Publication Information

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3715, 3719, 3756, 3789, 3821, 3845, 3849, 3886, 3919, 3930, 3934, 3940, 3960, 3963, 3984, 4002, 4013, 4024, 4036, 4042, 4056, 4079, 4114, 4126, 4155, 4198, 4212, 4232, 4264, 4278, 4298, 4310, 4370, 4386, 4394, 4398, 4405, 4423, 4428, 4433, 4453], 'second': [5, 155, 1092, 2381, 2456, 2542, 2862, 2898, 2920], 'extracellular': [6, 156, 641, 1017, 1093, 2382, 2457, 2543, 2863, 2899, 2921, 4004], 'loop': [7, 157, 2383, 2485, 2544, 2577, 2864, 2900, 4005], 'human': [10, 160, 969, 2758], 'lutropin': [11, 161, 309, 575], 'receptor': [12, 121, 162, 271, 302, 305, 308, 310, 312, 318, 419, 769, 898, 982, 1099, 1124, 1132, 1861, 2160, 2564, 2590, 3436, 3453, 3470, 3503, 3520, 3551, 3568, 3585, 3618, 3635, 3666, 3683, 3700, 3823, 3965, 4039], '(hLHR)': [13, 163], 'showed': [14, 56, 164, 206, 2566, 3062], 'that': [15, 42, 50, 57, 61, 79, 165, 192, 200, 207, 211, 229, 329, 545, 632, 698, 765, 961, 1095, 1119, 1467, 1611, 1643, 1883, 2048, 2094, 2431, 2442, 2459, 2549, 2567, 2731, 2766, 2820, 2849, 2913, 2952, 3063, 3109, 3114, 3137, 3146, 3358, 3367, 3388, 3983, 4033, 4062], 'mutation': [16, 166, 2452, 2552, 2569, 3079, 3091], 'most': [18, 168, 407], 'residues': [21, 171, 2538, 2573, 2901, 2934, 2959, 3082, 3094], 'present': [22, 172, 2539, 2574, 2992], 'in': [23, 68, 85, 110, 123, 145, 173, 218, 235, 260, 273, 295, 334, 554, 710, 725, 976, 1090, 1116, 1138, 1439, 1461, 1879, 1910, 1983, 1988, 2014, 2091, 2117, 2122, 2129, 2151, 2185, 2237, 2387, 2427, 2445, 2454, 2486, 2540, 2558, 2575, 2623, 2638, 2870, 2888, 2907, 2938, 2947, 2965, 3041, 3084, 3087, 3096, 3099, 3122, 3140, 3169, 3290, 3382, 3830, 3967, 3978, 3987, 4029, 4211, 4249, 4277, 4326, 4331, 4342, 4404, 4416, 4437], 'this': [24, 174, 981, 1971, 2484, 2576, 2589, 2683, 2748, 3013], 'region': [25, 175, 1275, 2591], 'either': [26, 176], 'enhance': [27, 177, 1096, 2579], 'or': [28, 178, 448, 1097, 1248, 1464, 1481, 1591, 2017, 2580, 2616, 2627, 3207, 3338, 3971, 3991, 3996, 4157, 4455], 'impair': [29, 179, 1098, 2436], 'internalization': [31, 44, 52, 63, 81, 125, 181, 194, 202, 213, 231, 275, 386, 754, 909, 979, 1023, 1113, 1141, 1538, 1609, 1631, 1652, 1712, 1847, 1873, 2391, 2438, 2446, 2555, 2582, 2602, 2810, 2874, 3088, 3111, 3116, 3166, 3245, 3300, 3317, 3331, 3351, 3393, 3409, 3723, 3853, 3943], 'agonist.': [33, 183], 'A': [34, 184, 4306], 'more': [35, 185, 2763, 2880, 2889, 3129], 'complete': [36, 186], 'analysis': [37, 187, 2403], 'four': [39, 189, 3309, 3964, 3985, 4003, 4318], 'mutants,': [40, 190, 4057], 'two': [41, 49, 59, 77, 191, 199, 209, 227, 2396, 2933, 3107, 3113, 3323, 3343], 'enhanced': [43, 80, 193, 230, 3110], '(F515A': [45, 195, 3332], 'and': [46, 48, 54, 196, 198, 204, 409, 425, 435, 438, 454, 459, 477, 576, 581, 712, 718, 771, 773, 781, 965, 1003, 1126, 1151, 1243, 1284, 1297, 1437, 1452, 1473, 1497, 1522, 1650, 1667, 1961, 2055, 2100, 2115, 2121, 2126, 2142, 2191, 2197, 2227, 2232, 2255, 2259, 2305, 2319, 2329, 2332, 2340, 2353, 2359, 2492, 2565, 2595, 2634, 2696, 2806, 2875, 2926, 2936, 2945, 3048, 3089, 3112, 3307, 3321, 3333, 3353, 3416, 3438, 3455, 3472, 3486, 3505, 3522, 3536, 3553, 3570, 3587, 3601, 3620, 3637, 3651, 3668, 3685, 3702, 3718, 3732, 3739, 3809, 3825, 3848, 3862, 3869, 3981, 4010, 4031, 4120, 4137, 4201, 4208, 4210, 4227, 4267, 4274, 4276, 4293, 4334, 4377, 4388, 4413], 'T521A)': [47, 197, 3334], 'impaired': [51, 62, 201, 212], '(S512A': [53, 203, 3352], 'V519A),': [55, 205], 'mutants': [60, 78, 95, 210, 228, 245, 2587, 2636, 3108, 3139, 3310, 3324, 3344, 3361, 3399, 3417, 3966, 4006, 4037, 4158, 4319, 4396, 4435], 'also': [64, 214, 1006, 2578, 3385, 3937], 'show': [65, 82, 215, 232, 3982, 4032], 'a': [66, 216, 326, 430, 439, 543, 551, 620, 763, 1080, 1117, 1583, 1592, 1657, 1927, 2002, 2019, 2066, 2167, 2173, 2230, 2238, 2376, 2401, 2419, 2879, 3097, 3174, 3210, 3326, 3346, 3365, 3831, 4250, 4335], 'decrease': [67, 217, 2444, 2581, 3098], 'sensitivity': [70, 87, 220, 237], 'for': [71, 88, 221, 238, 1015, 1148, 1251, 1295, 1340, 1524, 1586, 1595, 1661, 1664, 1668, 1671, 1893, 1904, 2241, 2310, 2601, 2932, 3053, 3128, 4048, 4076, 4129, 4382], 'agonist-induced': [72, 89, 101, 140, 222, 239, 251, 290, 963, 978, 1105, 1140, 3931, 3997], 'cAMP': [73, 90, 223, 240, 1981, 1995, 4016, 4327, 4371, 4390, 4401], 'accumulation,': [74, 224], 'whereas': [75, 225, 4132], 'an': [83, 97, 233, 247, 1008, 1515, 1525, 1608, 2107, 2450, 3039, 3085, 3295], 'increase': [84, 234, 3086], 'accumulation.': [91, 241], 'None': [92, 242], 'these': [94, 244, 1376, 1603, 2050, 2611, 2886, 3103, 3398, 4317, 4445], 'had': [96, 246, 1468, 1884, 2095, 2737, 3068, 3336, 3989], 'effect': [98, 248, 2857, 3070, 3340, 3993, 4144], 'on': [99, 249, 415, 768, 895, 905, 999, 1019, 1123, 1732, 2220, 2375, 2687, 3071, 3102, 3341, 3371, 3747, 3751, 3877, 3881, 3994, 4145], 'phosphorylation': [102, 122, 131, 252, 272, 281, 422, 772, 904, 966, 3932, 3961], 'hLHR,': [105, 255], 'however.': [106, 256, 2694, 4067], 'We': [107, 257, 2685, 3132], 'conclude': [108, 258], 'that,': [109, 259], 'contrast': [111, 261], 'to': [112, 262, 462, 470, 475, 478, 535, 701, 749, 1136, 1530, 1535, 1871, 1926, 1953, 1967, 2028, 2065, 2156, 2435, 2449, 2607, 2853, 2884, 2957, 2987, 3017, 3025, 3240, 3430, 3447, 3464, 3481, 3497, 3514, 3531, 3545, 3562, 3579, 3596, 3612, 3629, 3646, 3660, 3677, 3694, 3795, 3804, 3817, 3925, 3939, 4007, 4011, 4051, 4118, 4124, 4135, 4141, 4152, 4214, 4280, 4320, 4322, 4380, 4397], 'prevailing': [114, 264], 'view': [115, 265], 'relative': [118, 268], 'importance': [119, 269, 901, 1130], 'G': [127, 277, 300, 303, 321, 417, 695], 'protein-coupled': [128, 278, 301, 304, 322, 418, 696], 'receptors,': [129, 279, 631], 'hLHR': [134, 144, 284, 294, 1150, 1647, 1673, 2816, 2852, 2904, 2928, 2978, 3035, 3119, 3935, 4156, 4454], 'is': [135, 285, 325, 413, 633, 766, 1612, 1639, 1654, 1850, 2637, 2761, 2817, 2960, 2979, 2985, 3011, 3023, 3368, 3936, 4329, 4340, 4363, 4440], 'less': [136, 286], 'important': [137, 287, 3938], 'than': [138, 288, 1642, 2765, 2819, 4061, 4073], 'activation': [141, 291, 332, 770, 964, 1100, 1125], 'process': [147, 297, 544, 907, 3941], 'internalization.': [149, 299, 3054, 3072, 3100, 3752, 3882], 'kinase': [306, 420], 'follitropin': [307], 'thyrotropin': [311, 577], 'chorionic': [313], 'gonadotropin': [314], 'wild': [315], 'type': [316], 'β2-adrenergic': [317, 897], 'Internalization': [319], 'receptors': [323, 578, 697, 705, 1030], '(GPCRs)1': [324], 'ubiquitous': [327], 'response': [328, 4402], 'follows': [330], 'agonist': [331, 748, 1115], '(reviewed': [333, 724], 'Refs.': [335], '1Lefkowitz': [336], 'R.J.': [337, 911], 'J.': [338, 373, 396, 517, 593, 597, 785, 808, 833, 855, 912, 947, 1037, 1229, 1309, 1350, 1550, 1680, 1768, 1804, 1820, 1938, 2077, 2505, 2514, 2653, 2662, 2705, 2714, 2776, 2831, 3191, 3223, 3258, 4088, 4097], 'Biol.': [339, 518, 787, 810, 834, 856, 913, 1038, 1310, 1352, 1505, 1551, 1681, 1769, 1805, 1822, 2515, 2663, 2715, 2777, 2832, 3192, 3225, 3259, 4098], 'Chem.': [340, 519, 835, 857, 914, 1039, 1311, 1552, 1682, 1770, 1806, 2516, 2664, 2716, 2778, 2833, 3193, 3260, 4099], '1998;': [341, 361, 684, 836, 915, 935, 1235, 2517, 2665, 2717, 4100], '273:': [342, 837, 916, 2518, 2666, 2718, 4101], '18677-18680Abstract': [343, 917], 'Full': [344, 346, 523, 525, 839, 841, 861, 863, 918, 920, 1043, 1045, 1315, 1317, 1556, 1558, 1686, 1688, 1774, 1776, 1792, 1810, 2520, 2522, 2668, 2670, 2720, 2722, 2782, 2784, 2837, 2839, 3197, 3199, 3264, 3266, 4103, 4105], 'Text': [345, 347, 524, 526, 840, 842, 862, 864, 919, 921, 1044, 1046, 1316, 1318, 1557, 1559, 1687, 1689, 1775, 1777, 1793, 1811, 2521, 2523, 2669, 2671, 2721, 2723, 2783, 2785, 2838, 2840, 3198, 3200, 3265, 3267, 4104, 4106], 'PDF': [348, 527, 843, 865, 922, 1047, 1319, 1560, 1690, 1778, 1794, 1812, 2524, 2672, 2724, 2786, 2841, 3201, 3268, 4107], 'PubMed': [349, 364, 378, 401, 502, 528, 568, 601, 613, 669, 687, 736, 791, 814, 844, 866, 880, 923, 938, 952, 992, 1048, 1070, 1174, 1199, 1223, 1238, 1320, 1356, 1397, 1417, 1509, 1561, 1691, 1779, 1795, 1813, 1826, 1839, 1943, 2041, 2082, 2211, 2291, 2413, 2525, 2673, 2725, 2787, 2801, 2842, 3202, 3229, 3269, 3283, 3781, 3911, 3953, 4108, 4357], 'Scopus': [350, 365, 379, 402, 503, 529, 569, 602, 614, 670, 688, 737, 792, 815, 845, 867, 881, 924, 939, 953, 993, 1049, 1071, 1175, 1200, 1224, 1239, 1321, 1357, 1398, 1418, 1510, 1562, 1692, 1780, 1796, 1827, 1840, 2042, 2212, 2292, 2414, 2526, 2674, 2726, 2788, 2802, 2843, 3203, 3230, 3270, 3284, 3782, 3912, 3954, 4109, 4358], '(908)': [351, 925], 'Google': [352, 367, 381, 404, 505, 531, 571, 604, 616, 656, 672, 690, 739, 794, 817, 847, 869, 883, 926, 941, 955, 995, 1051, 1073, 1177, 1202, 1226, 1241, 1323, 1359, 1400, 1420, 1512, 1564, 1575, 1694, 1705, 1782, 1798, 1814, 1829, 1842, 1944, 2044, 2083, 2214, 2294, 2416, 2528, 2676, 2728, 2790, 2804, 2845, 3205, 3232, 3272, 3286, 3784, 3914, 3956, 4111, 4360], 'Scholar,': [353, 368, 506, 605, 657, 673, 795, 818, 848, 870, 927, 942, 1052, 1178, 1227, 1401, 1565, 1695, 1783, 1799, 1815, 1830, 2791, 3273], '2Carman': [354, 928], 'C.V.': [355, 929], 'Benovic': [356, 496, 829, 930, 1307, 1331, 1388, 3189], 'J.L.': [357, 497, 830, 931, 1308, 1389, 3190], 'Curr.': [358, 932], 'Opin.': [359, 933], 'Neurobiol.': [360, 934], '8:': [362, 936], '335-344Crossref': [363, 937], '(241)': [366, 940], '3Bünemann': [369, 943], 'M.': [370, 393, 650, 784, 832, 854, 874, 944, 986, 1036, 1166, 1186, 1217, 1233, 1391, 1411, 1549, 1569, 1679, 1699, 1767, 1819, 1832, 2035, 2205, 2278, 2405, 2407, 2775, 2795, 2830, 3257, 3277, 3775, 3905, 3947, 4351], 'Hosey': [371, 394, 945], 'M.M.': [372, 395, 946], 'Physiol.': [374, 397, 948, 1939, 2078], '1999;': [375, 398, 598, 949, 1040, 1067, 1394, 1414, 1553, 1572, 1683, 1702, 1771, 3778, 3908], '517:': [376, 399, 950], '5-23Crossref': [377, 400, 951], '(165)': [380, 403, 954, 1797], 'Scholar).': [382, 532, 572, 617, 691, 740, 884, 996, 1074, 1421, 1513, 1576, 1706, 1843, 2045, 2215, 2295, 2529, 3233, 3287, 3785, 3915, 4112], 'Although': [383], 'several': [384, 4338], 'GPCR': [385, 903], 'pathways': [387, 3145], 'can': [388, 3400], 'now': [389], 'be': [390, 2029, 2599, 2878, 2989, 3026, 3051, 3401], 'recognized': [391], '(3Bünemann': [392], 'Scholar),': [405, 956, 2846, 3206, 4361], 'common': [408], 'best': [410, 4441], 'understood': [411], 'pathway': [412, 764, 3366], 'dependent': [414, 767, 3370], '(GRK)-catalyzed': [421], 'GPCRs': [424, 437, 461, 539, 591], 'subsequent': [427], 'formation': [428], 'complex': [431, 758], 'between': [432], 'agonist-activated': [434], 'phosphorylated': [436, 460], 'family': [440], 'proteins': [442, 3758, 3888], 'known': [443, 626, 723, 2027], 'as': [444, 627, 1011, 1134, 1607, 1614, 1656, 1852, 2012, 2085, 2103, 2179, 2199, 2274, 3728, 3858, 4204, 4223, 4270, 4289], 'nonvisual': [446, 451, 779, 3179, 3377], 'arrestins': [447, 452, 780, 3155, 3180], 'β-arrestins.': [449], 'The': [450, 573, 1075, 1261, 1373, 1532, 1600, 1620, 1736, 1844, 1854, 1921, 2046, 2148, 2182, 2216, 2625, 2891, 3379, 3734, 3753, 3864, 3883, 3999, 4021, 4045, 4217, 4283], '(arrestin-2': [453], '-3)': [455], 'target': [456], 'activated': [458], 'clathrin-coated': [463, 536, 558, 760], 'pits': [464, 559, 761], 'by': [465, 542, 635, 762, 1268, 1277, 1328, 1363, 1634, 1645, 1750, 1979, 2060, 2162, 2251, 2814, 2822, 2943, 2963, 3144, 3161, 3249, 3304, 3364, 3397, 3403, 3413, 3763, 3893, 4384, 4393, 4443], 'virtue': [466], 'their': [468, 716, 1016, 1121, 3748, 3878], 'ability': [469, 4000, 4311], 'bind': [471, 4008], 'with': [472, 1206, 1471, 1475, 1869, 1887, 2007, 2018, 2098, 2610, 2621, 2640, 3038, 3172, 3208, 3325, 3345, 3433, 3450, 3467, 3484, 3500, 3517, 3534, 3548, 3565, 3582, 3599, 3615, 3632, 3649, 3663, 3680, 3697, 3709, 3807, 3820, 3839, 3970, 4192, 4258, 4324, 4368], 'high': [473], 'affinity': [474, 2491], 'clathrin': [476], 'adaptor': [479], 'protein-2': [480], '(4Goodman': [481], 'J.,': [482, 660], 'O.B.': [483], 'Krupnick': [484, 827], 'J.G.': [485, 828, 1300, 3182], 'Santini': [486, 1301, 3183], 'F.': [487, 1302, 3184], 'Gurevich': [488], 'V.V.': [489], 'Penn': [490], 'R.B.': [491], 'Gagnon': [492, 1303, 3185], 'A.W.': [493, 1304, 3186], 'Keen': [494, 1305, 3187], 'J.H.': [495, 1306, 3188], 'Nature.': [498], '1996;': [499, 565], '383:': [500], '447-450Crossref': [501], '(1179)': [504], '5Laporte': [507], 'S.A.': [508], 'Oakley': [509], 'R.H.': [510], 'Holt': [511], 'J.A.': [512], 'Barak': [513], 'L.S.': [514], 'Caron': [515], 'M.G.': [516], '2000;': [520, 610, 733, 858, 877, 989, 1220, 2038, 2208, 2410, 2779, 2798, 2834, 3261, 3280, 3950, 4354], '275:': [521, 859, 2780, 2835, 3262], '23120-23126Abstract': [522], '(314)': [530], 'Once': [533], 'localized': [534], 'pits,': [537], 'are': [540, 584, 699, 720, 1605, 2619, 2905, 2929, 2941, 3976, 4027, 4070], 'internalized': [541, 1029, 1753, 3143], 'requires': [546, 774], 'participation': [548, 776, 3151], 'dynamin,': [550], 'GTPase': [552], 'involved': [553], 'fission': [556], '(6Warnock': [560], 'D.': [561, 677, 805, 1936, 2075, 2280], 'Schmid': [562, 1348, 1366, 3221], 'S.': [563, 1231, 1407, 2286, 2503, 2651, 2703, 3771, 3901, 4086], 'BioEssays.': [564], '18:': [566, 599, 667], '885-893Crossref': [567], '(137)': [570], 'follitropin,': [574], '(FSHR,': [579], 'LHR,': [580, 1001], 'TSHR,': [582], 'respectively)': [583], 'members': [585], 'rhodopsin/β2-adrenergic-like': [588], 'subfamily': [589, 622], '(7Bockaert': [592], 'Pin': [594], 'J.P.': [595], 'EMBO': [596], '1723-1729Crossref': [600], '(1233)': [603], '8Gether': [606], 'U.': [607, 2285], 'Endocrine': [608, 651, 664, 682], 'Rev.': [609, 652, 665, 683], '21:': [611], '90-113Crossref': [612], '(1000)': [615], 'They': [618], 'form': [619], 'small': [621], 'GPCRs,': [624, 744], 'collectively': [625], 'glycoprotein': [629, 703], 'hormone': [630, 704, 1960], 'characterized': [634], 'presence': [637, 1912], 'relatively': [639], 'large': [640, 891], 'domains': [642, 1018], 'composed': [643], 'leucine-rich': [645, 693], 'repeats': [646], '(9Segaloff': [647], 'D.L.': [648, 1192, 1834], 'Ascoli': [649, 831, 853, 873, 985, 1035, 1216, 1232, 1390, 1410, 1548, 1568, 1678, 1698, 1766, 1818, 2034, 2204, 2406, 2774, 2794, 2829, 3256, 3276, 3774, 3904, 3946, 4350], '1993;': [653], '14:': [654, 734, 878, 990, 1221, 2039, 2209, 2411, 2799, 3281, 3951, 4355], '324-347PubMed': [655], '10Simoni': [658], 'M.,': [659], 'G.': [661], 'Nieschlag': [662], 'E.': [663, 807, 1064], '1997;': [666, 1312, 3194], '739-773Crossref': [668], '(0)': [671], '11Rapoport': [674], 'B.': [675], 'Chazenbalk': [676], 'Jaume': [678], 'J.C.': [679], 'McLachlan': [680], 'S.M.': [681], '19:': [685], '673-716Crossref': [686], '(517)': [689], 'Additional': [692, 997], 'repeat-containing': [694], 'homologous': [700], 'have': [706, 1005, 1541, 2478, 3236, 4142], 'been': [707, 1379, 1469, 1542, 1885, 2096, 3237, 3760, 3890], 'recently': [708, 2201], 'identified': [709], 'mammals': [711], 'other': [713, 743, 2365, 2476, 2572], 'organisms,': [714], 'but': [715, 1010, 1101, 3335, 3373], 'ligands': [717], 'functions': [719], 'not': [721, 1103, 2598, 2980, 3045, 3050, 3148], 'yet': [722, 1012], 'Ref.': [726], '12Hsu': [727], 'S.Y.': [728], 'Hsueh': [729], 'A.J.': [730], 'Mol.': [731, 875, 987, 1065, 1218, 1392, 1412, 1503, 1570, 1700, 2036, 2206, 2408, 2796, 3278, 3776, 3906, 3948, 4352], 'Endocrinol.': [732, 876, 988, 1066, 1219, 1393, 1413, 2037, 2207, 2409, 2797, 3279, 3777, 3907, 3949, 4353], '594-604Crossref': [735], '(30)': [738], 'Like': [741], 'many': [742, 2571], 'binding': [746, 1856, 1900, 1922, 2165, 2315, 2490, 2605, 4025, 4050, 4131, 4147, 4219, 4285], 'LHR': [751, 971, 1087, 2386, 2760], 'triggers': [752], 'agonist-receptor': [757], 'via': [759], 'dynamin': [782, 3214, 3372, 3740, 3870, 4202, 4268], '(13Ascoli': [783], 'Cell': [786, 809, 1351, 1821, 2333, 3224], '1984;': [788], '99:': [789], '1242-1250Crossref': [790], '(72)': [793], '14Ghinea': [796], 'N.': [797, 1056, 1188], 'Vuhai': [798], 'M.T.': [799], 'Groyer-Picard': [800], 'M.-T.': [801], 'Houllier': [802], 'A.': [803, 1932, 2071, 2287], 'Schoëvaërt': [804], 'Milgrom': [806, 1063], '1992;': [811], '118:': [812], '1347-1358Crossref': [813], '(87)': [816], '15Lazari': [819], 'M.F.M.': [820, 1383, 1405, 3769, 3899], 'Bertrand': [821], 'J.E.': [822], 'Nakamura': [823, 1155, 1386], 'K.': [824, 850, 1032, 1156, 1160, 1190, 1387, 1403, 1545, 1567, 1675, 1697, 1763, 2771, 2826, 3253, 3767, 3897], 'Liu': [825, 851, 1033, 1384, 1546, 1676, 1764, 2772, 2827, 3254], 'X.': [826, 852, 1034, 1385, 1547, 1677, 1765, 2773, 2828, 3255], '18316-18324Abstract': [838], '(49)': [846], '16Nakamura': [849], '241-247Abstract': [860, 2781, 2836, 3263], '(44)': [868, 2789, 2844, 3271], '17Min': [871, 2792, 3274], 'L.': [872, 984, 1215, 2033, 2203, 2501, 2649, 2701, 2793, 3275, 3945, 4084, 4349], '1797-1810Crossref': [879, 991, 1222, 2040, 2210, 2800, 3282, 3952, 4356], '(59)': [882, 994, 1225, 2043, 2213, 2803, 3285, 3955, 4359], 'Whereas': [885], 'model': [887, 2882], 'derived': [888], 'from': [889, 1429, 1743, 2303, 2325, 2357, 2369, 2395, 4172, 4245, 4491, 4509, 4523, 4534], 'number': [892, 2983, 3028, 4230, 4296], 'studies': [894, 959, 998, 1076], 'emphasizes': [899], '(1Lefkowitz': [910], 'recent': [957, 2402], 'suggest': [960], '(h)': [970, 2759], 'may': [972, 2865], 'play': [973], 'redundant': [974], 'roles': [975], '(17Min': [983, 1214, 2032, 2202, 3944, 4348], 'FSHR,': [1002], 'TSHR': [1004], 'uncovered': [1007], 'unusual,': [1009], 'unexplained,': [1013], 'role': [1014, 2378], 'rate': [1021, 1111, 1738, 2389, 2808, 2872, 3391], 'and/or': [1024, 3156], 'fate': [1026], '(18Nakamura': [1031, 1544, 1674, 1762], '274:': [1041, 1554, 1684, 1772], '25426-25432Abstract': [1042, 1555, 1685, 1773], '(18)': [1050, 1563, 1693, 1781], '19Baratti-Elbaz': [1053], 'C.': [1054, 1062, 1409, 1500, 3773, 3903], 'Chinea': [1055], 'Lahuna': [1057], 'O.': [1058], 'Loosfelt': [1059], 'H.': [1060, 1343, 1502, 3216], 'Pichon': [1061], '13:': [1068, 1395, 1415, 3779, 3909], '1751-1765Crossref': [1069], '(71)': [1072], 'presented': [1077, 3381, 3977, 4028, 4341], 'herein': [1078], 'describe': [1079, 2049], 'novel': [1081], 'set': [1082], 'mutations': [1084, 1108, 2859, 3986, 4077, 4116, 4133], '(all': [1088], 'located': [1089], 'loop)': [1094, 2458], 'do': [1102, 3147], 'affect': [1104, 1109], 'phosphorylation.': [1106, 3998], 'These': [1107, 3234, 3974, 4068], 'manner': [1118], 'parallels': [1120], 'effects': [1122, 2887, 3750, 3880], 'thus': [1127], 'highlight': [1128], 'activation,': [1133], 'opposed': [1135], 'phosphorylation,': [1137], 'LHR.': [1144], 'Full-length': [1145], 'cDNAs': [1146], 'encoding': [1147], 'rLHR': [1152, 1590, 1636, 1666, 2423, 2497, 2547, 2769, 2824, 2925, 2940, 3010, 4080], '(20Minegishi': [1153], 'T.': [1154, 1345, 3218], 'Takakura': [1157], 'Y.': [1158, 1162, 1164], 'Miyamoto': [1159], 'Hasegawa': [1161], 'Ibuki': [1163], 'Igarashi': [1165], 'Biochem.': [1167], 'Biophys.': [1168], 'Res.': [1169], 'Commun.': [1170], '1990;': [1171], '172:': [1172], '1049-1054Crossref': [1173], '(243)': [1176], '21McFarland': [1179], 'K.C.': [1180], 'Sprengel': [1181], 'R.': [1182], 'Phillips': [1183], 'H.S.': [1184, 1785, 1801], 'Kohler': [1185], 'Rosemblit': [1187], 'Nikolics': [1189], 'Segaloff': [1191, 1833], 'Seeburg': [1193], 'P.H.': [1194], 'Science.': [1195], '1989;': [1196], '245:': [1197], '494-499Crossref': [1198], '(808)': [1201], 'Scholar)': [1203, 1242, 1324, 1360, 1945, 2084, 2417, 2677, 2729, 2805, 3957], 'were': [1204, 1325, 1427, 1459, 1520, 1580, 1713, 1863, 1902, 1924, 2058, 2089, 2101, 2112, 2154, 2189, 2195, 2218, 2225, 2235, 2323, 2355, 2367, 3142, 3706, 3744, 3836, 3874, 4018, 4122, 4139, 4189, 4221, 4255, 4287], 'modified': [1205, 1441, 2131], 'Myc': [1208], 'epitope': [1209], 'at': [1210, 1716, 1723, 1896, 1998, 2176, 2993, 4041], 'N': [1212, 2973, 2995, 3005], 'terminus': [1213, 2974, 2996, 3006], '22Fabritz': [1228], 'Ryan': [1230], 'Biochemistry.': [1234], '37:': [1236], '664-672Crossref': [1237], '(40)': [1240], 'subcloned': [1244], 'into': [1245, 4015], 'pcDNAI/Neo': [1246], '(rLHR)': [1247], 'pcDNA': [1249, 3439, 3456, 3473, 3487, 3506, 3523, 3537, 3554, 3571, 3588, 3602, 3621, 3638, 3652, 3669, 3686, 3703, 3810, 3826], '3.1(hLHR)': [1250], 'expression.': [1252], 'Site-directed': [1253], 'was': [1255, 1266, 1361, 1625, 1741, 1877, 1908, 1977, 1996, 2248, 2272, 2301, 2307, 2432, 2447, 2460, 2613, 2750, 3044, 3159, 3294, 3726, 3856, 4059], 'performed': [1256], 'using': [1257, 1490, 1582, 1715, 1865, 1946, 2229, 2850, 4422, 4444], 'conventional': [1258], 'PCR': [1259], 'strategies.': [1260], 'identity': [1262], 'each': [1264, 2534, 3713, 3843, 4196, 4262, 4315], 'mutant': [1265, 2736, 2749, 3032, 3176, 3212, 4456], 'verified': [1267], 'automated': [1269], 'DNA': [1270, 1279], 'sequencing': [1271], 'mutated': [1274], '(performed': [1276], 'core': [1280], 'Diabetes': [1283, 2339], 'Endocrinology': [1285, 2341], 'Research': [1286, 1368, 2342], 'Center': [1287, 2343], 'University': [1290, 2346], 'Iowa).': [1292], 'Expression': [1293], 'vectors': [1294], 'arrestin-3': [1296], 'arrestin-3-(284–489)': [1298], '(23Krupnick': [1299, 3181], '272:': [1313, 3195], '32507-32512Abstract': [1314, 3196], '(180)': [1322, 3204], 'generously': [1326], 'provided': [1327, 2250], 'Dr.': [1329, 1364, 2252], 'Jeff': [1330], '(Thomas': [1332], 'Jefferson': [1333], 'University,': [1334], 'Philadelphia,': [1335], 'PA).': [1336], 'An': [1337], 'expression': [1338, 1374, 2161, 2629, 2689, 2746, 2755, 3754, 3884, 4040], 'vector': [1339], 'dynamin-K44A': [1341, 1870, 3293], '(24Damke': [1342, 3215], 'Baba': [1344, 3217], 'Warnock': [1346, 3219], 'D.E.': [1347, 3220], 'S.L.': [1349, 3222], '1994;': [1353, 3226], '127:': [1354, 3227], '915-934Crossref': [1355, 3228], '(1046)': [1358, 3231], 'donated': [1362], 'Sandra': [1365], '(Scripps': [1367], 'Institute,': [1369], 'La': [1370], 'Jolla,': [1371], 'CA).': [1372], 'constructs': [1377, 1862, 3235, 3717, 3742, 3847, 3872, 4200, 4266], 'has': [1378, 3759, 3889], 'documented': [1380, 2479, 3761, 3891], 'previously': [1381, 3238, 3762, 3892], '(25Lazari': [1382], '866-878Crossref': [1396], '(97)': [1399], '26Nakamura': [1402], 'Lazari': [1404, 3768, 3898], 'Li': [1406, 3770, 3900], 'Korgaonkar': [1408, 3772, 3902], '1295-1304Crossref': [1416, 3780, 3910], '(42)': [1419, 3783, 3913], 'Human': [1422], 'embryonic': [1423], 'kidney': [1424], '(293)': [1425], 'cells': [1426, 1519, 1587, 1596, 1867, 1882, 1986, 2111, 2149, 2183, 2608, 2732, 3170, 3431, 3448, 3465, 3482, 3498, 3515, 3532, 3546, 3563, 3580, 3597, 3613, 3630, 3647, 3661, 3678, 3695, 3705, 3805, 3818, 3835, 3968, 4052, 4064, 4153, 4188, 4254, 4313, 4376, 4407, 4431, 4451], 'obtained': [1428, 1749, 2064, 2324, 2356, 2368], 'American': [1431], 'Type': [1432], 'Culture': [1433], 'Collection': [1434], '(CRL': [1435], '1573)': [1436], 'maintained': [1438], "Dulbecco's": [1440, 2130], "Eagle's": [1442, 2132], 'medium': [1443, 2133, 2322], 'containing': [1444, 2134], '10': [1445, 1482, 2135], 'mm': [1446, 2136], 'Hepes,': [1447, 2137], '10%': [1448], 'newborn': [1449], 'calf': [1450], 'serum,': [1451], '50': [1453, 1914, 2143], 'μg/ml': [1454, 2144], 'gentamicin,': [1455, 2145], 'pH': [1456, 2146], '7.4.': [1457, 2147], 'Cells': [1458, 2088], 'plated': [1460, 1987, 2090, 2116, 2150, 2184], '100-mm': [1462, 2092, 2119, 2187], 'dishes': [1463, 2093, 2120, 2188], '35-mm': [1465, 1990, 2124, 2152], 'wells': [1466, 1991, 2125, 2153], 'coated': [1470, 2097], 'gelatin': [1472, 2099], 'transfected': [1474, 1985, 2102, 2609, 3708, 3743, 3838, 3873, 4191, 4257, 4375], '0.5–1': [1476], 'μg': [1477, 1483, 3711, 3841, 4194, 4260], 'plasmid/35-mm': [1479], 'well': [1480], 'plasmid/100-mm': [1485], 'dish': [1486], 'when': [1487, 3428, 3445, 3462, 3479, 3495, 3512, 3529, 3543, 3560, 3577, 3594, 3610, 3627, 3644, 3658, 3675, 3692, 3802, 3815], '70–80%': [1488], 'confluent': [1489], 'calcium': [1492], 'phosphate': [1493], 'method': [1494], 'Chen': [1496], 'Okayama': [1498, 1501], '(27Chen': [1499], 'Cell.': [1504, 1788], '1987;': [1506, 1836], '7:': [1507], '2745-2752Crossref': [1508], '(4824)': [1511], 'After': [1514, 2106], 'overnight': [1516, 2108, 2128], 'incubation,': [1517, 2109], 'washed': [1521], 'incubated': [1523, 1886, 2127, 3969], 'additional': [1526, 2451], '24': [1527], 'h': [1528, 1895], 'prior': [1529], 'use.': [1531], 'methods': [1533], 'used': [1534, 2155, 2308, 2371], 'measure': [1536], '125I-hCG': [1540, 1730, 1892, 2271, 3725, 3855], 'described': [1543, 2086, 2104, 2180, 2200, 2275, 3729, 3859, 4205, 4224, 4271, 4290], '28Nakamura': [1566, 1696], 'Pharmacol.': [1571, 1701], '56:': [1573, 1703], '728-736PubMed': [1574, 1704], 'Single': [1577], 'point': [1578], 'assays': [1579, 1901, 4026], 'done': [1581, 1714], '30-min': [1584], 'incubation': [1585, 1594, 2004, 2175], 'expressing': [1588, 1597, 2733, 4053, 4065, 4154, 4314, 4432, 4452], '10-min': [1593], 'hLHR.': [1599], 'results': [1601, 2892, 3104, 3975, 4022], 'experiments': [1604, 4339], 'expressed': [1606, 3047], 'index': [1610, 1653], 'defined': [1613, 1851], 'ratio': [1616], 'internalized/surface-bound': [1618], 'hormone.': [1619], 'length': [1621], 'incubations': [1624], 'different': [1626, 1719, 1860, 1889, 2954, 4072, 4168, 4241, 4395, 4434, 4487, 4505, 4519, 4530], 'because': [1627, 2603], 'half-time': [1629, 1845], 'of125I-hCG': [1632, 2171, 2606], 'mediated': [1633, 1644, 2813, 2821, 3248, 3303, 3396, 3412, 4392], '(∼120': [1637], 'min)': [1638, 1649], 'much': [1640, 2762], 'slower': [1641], '(∼20': [1648], 'linear': [1655], 'function': [1658], 'time': [1660], '∼60': [1662], 'min': [1663, 1670], '∼30': [1669], 'Determinations': [1707], 'rates': [1710, 3164], 'least': [1717], 'five': [1718, 3796, 3926, 4237, 4303], 'data': [1720, 1923, 2063, 3380, 4069], 'points': [1721], 'collected': [1722], '3–10-min': [1724], 'intervals': [1725], 'after': [1726], 'addition': [1728], '(depending': [1731], 'construct': [1734], 'transfected).': [1735], 'endocytotic': [1737], 'constant': [1739], '(ke)': [1740], 'calculated': [1742, 2059], 'slope': [1745], 'line': [1748], 'plotting': [1751], 'radioactivity': [1754, 1761], 'against': [1755], 'integral': [1757], 'surface-bound': [1760], '29Wiley': [1784], 'Cunningham': [1786, 1802], 'D.D.': [1787, 1803], '1981;': [1789], '25:': [1790], '433-440Abstract': [1791], '30Wiley': [1800], '1982;': [1807], '257:': [1808], '4222-4229Abstract': [1809], '31Lloyd': [1816], 'C.E.': [1817], '1983;': [1823], '96:': [1824], '521-526Crossref': [1825], '(81)': [1828], '32Ascoli': [1831], 'Endocrinology.': [1835], '120:': [1837], '1161-1172Crossref': [1838], '(36)': [1841], '(t': [1848], '12)': [1849], '0.693/ke.': [1853], 'hCG': [1855, 1918, 1965, 2011, 2244, 2298, 2393, 2440, 2489, 2557, 2812, 3168, 3247, 3302, 3363, 3395, 3411, 4009, 4049, 4130, 4146, 4151, 4218, 4284, 4323], 'properties': [1857, 2494], 'ascertained': [1864], 'intact': [1866, 1984], 'cotransfected': [1868, 1881, 3171], 'prevent': [1872], '(see': [1874, 1992, 2316, 3120, 4408], '"Results").': [1875], 'Binding': [1876], 'measured': [1878, 1909, 1997, 3727, 3857, 3959, 4222, 4288, 4403], 'seven': [1888], 'concentrations': [1890, 2009], '1': [1894, 2984, 3043], 'room': [1897, 2177], 'temperature.': [1898], 'All': [1899, 2364], 'corrected': [1903], 'nonspecific': [1905, 2314], 'binding,': [1906], 'which': [1907], 'IU/ml': [1915], 'partially': [1916], 'purified': [1917, 2297], '(3,000': [1919], 'IU/mg).': [1920], 'fitted': [1925], 'sigmoidal': [1928, 2067], 'equation': [1929, 2068], '(33De': [1930, 2069], 'Lean': [1931, 2070], 'Munson': [1933, 2072], 'P.J.': [1934, 2073], 'Rodbard': [1935, 2074], 'Am.': [1937, 2076], '1978;': [1940, 2079, 2288], '235:': [1941, 2080], 'E97-E102Crossref': [1942, 2081], 'DeltaGraph®': [1947], 'software': [1948], '(Delta': [1949], 'Point,': [1950], 'Monterey,': [1951], 'CA)': [1952], 'calculate': [1954], 'maximal': [1956, 2056, 3749, 3879], 'amount': [1957, 3735, 3865], 'cell-associated': [1959], 'concentration': [1963, 2021, 2170], 'required': [1966], 'attain': [1968], 'half': [1969], 'value': [1972, 3787, 3917], '(apparentK': [1973], 'd).': [1974], 'Hormonal': [1975], 'responsiveness': [1976, 4429], 'assessed': [1978], 'measuring': [1980, 2163, 3162, 4369], 'accumulation': [1982, 4017, 4328], 'gelatin-coated': [1989, 2118, 2123], 'above).': [1993, 2317], 'Total': [1994], 'end': [2000], '2-h': [2003], '(37': [2005], '°C)': [2006], 'increasing': [2008], 'shown': [2013, 2906, 3239, 3289, 4330, 4436], 'Fig.': [2015, 2908, 3042, 3126, 3979, 4332], '3': [2016, 4333], 'single': [2020], 'cholera': [2023, 4399, 4460], 'toxin': [2024, 4412, 4415], '(0.6': [2025], 'nm)': [2026], 'maximally': [2030], 'effective': [2031, 3296], 'parameters': [2047, 4220, 4286], 'dose': [2051], 'responses': [2052, 4372, 4391, 4449], '(i.e.': [2053], 'EC50': [2054], 'response)': [2057], 'fitting': [2061], 'above.': [2087, 2105, 2181], 'washed,': [2113], 'trypsinized,': [2114], '1%': [2138], 'bovine': [2139], 'serum': [2140], 'albumin,': [2141], 'assess': [2157], 'cell': [2158, 2320, 2350, 4043], 'surface': [2159], 'single,': [2168], 'saturating': [2169], 'during': [2172, 2466], '1-h': [2174], 'temperature': [2178], 'lysed,': [2190], 'crude': [2193], 'lysates': [2194], 'immunoprecipitated': [2196], 'analyzed': [2198, 2600, 3052], 'immunoprecipitates': [2217], 'resolved': [2219], 'SDS': [2221], 'gels,': [2222], 'gels': [2224], 'visualized': [2226], 'quantitated': [2228], 'PhosphorImager': [2231], 'images': [2234], 'captured': [2236], 'digital': [2239], 'format': [2240], 'presentation.': [2242], 'Purified': [2243], '(CR-127,': [2245], '∼13,000': [2246], 'IU/mg)': [2247, 2300], 'kindly': [2249], 'Al': [2253], 'Parlow': [2254], 'National': [2257, 2265], 'Hormone': [2258], 'Pituitary': [2260], 'Agency': [2261], 'NIDDK,': [2264], 'Institutes': [2266], 'Health': [2268], '(Bethesda,': [2269], 'MD).': [2270], 'prepared': [2273], 'elsewhere': [2276], '(34Ascoli': [2277], 'Puett': [2279], 'Proc.': [2281], 'Natl.': [2282], 'Acad.': [2283], 'Sci.': [2284], '75:': [2289], '99-102Crossref': [2290], '(123)': [2293], 'Partially': [2296], '(∼3,000': [2299], 'purchased': [2302], 'Sigma,': [2304], 'it': [2306, 2876, 3356, 4383], 'only': [2309, 3064], 'determination': [2312], '125I-cAMP': [2318], 'culture': [2321, 2351], 'Iodination': [2327], 'Core': [2328], 'Media': [2331], 'Production': [2334], 'Core,': [2335], 'respectively,': [2336], 'Iowa.': [2348], 'Other': [2349], 'supplies': [2352], 'reagents': [2354], 'Corning': [2358], 'Life': [2360], 'Technologies,': [2361], 'Inc.,': [2362], 'respectively.': [2363], 'chemicals': [2366], 'commonly': [2370], 'suppliers.': [2372], 'Our': [2373], 'interest': [2374], 'potential': [2377, 2481, 2856], 'arose': [2394], 'sets': [2397], 'studies.': [2399, 3131], 'First,': [2400], '(35Kishi': [2404], '926-936Crossref': [2412], '(16)': [2415], 'truncation': [2420], '(at': [2424], 'residue': [2425, 2982, 3014, 3018, 3027, 3066], '653': [2426], 'C-terminal': [2429], 'tail)': [2430], 'initially': [2433], 'reported': [2434, 2730, 4075, 4123, 4140], 'revealed': [2441], 'due': [2448], '(V497A': [2453], 'inadvertently': [2461], 'introduced': [2462], '(and': [2463], 'went': [2464], 'unnoticed)': [2465], 'construction': [2468], 'original': [2471], 'C-terminally': [2472], 'truncated': [2473], 'mutant.': [2474], 'Second,': [2475], 'investigators': [2477], 'involvement': [2482], 'modulation': [2487], 'signaling': [2493], '(36Ryu': [2498, 2646, 2698, 4081], 'K.,': [2499, 2647, 2699, 4082], 'H.,': [2500, 2648, 2700, 4083], 'Kim': [2502, 2650, 2702, 4085], 'Beauchamp': [2504, 2652, 2704, 4087], 'Tung': [2506, 2654, 2706, 4089], 'C.S.': [2507, 2655, 2707, 4090], 'Isaacs': [2508, 2656, 2708, 4091], 'N.W.': [2509, 2657, 2709, 4092], 'Ji': [2510, 2512, 2658, 2660, 2710, 2712, 4093, 4095], 'I.': [2511, 2659, 2711, 4094, 4216, 4282], 'T.H.': [2513, 2661, 2713, 4096], '6285-6291Abstract': [2519, 2667, 2719, 4102], '(41)': [2527, 2675, 2727, 4110], '20': [2537], 'confirmed': [2548], 'V497A': [2551], 'decreases': [2553], 'context': [2560], 'full-length': [2563], '(Fig.': [2583], '1,right': [2584], 'panel).': [2585], 'Four': [2586], '(Y486A,': [2592], 'I491A,': [2593, 2632], 'C492A,': [2594, 2633], 'P494A)': [2596], 'could': [2597, 3049], 'plasmids': [2612], 'very': [2614], 'low': [2615], 'undetectable': [2617, 2628], '(these': [2618], 'marked': [2620, 3037], 'asterisks': [2622], 'Fig.1).': [2624], 'reduced': [2626], 'P494A': [2635], 'agreement': [2639], 'previous': [2642], 'study': [2643], 'cited': [2644], 'above': [2645], 'involving': [2678], 'alanine': [2679], 'region.': [2684], 'disagree': [2686], 'S484A': [2692, 2735], 'mutant,': [2693], 'Ryu': [2695], 'co-workers': [2697], 'no': [2738, 3069, 3339, 3992, 4143], 'detectable125I-hCG': [2739], 'binding.': [2740], 'In': [2741, 3001, 3312, 4113], 'our': [2742], 'experiments,': [2743], 'however,': [2744, 3387], 'normal.': [2751], 'Since': [2752, 2971, 3929], 'transient': [2754], 'robust': [2764], '(16Nakamura': [2770, 2825, 3252], 'faster': [2818], 'we': [2847, 3105, 3958, 4378], 'reasoned': [2848], 'examine': [2854, 2885], 'facilitate': [2866], 'detection': [2867], 'changes': [2869], 'would': [2877], 'amenable': [2881], 'system': [2883], 'detail.': [2890], 'alanine-scanning': [2894], '1,': [2909], 'left': [2910, 3124], 'panel.': [2911], '2Note': [2912], 'amino': [2915, 2969], 'acid': [2916], 'sequences': [2917], 'loops': [2922], 'identical': [2930], 'except': [2931], '(Leu493': [2935], 'Ser499': [2937], 'replaced': [2942], 'Phe515': [2944], 'Thr521': [2946], 'hLHR).': [2949], 'Additionally,': [2950], 'note': [2951], 'numbers': [2955], 'assigned': [2956], 'equivalent': [2958, 4117, 4134], 'artificially': [2961], 'caused': [2962], 'differences': [2964], 'numbering': [2967], 'acids.': [2970], 'mature': [2977, 3009], 'known,': [2981, 3012], 'taken': [2986, 3024], 'methionine': [2991], 'signal': [2999, 4014], 'peptide.': [3000], 'contrast,': [3002, 3313], 'since': [3003], '(which': [3015], 'corresponds': [3016], '23': [3019], 'hLHR)': [3022], '1.': [3029], 'Only': [3030], 'one': [3031, 3065, 4054], '(C514A,': [3036], 'asterisk': [3040], 'properly': [3046], 'remaining': [3059, 3075], '19': [3060], 'residues,': [3061, 3077], '(Glu520)': [3067], 'Of': [3073], '18': [3076, 4528], '12': [3081, 3243, 3329, 3349], 'resulted': [3083, 3095], '6': [3093], 'Based': [3101], 'chose': [3106], 'decreased': [3115], 'arrows': [3121], 'panelof': [3125], '1)': [3127], 'detailed': [3130], 'first': [3133], 'considered': [3134], 'possibility': [3136], 'question': [3141, 3988], 'require': [3149], 'visual': [3154], 'dynamin.': [3157], 'This': [3158], 'tested': [3160], 'arrestin-3-(284–409),': [3173], 'dominant-negative': [3175, 3211], 'dynamin-K44A,': [3209], 'slow': [3241, 3347, 3360, 3390], 'thet': [3242], 'hLHR-wt': [3251, 3306, 3320, 3485, 3535, 3600, 3650, 3808], 'As': [3288, 4344], 'Table': [3291, 3383, 4215, 4281, 4417, 4438], 'I,': [3292], 'inhibitor': [3297], 'tested.': [3311], 'arrestin-3-(284–409)': [3314], 'inhibited': [3315], 'fast': [3327], 't': [3328, 3348, 3720, 3850], 'little': [3337, 3990], 'V519A).': [3354], 'Thus,': [3355, 4419], 'appears': [3357], 'internalize': [3362], 'still': [3369], 'independent': [3374, 3797, 3927, 4238, 4304], 'arrestins.': [3378], 'I': [3384], 'show,': [3386], 'rescued': [3402], 'overexpression': [3404], 'arrestin-3.Table': [3406], 'IHalf-times': [3407], 'hLHR-wt,': [3415, 4066], 'thereofReceptort1/2': [3418], 'internalizationpcDNA3.1Arrestin-3(284–409)Dynamin-K44AArrestin-3minwt24': [3420], '±': [3421, 3423, 3441, 3458, 3475, 3489, 3491, 3508, 3525, 3539, 3556, 3573, 3590, 3604, 3606, 3623, 3640, 3654, 3671, 3688, 3791, 3921, 4162, 4164, 4166, 4174, 4176, 4178, 4180, 4182, 4184, 4186, 4234, 4300, 4471, 4473, 4475, 4477, 4479, 4481, 4483, 4485, 4493, 4495, 4497, 4499, 4501, 4503, 4511, 4513, 4515, 4517, 4525, 4527, 4536, 4538, 4540, 4542, 4544, 4546], '167': [3422], '2': [3424, 3980], 'bp': [3425], '<': [3426, 3443, 3460, 3477, 3493, 3510, 3527, 3541, 3558, 3575, 3592, 3608, 3625, 3642, 3656, 3673, 3690, 3800, 3813, 4170, 4243, 4489, 4507, 4521, 4532], '0.05': [3427, 3444, 3461, 3478, 3494, 3511, 3528, 3542, 3559, 3576, 3593, 3609, 3626, 3643, 3657, 3674, 3691, 3801, 3814], 'compared': [3429, 3446, 3463, 3480, 3496, 3513, 3530, 3544, 3561, 3578, 3595, 3611, 3628, 3645, 3659, 3676, 3693, 3803, 3816, 4442], 'co-transfected': [3432, 3449, 3466, 3483, 3499, 3516, 3533, 3547, 3564, 3581, 3598, 3614, 3631, 3648, 3662, 3679, 3696, 3806, 3819], 'same': [3435, 3452, 3469, 3502, 3519, 3550, 3567, 3584, 3617, 3634, 3665, 3682, 3699, 3822, 4406], 'plasmid': [3437, 3454, 3471, 3504, 3521, 3552, 3569, 3586, 3619, 3636, 3667, 3684, 3701, 3824], '3.1.201': [3440], '17bp': [3442, 3607], '3.1.3': [3457, 3572], '1bp': [3459, 3574, 3689], '3.1.S512A163': [3474], '17ap': [3476], '3.1.169': [3488], '15272': [3490], '34bp': [3492], '3.1.29': [3507], '6bp': [3509], '3.1.F515A10': [3524], '3ap': [3526], '3.1.55': [3538], '2bp': [3540], '3.1.146': [3555], '10bp': [3557], '3.1.V519A118': [3589], '8ap': [3591], '3.1.117': [3603], '17235': [3605], '3.1.24': [3622], '3bp': [3624], '3.1.T521A12': [3639], '1ap': [3641], '3.1.57': [3653], '8bp': [3655], '3.1.247': [3670], '27bp': [3672], '3.1.4': [3687], '3.1.293': [3704], 'transiently': [3707, 3837, 4190, 4256, 4374], '0.5': [3710, 3840, 4193, 4259], 'indicated': [3716, 3846, 4199, 4265], '1/2': [3721, 3851], 'under': [3730, 3860, 4206, 4225, 4272, 4291], '"Materials': [3731, 3861, 4207, 4226, 4273, 4292], 'Methods."': [3733, 3863, 4228, 4294], 'arrestin-3,': [3737, 3867], 'arrestin-3-(384–409),': [3738, 3868], 'K44A': [3741, 3871, 4203, 4269], 'chosen': [3745, 3875], 'based': [3746, 3876], 'encoded': [3757, 3887], 'Western': [3764, 3894], 'blotting': [3765, 3895], '(26Nakamura': [3766, 3896], 'Each': [3786, 3916, 4229, 4295], 'represents': [3788, 3918, 4231, 4297], 'mean': [3790, 3920], 'S.E.': [3792, 3922, 4235, 4301], 'three': [3794, 3924], 'transfections.a': [3798, 4239], 'p': [3799, 3812], '3.1.b': [3811], '3.1.': [3827], 'Open': [3828, 4247], 'table': [3829, 4248], 'new': [3832, 4251], 'tab': [3833, 4252], '293': [3834, 4253], 'transfections.': [3928, 4305], 'without': [3972], 'hCG.': [3973], 'basal': [3995, 4387], 'transduce': [4012], 'next': [4019], 'measured.': [4020], 'TableII': [4030], 'none': [4034], 'affected': [4038], 'surface.': [4044], 'apparentK': [4046], 'd': [4047, 4128], 'S512A,': [4058], 'higher': [4060], 'somewhat': [4071], 'those': [4074], 'rLHR,': [4115], 'S512A': [4119], 'T521A': [4121], 'reduce': [4125], 'K': [4127], 'F515A': [4136], 'V519A': [4138], 'affinity.Table': [4148], 'IIBinding': [4149], 'thereofReceptorApparentK': [4159], 'dMaximal': [4160], 'bindingnmmolecules/cellwt2.2': [4161], '0.6188,000': [4163], '16,000S512A8.5': [4165], '2.3aStatistically': [4167], '(p': [4169, 4242, 4488, 4506, 4520, 4531], '0.05)': [4171, 4244, 4490, 4508, 4522, 4533], 'hLHR-wt.172,000': [4173], '31,000F515A4.3': [4175], '1.5188,000': [4177], '32,000V519A1.1': [4179], '0.2141,000': [4181], '16,000T521A1.2': [4183], '0.2188,000': [4185], '47,000293': [4187], 'Methods"': [4209, 4275], 'legend': [4213, 4279], 'average': [4233, 4299], 'Statistically': [4240], 'hLHR-wt.': [4246], 'representative': [4307], 'experiment': [4308], 'documenting': [4309], 'respond': [4321], 'increases': [4325], 'summary': [4336], 'TableIII.': [4343], 'pointed': [4345], 'out': [4346], 'before': [4347], 'there': [4362], 'some': [4364], 'inherent': [4365], 'variability': [4366], 'associated': [4367], 'attempted': [4379], 'correct': [4381], 'normalizing': [4385], 'hCG-induced': [4389], 'toxin-induced': [4400, 4461], 'columns': [4409], 'labeled': [4410], 'basal/cholera': [4411], 'hCG/cholera': [4414], 'III).': [4418], 'instead': [4420], 'absolute': [4424], 'levels': [4425], 'cAMP,': [4427], 'III': [4439], 'ratios.Table': [4446], 'IIICyclic': [4447], 'AMP': [4448], 'thereofReceptorBasal': [4457], 'cAMPhCG-induced': [4458], 'responseMaximal': [4459], 'responseResponse': [4462], 'ratioEC50MaximalBasal/cholera': [4463], 'toxinhCG/cholera': [4464], 'toxinpmol/106': [4465], 'cellspmpmol': [4466], 'cAMP/106': [4467, 4469], 'cellspmol': [4468], 'cellswt33': [4470], '5104': [4472], '2695': [4474], '53189': [4476], '320.18': [4478], '0.043.57': [4480], '0.29S512A30': [4482], '5312': [4484], '23aStatistically': [4486], 'hLHR-wt.655': [4492], '96174': [4494], '80.17': [4496], '0.033.38': [4498], '0.67F515A37': [4500], '470': [4502], '5aStatistically': [4504], 'hLHR-wt.483': [4510], '56212': [4512], '240.17': [4514], '0.022.21': [4516], '0.02aStatistically': [4518], 'hLHR-wt.V519A30': [4524], '5278': [4526], 'aStatistically': [4529], 'hLHR-wt.735': [4535], '107191': [4537], '90.16': [4539], '0.033.37': [4541], '0.28T521A38': [4543], '770': [4545], '2aStati': [4547]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078432352', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-04T00:52:51.577476', 'created_date': '2016-06-24'}