Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3107169140', 'doi': 'https://doi.org/10.1002/iub.2418', 'title': 'Structure, catalysis, and inhibition mechanism of prenyltransferase', 'display_name': 'Structure, catalysis, and inhibition mechanism of prenyltransferase', 'publication_year': 2020, 'publication_date': '2020-11-27', 'ids': {'openalex': 'https://openalex.org/W3107169140', 'doi': 'https://doi.org/10.1002/iub.2418', 'mag': '3107169140', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33246356', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7839719'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/iub.2418', 'pdf_url': 'https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iub.2418', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iub.2418', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023220313', 'display_name': 'Hsin‐Yang Chang', 'orcid': 'https://orcid.org/0000-0001-6139-4937'}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Hsin‐Yang Chang', 'raw_affiliation_strings': ['Department of Life Sciences and Institute of Genome Sciences National Yang-Ming University Taipei Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Sciences and Institute of Genome Sciences National Yang-Ming University Taipei Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046429270', 'display_name': 'Tien‐Hsing Cheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Tien‐Hsing Cheng', 'raw_affiliation_strings': ['Department of Life Sciences and Institute of Genome Sciences National Yang-Ming University Taipei Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Life Sciences and Institute of Genome Sciences National Yang-Ming University Taipei Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016567722', 'display_name': 'Andrew H.‐J. Wang', 'orcid': 'https://orcid.org/0000-0002-0016-5337'}, 'institutions': [{'id': 'https://openalex.org/I4210092384', 'display_name': 'Institute of Biological Chemistry, Academia Sinica', 'ror': 'https://ror.org/00jt3dw39', 'country_code': 'TW', 'type': 'facility', 'lineage': ['https://openalex.org/I4210092384', 'https://openalex.org/I84653119']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Andrew H.‐J. Wang', 'raw_affiliation_strings': ['Institute of Biological Chemistry Academia Sinica Taipei Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biological Chemistry Academia Sinica Taipei Taiwan', 'institution_ids': ['https://openalex.org/I4210092384']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5023220313', 'https://openalex.org/A5046429270', 'https://openalex.org/A5016567722'], 'corresponding_institution_ids': ['https://openalex.org/I148366613', 'https://openalex.org/I148366613', 'https://openalex.org/I4210092384'], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'fwci': 0.71, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.367382, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '73', 'issue': '1', 'first_page': '40', 'last_page': '63'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prenyltransferase', 'display_name': 'Prenyltransferase', 'score': 0.98048353}, {'id': 'https://openalex.org/keywords/farnesyl-diphosphate-synthase', 'display_name': 'Farnesyl diphosphate synthase', 'score': 0.6631067}, {'id': 'https://openalex.org/keywords/isopentenyl-pyrophosphate', 'display_name': 'Isopentenyl pyrophosphate', 'score': 0.59581274}, {'id': 'https://openalex.org/keywords/farnesyl-pyrophosphate', 'display_name': 'Farnesyl pyrophosphate', 'score': 0.54238284}, {'id': 'https://openalex.org/keywords/isoprenoid-pathway', 'display_name': 'Isoprenoid Pathway', 'score': 0.53686}, {'id': 'https://openalex.org/keywords/squalene', 'display_name': 'Squalene', 'score': 0.46065873}], 'concepts': [{'id': 'https://openalex.org/C2776085463', 'wikidata': 'https://www.wikidata.org/wiki/Q7240581', 'display_name': 'Prenyltransferase', 'level': 4, 'score': 0.98048353}, {'id': 'https://openalex.org/C57790582', 'wikidata': 'https://www.wikidata.org/wiki/Q901141', 'display_name': 'Prenylation', 'level': 3, 'score': 0.9402413}, {'id': 'https://openalex.org/C206103511', 'wikidata': 'https://www.wikidata.org/wiki/Q426694', 'display_name': 'Terpenoid', 'level': 2, 'score': 0.8257472}, {'id': 'https://openalex.org/C2780069284', 'wikidata': 'https://www.wikidata.org/wiki/Q5198121', 'display_name': 'Cyclase', 'level': 3, 'score': 0.71690583}, {'id': 'https://openalex.org/C2775933503', 'wikidata': 'https://www.wikidata.org/wiki/Q25113781', 'display_name': 'Farnesyl diphosphate synthase', 'level': 4, 'score': 0.6631067}, {'id': 'https://openalex.org/C2777654137', 'wikidata': 'https://www.wikidata.org/wiki/Q417403', 'display_name': 'Isopentenyl pyrophosphate', 'level': 4, 'score': 0.59581274}, {'id': 'https://openalex.org/C2776990775', 'wikidata': 'https://www.wikidata.org/wiki/Q2699676', 'display_name': 'Farnesyl pyrophosphate', 'level': 4, 'score': 0.54238284}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5346538}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.51002795}, {'id': 'https://openalex.org/C112243037', 'wikidata': 'https://www.wikidata.org/wiki/Q22327117', 'display_name': 'ATP synthase', 'level': 3, 'score': 0.48460278}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48266461}, {'id': 'https://openalex.org/C2776703722', 'wikidata': 'https://www.wikidata.org/wiki/Q407560', 'display_name': 'Squalene', 'level': 2, 'score': 0.46065873}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.4049024}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3559465}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.16252288}], 'mesh': [{'descriptor_ui': 'D004122', 'descriptor_name': 'Dimethylallyltranstransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004122', 'descriptor_name': 'Dimethylallyltranstransferase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004122', 'descriptor_name': 'Dimethylallyltranstransferase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D004122', 'descriptor_name': 'Dimethylallyltranstransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/iub.2418', 'pdf_url': 'https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iub.2418', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7839719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33246356', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/iub.2418', 'pdf_url': 'https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/iub.2418', 'source': {'id': 'https://openalex.org/S203723150', 'display_name': 'IUBMB Life', 'issn_l': '1521-6543', 'issn': ['1521-6543', '1521-6551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320309618', 'funder_display_name': 'Ministry of Science and Technology', 'award_id': '109‐2311‐B‐110 ‐001 ‐MY3'}], 'datasets': [], 'versions': [], 'referenced_works_count': 151, 'referenced_works': ['https://openalex.org/W1489966042', 'https://openalex.org/W1522208682', 'https://openalex.org/W1534973403', 'https://openalex.org/W1583923863', 'https://openalex.org/W1826883745', 'https://openalex.org/W1830891822', 'https://openalex.org/W1959649751', 'https://openalex.org/W1969555177', 'https://openalex.org/W1972387662', 'https://openalex.org/W1972401663', 'https://openalex.org/W1976556627', 'https://openalex.org/W1977028607', 'https://openalex.org/W1983707447', 'https://openalex.org/W1985541198', 'https://openalex.org/W1986930831', 'https://openalex.org/W1992306108', 'https://openalex.org/W1993564578', 'https://openalex.org/W1993829583', 'https://openalex.org/W1998406048', 'https://openalex.org/W2000762807', 'https://openalex.org/W2002252224', 'https://openalex.org/W2009233681', 'https://openalex.org/W2010338458', 'https://openalex.org/W2011070858', 'https://openalex.org/W2011343062', 'https://openalex.org/W2014451351', 'https://openalex.org/W2016033634', 'https://openalex.org/W2016644494', 'https://openalex.org/W2016970694', 'https://openalex.org/W2019188215', 'https://openalex.org/W2022996178', 'https://openalex.org/W2023025710', 'https://openalex.org/W2023943027', 'https://openalex.org/W2025289529', 'https://openalex.org/W2026448915', 'https://openalex.org/W2027369973', 'https://openalex.org/W2031861922', 'https://openalex.org/W2036974504', 'https://openalex.org/W2041156247', 'https://openalex.org/W2041713157', 'https://openalex.org/W2042066399', 'https://openalex.org/W2042200046', 'https://openalex.org/W2042394334', 'https://openalex.org/W2047137800', 'https://openalex.org/W2052132094', 'https://openalex.org/W2053970377', 'https://openalex.org/W2055159866', 'https://openalex.org/W2056400844', 'https://openalex.org/W2058184221', 'https://openalex.org/W2058390644', 'https://openalex.org/W2058997347', 'https://openalex.org/W2061275245', 'https://openalex.org/W2062507791', 'https://openalex.org/W2064068411', 'https://openalex.org/W2064129143', 'https://openalex.org/W2066864568', 'https://openalex.org/W2068056765', 'https://openalex.org/W2068799782', 'https://openalex.org/W2069172641', 'https://openalex.org/W2071043287', 'https://openalex.org/W2071484354', 'https://openalex.org/W2072684305', 'https://openalex.org/W2074307683', 'https://openalex.org/W2074929631', 'https://openalex.org/W2077231529', 'https://openalex.org/W2080082312', 'https://openalex.org/W2080690387', 'https://openalex.org/W2082080415', 'https://openalex.org/W2083759849', 'https://openalex.org/W2087907807', 'https://openalex.org/W2090438210', 'https://openalex.org/W2090466503', 'https://openalex.org/W2090702802', 'https://openalex.org/W2091078202', 'https://openalex.org/W2091125333', 'https://openalex.org/W2092452589', 'https://openalex.org/W2093794669', 'https://openalex.org/W2097099899', 'https://openalex.org/W2104717964', 'https://openalex.org/W2119599011', 'https://openalex.org/W2123126142', 'https://openalex.org/W2125763262', 'https://openalex.org/W2134266820', 'https://openalex.org/W2134402164', 'https://openalex.org/W2137157580', 'https://openalex.org/W2138886701', 'https://openalex.org/W2141622431', 'https://openalex.org/W2148694111', 'https://openalex.org/W2151227595', 'https://openalex.org/W2152553492', 'https://openalex.org/W2152704187', 'https://openalex.org/W2156561022', 'https://openalex.org/W2162733327', 'https://openalex.org/W2163590985', 'https://openalex.org/W2165029635', 'https://openalex.org/W2171745736', 'https://openalex.org/W2176744910', 'https://openalex.org/W2188189100', 'https://openalex.org/W2209833992', 'https://openalex.org/W2225133693', 'https://openalex.org/W2239039690', 'https://openalex.org/W2272329318', 'https://openalex.org/W2275074802', 'https://openalex.org/W2279314794', 'https://openalex.org/W2285215250', 'https://openalex.org/W2293742853', 'https://openalex.org/W2324956847', 'https://openalex.org/W2326817577', 'https://openalex.org/W2344008260', 'https://openalex.org/W2414567253', 'https://openalex.org/W2462104816', 'https://openalex.org/W2484071087', 'https://openalex.org/W2497220292', 'https://openalex.org/W2517176893', 'https://openalex.org/W2589005863', 'https://openalex.org/W2592452129', 'https://openalex.org/W2596426394', 'https://openalex.org/W2597116873', 'https://openalex.org/W2600924352', 'https://openalex.org/W2750432728', 'https://openalex.org/W2756026772', 'https://openalex.org/W2765125878', 'https://openalex.org/W2768456628', 'https://openalex.org/W2769308397', 'https://openalex.org/W2772201629', 'https://openalex.org/W2791655484', 'https://openalex.org/W2792377336', 'https://openalex.org/W2793517772', 'https://openalex.org/W2799347062', 'https://openalex.org/W2801495739', 'https://openalex.org/W2896100334', 'https://openalex.org/W2896459790', 'https://openalex.org/W2924111117', 'https://openalex.org/W2934267501', 'https://openalex.org/W2947849484', 'https://openalex.org/W2951246248', 'https://openalex.org/W2952718668', 'https://openalex.org/W2959207544', 'https://openalex.org/W2990020054', 'https://openalex.org/W299070987', 'https://openalex.org/W3013216021', 'https://openalex.org/W3017381091', 'https://openalex.org/W3023922390', 'https://openalex.org/W3107169140', 'https://openalex.org/W4231873697', 'https://openalex.org/W4245890067', 'https://openalex.org/W4253258361', 'https://openalex.org/W4255289888', 'https://openalex.org/W4291299342', 'https://openalex.org/W651781535', 'https://openalex.org/W939892911'], 'related_works': ['https://openalex.org/W2120060204', 'https://openalex.org/W2088730128', 'https://openalex.org/W2058275176', 'https://openalex.org/W2050727300', 'https://openalex.org/W2019160327', 'https://openalex.org/W1994663604', 'https://openalex.org/W1974896328', 'https://openalex.org/W1522208682', 'https://openalex.org/W125284824', 'https://openalex.org/W1121154265'], 'abstract_inverted_index': {'Abstract': [0], 'Isoprenoids,': [1], 'also': [2, 167], 'known': [3, 64], 'as': [4, 25, 65, 68], 'terpenes': [5], 'or': [6, 20], 'terpenoids,': [7], 'represent': [8], 'a': [9, 60], 'large': [10], 'family': [11], 'of': [12, 16, 47, 55, 62, 110, 142, 159], 'natural': [13], 'products': [14], 'composed': [15], 'five‐carbon': [17], 'isopentenyl': [18], 'diphosphate': [19, 24], 'its': [21], 'isomer': [22], 'dimethylallyl': [23], 'the': [26, 44, 157], 'building': [27], 'blocks.': [28], 'Isoprenoids': [29], 'are': [30, 57, 85, 94, 113, 151, 166], 'structurally': [31, 114], 'and': [32, 35, 49, 77, 79, 90, 115, 137], 'functionally': [33], 'diverse': [34], 'include': [36], 'dolichols,': [37], 'steroid': [38], 'hormones,': [39], 'carotenoids,': [40], 'retinoids,': [41], 'aromatic': [42, 75, 135], 'metabolites,': [43], 'isoprenoid': [45, 50], 'side‐chain': [46], 'ubiquinone,': [48], 'attached': [51], 'signaling': [52], 'proteins.': [53], 'Productions': [54], 'isoprenoids': [56], 'catalyzed': [58], 'by': [59], 'group': [61], 'enzymes': [63, 84, 144], 'prenyltransferases,': [66], 'such': [67], 'farnesyltransferases,': [69], 'geranylgeranyltransferases,': [70], 'terpenoid': [71, 132], 'cyclase,': [72, 133], 'squalene': [73], 'synthase,': [74, 122, 126, 130], 'prenyltransferase,': [76, 136], 'cis‐': [78], 'trans‐': [80], 'prenyltransferases.': [81], 'Because': [82], 'these': [83], 'key': [86], 'in': [87, 100], 'cellular': [88], 'processes': [89], 'metabolic': [91], 'pathways,': [92], 'they': [93], 'expected': [95], 'to': [96], 'be': [97], 'potential': [98, 146], 'targets': [99], 'new': [101], 'drug': [102], 'discovery.': [103], 'In': [104], 'this': [105], 'review,': [106], 'six': [107], 'distinct': [108], 'subsets': [109], 'characterized': [111], 'prenyltransferases': [112], 'mechanistically': [116], 'classified,': [117], 'including': [118], '(1)': [119], 'head‐to‐tail': [120], 'prenyl': [121, 125, 129], '(2)': [123], 'head‐to‐head': [124], '(3)': [127], 'head‐to‐middle': [128], '(4)': [131], '(5)': [134], '(6)': [138], 'protein': [139], 'prenylation.': [140], 'Inhibitors': [141], 'those': [143], 'for': [145], 'therapies': [147], 'against': [148], 'several': [149], 'diseases': [150], 'discussed.': [152, 168], 'Lastly,': [153], 'recent': [154], 'results': [155], 'on': [156], 'structures': [158], 'integral': [160], 'membrane': [161], 'enzyme,': [162], 'undecaprenyl': [163], 'pyrophosphate': [164], 'phosphatase,': [165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3107169140', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-13T15:32:42.811980', 'created_date': '2020-12-07'}