Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078288268', 'doi': 'https://doi.org/10.1080/13684730050515813', 'title': 'Use of G-CSF for granulocyte transfusion therapy', 'display_name': 'Use of G-CSF for granulocyte transfusion therapy', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2078288268', 'doi': 'https://doi.org/10.1080/13684730050515813', 'mag': '2078288268', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11108574'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13684730050515813', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35871717', 'display_name': 'Cytokines Cellular & Molecular Therapy', 'issn_l': '1368-4736', 'issn': ['1368-4736', '1471-177X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084791226', 'display_name': 'Kai Hübel', 'orcid': 'https://orcid.org/0000-0002-7958-4664'}, 'institutions': [{'id': 'https://openalex.org/I180923762', 'display_name': 'University of Cologne', 'ror': 'https://ror.org/00rcxh774', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I180923762']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['DE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Kai Hübel', 'raw_affiliation_strings': ['Department of Medicine, University of Washington, Seattle, WA, USA and Department I of Internal Medicine, University of Cologne, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Washington, Seattle, WA, USA and Department I of Internal Medicine, University of Cologne, Germany', 'institution_ids': ['https://openalex.org/I180923762', 'https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111628804', 'display_name': 'David C. Dale', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David C Dale', 'raw_affiliation_strings': ['Dept. of Medicine, University of Washington, Seattle, WA, USA.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Medicine, University of Washington, Seattle, WA, USA.', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057387418', 'display_name': 'Andreas Engert', 'orcid': 'https://orcid.org/0000-0002-1890-1523'}, 'institutions': [{'id': 'https://openalex.org/I180923762', 'display_name': 'University of Cologne', 'ror': 'https://ror.org/00rcxh774', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I180923762']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Engert', 'raw_affiliation_strings': ['Department I of Internal Medicine, University of Cologne, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department I of Internal Medicine, University of Cologne, Germany', 'institution_ids': ['https://openalex.org/I180923762']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023854052', 'display_name': 'W. Conrad Liles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W Conrad Liles', 'raw_affiliation_strings': ['Dept. of Medicine, University of Washington, Seattle, WA, USA.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Medicine, University of Washington, Seattle, WA, USA.', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.101, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.238562, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 78}, 'biblio': {'volume': '6', 'issue': '2', 'first_page': '89', 'last_page': '95'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12172', 'display_name': 'Neutropenia and Cancer Infections', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12172', 'display_name': 'Neutropenia and Cancer Infections', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12919', 'display_name': 'Blood disorders and treatments', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12167', 'display_name': 'Bacterial Identification and Susceptibility Testing', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leukapheresis', 'display_name': 'Leukapheresis', 'score': 0.8008256}, {'id': 'https://openalex.org/keywords/transfusion-therapy', 'display_name': 'Transfusion Therapy', 'score': 0.69620264}, {'id': 'https://openalex.org/keywords/leukopenia', 'display_name': 'Leukopenia', 'score': 0.43612057}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.80877984}, {'id': 'https://openalex.org/C2777371436', 'wikidata': 'https://www.wikidata.org/wiki/Q3237071', 'display_name': 'Leukapheresis', 'level': 4, 'score': 0.8008256}, {'id': 'https://openalex.org/C2777063308', 'wikidata': 'https://www.wikidata.org/wiki/Q1435822', 'display_name': 'Neutropenia', 'level': 3, 'score': 0.7935817}, {'id': 'https://openalex.org/C2777983669', 'wikidata': 'https://www.wikidata.org/wiki/Q223143', 'display_name': 'Granulocyte', 'level': 2, 'score': 0.79054284}, {'id': 'https://openalex.org/C2779817106', 'wikidata': 'https://www.wikidata.org/wiki/Q7834210', 'display_name': 'Transfusion therapy', 'level': 3, 'score': 0.69620264}, {'id': 'https://openalex.org/C2777767877', 'wikidata': 'https://www.wikidata.org/wiki/Q419327', 'display_name': 'Granulocyte colony-stimulating factor', 'level': 3, 'score': 0.6912053}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.68306386}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5301484}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.47460645}, {'id': 'https://openalex.org/C2780873365', 'wikidata': 'https://www.wikidata.org/wiki/Q496812', 'display_name': 'Leukopenia', 'level': 3, 'score': 0.43612057}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38576394}, {'id': 'https://openalex.org/C2780014101', 'wikidata': 'https://www.wikidata.org/wiki/Q183605', 'display_name': 'Blood transfusion', 'level': 2, 'score': 0.3049184}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23669541}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.21067476}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.09125969}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.05469042}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C10205521', 'wikidata': 'https://www.wikidata.org/wiki/Q4035578', 'display_name': 'CD34', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016179', 'descriptor_name': 'Granulocyte Colony-Stimulating Factor', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006098', 'descriptor_name': 'Granulocytes', 'qualifier_ui': 'Q000637', 'qualifier_name': 'transplantation', 'is_major_topic': True}, {'descriptor_ui': 'D019650', 'descriptor_name': 'Hematopoietic Stem Cell Mobilization', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D017708', 'descriptor_name': 'Leukocyte Transfusion', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D001782', 'descriptor_name': 'Blood Donors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016179', 'descriptor_name': 'Granulocyte Colony-Stimulating Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006098', 'descriptor_name': 'Granulocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019650', 'descriptor_name': 'Hematopoietic Stem Cell Mobilization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017708', 'descriptor_name': 'Leukocyte Transfusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009503', 'descriptor_name': 'Neutropenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014019', 'descriptor_name': 'Tissue Donors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13684730050515813', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35871717', 'display_name': 'Cytokines Cellular & Molecular Therapy', 'issn_l': '1368-4736', 'issn': ['1368-4736', '1471-177X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11108574', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W943875344', 'https://openalex.org/W4244540013', 'https://openalex.org/W2409060369', 'https://openalex.org/W2396869482', 'https://openalex.org/W2318813781', 'https://openalex.org/W2314217129', 'https://openalex.org/W2145312869', 'https://openalex.org/W2106803404', 'https://openalex.org/W2016282680', 'https://openalex.org/W2014758028'], 'abstract_inverted_index': {'Patients': [0], 'with': [1, 35, 50, 130], 'neutropenia,': [2], 'especially': [3], 'neutropenia': [4], 'following': [5], 'aggressive': [6], 'myeloablative': [7], 'therapy,': [8, 165], 'are': [9, 43], 'at': [10], 'high': [11], 'risk': [12], 'for': [13, 45, 77], 'developing': [14], 'infectious': [15], 'complications': [16], 'caused': [17], 'by': [18, 85], 'bacteria': [19], 'and': [20, 39, 88, 135, 172, 176, 183], 'opportunistic': [21], 'fungi.': [22], 'Infections': [23], 'remain': [24], 'one': [25], 'of': [26, 30, 47, 58, 99, 160, 169], 'the': [27, 55, 158], 'leading': [28], 'causes': [29], 'treatment': [31, 181], 'failure': [32], 'in': [33, 120, 132, 151, 162], 'patients': [34, 49, 147], 'cancer.': [36], 'Thus,': [37], 'new': [38], 'innovative': [40], 'therapeutic': [41, 68], 'strategies': [42], 'needed': [44], 'management': [46], 'neutropenic': [48], 'infection.': [51], 'Because': [52], 'neutrophils': [53], 'represent': [54], 'first': [56], 'line': [57], 'host': [59], 'defense,': [60], 'granulocyte': [61, 90, 100, 121, 163, 170], 'transfusion': [62, 122, 164], 'therapy': [63, 72], 'should': [64], 'be': [65], 'a': [66, 105], 'logical': [67], 'approach.': [69], 'Although': [70], 'such': [71], 'has': [73, 82, 117, 126, 143], 'been': [74, 83, 127, 139, 144], 'employed': [75], 'sporadically': [76], 'several': [78], 'decades,': [79], 'clinical': [80, 133], 'benefit': [81], 'compromised': [84], 'technical': [86, 167], 'problems': [87], 'low': [89], 'yields': [91], 'resulting': [92], 'from': [93], 'inadequate': [94], 'donor': [95, 174], 'stimulation.': [96], 'The': [97], 'discovery': [98], 'colony-stimulating': [101], 'factor': [102], '(G-CSF)': [103], 'as': [104, 178, 180], 'means': [106], 'to': [107, 114, 146], 'elevate': [108], 'blood': [109], 'neutrophil': [110], 'counts': [111], 'when': [112, 141], 'administered': [113, 145], 'normal': [115], 'donors': [116], 'rekindled': [118], 'interest': [119], 'therapy.': [123], 'Extensive': [124], 'experience': [125], 'gained': [128], 'worldwide': [129], 'G-CSF': [131, 142, 161], 'practice,': [134], 'adverse': [136], 'events': [137], 'have': [138], 'minimal': [140], 'or': [148], 'healthy': [149], 'persons': [150], 'human': [152], 'trials.': [153], 'This': [154], 'review': [155], 'focuses': [156], 'on': [157], 'use': [159], 'including': [166], 'considerations': [168], 'leukapheresis': [171], 'storage,': [173], 'selection': [175], 'stimulation,': [177], 'well': [179], 'results': [182], 'associated': [184], 'risks.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078288268', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2025-01-15T06:58:19.799877', 'created_date': '2016-06-24'}