Publication Information

{'id': 'https://openalex.org/W2073908163', 'doi': 'https://doi.org/10.1074/jbc.272.8.5192', 'title': 'Conversion from Archaeal Geranylgeranyl Diphosphate Synthase to Farnesyl Diphosphate Synthase', 'display_name': 'Conversion from Archaeal Geranylgeranyl Diphosphate Synthase to Farnesyl Diphosphate Synthase', 'publication_year': 1997, 'publication_date': '1997-02-01', 'ids': {'openalex': 'https://openalex.org/W2073908163', 'doi': 'https://doi.org/10.1074/jbc.272.8.5192', 'mag': '2073908163', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9030588'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.8.5192', 'pdf_url': 'http://www.jbc.org/article/S0021925819793594/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819793594/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004979383', 'display_name': 'Shin‐ichi Ohnuma', 'orcid': 'https://orcid.org/0000-0002-3305-5126'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shin-ichi Ohnuma', 'raw_affiliation_strings': ['From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020253882', 'display_name': 'Kazutake Hirooka', 'orcid': 'https://orcid.org/0000-0001-5879-936X'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazutake Hirooka', 'raw_affiliation_strings': ['From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049050488', 'display_name': 'Chikara Ohto', 'orcid': 'https://orcid.org/0009-0006-5782-1549'}, 'institutions': [{'id': 'https://openalex.org/I4210137853', 'display_name': 'Toyota Motor Corporation (Japan)', 'ror': 'https://ror.org/02zqm6r10', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210125472', 'https://openalex.org/I4210137853']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chikara Ohto', 'raw_affiliation_strings': ['Bio Research Laboratory, Toyota Motor Corporation, 1, Toyota-cho, Toyota 471-71, Japan'], 'affiliations': [{'raw_affiliation_string': 'Bio Research Laboratory, Toyota Motor Corporation, 1, Toyota-cho, Toyota 471-71, Japan', 'institution_ids': ['https://openalex.org/I4210137853']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110855499', 'display_name': 'Tokuzo Nishino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tokuzo Nishino', 'raw_affiliation_strings': ['From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Biochemistry and Engineering, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai 980-77, Japan, and', 'institution_ids': ['https://openalex.org/I201537933']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.672, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.890601, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '272', 'issue': '8', 'first_page': '5192', 'last_page': '5198'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13127', 'display_name': 'Biotin and Related Studies', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/farnesyl-diphosphate-synthase', 'display_name': 'Farnesyl diphosphate synthase', 'score': 0.8907716}, {'id': 'https://openalex.org/keywords/mevalonate-pathway', 'display_name': 'Mevalonate pathway', 'score': 0.49155363}, {'id': 'https://openalex.org/keywords/prenyltransferase', 'display_name': 'Prenyltransferase', 'score': 0.4164638}], 'concepts': [{'id': 'https://openalex.org/C2775933503', 'wikidata': 'https://www.wikidata.org/wiki/Q25113781', 'display_name': 'Farnesyl diphosphate synthase', 'level': 4, 'score': 0.8907716}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.7028046}, {'id': 'https://openalex.org/C112243037', 'wikidata': 'https://www.wikidata.org/wiki/Q22327117', 'display_name': 'ATP synthase', 'level': 3, 'score': 0.67693675}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.563077}, {'id': 'https://openalex.org/C57790582', 'wikidata': 'https://www.wikidata.org/wiki/Q901141', 'display_name': 'Prenylation', 'level': 3, 'score': 0.55806524}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5371865}, {'id': 'https://openalex.org/C2779982574', 'wikidata': 'https://www.wikidata.org/wiki/Q14913010', 'display_name': 'Mevalonate pathway', 'level': 4, 'score': 0.49155363}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.48127908}, {'id': 'https://openalex.org/C2781264208', 'wikidata': 'https://www.wikidata.org/wiki/Q118026', 'display_name': 'Isomerase', 'level': 3, 'score': 0.46024412}, {'id': 'https://openalex.org/C2776085463', 'wikidata': 'https://www.wikidata.org/wiki/Q7240581', 'display_name': 'Prenyltransferase', 'level': 4, 'score': 0.4164638}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.34443182}], 'mesh': [{'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051231', 'descriptor_name': 'Farnesyltranstransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005785', 'descriptor_name': 'Gene Conversion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051228', 'descriptor_name': 'Geranyltranstransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017421', 'descriptor_name': 'Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.8.5192', 'pdf_url': 'http://www.jbc.org/article/S0021925819793594/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9030588', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.8.5192', 'pdf_url': 'http://www.jbc.org/article/S0021925819793594/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1489966042', 'https://openalex.org/W1498020519', 'https://openalex.org/W1511973692', 'https://openalex.org/W1534973403', 'https://openalex.org/W1536336106', 'https://openalex.org/W1579034919', 'https://openalex.org/W1582794275', 'https://openalex.org/W1587819187', 'https://openalex.org/W1703814589', 'https://openalex.org/W1867705637', 'https://openalex.org/W1939544560', 'https://openalex.org/W1974033238', 'https://openalex.org/W2003250958', 'https://openalex.org/W2024468292', 'https://openalex.org/W2029392258', 'https://openalex.org/W2036931150', 'https://openalex.org/W2043002903', 'https://openalex.org/W2043653118', 'https://openalex.org/W2061849541', 'https://openalex.org/W2062780141', 'https://openalex.org/W2064454451', 'https://openalex.org/W2074105121', 'https://openalex.org/W2076866240', 'https://openalex.org/W2096778635', 'https://openalex.org/W2115754177', 'https://openalex.org/W2149036971', 'https://openalex.org/W2168064477', 'https://openalex.org/W2170924459', 'https://openalex.org/W2314225431'], 'related_works': ['https://openalex.org/W3107169140', 'https://openalex.org/W2774148162', 'https://openalex.org/W2566708621', 'https://openalex.org/W2225317520', 'https://openalex.org/W2171663905', 'https://openalex.org/W2148465426', 'https://openalex.org/W2133348272', 'https://openalex.org/W2034267746', 'https://openalex.org/W2024400357', 'https://openalex.org/W1985137291'], 'abstract_inverted_index': {'Farnesyl': [0, 248], 'diphosphate': [1, 5, 35, 249, 253, 283], '(FPP)': [2, 250], 'and': [3, 20, 26, 39, 74, 111, 145, 182, 225, 251, 268, 274, 287, 322, 359, 393, 430, 473], 'geranylgeranyl': [4, 252], '(GGPP)': [6, 254], 'are': [7, 255], 'precursors': [8, 256], 'for': [9, 137, 257, 385], 'a': [10, 258], 'variety': [11, 259], 'of': [12, 33, 68, 97, 121, 141, 149, 163, 172, 199, 260, 281, 316, 345, 369, 389, 397, 411, 420, 447], 'important': [13, 261], 'natural': [14, 262], 'products,': [15, 263], 'such': [16, 264], 'as': [17, 265], 'sterols,': [18, 266], 'carotenoids,': [19, 267], 'prenyl': [21, 269], 'quinones.': [22, 270], 'Although': [23, 271], 'FPP': [24, 75, 98, 143, 155, 165, 170, 232, 272, 323, 346, 391, 403, 413, 418, 480], 'synthase': [25, 28, 73, 244, 273, 276, 321, 492], 'GGPP': [27, 72, 82, 243, 275, 320, 330, 491], 'catalyze': [29, 277], 'similar': [30, 278], 'consecutive': [31, 279], 'condensations': [32, 280], 'isopentenyl': [34, 282], 'with': [36, 93, 284, 341], 'allylic': [37, 285], 'diphosphates': [38, 286], 'have': [40, 234, 288, 482], 'several': [41, 289], 'homologous': [42, 290], 'regions': [43, 85, 96, 291, 333, 344], 'in': [44, 153, 222, 245, 292, 401, 470, 493], 'their': [45, 191, 293, 439], 'amino': [46, 176, 209, 219, 294, 424, 457, 467], 'acid': [47, 210, 295, 458], 'sequences,': [48, 296], 'nothing': [49, 297], 'is': [50, 135, 159, 204, 298, 383, 407, 452], 'known': [51, 299], 'about': [52, 300], 'how': [53, 301], 'these': [54, 122, 302, 370], 'enzymes': [55, 203, 303, 451], 'form': [56, 304], 'the': [57, 62, 66, 87, 94, 119, 128, 131, 138, 147, 150, 180, 183, 187, 196, 200, 212, 216, 223, 237, 241, 305, 310, 314, 335, 342, 367, 376, 379, 386, 395, 398, 428, 431, 435, 444, 448, 460, 464, 471, 485, 489], 'specific': [58, 306], 'products.': [59, 307], 'To': [60, 308], 'locate': [61, 309], 'region': [63, 129, 311, 377], 'that': [64, 127, 146, 231, 312, 375, 394, 479], 'causes': [65, 313], 'difference': [67, 315], 'final': [69, 317], 'products': [70, 318], 'between': [71, 319], 'synthase,': [76, 324], 'we': [77, 125, 325, 373], 'constructed': [78, 326], 'six': [79, 327], 'mutated': [80, 116, 123, 328, 364, 371], 'archaeal': [81, 242, 329, 490], 'synthases': [83, 99, 144, 156, 166, 171, 233, 331, 347, 392, 404, 414, 419, 481], 'whose': [84, 332], 'around': [86, 130, 334, 378], 'first': [88, 132, 336, 380], 'aspartate-rich': [89, 133, 337, 381], 'motif': [90, 134, 188, 338, 382, 436], 'were': [91, 339], 'replaced': [92, 340], 'corresponding': [95, 239, 343, 487], 'from': [100, 112, 161, 236, 348, 360, 409, 484], 'human,': [101, 349], 'rat,': [102, 350], 'Arabidopsis': [103, 351], 'thaliana,': [104, 352], 'Saccharomyces': [105, 353], 'cerevisiae,': [106, 354], 'Escherichia': [107, 355], 'coli,': [108, 356], 'Bacillus': [109, 357], 'stearothermophilus,': [110, 358], 'some': [113, 361], 'other': [114, 226, 362, 474], 'related': [115, 363], 'enzymes.': [117, 365], 'From': [118, 366], 'analysis': [120, 368], 'enzymes,': [124, 372], 'revealed': [126, 374], 'essential': [136, 384], 'product': [139, 192, 197, 387, 440, 445], 'specificity': [140, 198, 388, 446], 'all': [142, 390], 'mechanism': [148, 396], 'chain': [151, 193, 399, 441], 'termination': [152, 400], 'eukaryotic': [154, 402], '(type': [157, 167, 405, 415], 'I)': [158, 406], 'different': [160, 408], 'those': [162, 410], 'prokaryotic': [164, 412], 'II).': [168, 416], 'In': [169, 417], 'type': [173, 201, 421, 449], 'I,': [174, 422], 'two': [175, 218, 246, 423, 466, 494], 'acids': [177, 220, 425, 468], 'situated': [178, 426], 'at': [179, 211, 427, 459], 'fourth': [181, 429], 'fifth': [184, 213, 432, 461], 'positions': [185, 433], 'before': [186, 215, 434, 463], 'solely': [189, 437], 'determine': [190, 438], 'length,': [194, 442], 'while': [195, 443], 'II': [202, 450], 'determined': [205, 453], 'by': [206, 454], 'one': [207, 455], 'aromatic': [208, 456], 'position': [214, 462], 'motif,': [217, 224, 465, 472], 'inserted': [221, 469], 'modifications.': [227, 475], 'These': [228, 476], 'data': [229, 477], 'indicate': [230, 478], 'evolved': [235, 483], 'progenitor': [238, 486], 'to': [240, 488], 'ways.': [247, 495]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2073908163', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T05:52:56.879450', 'created_date': '2016-06-24'}