Publication Information

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'elegans': [94, 720], 'gene,': [97], 'ced-3,': [98], 'had': [99], 'remarkable': [100], 'sequence': [101, 2146, 2216, 2233, 2410, 2550], 'similarity': [102, 2411], 'to': [103, 970, 2412, 2415, 2564, 2873, 2887, 2894, 3200, 3221, 3247, 3435, 3448, 3576], 'interleukin-1β-converting': [104], 'enzyme': [105, 2677, 2847, 3976], '(caspase-1),': [106], 'mammalian': [108], 'proteinase': [109, 4109], 'responsible': [110], 'for': [111, 269, 438, 565, 602, 764, 878, 1807, 2136, 2226, 2600, 3053, 3061, 3779, 3786, 3954, 4268], 'proteolytic': [112, 2595], 'maturation': [113], 'pro-interleukin-1β': [115], '(1Yuan': [116], 'J.': [117, 190, 198, 314, 317, 343, 365, 519, 621, 671, 955, 1025, 1093, 1096, 1122, 1141, 1266, 1312, 1506, 1552, 1700, 1746, 1852, 1855, 1881, 1900, 2024, 2070, 2113, 2249, 2301, 2377, 2458, 2461, 2487, 2506, 2611, 2637, 2687, 2735, 2759, 3295, 3360, 3418, 3669, 3704, 3755, 3826, 4013, 4063, 4068, 4099, 4158, 4179, 4232], 'Shaham': [118], 'S.': [119, 121, 512, 655, 663, 937, 1015, 1181, 1299, 1421, 1539, 1615, 1733, 1939, 2057, 2106, 2367, 2708, 3559, 3745, 4030, 4044], 'Ledoux': [120], 'Ellis': [122], 'H.M.': [123, 3813, 4000, 4145, 4219], 'Horvitz': [124, 738], 'H.R.': [125, 739, 2632, 2730, 3799, 3986, 4131, 4205], 'Cell.': [126, 707, 740, 775, 809, 1000, 1026, 1222, 1462, 1656, 1980, 2352, 2378, 2782, 2805, 3034, 3116, 3312, 3334, 3479, 3756, 3903], '1993;': [127], '19:': [128], '641-652Abstract': [129], 'Full': [130, 323, 325, 349, 351, 385, 525, 527, 640, 711, 744, 779, 781, 813, 815, 863, 865, 1004, 1006, 1030, 1032, 1102, 1104, 1128, 1130, 1160, 1226, 1318, 1320, 1466, 1558, 1560, 1660, 1752, 1754, 1861, 1863, 1887, 1889, 1919, 1984, 2076, 2078, 2119, 2121, 2256, 2320, 2356, 2358, 2382, 2384, 2467, 2469, 2493, 2495, 2525, 2617, 2619, 2643, 2645, 2693, 2695, 2741, 2743, 2765, 2767, 2786, 2788, 2809, 2811, 3038, 3040, 3120, 3122, 3316, 3318, 3338, 3340, 3366, 3368, 3483, 3485, 3675, 3677, 3710, 3712, 3760, 3762, 3832, 3834, 3907, 3909, 4019, 4021, 4164, 4166, 4238, 4240], 'Text': [131, 324, 326, 350, 352, 386, 526, 528, 641, 712, 745, 780, 782, 814, 816, 864, 866, 1005, 1007, 1031, 1033, 1103, 1105, 1129, 1131, 1161, 1227, 1319, 1321, 1467, 1559, 1561, 1661, 1753, 1755, 1862, 1864, 1888, 1890, 1920, 1985, 2077, 2079, 2120, 2122, 2257, 2321, 2357, 2359, 2383, 2385, 2468, 2470, 2494, 2496, 2526, 2618, 2620, 2644, 2646, 2694, 2696, 2742, 2744, 2766, 2768, 2787, 2789, 2810, 2812, 3039, 3041, 3121, 3123, 3317, 3319, 3339, 3341, 3367, 3369, 3484, 3486, 3676, 3678, 3711, 3713, 3761, 3763, 3833, 3835, 3908, 3910, 4020, 4022, 4165, 4167, 4239, 4241], 'PDF': [132, 327, 353, 387, 529, 642, 713, 746, 783, 817, 867, 1008, 1034, 1106, 1132, 1162, 1228, 1322, 1468, 1562, 1662, 1756, 1865, 1891, 1921, 1986, 2080, 2123, 2258, 2322, 2360, 2386, 2471, 2497, 2527, 2621, 2647, 2697, 2745, 2769, 2790, 2813, 3042, 3124, 3320, 3342, 3370, 3487, 3679, 3714, 3764, 3836, 3911, 4023, 4168, 4242], 'Scopus': [133, 167, 234, 307, 329, 355, 370, 389, 531, 626, 644, 685, 715, 748, 785, 819, 869, 900, 962, 1010, 1036, 1086, 1108, 1134, 1146, 1164, 1230, 1261, 1324, 1470, 1501, 1564, 1664, 1695, 1758, 1845, 1867, 1893, 1905, 1923, 1988, 2019, 2082, 2125, 2260, 2273, 2306, 2324, 2336, 2362, 2388, 2451, 2473, 2499, 2511, 2529, 2623, 2649, 2699, 2747, 2771, 2792, 2815, 2830, 2997, 3022, 3044, 3079, 3104, 3126, 3235, 3280, 3322, 3344, 3372, 3424, 3488, 3565, 3591, 3716, 3766, 3838, 3913, 4025, 4050, 4075, 4090, 4104, 4170, 4184, 4244], '(2238)': [134], 'Google': [135, 169, 236, 309, 331, 357, 372, 391, 533, 628, 646, 687, 717, 750, 787, 821, 871, 902, 964, 1012, 1038, 1088, 1110, 1136, 1148, 1166, 1232, 1263, 1326, 1472, 1503, 1566, 1666, 1697, 1760, 1847, 1869, 1895, 1907, 1925, 1990, 2021, 2084, 2127, 2262, 2275, 2308, 2326, 2338, 2364, 2390, 2453, 2475, 2501, 2513, 2531, 2625, 2651, 2701, 2749, 2773, 2794, 2817, 2832, 2999, 3024, 3046, 3081, 3106, 3128, 3237, 3282, 3324, 3346, 3374, 3426, 3490, 3567, 3593, 3614, 3681, 3718, 3768, 3840, 3915, 4027, 4052, 4077, 4092, 4106, 4172, 4186, 4246], 'Scholar,': [136, 170, 310, 332, 629, 647, 688, 822, 1013, 1089, 1111, 1137, 1149, 1167, 1233, 1264, 1294, 1473, 1504, 1534, 1667, 1698, 1728, 1848, 1870, 1896, 1908, 1991, 2022, 2052, 2263, 2309, 2365, 2454, 2476, 2502, 2514, 2626, 2750, 2774, 2795, 2818, 3000, 3025, 3082, 3107, 3283, 3325, 3594, 4028, 4053, 4078, 4093, 4173], '2Cerretti': [137], 'D.P.': [138], 'Kozolosky': [139], 'C.J.': [140, 151, 3823, 4010, 4155, 4229], 'Mosley': [141], 'B.': [142, 2983, 3004, 3065, 3086], 'Nelson': [143], 'N.': [144, 830, 3551], 'Van': [145, 283, 287, 294, 1062, 1066, 1073, 1821, 1825, 1832, 2427, 2431, 2438], 'Ness': [146], 'K.': [147, 159, 657, 694, 892, 2245, 2680, 2682, 3291, 3402, 3410, 3659, 3661, 4061], 'Greenstreet': [148], 'T.A.': [149, 498, 2092], 'March': [150], 'Kronheim': [152], 'S.R.': [153], 'Druck': [154], 'T.': [155, 504, 665, 844, 848, 852, 1183, 1423, 1617, 1941, 2098, 2801, 3606, 3899, 4059], 'Cannizzaro': [156], 'L.A.': [157, 202], 'Huebner': [158], 'Black': [160, 1236, 1476, 1670, 1994], 'R.A.': [161, 224, 1251, 1491, 1685, 2009], 'Science.': [162, 680, 895, 2268, 2331, 2825, 3230, 3275], '1992;': [163, 230], '256:': [164], '97-100Crossref': [165], 'PubMed': [166, 233, 306, 328, 354, 369, 388, 530, 625, 643, 684, 714, 747, 784, 818, 868, 899, 961, 1009, 1035, 1085, 1107, 1133, 1145, 1163, 1229, 1260, 1323, 1469, 1500, 1563, 1663, 1694, 1757, 1844, 1866, 1892, 1904, 1922, 1987, 2018, 2081, 2124, 2259, 2272, 2305, 2323, 2335, 2361, 2387, 2450, 2472, 2498, 2510, 2528, 2622, 2648, 2698, 2746, 2770, 2791, 2814, 2829, 2996, 3021, 3043, 3078, 3103, 3125, 3234, 3279, 3321, 3343, 3371, 3423, 3564, 3590, 3680, 3715, 3765, 3837, 3912, 4024, 4049, 4074, 4089, 4103, 4169, 4183, 4243], '(994)': [168], '3Thornberry': [171], 'N.A.': [172, 378, 496, 633, 1153, 1286, 1526, 1720, 1912, 2044, 2090, 2313, 2518], 'Bull': [173], 'H.G.': [174], 'Calaycay': [175], 'J.R.': [176, 188], 'Chapman': [177, 515, 2109], 'K.T.': [178, 516, 2110], 'Howard': [179], 'A.D.': [180], 'Kostura': [181], 'M.J.': [182, 228, 2758, 3014, 3096], 'Miller': [183, 676, 2609], 'D.K.': [184, 2610], 'Molineaux': [185], 'S.M.': [186, 210, 2797, 3472, 3598, 3895], 'Weidner': [187], 'Aunins': [189], 'Wlliston': [191], 'K.O.': [192], 'Ayala': [193, 2607], 'J.M.': [194, 2608, 3801, 3988, 4133, 4207], 'Casano': [195], 'F.J.': [196], 'Chin': [197], 'Ding': [199], 'G.J.-F.': [200], 'Egger': [201], 'Gaffney': [203], 'E.P.': [204, 500, 1278, 1518, 1712, 2036, 2094], 'Limjuco': [205], 'G.': [206, 289, 340, 929, 1068, 1119, 1827, 1878, 2433, 2484, 2684, 2707, 3033, 3115, 3553, 3604], 'Palyha': [207], 'O.C.': [208, 840], 'Raju': [209], 'Rolando': [211], 'A.M.': [212, 3287], 'Salley': [213], 'J.P.': [214, 514, 1211, 1243, 1284, 1307, 1451, 1483, 1524, 1547, 1645, 1677, 1718, 1741, 1969, 2001, 2042, 2065, 2108], 'Yamin': [215], 'T.-T.': [216], 'Lee': [217], 'T.D.': [218], 'Shively': [219], 'J.E.': [220], 'MacCross': [221], 'M.': [222, 278, 506, 651, 653, 690, 826, 1017, 1057, 1191, 1201, 1209, 1272, 1276, 1431, 1441, 1449, 1512, 1516, 1625, 1635, 1643, 1706, 1710, 1816, 1949, 1959, 1967, 2030, 2034, 2100, 2369, 2422, 2628, 2726, 2799, 2985, 3002, 3067, 3084, 3285, 3301, 3305, 3394, 3396, 3398, 3408, 3474, 3596, 3657, 3747, 3897, 4057], 'Mumford': [223], 'Schmidt': [225], 'J.A.': [226, 941, 1195, 1239, 1435, 1479, 1629, 1673, 1953, 1997], 'Tocci': [227], 'Nature.': [229, 1256, 1496, 1690, 2014, 2992, 3017, 3074, 3099, 3419, 3586, 4085], '356:': [231], '768-774Crossref': [232], '(2194)': [235], 'Scholar).': [237, 718, 751, 788, 872, 903, 965, 1039, 1327, 1567, 1761, 2085, 2276, 2339, 2391, 2532, 2652, 2702, 2833, 3047, 3129, 3238, 3347, 3375, 3427, 3491, 3568, 3615, 3682, 3769, 3916, 4107, 4187, 4247], 'This': [238, 1762, 2834, 4108], 'seminal': [239], 'finding': [240], 'delineated': [241], 'first': [243], 'two': [244, 1370, 1404, 1781, 3384], 'members': [245, 267], 'family': [249, 266, 3535, 3881], 'suggested': [251], 'these': [253, 911, 2403, 2534, 3542], 'might': [255], 'function': [256, 1399, 2152, 2222, 2345, 3652], 'during': [257], 'apoptosis.': [258, 603], 'Subsequent': [259, 3264, 3524], 'studies': [260], 'identified': [261], 'over': [262], 'dozen': [264], 'important': [268, 601, 3052], 'apoptosis': [270, 612, 617, 767, 2724, 3392, 3539, 3984], 'and/or': [271], 'inflammation': [272, 769], '(Table': [273, 2161, 2217, 2242], 'I)': [274, 2243], '(4Van': [275, 1054, 1813, 2419], 'de': [276, 1055, 1814, 2420], 'Craen': [277, 1056, 1815, 2421], 'Vandenabeele': [279, 1058, 1817, 2423], 'P.': [280, 293, 659, 667, 669, 856, 1059, 1072, 1205, 1445, 1639, 1818, 1831, 1963, 2247, 2424, 2437, 3400, 3466, 3703], 'Declercq': [281, 1060, 1819, 2425], 'W.': [282, 296, 300, 949, 1061, 1075, 1079, 1193, 1433, 1627, 1820, 1834, 1838, 1951, 2426, 2440, 2444], 'den': [284, 1063, 1822, 2428], 'Brande': [285, 1064, 1823, 2429], 'I.': [286, 1065, 1824, 2430, 3470], 'Loo': [288, 1067, 1826, 2432], 'Molemans': [290, 1069, 1828, 2434], 'F.': [291, 1070, 1829, 2435, 3663, 3695], 'Schotte': [292, 1071, 1830, 2436], 'Criekinge': [295, 1074, 1833, 2439], 'Beyaert': [297, 1076, 1835, 2441], 'R.': [298, 1077, 1219, 1282, 1459, 1522, 1653, 1716, 1836, 1977, 2040, 2442, 2704, 3303, 4065], 'Fiers': [299, 1078, 1837, 2443], 'FEBS': [301, 1080, 1839, 2445], 'Lett.': [302, 1081, 1840, 2446], '1997;': [303, 366, 382, 522, 622, 637, 896, 1082, 1142, 1157, 1315, 1555, 1749, 1841, 1901, 1916, 2073, 2116, 2253, 2302, 2317, 2447, 2507, 2522, 3363, 3420, 3480, 3587, 3611, 3707, 4071, 4100, 4180], '403:': [304, 1083, 1842, 2448], '61-69Crossref': [305, 1084, 1843, 2449], '(186)': [308, 1087, 1846, 2452], '5Humke': [311, 1090, 1849, 2455], 'E.W.': [312, 1091, 1850, 2456], 'Ni': [313, 1092, 1851, 2457, 3294], 'Dixit': [315, 341, 705, 1094, 1120, 1853, 1879, 2266, 2329, 2459, 2485, 2635, 2685, 2733, 3228, 3273, 3310, 3358, 3584], 'V.M.': [316, 342, 508, 706, 838, 1095, 1121, 1854, 1880, 2102, 2267, 2330, 2460, 2486, 2636, 2686, 2734, 3229, 3274, 3311, 3359, 3585], 'Biol.': [318, 344, 520, 1097, 1123, 1313, 1553, 1747, 1856, 1882, 2071, 2114, 2462, 2488, 2612, 2638, 2688, 2736, 2760, 3361, 3671, 3705, 3827, 4014, 4159, 4233], 'Chem.': [319, 345, 521, 1098, 1124, 1314, 1554, 1748, 1857, 1883, 2072, 2115, 2463, 2489, 2613, 2639, 2689, 2737, 2761, 3362, 3706, 3828, 4015, 4160, 4234], '1998;': [320, 346, 776, 810, 860, 958, 1001, 1027, 1099, 1125, 1858, 1884, 2269, 2332, 2353, 2379, 2464, 2490, 2640, 2738, 2762, 2783, 2806, 2826, 3018, 3035, 3100, 3117, 3231, 3276, 3561, 3672, 3757, 3829, 3904, 4016, 4161, 4235], '273:': [321, 347, 1100, 1126, 1859, 1885, 2465, 2491, 2641, 2739, 2763, 3830, 4017, 4162, 4236], '15702-15707Abstract': [322, 1101, 1860, 2466], '(99)': [330, 1109, 1868, 2474], '6Shimin': [333, 1112, 1871, 2477], 'H.': [334, 737, 854, 894, 945, 1021, 1113, 1872, 2373, 2478, 3029, 3031, 3111, 3113, 3583, 3699, 3751, 3803, 3990, 4135, 4209], 'Snipas': [335, 1114, 1873, 2479], 'S.J.': [336, 1115, 1874, 2480], 'Vincenz': [337, 1116, 1875, 2481], 'C.': [338, 661, 1117, 1876, 2482, 3297, 3357, 3412, 3667], 'Salvesen': [339, 703, 1118, 1877, 2483, 2633, 2683, 2731, 3824, 4011, 4096, 4156, 4176, 4230], '29648-29653Abstract': [348, 1127, 1886, 2492], '(136)': [356, 1135, 1894, 2500], 'Scholar)': [358, 2128], '(reviewed': [359, 770], 'Refs.': [361], '7Cohen': [362, 1138, 1897, 2503], 'G.M.': [363, 619, 1139, 1898, 2299, 2504], 'Biochem.': [364, 380, 620, 635, 1140, 1155, 1899, 1914, 2251, 2300, 2315, 2505, 2520, 4098, 4178], '326:': [367, 623, 1143, 1902, 2303, 2508], '1-16Crossref': [368, 624, 1144, 1903, 2304, 2509], '(4112)': [371, 627, 1147, 1906, 2307, 2512], 'Scholar': [373], '8Nicholson': [375, 630, 1150, 1909, 2310, 2515], 'D.W.': [376, 518, 631, 1151, 1268, 1508, 1702, 1910, 2026, 2112, 2311, 2516, 4082], 'Thornberry': [377, 632, 1152, 1285, 1525, 1719, 1911, 2043, 2086, 2312, 2517], 'Trends': [379, 634, 1154, 1913, 2250, 2314, 2519], 'Sci.': [381, 636, 1156, 1915, 2252, 2316, 2521, 3557, 4042], '22:': [383, 638, 1158, 1917, 2254, 2318, 2523], '299-306Abstract': [384, 639, 1159, 1918, 2319, 2524], '(2176)': [390, 645, 1165, 1924, 2325, 2530], 'Scholar).Table': [392], 'ICaspase': [393], 'characteristicsZymogenProdomain,': [394], 'length': [395, 2214], 'motifActive': [397], 'subunitsActivation': [398], 'adapterTetrapeptide': [399], 'preference1-aAdapted': [400], 'from': [401, 493, 910, 1359, 1578], 'Ref.': [402, 494, 772], '21.kDakDaApoptotic': [403], 'initiatorsCaspase-2': [404], '(51)Long,': [405], 'CARD20': [406, 469, 472], '/12RAIDDDXXD1-bThe': [407], 'tetrapeptides': [408, 536], 'listed': [410, 437, 447, 538, 564, 574, 2168], 'P4–P1direction.': [413, 541], 'Proteolysis': [414, 542], 'occurs': [415, 543], 'P1': [419, 547, 1600, 1811], 'aspartate.,1-cX': [420], 'denotes': [421, 476, 550, 583], 'subsites': [422, 551], 'broad': [424, 553], 'amino': [425, 434, 443, 554, 561, 570], 'acid': [426, 435, 444, 555, 562, 571], 'specificity.Caspase-8': [427], '(55)Long,': [428, 455], 'DED18': [429], '/11FADD(L/V/D)EXD1-dWhen': [430], 'more': [431, 558], 'than': [432, 559, 2414, 4196, 4202], 'one': [433, 560, 1368, 2881], 'is': [436, 446, 563, 573, 1766, 2393, 3627, 3726, 3855, 4110, 4265], 'given': [440, 567], 'subsite,': [441, 568], 'each': [442, 569, 1570, 3935], 'possibility': [445, 572], 'order': [449, 576], 'preference.Caspase-9': [451], '(45)Long,': [452, 468], 'CARD17': [453, 487], '/10APAF-1(I/V/L)EHDCaspase-10': [454], 'DED17': [456], '/12FADDUnknownApoptotic': [457], 'executionersCaspase-3': [458], '(32)Short17': [459], '/12NA1-eNA,': [460], 'applicable.DEXDCaspase-6': [462], '(34)Short18': [463], '/11NA(V/T/I)EXDCaspase-7': [464], '(35)Short20': [465], '/12NADEXDCytokine': [466], 'processorsCaspase-1': [467], '/10?CARDIAK(W/Y/F)EHDCaspase-4': [470], '(43)Long,': [471], '/10Unknown(W/L/F)EHDCaspase-5': [473], '(48)Long20': [474], '/10Unknown(W/L/F)EHDmCaspase-111-fm': [475], 'murine.(42)Long20': [477], '/10UnknownUnknownmCaspase-12': [478], '(50)Long20': [479], '/10UnknownUnknownCaspase-13': [480], '(43)Long20': [481], '/10UnknownUnknownmCaspase-14': [482], '(30)Short20': [483], '/10NAUnknownInvertebrate': [484], 'caspasesCED-3': [485], '(56)Long,': [486], '/14CED-4DEXDDCP-1gDrosophila': [488], 'caspase-1.': [489, 586], '(36)Short22': [490], '/13NAUnknowna': [491], 'Adapted': [492], '21Thornberry': [495], 'Rano': [497, 2091], 'Peterson': [499, 1277, 1517, 1711, 2035, 2093], 'Rasper': [501, 1279, 1519, 1713, 2037, 2095], 'D.M.': [502, 1280, 1520, 1714, 2038, 2096, 4032], 'Timkey': [503, 2097], 'Garcia-Calvo': [505, 2099], 'Houtzager': [507, 2101], 'Nordstrom': [509, 2103], 'P.A.': [510, 2104], 'Roy': [511, 2105], 'Vaillancourt': [513, 1283, 1523, 1717, 2041, 2107], 'Nicholson': [517, 1267, 1507, 1701, 2025, 2111, 4081], '272:': [523, 1316, 1556, 1750, 2074, 2117, 3364, 3708], '17907-17911Abstract': [524, 2118], '(1842)': [532, 2126], 'Scholar.b': [534], 'The': [535, 1396, 1568, 1777, 2145, 2277, 3191, 3508, 3956], 'aspartate.c': [548], 'X': [549], 'specificity.d': [556], 'When': [557], 'preference.e': [578], 'NA,': [579], 'applicable.f': [581], 'm': [582], 'murine.g': [584], 'Drosophila': [585], 'Open': [587], 'table': [588], 'new': [591], 'tab': [592], 'Several': [593], 'lines': [594], 'evidence': [596, 2571], 'indicate': [597], 'caspases': [599, 765, 1049, 1771, 1779, 2138, 2221, 2404, 2418, 2535, 2555, 3772, 3866, 3927, 3980], 'First,': [604, 1785], 'activation': [606, 2574, 3240, 3437, 3462, 3630, 3640, 3655, 3691, 3725, 3739, 3947], 'correlates': [607], 'onset': [610], 'inhibition': [615], 'attenuates': [616], '(7Cohen': [618, 2298], '9Bump': [648], 'N.J.': [649, 1177, 1417, 1611, 1935], 'Hackett': [650, 1184, 1424, 1618, 1942], 'Hugunin': [652, 1190, 1430, 1624, 1948], 'Seshagiri': [654], 'Brady': [656, 1172, 1412, 1606, 1930], 'Chen': [658, 3005, 3087], 'Ferenz': [660, 1178, 1418, 1612, 1936], 'Franklin': [662, 1180, 1420, 1614, 1938], 'Ghayur': [664, 1182, 1422, 1616, 1940], 'Li': [666, 948, 1022, 2374, 3752], 'Licari': [668], 'Mankovich': [670, 1194, 1434, 1628, 1952], 'Shi': [672, 930], 'L.': [673, 925, 931, 1189, 1197, 1213, 1429, 1437, 1453, 1623, 1631, 1647, 1947, 1955, 1971, 2756, 3012, 3094, 3600], 'Greenberg': [674, 950], 'A.H.': [675], 'L.K.': [677], 'Wong': [678, 1220, 1460, 1654, 1978], 'W.W.': [679, 1221, 1461, 1655, 1979], '1995;': [681, 708, 4046, 4086], '269:': [682], '1885-1888Crossref': [683], '(600)': [686, 963], '10Tewari': [689], 'Quan': [691], 'L.T.': [692], "O'Rourke": [693, 2681, 3290], 'Desnoyers': [695], 'K.S.': [696], 'Zeng': [697], 'Z.': [698, 890, 3006, 3088], 'Beidler': [699], 'D.R.': [700, 774, 808, 999, 2351, 3819, 4006, 4151, 4225], 'Poirier': [701], 'G.G.': [702], 'G.S.': [704, 2634, 2732, 3825, 4012, 4097, 4157, 4177, 4231], '81:': [709], '801-809Abstract': [710], '(2268)': [716], 'Second,C.': [719], 'mutants': [721], 'lacking': [722], 'worm': [724], 'caspase,': [725, 3936], 'CED-3,': [726], 'have': [727, 986, 994, 1780, 2591, 3867], 'complete': [729], 'absence': [730], 'developmental': [732, 803], 'programmed': [733, 804], '(11Ellis': [736], '1986;': [741], '44:': [742], '817-829Abstract': [743], '(1344)': [749], 'More': [752], 'recently,': [753], 'targeted': [754], 'deletion': [755, 874], 'genes': [758], 'has': [759, 3859], 'shown': [760], 'definitive': [762], '12Green': [773], '94:': [777, 811, 1002, 2354, 3036, 3118], '695-698Abstract': [778, 812, 1003, 2355], '(1096)': [786, 820, 1011, 2363], 'Animals': [789], 'deficient': [790], 'caspase-3,': [792], 'caspase-8,': [793], 'or': [794, 915, 1369, 2228, 2580, 2717], 'caspase-9': [795, 3885], 'die': [796], 'perinatally': [797], 'because': [798, 3865], 'profound': [800], 'defects': [801, 997], 'deaths': [806], '(12Green': [807, 998, 2350], '13Varfolomeev': [823], 'E.E.': [824, 1241, 1481, 1675, 1999], 'Schuchmann': [825], 'Luria': [827], 'V.': [828, 3404], 'Chiannikulchai': [829], 'Beckmann': [831], 'J.S.': [832], 'Mett': [833], 'I.L.': [834], 'Rebrikov': [835], 'D.': [836, 846, 858, 2780, 2824, 3333, 3414, 3468, 3549, 3817, 4004, 4149, 4223], 'Brodianski': [837], 'Kemper': [839], 'Kollet': [841], 'O.': [842], 'Lapidot': [843], 'Soffer': [845], 'Sobe': [847], 'Avraham': [849], 'K.B.': [850], 'Boncharov': [851], 'Holtmann': [853], 'Lonai': [855], 'Wallach': [857, 3332], 'Immunity.': [859], '9:': [861], '267-276Abstract': [862], '(1024)': [870], 'Similarly,': [873], 'gene': [877, 2948, 3186], 'Drosophilacaspase-1': [879], 'causes': [880], 'larval': [881], 'lethality': [882], 'also': [884, 3215, 3688], 'promotes': [885, 2723, 3267, 3461, 3638, 3689], 'melanotic': [886], 'tumor': [887], 'development': [888], '(14Song': [889], 'McCall': [891], 'Stellar': [893], '275:': [897], '536-540Crossref': [898], '(249)': [901], 'Caspase-2-deficient': [904], 'mice': [905, 985], 'develop': [906, 991], 'normally,': [907], 'cells': [909], 'animals': [912], 'show': [913], 'diminished': [914], 'enhanced': [916], 'apoptosis,': [917], 'depending': [918], 'tissue': [921], 'origin': [923], '(15Bergeron': [924], 'Perez': [926], 'G.I.': [927], 'Macdonald': [928], 'Sun': [932], 'Y.': [933, 1019, 1274, 1514, 1708, 2032, 2371, 3545, 3749], 'Jurisicova': [934], 'A.': [935, 951, 1207, 1215, 1447, 1455, 1641, 1649, 1965, 1973, 2265, 2328, 3227, 3272, 3293, 3560, 4045, 4067], 'Varmuza': [936], 'Latham': [938], 'K.E.': [939], 'Flaws': [940], 'Salter': [942], 'J.C.M.': [943], 'Hara': [944], 'Moskowitz': [946], 'M.A.': [947, 1245, 1247, 1485, 1487, 1679, 1681, 2003, 2005, 3547], 'Tilly': [952], 'J.L.': [953, 3406], 'Yuan': [954, 1024, 2376, 3754], 'Genes': [956], 'Dev.': [957], '12:': [959], '1304-1314Crossref': [960], 'differences': [967], 'may': [968, 2206, 2575, 2673, 2836, 3537, 3736, 3847, 3875], 'relate': [969], 'tissue-specific': [971], 'expression': [972], 'pro-': [974], 'anti-apoptotic': [976, 3533], 'caspase-2': [977], 'isoforms.': [978], 'By': [979, 2340], 'contrast,': [980, 2341], 'caspase-1': [981, 2342, 2413], 'caspase-11': [983, 2344, 3729], 'knockout': [984], 'defective': [987], 'interleukin-1β': [988, 2923, 3153], 'production': [989], 'normally': [992], 'minimal': [995], '16Wang': [1014, 2366], 'Miura': [1016, 2368, 3746], 'Jung': [1018, 2370, 3748], 'Zhu': [1020, 2372, 3750], 'E.': [1023, 1199, 1439, 1633, 1957, 2375, 3753], '92:': [1028, 2380, 3758, 4047], '501-509Abstract': [1029, 2381, 3759], '(584)': [1037, 2389, 3767], 'Sequence': [1040], 'analysis': [1041], 'x-ray': [1043], 'crystallography': [1044], 'data': [1045], 'suggest': [1046], 'all': [1048, 1770, 2966, 3879], 'share': [1050], 'common': [1052], 'structure': [1053], '17Walker': [1168], 'N.P.C.': [1169, 1409, 1603, 1927], 'Talanian': [1170, 1410, 1604, 1928, 3601], 'R.V.': [1171, 1411, 1605, 1929, 3602], 'K.D.': [1173, 1413, 1607, 1931], 'Dang': [1174, 1414, 1608, 1932], 'L.C.': [1175, 1415, 1609, 1933], 'Bump': [1176, 1416, 1610, 1934], 'C.R.': [1179, 1419, 1613, 1937], 'M.C.': [1185, 1425, 1619, 1943], 'Hammil': [1186, 1426, 1620, 1944], 'L.D.': [1187, 1427, 1621, 1945], 'Herzog': [1188, 1428, 1622, 1946], 'Houy': [1192, 1432, 1626, 1950], 'McGuiness': [1196, 1436, 1630, 1954], 'Oriewicz': [1198, 1438, 1632, 1956], 'Paskind': [1200, 1440, 1634, 1958], 'Pratt': [1202, 1442, 1636, 1960], 'C.A.': [1203, 1443, 1637, 1961], 'Reis': [1204, 1444, 1638, 1962], 'Summani': [1206, 1446, 1640, 1964], 'Terranova': [1208, 1448, 1642, 1966], 'Welch': [1210, 1450, 1644, 1968], 'Xiong': [1212, 1452, 1646, 1970], 'Moller': [1214, 1454, 1648, 1972], 'Tracey': [1216, 1456, 1650, 1974], 'D.E.': [1217, 1457, 1651, 1975], 'Kamen': [1218, 1458, 1652, 1976], '1994;': [1223, 1257, 1463, 1497, 1657, 1691, 1981, 2015], '78:': [1224, 1464, 1658, 1982], '343-352Abstract': [1225, 1465, 1659, 1983], '(527)': [1231, 1471, 1665, 1989], '18Wilson': [1234, 1474, 1668, 1992], 'K.P.': [1235, 1475, 1669, 1993], 'J.F.': [1237, 1301, 1477, 1541, 1671, 1735, 1995, 2059], 'Thomson': [1238, 1478, 1672, 1996], 'Kim': [1240, 1480, 1674, 1998], 'Griffith': [1242, 1482, 1676, 2000], 'Navia': [1244, 1484, 1678, 2002], 'Murcko': [1246, 1486, 1680, 2004], 'Chambers': [1248, 1488, 1682, 2006], 'S.P.': [1249, 1489, 1683, 2007], 'Aldape': [1250, 1490, 1684, 2008], 'Raybuck': [1252, 1492, 1686, 2010], 'S.A.': [1253, 1493, 1687, 2011], 'Livingston': [1254, 1494, 1688, 2012], 'D.J.': [1255, 1495, 1689, 2013], '370:': [1258, 1498, 1692, 2016], '270-275Crossref': [1259, 1499, 1693, 2017], '(753)': [1262, 1502, 1696, 2020], '19Rotonda': [1265, 1505, 1699, 2023], 'Fazil': [1269, 1509, 1703, 2027], 'K.M.': [1270, 1510, 1704, 2028], 'Gallant': [1271, 1511, 1705, 2029], 'Gareau': [1273, 1513, 1707, 2031], 'Labelle': [1275, 1515, 1709, 2033], 'Ruel': [1281, 1521, 1715, 2039], 'Becker': [1287, 1527, 1721, 2045], 'J.W.': [1288, 1528, 1722, 2046, 4034], 'Nature': [1289, 1529, 1723, 2047], 'Biotechnol.': [1290, 1530, 1724, 2048], '1996;': [1291, 1531, 1725, 2049, 2614, 2690, 2993, 3075, 3313, 3335], '3:': [1292, 1532, 1726, 2050], '619-625Google': [1293, 1533, 1727, 2051], '20Mittl': [1295, 1535, 1729, 2053], 'P.R.E.': [1296, 1536, 1730, 2054], 'Di': [1297, 1537, 1731, 2055], 'Marco': [1298, 1538, 1732, 2056], 'Krebs': [1300, 1540, 1734, 2058], 'Bai': [1302, 1542, 1736, 2060], 'X.': [1303, 1543, 1737, 2061, 2776, 2820, 3478, 3809, 3996, 4141, 4215], 'Karanewsky': [1304, 1544, 1738, 2062], 'D.S.': [1305, 1545, 1739, 2063], 'Priestle': [1306, 1546, 1740, 2064], 'Tomaselli': [1308, 1548, 1742, 2066], 'K.J.': [1309, 1549, 1743, 2067], 'Grutter': [1310, 1550, 1744, 2068], 'M.G.': [1311, 1551, 1745, 2069], '6539-6547Abstract': [1317, 1557, 1751, 2075], '(223)': [1325, 1565, 1759, 2083], 'Each': [1328, 1585], 'zymogen': [1329, 2720, 3738], 'contains': [1330, 1588, 3203, 3216], 'N-terminal': [1332], 'prodomain,': [1333], 'large': [1335, 1361, 1376, 1583], 'subunit': [1336, 1406], 'containing': [1337, 1367], 'active': [1339, 1397, 1573, 1586, 3843], 'site': [1340, 1355, 1574, 1587, 1765], 'within': [1342], 'conserved': [1344], 'QACXG': [1345], 'motif,': [1346], 'C-terminal': [1349], 'small': [1350, 1378, 1581, 2290], 'subunit.': [1351], 'An': [1352], 'cleavage': [1354, 1372], 'separates': [1356, 1374], 'prodomain': [1358, 2220, 2291, 2546, 2549, 2860, 2896], 'subunit,': [1362], 'interdomain': [1365, 1385], 'linker': [1366, 1386], 'sites': [1373, 1791], 'subunits.': [1379, 1584], 'Activation': [1380], 'accompanies': [1381], 'proteolysis': [1382, 2581], 'usually': [1388], 'results': [1389, 2664], 'subsequent': [1391], 'removal': [1392], 'prodomain.': [1395], 'tetramers,': [1401], 'consisting': [1402], 'large/small': [1405], 'heterodimers': [1407, 1569], '(17Walker': [1408, 1602], 'contain': [1571, 2232, 2880, 2967], 'composed': [1575], 'residues': [1577], 'both': [1579, 2194], 'positively': [1590], 'charged': [1591, 1599], 'S1': [1592, 1763], 'subsite': [1593], 'binds': [1595, 2893, 3220, 3447], "substrate's": [1597], 'negatively': [1598], 'binding': [1764, 1790, 3242], 'conserved;': [1768], 'therefore,': [1769], 'cleave': [1772], 'individual': [1778, 2203, 3943], 'major': [1782], 'structural': [1783], 'differences.': [1784], 'predicted': [1787], 'S2–S4': [1788], 'substrate': [1789, 1797, 2134, 2544, 3869], 'vary': [1792, 2212], 'significantly,': [1793], 'resulting': [1794], 'varied': [1796, 3868], 'specificity': [1798, 2135, 4264], 'P2–P4': [1801], 'positions,': [1802], 'despite': [1803], 'absolute': [1805, 2174], 'requirement': [1806], 'position': [1812], 'Scholar,17Walker': [1926], 'et': [2087], 'al.': [2088], '(21Thornberry': [2089], 'recently': [2129], 'defined': [2130], 'optimal': [2132], 'tetrapeptide': [2133, 2166], '10': [2137], 'using': [2139], 'synthetic': [2141], 'combinatorial': [2142], 'peptide': [2143], 'library.': [2144], 'preferences': [2147, 2167, 2178], 'generally': [2148, 2285, 2879], 'correlate': [2149], 'initiators,': [2155], 'executioners,': [2157], 'cytokine': [2159, 2348, 2540], 'processors': [2160, 2349], 'I).': [2162, 2218], 'Note': [2163], 'Table': [2170], 'I': [2171], 'do': [2179], 'represent': [2181], 'kinetic': [2182, 3939], 'values': [2183], 'can': [2185, 3513, 3977], 'be': [2186], 'directly': [2187, 3732, 3877], 'compared.': [2188], 'For': [2189, 3883], 'example,': [2190, 3884], 'caspase-3': [2191, 3844], 'caspase-7': [2193], 'prefer': [2195], 'DEXD-based': [2196], 'peptides;': [2197], 'kinetics': [2200], 'hydrolysis': [2204], 'reactions': [2205], 'differ': [2207], 'significantly.': [2208], 'Second,': [2209], 'prodomains': [2211], 'Long': [2219], 'signal': [2224], 'integrators': [2225], 'pro-inflammatory': [2229, 3632], 'signals': [2230, 3431], 'motifs': [2234], 'promote': [2236], 'interaction': [2238, 3261, 3521, 3743], 'activator': [2240, 4114], '(22Hoffman': [2244], 'Bucher': [2246], 'Tschopp': [2248, 3417, 3668, 4062], '155-156Abstract': [2255], '(447)': [2261], '23Ashkenazi': [2264], '281:': [2270, 2333, 2827, 3232, 3277], '1305-1308Crossref': [2271, 2334, 3233, 3278], '(5124)': [2274, 2337, 3236, 3281], 'initiators': [2279], '(caspase-2,': [2280], '-8,': [2281], '-9,': [2282], '-10)': [2284], 'act': [2286], 'upstream': [2287], 'executioners': [2293], '(caspase-3,': [2294], '-6,': [2295], '-7)': [2297], 'Scholar,23Ashkenazi': [2327], 'predominantly': [2346], 'Less': [2392, 3626], 'known': [2394, 3628], 'about': [2395, 3629], 'caspase-4,': [2396], '-5,': [2397], '-12,': [2398], '-13,': [2399], '-14;': [2401], 'demonstrate': [2405, 2587], 'higher': [2407], 'degree': [2408], 'Therefore,': [2533], 'grouped': [2537], 'processors.': [2541], 'Overall,': [2542], 'specificity,': [2545, 3870], 'length,': [2547], 'determine': [2551], 'function.': [2553], 'Because': [2554], 'zymogens,': [2559], 'question': [2561], 'remains': [2562], 'how': [2565], 'zymogens': [2567, 2590, 2838], 'activated.': [2569], 'Current': [2570], 'suggests': [2572], 'proceed': [2576], 'autoactivation,': [2578], 'transactivation,': [2579], 'other': [2583, 3774, 3880], 'proteinases.': [2584], 'Affinity-labeling': [2585], 'experiments': [2586], 'low': [2592], 'detectable': [2594], 'activity,': [2596], 'suggesting': [2597, 3647], 'potential': [2599], 'autoactivation': [2601, 2672, 2721, 3269], 'under': [2602], 'certain': [2603], 'circumstances': [2604], '(24Yamin': [2605], 'T.T.': [2606], '271:': [2615, 2691], '13273-13282Abstract': [2616], '(161)': [2624], '25Muzio': [2627], 'Stockwell': [2629, 2727], 'B.R.': [2630, 2728], 'Stennicke': [2631, 2705, 2729], '2926-2930Abstract': [2642, 2740], '(884)': [2650, 2748], 'Furthermore,': [2653], 'overexpression': [2654], 'wild': [2656], 'type': [2657], 'caspases,': [2658], 'catalytically': [2661, 3379], 'inactive': [2662, 3380], 'mutants,': [2663], 'processing': [2667], 'indicating': [2670, 4261], 'occur': [2674], 'at': [2675], 'high': [2676], 'concentration': [2678, 2848], '(26Orth': [2679], '20977-20980Abstract': [2692], '(187)': [2700], '1H.': [2703], 'Salvesen,': [2709], 'personal': [2710], 'communication.': [2711], 'Forced': [2712], 'oligomerization': [2713, 2857, 3265, 3526, 3650], 'procaspase-8,': [2715], 'procaspase-9,': [2716], 'CED-3': [2718], 'facilitates': [2719, 3528, 3723], '(25Muzio': [2725], '27Martin': [2751], 'D.A.': [2752], 'Siegel': [2753], 'R.M.': [2754], 'Zheng': [2755, 3011, 3093], 'Lenardo': [2757, 3013, 3095], '4345-4349Abstract': [2764], '(330)': [2772], '28Yang': [2775], 'Chang': [2777, 2821], 'H.Y.': [2778, 2822], 'Baltimore': [2779, 2823], 'Mol.': [2781, 2804, 3902], '1:': [2784, 2807, 3905], '319-325Abstract': [2785], '(368)': [2793], '29Srinivasula': [2796], 'Ahmad': [2798, 3473, 3896], 'Fernandes-Alnemri': [2800, 3605, 3898], 'Alnemri': [2802, 3475, 3607, 3900], 'E.S.': [2803, 3476, 3608, 3901], '949-957Abstract': [2808, 3906], '(962)': [2816, 3914], '30Yang': [2819], '1355-1357Crossref': [2828], '(234)': [2831], 'process': [2835, 3733], 'approximate': [2837], 'restrict': [2840], 'mobility,': [2842], 'thereby': [2843, 3390], 'increasing': [2844], 'local': [2846], 'promoting': [2850], 'autoactivation.': [2851, 3530], 'vivo,': [2853], 'adapter': [2854, 2886, 3192, 3438], 'mediate': [2856], 'long': [2859, 2895], 'procaspases.': [2861, 2874, 2897], 'Adapter': [2862], 'link': [2864], 'sensors': [2866], 'such': [2867], 'receptors': [2870, 3578], 'mitochondria': [2872], 'To': [2875], 'accomplish': [2876], 'this,': [2877], 'adapters': [2878], 'domain': [2882, 3131, 3134, 3137, 3140, 3148, 3211, 3250, 3512], 'couples': [2884, 3195, 3574], 'sensor': [2889], 'another': [2891, 3952], 'domains': [2899, 2902, 2954, 2959], 'include': [2900], '(DDs),': [2903], '2The': [2904], 'abbreviations': [2905], 'DDdeath': [2906], 'domainDEDdeath': [2907], 'effector': [2908, 2953, 3133], 'domainCARDcaspase': [2909], 'recruitment': [2910, 2958, 3136], 'domainFADDFas-associated': [2911], 'domainRAIDDRip-associated': [2913], 'ICH-1/CED-3': [2914, 3142], 'homologous': [2915, 3143], 'protein': [2916, 2933, 3144, 3167, 3172, 3178], 'domainAPAF-1apoptotic': [2920], 'protease-activating': [2921, 3150], 'factor-1CARDIAKCARD-containing': [2922], 'converting': [2924, 3154], 'enzyme-associated': [2925, 3155], 'kinaseCADcaspase-activated': [2926], 'DNaseICADinhibitor': [2927], 'caspase-activated': [2929, 3157, 3161], 'DNasePAK2p21-activated': [2930], 'kinase': [2931, 2936, 2938, 2951, 3156, 3164, 3170, 3173, 3190], '2MEKK1mitogen-activated': [2932], 'kinase/extracellular': [2934, 3168], 'signal-regulated': [2935, 3169], 'kinase-1PKCprotein': [2937], 'CNuManuclear': [2939], 'mitotic': [2940, 3176], 'apparatus': [2941, 3177], 'proteinSAF-Ascaffold': [2942], 'attachment': [2943, 3180], 'factor': [2944, 3181], 'AGas2growth': [2945], 'arrest': [2946, 3184], '2FAKfocal': [2949], 'adhesion': [2950, 3189], '(DEDs),': [2955], '(CARDs)': [2960], '(TableI).': [2961], 'DDs,': [2962], 'DEDs,': [2963, 3385], 'CARDs': [2965], 'six': [2968], 'anti-parallel': [2969], 'α-helices': [2970], 'arranged': [2971], 'similar': [2974, 3210, 3354], 'three-dimensional': [2975], 'fold': [2976], 'associate': [2978], 'like-like': [2980], 'interactions': [2981, 3050, 3058, 3063, 3388, 3543, 3581, 3619], '(31Huang': [2982, 3064], 'Eberstadt': [2984, 3066], 'Olejniczak': [2986, 3068], 'E.T.': [2987, 3069], 'Meadows': [2988, 3007, 3070, 3089], 'R.P.': [2989, 3008, 3071, 3090], 'Fesik': [2990, 3015, 3072, 3097], 'S.W.': [2991, 3016, 3073, 3098], '384:': [2994, 3076], '638-641Crossref': [2995, 3077], '(319)': [2998, 3080], '32Eberstadt': [3001, 3083], 'Huang': [3003, 3085], 'Ng': [3009, 3091], 'S.-C.': [3010, 3092], '392:': [3019, 3101], '941-945Crossref': [3020, 3102], '(204)': [3023, 3105], '33Chou': [3026, 3108], 'J.J.': [3027, 3109], 'Matsuo': [3028, 3110], 'Duan': [3030, 3112], 'Wagner': [3032, 3114], '171-180Abstract': [3037, 3119], '(279)': [3045, 3127], 'However,': [3048], 'hydrophobic': [3049], 'DED-DED': [3054], 'interactions,': [3055], 'whereas': [3056], 'electrostatic': [3057], 'CARD-CARD': [3062, 3580, 3645], 'Fas-associated': [3138], 'Rip-associated': [3141], 'factor-1': [3151], 'CARD-containing': [3152, 3571, 3636], 'DNase': [3158, 3162], 'inhibitor': [3159], 'p21-activated': [3163], '2': [3165, 3187], 'mitogen-activated': [3166], 'kinase-1': [3171], 'C': [3174], 'nuclear': [3175], 'scaffold': [3179], 'A': [3182, 3569, 4248], 'growth': [3183], 'focal': [3188], 'molecule': [3193, 3382], 'FADD': [3194, 3202, 3348], 'Fas': [3197, 3213, 3239], 'receptor': [3199, 3687], 'procaspase-8.': [3201, 3849], 'DD': [3205, 3246], 'interacts': [3207], 'DED': [3218], 'DEDs': [3223], 'procaspase-8': [3225, 3257, 3268], '(23Ashkenazi': [3226, 3271], 'stimulates': [3241], "receptor's": [3245], 'corresponding': [3249], 'FADD,': [3252], 'which': [3253, 3926], 'turn': [3255, 3515, 3846], 'recruits': [3256], 'homophilic': [3260, 3520], 'involving': [3262, 3522], 'DEDs.': [3263], 'then': [3266, 3527], '(Fig.1)': [3270], '34Muzio': [3284], 'Chinnaiyan': [3286], 'Kischkel': [3288], 'F.C.': [3289], 'Shevchenko': [3292], 'Scaffidi': [3296], 'Bretz': [3298], 'J.D.': [3299], 'Zhang': [3300], 'Gentz': [3302], 'Mann': [3304], 'Krammer': [3306], 'P.H.': [3307], 'Peter': [3308], 'M.E.': [3309], '85:': [3314, 3336], '817-827Abstract': [3315], '(2727)': [3323], '35Boldin': [3326], 'M.P.': [3327], 'Goncharov': [3328], 'T.M.': [3329], 'Goltsev': [3330], 'Y.V.': [3331], '803-815Abstract': [3337], '(2102)': [3345], 'probably': [3349], 'activates': [3350, 3789, 3886, 4191, 4255], 'procaspase-10': [3351], 'through': [3352], 'mechanism': [3355, 3953], '(36Vincenz': [3356], '6578-6583Abstract': [3365], '(239)': [3373], 'Interestingly,': [3376], 'FLIP,': [3377], 'caspase-8-like': [3381], 'inhibits': [3386, 3391], 'Fas-FADD-procaspase-8': [3387], '(37Irmler': [3393], 'Thome': [3395], 'Hahne': [3397], 'Schneider': [3399], 'Hofmann': [3401, 3658], 'Steiner': [3403], 'Bodmer': [3405, 3664], 'Schreoter': [3407], 'Burns': [3409, 3660], 'Mattmann': [3411, 3666], 'Rimoldi': [3413], 'French': [3415], 'L.E.': [3416], '388:': [3421], '190-195Crossref': [3422], '(2217)': [3425], 'Mitochondria': [3428], 'sense': [3429], 'convey': [3433], 'them': [3434], 'APAF-1': [3439, 3505, 3510], 'release': [3442], 'cytochrome': [3444], 'c.': [3445], 'Cytochromec': [3446], 'APAF-1,': [3449], 'presence': [3453], 'adenine': [3455, 3495], 'nucleotides,': [3456], 'APAF-1-cytochrome': [3458], 'c': [3459, 3493], 'complex': [3460], 'procaspase-9': [3464, 3517, 3525], '(38Li': [3465], 'Nijhawan': [3467], 'Budihardjo': [3469], 'Srinivasula': [3471, 3597], 'Wang': [3477, 3599], '91:': [3481], '470-489Abstract': [3482], '(6197)': [3489], 'Cytochrome': [3492], 'nucleotides': [3496], 'likely': [3497], 'induce': [3498], 'conformational': [3500], 'change': [3501], 'exposes': [3503], 'CARD': [3506, 3511], 'domain.': [3507], 'exposed': [3509], 'recruit': [3516], 'CARDs.': [3523], 'Bcl-XL,': [3531], 'Bcl-2': [3534], 'protein,': [3536], 'inhibit': [3538], 'blocking': [3541], '(39Hu': [3544], 'Benedict': [3546], 'Wu': [3548], 'Inohara': [3550], 'Nunez': [3552], 'Proc.': [3554, 4039], 'Natl.': [3555, 4040], 'Acad.': [3556, 4041], 'U.': [3558, 3693, 4043], '95:': [3562], '4386-4391Crossref': [3563], '(496)': [3566], 'second': [3570, 4249], 'adapter,': [3572], 'RAIDD,': [3573], 'procaspase-2': [3575], '(40Duan': [3582], '385:': [3588], '86-89Crossref': [3589], '(469)': [3592], '41Ahmad': [3595], 'Litwack': [3603], 'Cancer': [3609], 'Res.': [3610], '57:': [3612], '615-619PubMed': [3613], 'Thus,': [3616], 'adapter-mediated': [3617], 'protein-protein': [3618], 'widespread': [3621], 'among': [3622], 'caspases.': [3625, 3633], 'CARDIAK,': [3634], 'kinase,': [3637], 'procaspase-1': [3639, 3654, 3690, 3734], 'vitro': [3642], 'interaction,': [3646], 'CARD-mediated': [3649], 'could': [3651], '(42Thome': [3656], 'Martinon': [3662], 'J.-L.': [3665], 'Curr.': [3670], '8:': [3673], '885-888Abstract': [3674], 'Ligation': [3683], 'CD40': [3686], '(43Schonbeck': [3692], 'Mach': [3694], 'Bonnefoy': [3696], 'J.-Y.': [3697], 'Loppnow': [3698], 'Flad': [3700], 'H.-D.': [3701], 'Libby': [3702], '19569-19574Abstract': [3709], '(107)': [3717], 'Scholar);': [3719], 'whether': [3721], 'CARDIAK': [3722], 'unknown.': [3727], 'Finally,': [3728], 'does': [3730], 'facilitate': [3737], 'non-proteolytic': [3742], '(16Wang': [3744], 'Once': [3770], 'activated,': [3771], 'transactivate': [3773], 'procaspases,': [3775], 'providing': [3776], 'opportunity': [3778], 'cascade': [3780, 3921], 'amplification': [3781], 'positive': [3783, 3852], 'feedback.': [3784], 'Caspase-8': [3785], 'efficiently': [3788, 4254], 'procaspase-3': [3790, 3887, 4116, 4192], '(k': [3791, 4119], 'cat/Km': [3792], '=': [3793], '8.7': [3794], '×': [3795, 4122, 4126], '105m–1': [3796], 's–1)': [3797], '(44Stennicke': [3798, 3985, 4130, 4204], 'Jurgensmeier': [3800, 3987, 4132, 4206], 'Shin': [3802, 3989, 4134, 4208], 'Deveraux': [3804, 3991, 4136, 4210], 'Q.': [3805, 3811, 3992, 3998, 4095, 4137, 4143, 4175, 4211, 4217], 'Wolf': [3806, 3993, 4138, 4212], 'B.B.': [3807, 3994, 4139, 4213], 'Yang': [3808, 3995, 4140, 4214], 'Zhou': [3810, 3997, 4142, 4216], 'Ellerby': [3812, 3814, 3999, 4001, 4144, 4146, 4218, 4220], 'L.M.': [3815, 4002, 4147, 4221], 'Bredesen': [3816, 4003, 4148, 4222], 'Green': [3818, 4005, 4150, 4224], 'Reed': [3820, 4007, 4152, 4226], 'J.C.': [3821, 4008, 4153, 4227], 'Froelich': [3822, 4009, 4154, 4228], '27084-27090Abstract': [3831, 4018, 4163, 4237], '(643)': [3839, 4026, 4091, 4171, 4245], 'Scholar),': [3841], 'activate': [3848, 3878, 3892, 3978], 'Although': [3850], 'feedback': [3853], 'loop': [3854], 'theoretically': [3856], 'possible,': [3857], 'it': [3858], 'yet': [3861], 'been': [3862], 'demonstrated.': [3863], 'Additionally,': [3864], 'single': [3872], 'members.': [3882], 'procaspase-7': [3889, 4118, 4256], 'cannot': [3891], 'procaspase-6': [3893], '(29Srinivasula': [3894], 'Propagation': [3917], 'will': [3922], 'thus': [3923], 'depend': [3924], 'expresses,': [3930], 'relative': [3932], 'concentrations': [3933], 'efficiency': [3940], 'transactivation': [3944], 'reactions.': [3945], 'non-caspase': [3949], 'represents': [3951], 'activation.': [3955], 'cytotoxic': [3957], 'T': [3958], 'proteinase,': [3960, 3966, 4251], 'granzyme': [3961, 4189], 'B,': [3962], 'aspartate-specific': [3964], 'serine': [3965, 4250], 'provides': [3967], 'best': [3969], 'concept': [3973], 'several': [3979], 'potently': [3982], 'induces': [3983], '45Shresta': [4029], 'MacIvor': [4031], 'Heusel': [4033], 'Russell': [4035], 'J.H.': [4036], 'Ley': [4037], 'T.J.': [4038], '5679-5683Crossref': [4048], '(206)': [4051], '46Simon': [4054], 'M.M.': [4055], 'Hausmann': [4056], 'Tran': [4058], 'Ebnet': [4060], 'ThaHla': [4064], 'Mullbacher': [4066], 'Exp.': [4069], 'Med.': [4070], '186:': [4072], '1781-1786Crossref': [4073], '(164)': [4076], '47Darmon': [4079], 'A.J.': [4080], 'Bleackley': [4083], 'R.C.': [4084], '377:': [4087], '446-448Crossref': [4088], '48Zhou': [4094, 4174], '324:': [4101, 4181], '361-363Crossref': [4102, 4182], '(122)': [4105, 4185], 'extremely': [4112], 'efficient': [4113], 'cat/Km,': [4120], '4.8': [4121], '106m–1': [4123], 's–1,': [4124, 4128], '8.6': [4125], '107m–1': [4127], 'respectively)': [4129], 'Remarkably,': [4188], 'B': [4190], '5.5': [4193], 'times': [4194, 4200], 'faster': [4195, 4201], 'caspase-8': [4197], '17': [4199], 'caspase-10': [4203], 'cathepsin': [4252], 'G,': [4253], 'Gln-194,': [4260], 'required': [4267], 'activatio': [4270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2075226068', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 30}], 'updated_date': '2024-12-13T15:17:47.586681', 'created_date': '2016-06-24'}