Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2076265695', 'doi': 'https://doi.org/10.1042/bj20061081', 'title': 'The regulation of ATF3 gene expression by mitogen-activated protein kinases', 'display_name': 'The regulation of ATF3 gene expression by mitogen-activated protein kinases', 'publication_year': 2006, 'publication_date': '2006-12-21', 'ids': {'openalex': 'https://openalex.org/W2076265695', 'doi': 'https://doi.org/10.1042/bj20061081', 'mag': '2076265695', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17014422', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1820813'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20061081', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1820813?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041166489', 'display_name': 'Dan Lü', 'orcid': 'https://orcid.org/0000-0002-6952-9194'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dan Lu', 'raw_affiliation_strings': ['The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031448999', 'display_name': 'Jingchun Chen', 'orcid': 'https://orcid.org/0000-0001-9408-0117'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jingchun Chen', 'raw_affiliation_strings': ['The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111897889', 'display_name': 'Tsonwin Hai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tsonwin Hai', 'raw_affiliation_strings': ['The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'The Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry, and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, U.S.A.', 'institution_ids': ['https://openalex.org/I52357470']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.43, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 165, 'citation_normalized_percentile': {'value': 0.927411, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '401', 'issue': '2', 'first_page': '559', 'last_page': '567'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9841, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atf3', 'display_name': 'ATF3', 'score': 0.7777494}, {'id': 'https://openalex.org/keywords/activating-transcription-factor', 'display_name': 'Activating transcription factor', 'score': 0.66626525}, {'id': 'https://openalex.org/keywords/anisomycin', 'display_name': 'Anisomycin', 'score': 0.6324433}, {'id': 'https://openalex.org/keywords/ask1', 'display_name': 'ASK1', 'score': 0.5308265}], 'concepts': [{'id': 'https://openalex.org/C157880135', 'wikidata': 'https://www.wikidata.org/wiki/Q17832633', 'display_name': 'ATF3', 'level': 5, 'score': 0.7777494}, {'id': 'https://openalex.org/C1629964', 'wikidata': 'https://www.wikidata.org/wiki/Q106950729', 'display_name': 'CREB', 'level': 4, 'score': 0.6941253}, {'id': 'https://openalex.org/C77179829', 'wikidata': 'https://www.wikidata.org/wiki/Q4677459', 'display_name': 'Activating transcription factor', 'level': 4, 'score': 0.66626525}, {'id': 'https://openalex.org/C2778073123', 'wikidata': 'https://www.wikidata.org/wiki/Q378498', 'display_name': 'Anisomycin', 'level': 3, 'score': 0.6324433}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5559078}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5325683}, {'id': 'https://openalex.org/C124160383', 'wikidata': 'https://www.wikidata.org/wiki/Q14914383', 'display_name': 'ASK1', 'level': 5, 'score': 0.5308265}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.527191}, {'id': 'https://openalex.org/C137361374', 'wikidata': 'https://www.wikidata.org/wiki/Q6714442', 'display_name': 'MAP kinase kinase kinase', 'level': 4, 'score': 0.50976413}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.5064348}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.49193406}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.49110767}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48659527}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.4606661}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.43240625}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3274173}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.30672657}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.15787715}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15052453}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.13806659}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11656207}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.059144616}], 'mesh': [{'descriptor_ui': 'D051700', 'descriptor_name': 'Activating Transcription Factor 3', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000841', 'descriptor_name': 'Anisomycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D048688', 'descriptor_name': 'MAP Kinase Kinase 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048051', 'descriptor_name': 'p38 Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20061081', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1820813', 'pdf_url': 'https://europepmc.org/articles/pmc1820813?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820813', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17014422', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1820813', 'pdf_url': 'https://europepmc.org/articles/pmc1820813?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1483505747', 'https://openalex.org/W1583270829', 'https://openalex.org/W1658092509', 'https://openalex.org/W1969281472', 'https://openalex.org/W1971915141', 'https://openalex.org/W1972145919', 'https://openalex.org/W1972304405', 'https://openalex.org/W1984665850', 'https://openalex.org/W1984903682', 'https://openalex.org/W1992361007', 'https://openalex.org/W1992879938', 'https://openalex.org/W1996405087', 'https://openalex.org/W1996880196', 'https://openalex.org/W2006316667', 'https://openalex.org/W2007525154', 'https://openalex.org/W2009172514', 'https://openalex.org/W2022914311', 'https://openalex.org/W2026951979', 'https://openalex.org/W2032418919', 'https://openalex.org/W203470123', 'https://openalex.org/W2035500640', 'https://openalex.org/W2036771320', 'https://openalex.org/W2042773343', 'https://openalex.org/W2047025215', 'https://openalex.org/W2054363543', 'https://openalex.org/W2059190844', 'https://openalex.org/W2059995799', 'https://openalex.org/W2061711733', 'https://openalex.org/W2070430257', 'https://openalex.org/W2073541193', 'https://openalex.org/W2086981199', 'https://openalex.org/W2096965981', 'https://openalex.org/W2098296304', 'https://openalex.org/W2105668301', 'https://openalex.org/W2109532733', 'https://openalex.org/W2109659042', 'https://openalex.org/W2110072022', 'https://openalex.org/W2110595665', 'https://openalex.org/W2118229687', 'https://openalex.org/W2120165202', 'https://openalex.org/W2120955132', 'https://openalex.org/W2122537353', 'https://openalex.org/W2126746388', 'https://openalex.org/W2135398453', 'https://openalex.org/W2138363901', 'https://openalex.org/W2150868027', 'https://openalex.org/W2152487460', 'https://openalex.org/W2155124532', 'https://openalex.org/W2160487610', 'https://openalex.org/W2168659826', 'https://openalex.org/W2173670840', 'https://openalex.org/W2261440151', 'https://openalex.org/W2276520578', 'https://openalex.org/W2316637335', 'https://openalex.org/W2338761486', 'https://openalex.org/W4242736843', 'https://openalex.org/W4249197750'], 'related_works': ['https://openalex.org/W4386958895', 'https://openalex.org/W4303492420', 'https://openalex.org/W3029922474', 'https://openalex.org/W2908609913', 'https://openalex.org/W2746703687', 'https://openalex.org/W2340553685', 'https://openalex.org/W2148619403', 'https://openalex.org/W2051108345', 'https://openalex.org/W1969281472', 'https://openalex.org/W1544940603'], 'abstract_inverted_index': {'ATF3': [0, 41, 78, 115, 150, 204, 220, 252, 258], '(activating': [1], 'transcription': [2, 16, 163, 168], 'factor': [3, 142, 169], '3)': [4], 'gene': [5, 42, 50, 151], 'encodes': [6], 'a': [7, 23, 95, 167, 177, 237, 245], 'member': [8], 'of': [9, 15, 26, 77, 84, 98, 103, 113, 118, 147, 212, 224, 251, 267], 'the': [10, 40, 52, 62, 68, 75, 104, 111, 114, 119, 123, 148, 154, 162, 183, 206, 222, 241, 249, 264], 'ATF/CREB': [11], '(cAMP-response-element-binding': [12], 'protein)': [13], 'family': [14], 'factors.': [17], 'Its': [18], 'expression': [19, 83, 112], 'is': [20, 72, 107, 126, 156, 259], 'induced': [21], 'by': [22, 79, 174, 253], 'wide': [24], 'range': [25], 'signals,': [27, 255], 'including': [28, 134], 'stress': [29, 80, 208, 254], 'signals': [30, 32, 130], 'and': [31, 37, 144, 187, 256], 'that': [33, 67, 101, 122, 153, 217, 236, 257], 'promote': [34], 'cell': [35], 'proliferation': [36], 'motility.': [38], 'Thus': [39], 'can': [43], 'be': [44, 172], 'characterized': [45], 'as': [46], 'an': [47], '‘adaptive': [48], 'response’': [49], 'for': [51, 128], 'cells': [53], 'to': [54, 109, 131, 171, 202, 226, 262], 'cope': [55], 'with': [56], 'extra-': [57], 'and/or': [58], 'intra-cellular': [59], 'changes.': [60], 'In': [61], 'present': [63], 'study,': [64], 'we': [65], 'demonstrate': [66], 'p38': [69, 105, 124, 242], 'signalling': [70, 195, 239], 'pathway': [71, 106, 120, 125], 'involved': [73], 'in': [74, 159, 179, 205, 248], 'induction': [76, 250], 'signals.': [81], 'Ectopic': [82], 'CA': [85], '(constitutively': [86], 'active)': [87], 'MKK6': [88], '[MAPK': [89], '(mitogen-activated': [90], 'protein': [91, 193], 'kinase)': [92, 186, 194], 'kinase': [93, 96], '6],': [94], 'upstream': [97], 'p38,': [99, 175], 'indicated': [100, 121, 216], 'activation': [102, 215], 'sufficient': [108, 201], 'induce': [110, 132, 203], 'gene.': [116], 'Inhibition': [117], 'necessary': [127, 199], 'various': [129], 'ATF3,': [133], 'anisomycin,': [135], 'IL-1β': [136], '(interleukin': [137], '1β),': [138], 'TNFα': [139], '(tumour': [140], 'necrosis': [141], 'α)': [143], 'H2O2.': [145], 'Analysis': [146], 'endogenous': [149], 'indicates': [152], 'regulation': [155], 'at': [157, 161], 'least': [158], 'part': [160], 'level.': [164], 'Specifically,': [165], 'CREB,': [166], 'known': [170], 'phosphorylated': [173], 'plays': [176, 244], 'role': [178, 247], 'this': [180], 'induction.': [181], 'Interestingly,': [182], 'ERK': [184], '(extracellular-signal-regulated': [185], 'JNK': [188], '(c-Jun': [189], 'N-terminal': [190], 'kinase)/SAPK': [191], '(stress-activated': [192], 'pathways': [196], 'are': [197], 'neither': [198], 'nor': [200], 'anisomycin': [207], 'paradigm.': [209], 'Furthermore,': [210], 'analysis': [211], 'caspase': [213], '3': [214], 'knocking': [218], 'down': [219], 'reduced': [221], 'ability': [223], 'MKK6(CA)': [225], 'exert': [227], 'its': [228], 'pro-apoptotic': [229, 265], 'effect.': [230], 'Taken': [231], 'together,': [232], 'our': [233], 'results': [234], 'indicate': [235], 'major': [238], 'pathway,': [240, 243], 'critical': [246], 'functionally': [260], 'important': [261], 'mediate': [263], 'effects': [266], 'p38.': [268]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2076265695', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-11T11:55:16.202759', 'created_date': '2016-06-24'}