278], 'Only': [2279], 'constructs': [2280], 'residues': [2283, 2346, 2537, 2606, 2713, 3223], '1260–1309': [2284, 3224], 'similar': [2288, 2782, 3165], 'tail.': [2293], 'Fusion': [2294], 'NR2B-(1260–1309)': [2296, 2504, 2608, 2830], 'also': [2304, 2462], 'sufficient': [2305, 2661, 3094], 'autonomous': [2309, 3340], 'solution': [2314], 'assay': [2316], 'employed': [2318], 'examine': [2320], 'had': [2327], 'undergone': [2329], 'denaturation/renaturation': [2330], 'analysis.': [2334], 'saturably': [2337], '1260–1309,': [2347], 'construct': [2352], 'starts': [2354], '1310,': [2357], 'Scatchard': [2365], 'analysis': [2366], 'indicated': [2367], 'involves': [2370], 'simple': [2372], 'bimolecular': [2373], 'aKd': [2376], '138': [2378], '±': [2379, 2596], '60': [2380], 'nm(n': [2381], '=': [2382, 2598], 'C,': [2386], 'inset).': [2387], 'ThisKd': [2388], '∼100': [2390], 'lower': [2392], 'average': [2395], 'concentration': [2396], '23Erondu': [2421], 'N.E.': [2422], '1985;': [2427, 3278], '5:': [2428, 3279], '3270-3277Crossref': [2429], 'suggesting': [2433, 2603, 3053], 'readily': [2438], 'occur': [2439], 'neurons.': [2441], 'contains': [2447], 'phosphorylation': [2450, 2530, 2548, 2783, 3346], 'site,': [2451], 'Ser1303,': [2452], 'vitro': [2459], 'vivo': [2465], '(13Omkumar': [2466, 2558], 'However,': [2492], 'dependent': [2507, 2645], 'interaction.': [2511], 'First,': [2512], 'peptide': [2515], 'syntide-2': [2517], 'inhibits': [2520], '(∼30%)': [2523], 'concentrations': [2525], '∼100-fold': [2527], 'theKm': [2528], '(not': [2531], 'shown).': [2532], 'Second,': [2533], 'even': [2534, 3319], 'though': [2535], '1255–1298': [2538], '36%': [2540], 'identical': [2541], 'NR2B-(1260–1309),': [2543], 'sequences': [2545], 'surrounding': [2546], 'site': [2549, 2718, 2784], 'almost': [2551], 'perfectly': [2552], 'conserved': [2553], '(NR2B,': [2554], 'LRRQHSYD;': [2555], 'INRQHSYD)': [2557], 'NR2A-(1255–1298)': [2587], '∼10-fold': [2589], 'weaker': [2590], 'under': [2591], 'our': [2592], 'conditions': [2594], '(10.7': [2595], '1.8%,n': [2597], 'B),': [2602, 2964], 'nonconserved': [2605], 'important': [2610], 'Third,': [2615], '“pull-down”': [2616], 'experiments,': [2617], 'GST-NR2B': [2620, 2739], 'alone': [2630, 2871, 2930, 3019], 'did': [2631], 'promote': [2633], 'stoichiometric': [2640], 'instead': [2643], 'On': [2654], 'hand,': [2657], 'full': [2663], 'stabilizes': [2669], 'conformation': [2672], 'Thus,': [2711, 3087, 3182, 3328], 'outside': [2714], 'involved': [2720], 'NR2B.': [2725], 'Further': [2726], 'obtained': [2736], 'performing': [2738], 'pull-downs': [2740], 'incubation': [2754], 'GST-NR2B-(1260–1309),': [2756], 'alone.': [2760], 'Affinity-purified': [2761], 'an': [2764, 3114, 3329], 'upward': [2765], 'electrophoretic': [2766], 'mobility': [2767], 'shift': [2768], 'characteristic': [2769], 'E).': [2773], 'CaM': [2774], 'IV,': [2776], 'related': [2778], 'preference': [2785], '(24White': [2786], 'R.R.': [2787], 'Kwon': [2788], 'Y.-G.': [2789], 'Taing': [2790], 'Lawrence': [2792], 'D.S.': [2793], 'Edelman': [2794], 'A.M.': [2795], '273:': [2800], '3166-3179Abstract': [2801], '(121)': [2809], 'kinases': [2816], 'phosphatases': [2818, 3251], 'tested,': [2819], 'detected': [2822], 'material,': [2826], 'shown': [2843], 'target': [2845], 'coexpressed': [2854], 'various': [2856], 'combinations,': [2860], 'their': [2862], 'distributions': [2863], 'compared': [2865, 3014], '(Fig.3).': [2868], 'Whereas': [2869], 'does': [2872], 'form': [2874, 3116], 'functional': [2875, 3236], 'cells,': [2880], 'activation': [2881, 3031, 3056], 'NR1/NR2A': [2884, 2979], 'NR1/NR2B': [2886, 3033, 3176], 'leads': [2888], 'massive': [2890], '(25Grant': [2893], 'E.R.': [2894], 'Bacskai': [2895], 'B.J.': [2896], 'Pleasure': [2897], 'D.E.': [2898], 'Pritchett': [2899], 'D.B.': [2900], 'Gallagher': [2901], 'Kendrick': [2903], 'S.J.': [2904], 'Kricka': [2905], 'L.J.': [2906], 'Lynch': [2907, 3567], 'D.R.': [2908], '647-656Abstract': [2914], '(43)': [2922], 'Coexpression': [2925], 'resulted': [2931], 'low': [2933, 2953, 3323], 'unaffected': [2938], 'acute': [2940], 'treatment': [2941, 2988, 3013], 'coagonists': [2945], 'Perhaps': [2950], 'reflecting': [2951], '2,A': [2962], 'additional': [2965], 'led': [2971], 'small': [2974], 'increase': [2975, 3005], 'significantly': [2984], 'In': [2992, 3025], 'similarly': [3003], 'modest': [3004], 'C': [3022, 3049], 'contrast': [3026], 'NR2A-containing': [3028], 'caused': [3037], 'highly': [3039], 'significant': [3040], 'redistribution': [3041], 'receptor-positive': [3045], 'patches': [3046], 'D),': [3051], 'induced': [3057, 3210], 'formation': [3059], 'CaMKII·NR2B': [3062], 'complex.': [3063], 'Replacing': [3064], 'extracellular': [3065], 'barium,': [3068], 'receptor-permeable': [3071], 'calmodulin,': [3077], 'completely': [3078], 'effect': [3081], 'opening': [3088], 'formation,': [3097], 'essential,': [3102], 'presumably': [3103], 'stimulate': [3105], 'Consistent': [3110], 'interpretation,': [3113], 'autophosphorylation-incompetent': [3115], 'kinase,': [3119], 'T286A-CaMKIIα': [3120], '(26Fong': [3121], 'Y.L.': [3122], 'Taylor': [3123], 'W.L.': [3124], 'Means': [3125], 'A.R.': [3126, 3491], '1989;': [3132, 3152], '264:': [3133], '16759-16763Abstract': [3134], '27Hanson': [3141], 'P.I.': [3142], 'Kapiloff': [3143], 'M.S.': [3144], 'Lou': [3145], 'L.L.': [3146], 'Rosenfeld': [3147], 'M.G.': [3148], '3:': [3153], '59-70Abstract': [3154], '(237)': [3160], 'wild-type': [3168], 'failed': [3170], 'activity-induced': [3173], '(Fig.3': [3180], 'mediates': [3184], 'calcium-': [3193], 'Thr286autophosphorylation-dependent': [3195], 'manner': [3196], 'Our': [3200], 'data': [3201], 'support': [3202], 'subsequent': [3220], 'receptor.': [3232], 'What': [3233], 'consequences': [3237], 'interaction?': [3240], 'Autonomous': [3241], 'inactivated': [3247], 'serine/threonine': [3250], '28Shields': [3270], 'S.M.': [3271, 3505], 'Ingebritsen': [3272], 'T.S.': [3273, 3287], 'Kelly': [3274], 'P.T.': [3275], '3414-3422Crossref': [3280], '29Dosemeci': [3284], 'Reese': [3286], '61:': [3291], '550-555Crossref': [3292], '(60)': [3295], 'Once': [3298], 'dephosphorylated': [3299], 'Thr286,': [3301], 'positioned': [3303], 'near': [3304], 'mouth': [3306], 'channel': [3312], 'undergo': [3316, 3422], 'rapid': [3317, 3416], 're-autophosphorylation': [3318], 'periods': [3321], 'level': [3324], 'activation.': [3327], 'predicted': [3337], 'boosts': [3339], 'leading': [3343], 'enhanced': [3345], 'nearby': [3348], 'downstream': [3349], 'effectors': [3350], 'plasticity': [3353], 'Furthermore,': [3373], 'recruitment': [3374], 'structure': [3380], 'possibly': [3405], 'play': [3411], 'role': [3413], 'ultrastructural': [3417], 'changes': [3418], '(30Geinisman': [3424], 'deToledo-Morrell': [3426], 'Morrell': [3428], 'F.': [3429, 3554, 3611], 'Brain': [3430], '1991;': [3432], '566:': [3433], '77-88Crossref': [3434], '(233)': [3437], '31Buchs': [3440], 'P.-A.': [3441], '93:': [3452], '8040-8045Crossref': [3453], '(228)': [3456], 'appearance': [3461], 'down-regulation': [3465], 'mammalian': [3470], 'visual': [3471], 'system': [3472], 'correlate': [3473], 'end': [3476], '“critical': [3479], 'period”': [3480], 'synapse': [3482], 'maturation': [3483], '(32Flint': [3484], 'A.C.': [3485], 'Maisch': [3486], 'U.S.': [3487], 'Weishaupt': [3488], 'J.H.': [3489], 'Kriegstein': [3490], 'Monyer': [3492], '2469-2476Crossref': [3498], '33Shi': [3502], 'Aamodt': [3504], 'Constantine-Paton': [3506], '6264-6276Crossref': [3512], 'Preferential': [3516], 'over': [3522], 'therefore': [3525], 'composition': [3534], 'impact': [3536], 'plasticity.': [3538], 'We': [3539], 'thank': [3540], 'MacMillan': [3542], 'scoring': [3544], 'cells;': [3545], 'invaluable': [3549], 'technical': [3550], 'assistance;': [3551], 'Rema,': [3553], 'Ebner,': [3555, 3612], 'Maguire': [3558], '(Vanderbilt)': [3559, 3601], 'cultures;': [3565], '(Penn': [3568], 'State)': [3569], 'NR': [3571], 'plasmids;': [3573, 3581], 'T.': [3574], '(Vollum': [3576], 'Institute)': [3577], 'DNAX,': [3582], 'Inc.': [3583], '(Palo': [3584], 'Alto,': [3585], 'CA)': [3586], 'use': [3588], 'pME18S': [3591], 'vector;': [3593], 'Popp,': [3595], 'Sessoms,': [3597], 'help': [3603], 'HEK': [3605], 'cell': [3606], 'transfections;': [3607], 'Blakely,': [3610], 'Exton,': [3614], 'Limbird,': [3616], 'Lisman,': [3618], 'helpful': [3625], 'suggestions.': [3626]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2080213202', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-13T20:27:27.811727', 'created_date': '2016-06-24'}
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