Publication Information

{'id': 'https://openalex.org/W2078481163', 'doi': 'https://doi.org/10.1158/0008-5472.can-07-6059', 'title': 'TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells', 'display_name': 'TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells', 'publication_year': 2008, 'publication_date': '2008-05-01', 'ids': {'openalex': 'https://openalex.org/W2078481163', 'doi': 'https://doi.org/10.1158/0008-5472.can-07-6059', 'mag': '2078481163', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18451177'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-07-6059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112303721', 'display_name': 'Naoto Miyajima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164563', 'display_name': 'Neurology, Inc', 'ror': 'https://ror.org/05ne0gd95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164563']}, {'id': 'https://openalex.org/I4210164394', 'display_name': 'Institute of Cytochemistry and Molecular Pharmacology', 'ror': 'https://ror.org/05km36r23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164394']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'RU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Naoto Miyajima', 'raw_affiliation_strings': ['1Biochemistry and Departments of', '2Urology, and', 'Department of Biochemistry Hokkaido University Graduate School of Medicine Sapporo Japan'], 'affiliations': [{'raw_affiliation_string': '2Urology, and', 'institution_ids': ['https://openalex.org/I4210164563']}, {'raw_affiliation_string': '1Biochemistry and Departments of', 'institution_ids': ['https://openalex.org/I4210164394']}, {'raw_affiliation_string': 'Department of Biochemistry Hokkaido University Graduate School of Medicine Sapporo Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033361641', 'display_name': 'Satoru Maruyama', 'orcid': 'https://orcid.org/0000-0001-6547-0052'}, 'institutions': [{'id': 'https://openalex.org/I4210164394', 'display_name': 'Institute of Cytochemistry and Molecular Pharmacology', 'ror': 'https://ror.org/05km36r23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164394']}, {'id': 'https://openalex.org/I4210164563', 'display_name': 'Neurology, Inc', 'ror': 'https://ror.org/05ne0gd95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164563']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'RU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Satoru Maruyama', 'raw_affiliation_strings': ['1Biochemistry and Departments of', '2Urology, and', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry and Departments of', 'institution_ids': ['https://openalex.org/I4210164394']}, {'raw_affiliation_string': '2Urology, and', 'institution_ids': ['https://openalex.org/I4210164563']}, {'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035085923', 'display_name': 'Miyuki Bohgaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164394', 'display_name': 'Institute of Cytochemistry and Molecular Pharmacology', 'ror': 'https://ror.org/05km36r23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164394']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'RU'], 'is_corresponding': False, 'raw_author_name': 'Miyuki Bohgaki', 'raw_affiliation_strings': ['1Biochemistry and Departments of', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry and Departments of', 'institution_ids': ['https://openalex.org/I4210164394']}, {'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005371127', 'display_name': 'Satoshi Kano', 'orcid': 'https://orcid.org/0000-0003-4750-5332'}, 'institutions': [{'id': 'https://openalex.org/I4210164394', 'display_name': 'Institute of Cytochemistry and Molecular Pharmacology', 'ror': 'https://ror.org/05km36r23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164394']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'RU'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Kano', 'raw_affiliation_strings': ['1Biochemistry and Departments of', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry and Departments of', 'institution_ids': ['https://openalex.org/I4210164394']}, {'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005165221', 'display_name': 'Masahiko Shigemura', 'orcid': 'https://orcid.org/0000-0001-7767-6584'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masahiko Shigemura', 'raw_affiliation_strings': ['3First Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan'], 'affiliations': [{'raw_affiliation_string': '3First Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010806066', 'display_name': 'Nobuo Shinohara', 'orcid': 'https://orcid.org/0000-0002-6695-294X'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}, {'id': 'https://openalex.org/I4210164563', 'display_name': 'Neurology, Inc', 'ror': 'https://ror.org/05ne0gd95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164563']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Nobuo Shinohara', 'raw_affiliation_strings': ['2Urology, and', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}, {'raw_affiliation_string': '2Urology, and', 'institution_ids': ['https://openalex.org/I4210164563']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109080664', 'display_name': 'Katsuya Nonomura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164563', 'display_name': 'Neurology, Inc', 'ror': 'https://ror.org/05ne0gd95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164563']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Katsuya Nonomura', 'raw_affiliation_strings': ['2Urology, and', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': '2Urology, and', 'institution_ids': ['https://openalex.org/I4210164563']}, {'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068374303', 'display_name': 'Shigetsugu Hatakeyama', 'orcid': 'https://orcid.org/0000-0002-2150-9979'}, 'institutions': [{'id': 'https://openalex.org/I4210164394', 'display_name': 'Institute of Cytochemistry and Molecular Pharmacology', 'ror': 'https://ror.org/05km36r23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164394']}, {'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP', 'RU'], 'is_corresponding': False, 'raw_author_name': 'Shigetsugu Hatakeyama', 'raw_affiliation_strings': ['1Biochemistry and Departments of', 'Hokkaido University'], 'affiliations': [{'raw_affiliation_string': '1Biochemistry and Departments of', 'institution_ids': ['https://openalex.org/I4210164394']}, {'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.779, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.999963, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '68', 'issue': '9', 'first_page': '3486', 'last_page': '3494'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dihydrotestosterone', 'display_name': 'Dihydrotestosterone', 'score': 0.4544925}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8669609}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.79794794}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.7250249}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6250839}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.53963673}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.5098559}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50507885}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.49314827}, {'id': 'https://openalex.org/C2779881493', 'wikidata': 'https://www.wikidata.org/wiki/Q411054', 'display_name': 'Dihydrotestosterone', 'level': 4, 'score': 0.4544925}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.43835643}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42552572}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.37605304}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34203887}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33186072}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.27551982}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24906194}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.1367979}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07138321}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.059731603}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.051621318}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.049846143}], 'mesh': [{'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001324', 'descriptor_name': 'Autoantigens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051548', 'descriptor_name': 'Histone Acetyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051548', 'descriptor_name': 'Histone Acetyltransferases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051548', 'descriptor_name': 'Histone Acetyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074443', 'descriptor_name': 'Lysine Acetyltransferase 5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000070584', 'descriptor_name': 'Tripartite Motif Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050880', 'descriptor_name': 'p300-CBP Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050880', 'descriptor_name': 'p300-CBP Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050880', 'descriptor_name': 'p300-CBP Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-07-6059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18451177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1576720150', 'https://openalex.org/W1783699960', 'https://openalex.org/W1965734230', 'https://openalex.org/W1968455126', 'https://openalex.org/W1977532087', 'https://openalex.org/W1983073183', 'https://openalex.org/W1987338737', 'https://openalex.org/W1990529844', 'https://openalex.org/W1991995900', 'https://openalex.org/W2003696769', 'https://openalex.org/W2003955264', 'https://openalex.org/W2005658600', 'https://openalex.org/W2008044453', 'https://openalex.org/W2022376508', 'https://openalex.org/W2036041445', 'https://openalex.org/W2038208040', 'https://openalex.org/W2039974624', 'https://openalex.org/W2049651307', 'https://openalex.org/W2050826693', 'https://openalex.org/W2064180812', 'https://openalex.org/W2064850779', 'https://openalex.org/W2068592712', 'https://openalex.org/W2081506603', 'https://openalex.org/W2087818316', 'https://openalex.org/W2095766576', 'https://openalex.org/W2096285771', 'https://openalex.org/W2096496280', 'https://openalex.org/W2116205673', 'https://openalex.org/W2116773729', 'https://openalex.org/W2131037087', 'https://openalex.org/W2131422252', 'https://openalex.org/W2141466699', 'https://openalex.org/W2146027649', 'https://openalex.org/W2156575042', 'https://openalex.org/W2166987747', 'https://openalex.org/W4235786354'], 'related_works': ['https://openalex.org/W4361876095', 'https://openalex.org/W2169608764', 'https://openalex.org/W2155207531', 'https://openalex.org/W2118238803', 'https://openalex.org/W2109992434', 'https://openalex.org/W2077089952', 'https://openalex.org/W2044264814', 'https://openalex.org/W2037459571', 'https://openalex.org/W2005217671', 'https://openalex.org/W1967360911'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'androgen': [2], 'receptor': [3], '(AR)': [4], 'is': [5, 43, 67, 161, 189], 'a': [6, 183, 193, 198], 'transcription': [7, 187], 'factor': [8], 'belonging': [9], 'to': [10, 191], 'the': [11, 18, 31, 37, 60, 82, 85, 109, 131, 144, 170], 'family': [12], 'of': [13, 20, 30, 39, 81, 87, 104, 111, 114, 125, 130, 141, 146], 'nuclear': [14], 'receptors': [15], 'that': [16, 59, 92, 158, 179], 'mediate': [17], 'action': [19], 'androgen.': [21], 'AR': [22, 42, 76, 83], 'plays': [23], 'an': [24, 121], 'important': [25], 'role': [26], 'in': [27, 36, 70, 84, 108, 116, 123, 164, 172], 'normal': [28, 174], 'development': [29], 'prostate,': [32], 'as': [33, 35, 102, 182], 'well': [34], 'progression': [38], 'prostate': [40, 71, 117, 137, 166, 203], 'cancer.': [41, 204], 'regulated': [44], 'by': [45], 'several': [46], 'posttranslational': [47], 'modifications,': [48], 'including': [49], 'phosphorylation,': [50], 'acetylation,': [51], 'and': [52, 77, 98, 106, 148, 152, 188, 197], 'ubiquitination.': [53], 'In': [54], 'this': [55], 'study,': [56], 'we': [57, 156], 'found': [58, 91], 'putative': [61], 'E3': [62], 'ubiquitin': [63], 'ligase': [64], 'TRIM68,': [65], 'which': [66, 100], 'preferentially': [68], 'expressed': [69], 'cancer': [72, 118], 'cells,': [73], 'interacts': [74, 95], 'with': [75, 96, 169], 'enhances': [78], 'transcriptional': [79], 'activity': [80], 'presence': [86], 'dihydrotestosterone.': [88], 'We': [89], 'also': [90], 'TRIM68': [93, 115, 142, 159, 180], 'functionally': [94], 'TIP60': [97], 'p300,': [99], 'act': [101], 'coactivators': [103], 'AR,': [105], 'synergizes': [107], 'transactivation': [110], 'AR.': [112], 'Overexpression': [113], 'cells': [119], 'caused': [120], 'increase': [122], 'secretion': [124, 145], 'prostate-specific': [126], 'antigen': [127], '(PSA),': [128], 'one': [129], 'most': [132], 'reliable': [133], 'diagnostic': [134, 195], 'markers': [135], 'for': [136, 185, 202], 'cancer,': [138], 'whereas': [139], 'knockdown': [140], 'attenuated': [143], 'PSA': [147], 'inhibited': [149], 'cell': [150], 'growth': [151], 'colony-forming': [153], 'ability.': [154], 'Moreover,': [155], 'showed': [157], 'expression': [160, 171], 'significantly': [162], 'up-regulated': [163], 'human': [165], 'cancers': [167], 'compared': [168], 'adjacent': [173], 'tissues.': [175], 'These': [176], 'results': [177], 'indicate': [178], 'functions': [181], 'cofactor': [184], 'AR-mediated': [186], 'likely': [190], 'be': [192], 'novel': [194], 'tool': [196], 'potentially': [199], 'therapeutic': [200], 'target': [201], '[Cancer': [205], 'Res': [206], '2008;68(9):3486–94]': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078481163', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-09T04:47:13.334158', 'created_date': '2016-06-24'}