Publication Information

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1949, 2021, 2065, 2070], 'plant': [8, 184, 365, 1206], 'cell': [9, 185, 366, 1207], 'wall': [10, 186, 367, 1208], 'pectin.': [11, 187, 379, 1220], 'To': [12, 188, 1986], 'understand': [13, 189, 1143, 1987], 'the': [14, 28, 72, 77, 87, 90, 129, 144, 152, 161, 169, 173, 190, 204, 248, 253, 263, 266, 305, 320, 328, 337, 345, 349, 383, 411, 477, 480, 558, 572, 575, 736, 742, 775, 833, 886, 888, 968, 981, 989, 1016, 1019, 1028, 1032, 1048, 1085, 1096, 1107, 1112, 1144, 1149, 1155, 1165, 1175, 1181, 1194, 1224, 1252, 1318, 1321, 1400, 1414, 1417, 1578, 1584, 1617, 1675, 1729, 1731, 1811, 1824, 1832, 1859, 1862, 1871, 1875, 1891, 1928, 1939, 1950, 1955, 1988, 1993, 1999, 2009, 2019, 2025, 2038, 2062, 2071, 2077, 2093], 'catalytic': [15, 130, 191, 306, 1198, 2042], 'mechanism': [16, 192, 1199, 2043], 'and': [17, 19, 37, 65, 100, 159, 193, 195, 213, 241, 276, 335, 378, 394, 425, 548, 553, 561, 564, 566, 599, 710, 781, 825, 841, 914, 1152, 1172, 1219, 1235, 1266, 1390, 1395, 1403, 1406, 1408, 1441, 1552, 1623, 1667, 1683, 1757, 1996, 2016, 2091], 'substrate': [18, 122, 194, 298, 776, 977, 1618, 1820], 'product': [20, 196], 'specificity': [21, 197], 'these': [23, 117, 199, 293, 387, 1228], 'enzymes,': [24, 200], 'we': [25, 38, 201, 214, 1162, 2006], 'have': [26, 39, 202, 215, 540, 890, 1115, 1163, 1173, 1382, 1733, 1958, 2007, 2017], 'solved': [27, 203, 747, 1589], 'x-ray': [29, 205, 834, 1676], 'structure': [30, 206, 738, 1167, 1580, 2011], 'endopolygalacturonase': [32, 145, 208, 321, 740, 912, 1056, 1120, 1170, 1582, 1755, 1899, 1963, 2014, 2066], 'II': [33, 146, 209, 322, 913, 1171, 1756, 2015], 'Aspergillus': [35, 211, 659, 714, 1501, 1556], 'niger': [36, 212, 1061, 1169, 1904, 2013], 'carried': [40, 216], 'out': [41, 217, 2061], 'site-directed': [42, 218, 1185, 2029], 'mutagenesis': [43, 93, 219, 269], 'studies.': [44, 220], 'The': [45, 57, 126, 221, 233, 302, 364, 380, 397, 445, 513, 772, 984, 1205, 1221, 1238, 1286, 1354, 1614, 1827, 2068], 'enzyme': [46, 222], 'folds': [47, 223], 'into': [48, 224], 'right-handed': [50, 226, 847, 1689], 'parallel': [51, 63, 227, 239, 848, 1690], 'β-helix': [52, 58, 228, 234, 849, 1691], 'with': [53, 149, 229, 325, 885, 918, 978, 1728, 1761, 1821, 2103], '10': [54, 230], 'complete': [55, 231, 527, 1052, 1368, 1895], 'turns.': [56, 232], 'is': [59, 235, 382, 1223], 'composed': [60, 236], 'four': [62, 238], 'β-sheets,': [64, 240], 'has': [66, 242], 'one': [67, 243], 'very': [68, 244, 2051], 'small': [69, 245], 'α-helix': [70, 246], 'near': [71, 247], 'N': [73, 249], 'terminus,': [74, 250], 'which': [75, 102, 251, 278, 555, 569, 1397, 1411], 'shields': [76, 252], "enzyme's": [78, 254], 'hydrophobic': [79, 255], 'core.': [80, 256], 'Loop': [81, 257], 'regions': [82, 258], 'form': [83, 259], 'cleft': [85, 261], 'on': [86, 262, 571, 1413], 'exterior': [88, 264], 'β-helix.': [91, 267], 'Site-directed': [92, 268], 'Asp180,': [95, 271], 'Asp201,': [96, 272], 'Asp202,': [97, 273], 'His223,': [98, 274], 'Arg256,': [99, 275], 'Lys258,': [101, 277], 'are': [103, 119, 279, 295, 417, 580, 986, 1092, 1158, 1258, 1422, 1829, 1935, 2002, 2050, 2098], 'located': [104, 280], 'in': [105, 109, 137, 281, 285, 313, 468, 828, 1027, 1059, 1146, 1180, 1309, 1670, 1870, 1902, 1990, 2024, 2080], 'this': [106, 282], 'cleft,': [107, 283], 'results': [108, 284], 'severe': [111, 287], 'reduction': [112, 288], 'activity,': [114, 290, 1161, 2005], 'demonstrating': [115, 291], 'that': [116, 134, 150, 157, 292, 310, 326, 333, 967, 1157, 1810, 2001], 'residues': [118, 131, 294, 307, 447, 483, 1026, 1156, 1179, 1288, 1324, 1869, 2000, 2023], 'important': [120, 296], 'for': [121, 297, 988, 1111, 1119, 1160, 1193, 1200, 1831, 1954, 1962, 2004, 2037, 2044, 2059, 2100], 'binding': [123, 299], 'and/or': [124, 300, 489, 493, 1330, 1334], 'catalysis.': [125, 301], 'juxtaposition': [127, 303], 'differs': [132, 308], 'from': [133, 309, 504, 596, 658, 713, 741, 1122, 1345, 1438, 1500, 1555, 1583, 1965], 'normally': [135, 311], 'encountered': [136, 312], 'inverting': [138, 314], 'glycosyl': [139, 315, 897, 972, 1203, 1740, 1815, 2047], 'hydrolases.': [140, 316, 1204, 2048], 'A': [141, 317, 712, 916, 1554, 1759], 'comparison': [142, 318], 'active': [147, 323, 1182, 2026], 'site': [148, 324, 1183, 2027], 'P22': [153, 329], 'tailspike': [154, 330], 'rhamnosidase': [155, 331], 'suggests': [156, 332], 'Asp180': [158, 334], 'Asp202activate': [160, 336], 'attacking': [162, 338], 'nucleophilic': [163, 339], 'water': [164, 340], 'molecule,': [165, 341, 479, 1320], 'while': [166, 342], 'Asp201': [167, 343], 'protonates': [168, 344], 'glycosidic': [170, 346], 'oxygen': [171, 347], 'scissile': [174, 350], 'bond.': [175, 351], 'rhamnose': [352, 446, 1287], 'galacturonic': [353, 481, 1024, 1322, 1867], 'acid': [354, 408, 424, 482, 1025, 1249, 1265, 1323, 1868], 'polyethylene': [355], 'glycol': [356], 'root': [357], 'mean': [358], 'square': [359], 'deviation': [360], 'N-acetylglucosamine': [361], '2-(N-morpholino)ethanesulfonic': [362], 'acid.': [363], 'consists': [368, 1209], 'network': [371, 1212], 'complex': [373, 385, 519, 1214, 1226, 1360], 'carbohydrates': [374, 1215], 'like': [375, 1216], 'cellulose,': [376, 1217], 'hemicellulose,': [377, 1218], 'latter': [381, 1113, 1222, 1956], 'most': [384, 1225], 'carbohydrates.': [388, 1229], 'It': [389, 1230], 'contains': [390, 1231], 'so-called': [391, 1232], '"smooth': [392, 1233], 'regions"': [393, 1234], '"hairy': [395, 1236], 'regions."': [396, 1237], 'smooth': [398, 1239], 'regions,': [399, 413, 1240, 1254], 'also': [400, 974, 1241, 1817], 'known': [401, 581, 1242, 1423], 'as': [402, 1243], 'homogalacturonan,': [403, 1244], 'consist': [404, 1245], 'α(1,4)-linked': [406, 1247], 'd-galacturonic': [407, 1248], 'residues,': [409, 1250], 'whereas': [410, 779, 1251, 1621], 'hairy': [412, 1253], 'or': [414, 457, 526, 1100, 1255, 1298, 1367, 1943], 'rhamnogalacturonan': [415, 549, 551, 567, 1256, 1391, 1393, 1409], 'I,': [416, 1257], 'characterized': [418, 1259], 'by': [419, 455, 524, 529, 777, 1184, 1260, 1296, 1365, 1370, 1619, 2028], 'stretches': [420, 1261], 'alternating': [422, 991, 1263, 1834], 'α(1,2)-linkedd-galacturonic': [423, 1264], 'l-rhamnose': [426, 1267], '(1de': [427, 1268], 'Vries': [428, 1269], 'J.A.': [429, 1270], 'Rombouts': [430, 1271], 'F.M.': [431, 1272], 'Voragen': [432, 950, 1273, 1793], 'A.G.J.': [433, 951, 1274, 1794], 'Pilnik': [434, 1275], 'W.': [435, 642, 795, 1002, 1276, 1484, 1637, 1845], 'Carbohydr.': [436, 1277], 'Polym.': [437, 1278], '1982;': [438, 1279], '2:': [439, 1280], '25-33Crossref': [440, 1281], 'Scopus': [441, 613, 631, 652, 686, 706, 731, 768, 867, 881, 907, 938, 962, 1080, 1139, 1282, 1455, 1473, 1494, 1528, 1548, 1573, 1610, 1709, 1723, 1750, 1781, 1805, 1923, 1982], '(193)': [442, 1283], 'Google': [443, 615, 633, 654, 688, 708, 733, 770, 805, 817, 869, 883, 909, 940, 964, 1012, 1045, 1082, 1141, 1284, 1457, 1475, 1496, 1530, 1550, 1575, 1612, 1647, 1659, 1711, 1725, 1752, 1783, 1807, 1855, 1888, 1925, 1984], 'Scholar).': [444, 475, 515, 734, 771, 818, 910, 1013, 1046, 1285, 1316, 1356, 1576, 1613, 1660, 1726, 1753, 1856, 1889, 1985], 'can': [448, 484, 1289, 1325], 'be': [449, 485, 1290, 1326], 'substituted': [450, 1291], 'at': [451, 487, 491, 1292, 1328, 1332, 2076, 2092], 'their': [452, 820, 826, 976, 1089, 1293, 1662, 1668, 1819, 1932, 2101], 'O4': [453, 1294], 'atoms': [454, 1295], 'arabinose': [456, 1297], 'galactose': [458, 1299], "(2O'Neill": [459, 1300], 'M.A.': [460, 1301], 'Albersheim': [461, 1302], 'P.': [462, 923, 1303, 1766], 'Darvill': [463, 1304], 'A.G.': [464, 1305], 'Dey': [465, 1306], 'P.M.': [466, 1307], 'Methods': [467, 1308], 'Plant': [469, 625, 700, 1310, 1467, 1542], 'Biochemistry:Carbohydrates.': [470, 1311], 'Academic': [471, 1312], 'Press,': [472, 1313], 'London1990:': [473, 1314], '415-441Google': [474, 1315], 'Throughout': [476, 1317], 'pectin': [478, 523, 562, 656, 839, 1033, 1108, 1319, 1364, 1404, 1498, 1681, 1876, 1951], 'methylated': [486, 1327], 'O6': [488, 1329], 'acetylated': [490, 1331], 'O2': [492, 1333], 'O3': [494, 1335], '(3Schols': [495, 1336], 'H.': [496, 793, 1000, 1337, 1635, 1843], 'Structural': [497, 1338], 'Characterization': [498, 1339], 'Pectic': [500, 1341], 'Hairy': [501, 1342], 'Regions': [502, 1343], 'Isolated': [503, 1344], 'Apple': [505, 1346], 'Cell': [506, 1347], 'Walls.': [507, 1348], 'Ph.D.': [508, 1349], 'thesis.': [509, 1350], 'Agricultural': [510, 1351], 'University,': [511, 1352], 'Wageningen,': [512, 1353], 'Netherlands1995Google': [514, 1355], 'Due': [516, 1357], 'to': [517, 893, 1095, 1153, 1191, 1358, 1736, 1938, 1997, 2035, 2053], 'its': [518, 1359], 'structure,': [520, 1361], 'modification': [521, 1362], 'plants': [525, 1366], 'breakdown': [528, 1369], 'microorganisms': [530, 535, 1371, 1377], 'requires': [531, 1372], 'many': [532, 1373], 'different': [533, 822, 829, 1374, 1664, 1671], 'enzymes.In': [534], 'several': [536, 585, 1378, 1427], 'classes': [537, 544, 586, 1379, 1386, 1428], 'pectinases': [539, 1381], 'been': [541, 891, 1116, 1383, 1734, 1959], 'identified.': [542, 1384], 'These': [543, 592, 1187, 1385, 1434, 2031], 'comprise': [545, 1387], 'pectate-,': [546, 1388], 'pectin-,': [547, 1389], 'lyases,': [550, 1392], 'hydrolases,': [552, 1394], 'polygalacturonases,': [554, 1396], 'all': [556, 1093, 1398, 1936], 'depolymerize': [557, 1399], 'main': [559, 576, 588, 1401, 1418, 1430], 'chain;': [560, 1402], 'methylesterases': [563, 1405], 'pectin-': [565, 1407], 'acetylesterases,': [568, 1410], 'act': [570, 917, 1412, 1760], 'substituents': [573, 1415], 'chain.': [577, 1419], 'Crystal': [578, 1420], 'structures': [579, 835, 1421, 1677], 'members': [583, 1425], 'chain': [589, 1431], 'depolymerizing': [590, 1432], 'pectinases.': [591, 1433], 'include': [593, 1435], 'pectate': [594, 837, 1436, 1679], 'lyases': [595, 657, 773, 1437, 1499, 1615], 'Erwinia': [597, 744, 1439, 1586], 'chrysanthemi': [598, 1440], 'Bacillus': [600, 1442], 'subtilis': [601, 1443], '(4Yoder': [602, 1444], 'M.D.': [603, 622, 854, 872, 1445, 1464, 1696, 1714], 'Keen': [604, 1446], 'N.T.': [605, 1447], 'Jurnak': [606, 623, 698, 873, 1448, 1465, 1540, 1715], 'F.': [607, 624, 699, 852, 874, 1449, 1466, 1541, 1694, 1716], 'Science.': [608, 1450], '1993;': [609, 1451], '260:': [610, 1452], '1503-1507Crossref': [611, 1453], 'PubMed': [612, 630, 651, 685, 705, 730, 767, 804, 866, 880, 906, 937, 961, 1011, 1079, 1138, 1454, 1472, 1493, 1527, 1547, 1572, 1609, 1646, 1708, 1722, 1749, 1780, 1804, 1854, 1922, 1981], '(398)': [614, 1456], 'Scholar,': [616, 634, 689, 806, 870, 941, 1458, 1476, 1531, 1648, 1712, 1784], '5Lietzke': [617, 1459], 'S.E.': [618, 1460], 'Scavetta': [619, 1461], 'R.D.': [620, 1462], 'Yoder': [621, 853, 1463, 1695], 'Physiol.': [626, 701, 1468, 1543], '1996;': [627, 934, 1469, 1777], '111:': [628, 1470], '73-92Crossref': [629, 1471], '(47)': [632, 939, 1474, 1782], '6Pickersgill': [635, 1477], 'R.': [636, 673, 749, 856, 1478, 1515, 1591, 1698], 'Jenkins': [637, 674, 754, 857, 1479, 1516, 1596, 1699], 'J.': [638, 644, 669, 671, 675, 691, 697, 755, 756, 797, 810, 858, 876, 902, 931, 1004, 1038, 1072, 1074, 1131, 1133, 1480, 1486, 1511, 1513, 1517, 1533, 1539, 1597, 1598, 1639, 1652, 1700, 1718, 1745, 1774, 1847, 1881, 1915, 1917, 1974, 1976], 'Harris': [639, 1481], 'G.': [640, 953, 1482, 1796], 'Nasser': [641, 1483], 'Robert-Baudoy': [643, 1485], 'Nat.': [645, 1487], 'Struct.': [646, 861, 1488, 1703], 'Biol.': [647, 757, 862, 1489, 1599, 1704], '1994;': [648, 863, 1490, 1705], '1:': [649, 1491], '717-723Crossref': [650, 1492], '(186)': [653, 1495], 'Scholar),': [655, 709, 965, 1497, 1551, 1808], 'niger(7Mayans': [660, 1502], 'O.': [661, 1503], 'Scott': [662, 1504], 'M.': [663, 945, 1505, 1788], 'Connerton': [664, 1506], 'I.': [665, 1507], 'Gravesen': [666, 1508], 'T.': [667, 1509], 'Benen': [668, 924, 1126, 1510, 1767, 1969], 'Visser': [670, 696, 796, 809, 930, 1003, 1037, 1071, 1130, 1512, 1538, 1638, 1651, 1773, 1846, 1880, 1914, 1973], 'Pickersgill': [672, 855, 1514, 1697], 'Structure.': [676, 721, 1518, 1563], '1997;': [677, 722, 801, 1008, 1519, 1564, 1643, 1851], '5:': [678, 723, 1520, 1565], '677-689Abstract': [679, 1521], 'Full': [680, 682, 725, 727, 762, 764, 1522, 1524, 1567, 1569, 1604, 1606], 'Text': [681, 683, 726, 728, 763, 765, 1523, 1525, 1568, 1570, 1605, 1607], 'PDF': [684, 729, 766, 1526, 1571, 1608], '(167)': [687, 1529], '8Vitali': [690, 1532], 'Schick': [692, 1534], 'B.': [693, 900, 1535, 1743], 'Kester': [694, 788, 928, 995, 1128, 1536, 1630, 1771, 1838, 1971], 'H.C.M.': [695, 789, 808, 929, 996, 1036, 1129, 1537, 1631, 1650, 1772, 1839, 1879, 1972], '1998;': [702, 759, 958, 1135, 1544, 1601, 1801, 1978], '116:': [703, 1545], '69-80Crossref': [704, 1546], '(88)': [707, 882, 1549, 1724], 'rhamnogalacturonase': [711, 842, 915, 1553, 1684, 1758], 'aculeatus(9Petersen': [715, 1557], 'T.N.': [716, 1558], 'Kauppinen': [717, 1559], 'S.': [718, 720, 1560, 1562], 'Larsen': [719, 1561], '533-544Abstract': [724, 1566], '(123)': [732, 1574], 'Recently,': [735, 1577], 'crystal': [737, 1166, 1579, 2010], 'bacterium': [743, 1585], 'carotovora': [745, 1587], 'was': [746, 1588], '(10Pickersgill': [748, 1590], 'Smith': [750, 1592], 'D.': [751, 1593], 'Worboys': [752, 1594], 'K.': [753, 927, 1595, 1770], 'Chem.': [758, 1600], '273:': [760, 1602], '24660-24664Abstract': [761, 1603], '(147)': [769, 1611], 'cleave': [774, 975, 1616, 1818], 'β-elimination,': [778, 1620], 'rhamnogalacturonases': [780, 985, 1622, 1828], 'polygalacturonases': [782, 889, 1017, 1624, 1732, 1860], 'use': [783, 1625], 'acid/base-catalyzed': [784, 1626], 'hydrolysis': [785, 1627], '(11Suykerbuyk': [786, 993, 1628, 1836], 'M.E.G.': [787, 994, 1629, 1837], 'Schaap': [790, 997, 1632, 1840], 'P.J.': [791, 998, 1633, 1841], 'Stam': [792, 999, 1634, 1842], 'Musters': [794, 1001, 1636, 1844], 'Appl.': [798, 812, 1005, 1040, 1640, 1654, 1848, 1883], 'Environm.': [799, 1006, 1641, 1849], 'Microbiol.': [800, 1007, 1642, 1850], '63:': [802, 1009, 1644, 1852], '2507-2515Crossref': [803, 1010, 1645, 1853], '12Kester': [807, 1649], 'Biotech.': [811, 1039, 1653, 1882], 'Biochem.': [813, 901, 954, 1041, 1075, 1134, 1655, 1744, 1797, 1884, 1918, 1977], '1990;': [814, 1042, 1656, 1885], '12:': [815, 1043, 1657, 1886], '150-160PubMed': [816, 1044, 1658, 1887], 'Despite': [819, 1661], 'completely': [821, 1663], 'reaction': [823, 1665], 'mechanisms,': [824, 1666], 'groupings': [827, 1669], 'sequence': [830, 1672], 'homology': [831, 1673], 'families,': [832, 1674], 'lyase,': [838, 840, 1680, 1682], 'reveal': [843, 1685], 'similar': [845, 1687], 'unique': [846, 1688], 'topology': [850, 1692], '(13Jurnak': [851, 1693], 'Curr.': [859, 1701], 'Opin.': [860, 1702], '4:': [864, 1706], '802-806Crossref': [865, 1707], '(34)': [868, 1710], '14Yoder': [871, 1713], 'FASEB': [875, 1717], '1995;': [877, 1719], '9:': [878, 1720], '335-342Crossref': [879, 1721], 'Scholar).Together': [884], 'rhamnogalacturonases,': [887, 1730], 'assigned': [892, 1735], 'family': [894, 970, 1053, 1201, 1737, 1813, 1896, 2045], '28': [895, 971, 1202, 1738, 1814, 2046], 'hydrolases': [898, 973, 1741, 1816], '(15Henrissat': [899, 1742], '1991;': [903, 1746], '280:': [904, 1747], '309-316Crossref': [905, 1748], '(2590)': [908, 1751], 'Both': [911, 1754], 'inversion': [919, 979, 1762, 1822], 'configuration': [921, 1764], '(16Biely': [922, 1765], 'J.A.E.': [925, 1127, 1768, 1970], 'Heinrichová': [926, 1769], 'FEBS': [932, 1775], 'Lett.': [933, 1776], '382:': [935, 1778], '249-255Crossref': [936, 1779], '17Pitson': [942, 1785], 'S.M.': [943, 1786], 'Mutter': [944, 1787], 'van': [946, 1789], 'den': [947, 1790], 'Broek': [948, 1791], 'L.A.M.': [949, 1792], 'Beldman': [952, 1795], 'Biophys.': [955, 1798], 'Res.': [956, 1799], 'Commun.': [957, 1800], '242:': [959, 1802], '552-559Crossref': [960, 1803], '(22)': [963, 1806], 'suggesting': [966, 1809], 'other': [969, 1104, 1812, 1947], 'anomeric': [982, 1825], 'configuration.': [983, 1826], 'specific': [987, 1830], 'strictly': [990, 1833], 'α(1,4)-d-GalA-α(1,2)-l-Rha1sequence': [992, 1835], 'In': [1014, 1376, 1857], 'contrast,': [1015, 1858], 'α(1,4)-glycosidic': [1020, 1863], 'bonds': [1021, 1864], 'between': [1022, 1148, 1865, 1992], 'adjacent': [1023, 1866], '"smooth"': [1029, 1872], 'part': [1030, 1099, 1873, 1942], 'molecule': [1034, 1877], '(12Kester': [1035, 1878], 'However,': [1047, 1890], 'presence': [1049, 1892], 'seven': [1055, 1898], 'encoding': [1057, 1900], 'genes': [1058, 1901], 'A.': [1060, 1123, 1903, 1966], '(18Bussink': [1062, 1905], 'H.J.D.': [1063, 1906], 'Buxton': [1064, 1907], 'F.P.': [1065, 1908], 'Fraaye': [1066, 1909], 'B.A.': [1067, 1910], 'de': [1068, 1911], 'Graaf': [1069, 1912], 'L.H.': [1070, 1913], 'Eur.': [1073, 1132, 1916, 1975], '1992;': [1076, 1919], '208:': [1077, 1920], '83-90Crossref': [1078, 1921], '(110)': [1081, 1924], 'Scholar)': [1083, 1926], 'raises': [1084, 1927], 'intriguing': [1086, 1929], 'question': [1087, 1930], 'whether': [1088, 1101, 1931, 1944], 'gene': [1090, 1933], 'products': [1091, 1934], 'targeted': [1094, 1937], 'same': [1097, 1940], 'homogalacturonan': [1098, 1941], 'some': [1102, 1945], 'prefer': [1103, 1946], 'parts': [1105, 1948], 'molecule.': [1109, 1952], 'Indications': [1110, 1953], 'possibility': [1114, 1957], 'recently': [1117, 1960], 'described': [1118, 1961], 'E': [1121, 1964], 'niger(19Parenicová': [1124, 1967], 'L.': [1125, 1968], '251:': [1136, 1979], '72-80Crossref': [1137, 1980], '(87)': [1140, 1983], 'Scholar).To': [1142], 'differences': [1145, 1989], 'action': [1147, 1991], 'various': [1150, 1178, 1994, 2022], 'endopolygalacturonases': [1151, 1995], 'identify': [1154, 1998], 'critical': [1159, 2003], 'elucidated': [1164, 2008], 'ofA.': [1168, 2012], 'investigated': [1174, 2018], 'role': [1176, 2020], 'mutagenesis.': [1186, 2030], 'data': [1188, 2032, 2104], 'enable': [1189, 2033], 'us': [1190, 2034], 'propose': [1192, 2036], 'first': 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