CYP2C19 Genetic Polymorphism, Rabeprazole and Esomeprazole Have no Effect on the Antiplatelet Action of Clopidogrel

Name: Work Video:
Duration: 3 min 30 s
Mustapha El-Halabi; Nathalie K. Zgheib; Nabil Mansour; Ahmad Malli; Ola Ghaith; Rami Mahfouz; Samir Alam; Ala I. Sharara
{'id': 'https://openalex.org/W2073108797', 'doi': 'https://doi.org/10.1097/fjc.0b013e31828ecf44', 'title': 'CYP2C19 Genetic Polymorphism, Rabeprazole and Esomeprazole Have no Effect on the Antiplatelet Action of Clopidogrel', 'display_name': 'CYP2C19 Genetic Polymorphism, Rabeprazole and Esomeprazole Have no Effect on the Antiplatelet Action of Clopidogrel', 'publication_year': 2013, 'publication_date': '2013-03-08', 'ids': {'openalex': 'https://openalex.org/W2073108797', 'doi': 'https://doi.org/10.1097/fjc.0b013e31828ecf44', 'mag': '2073108797', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23474843'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/fjc.0b013e31828ecf44', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61167191', 'display_name': 'Journal of Cardiovascular Pharmacology', 'issn_l': '0160-2446', 'issn': ['0160-2446', '1533-4023'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054990206', 'display_name': 'Mustapha El-Halabi', 'orcid': 'https://orcid.org/0000-0002-7688-0732'}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': True, 'raw_author_name': 'Mustapha M. El-Halabi', 'raw_affiliation_strings': ['Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066947022', 'display_name': 'Nathalie K. Zgheib', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'Nathalie Zgheib', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089503247', 'display_name': 'Nabil Mansour', 'orcid': 'https://orcid.org/0000-0002-5660-8942'}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': True, 'raw_author_name': 'Nabil M. Mansour', 'raw_affiliation_strings': ['Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056258085', 'display_name': 'Ahmad Malli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': True, 'raw_author_name': 'Ahmad Malli', 'raw_affiliation_strings': ['Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056884379', 'display_name': 'Ola Ghaith', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': True, 'raw_author_name': 'Ola A. Ghaith', 'raw_affiliation_strings': ['Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032701156', 'display_name': 'Rami Mahfouz', 'orcid': 'https://orcid.org/0000-0002-0622-8191'}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'Rami Mahfouz', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109030757', 'display_name': 'Samir Alam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': False, 'raw_author_name': 'Samir Alam', 'raw_affiliation_strings': ['Division of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cardiology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.', 'institution_ids': ['https://openalex.org/I4210104580']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045626036', 'display_name': 'Ala I. Sharara', 'orcid': 'https://orcid.org/0000-0003-0248-9527'}, 'institutions': [{'id': 'https://openalex.org/I4210104580', 'display_name': 'American University of Beirut Medical Center', 'ror': 'https://ror.org/00wmm6v75', 'country_code': 'LB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210104580']}], 'countries': ['LB'], 'is_corresponding': True, 'raw_author_name': 'Ala I. Sharara', 'raw_affiliation_strings': ['Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon', 'institution_ids': ['https://openalex.org/I4210104580']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5054990206', 'https://openalex.org/A5089503247', 'https://openalex.org/A5056258085', 'https://openalex.org/A5056884379', 'https://openalex.org/A5045626036'], 'corresponding_institution_ids': ['https://openalex.org/I4210104580', 'https://openalex.org/I4210104580', 'https://openalex.org/I4210104580', 'https://openalex.org/I4210104580', 'https://openalex.org/I4210104580'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.445, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.80722, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '62', 'issue': '1', 'first_page': '41', 'last_page': '49'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 0.973, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/esomeprazole', 'display_name': 'Esomeprazole', 'score': 0.95097196}, {'id': 'https://openalex.org/keywords/rabeprazole', 'display_name': 'Rabeprazole', 'score': 0.9345157}, {'id': 'https://openalex.org/keywords/lansoprazole', 'display_name': 'Lansoprazole', 'score': 0.4274392}], 'concepts': [{'id': 'https://openalex.org/C2778204628', 'wikidata': 'https://www.wikidata.org/wiki/Q553223', 'display_name': 'Esomeprazole', 'level': 2, 'score': 0.95097196}, {'id': 'https://openalex.org/C140840227', 'wikidata': 'https://www.wikidata.org/wiki/Q3737532', 'display_name': 'CYP2C19', 'level': 4, 'score': 0.947703}, {'id': 'https://openalex.org/C2779116819', 'wikidata': 'https://www.wikidata.org/wiki/Q3515', 'display_name': 'Rabeprazole', 'level': 3, 'score': 0.9345157}, {'id': 'https://openalex.org/C2777849778', 'wikidata': 'https://www.wikidata.org/wiki/Q410237', 'display_name': 'Clopidogrel', 'level': 3, 'score': 0.86477816}, {'id': 'https://openalex.org/C2777498785', 'wikidata': 'https://www.wikidata.org/wiki/Q422210', 'display_name': 'Omeprazole', 'level': 2, 'score': 0.61490154}, {'id': 'https://openalex.org/C2781025758', 'wikidata': 'https://www.wikidata.org/wiki/Q421704', 'display_name': 'Proton-pump inhibitor', 'level': 2, 'score': 0.5669933}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.55323565}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.52044207}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48086792}, {'id': 'https://openalex.org/C2778715759', 'wikidata': 'https://www.wikidata.org/wiki/Q254296', 'display_name': 'Lansoprazole', 'level': 3, 'score': 0.4274392}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.41256416}, {'id': 'https://openalex.org/C2777628954', 'wikidata': 'https://www.wikidata.org/wiki/Q18216', 'display_name': 'Aspirin', 'level': 2, 'score': 0.2839427}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D064098', 'descriptor_name': 'Esomeprazole', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D064750', 'descriptor_name': 'Rabeprazole', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077144', 'descriptor_name': 'Clopidogrel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065731', 'descriptor_name': 'Cytochrome P-450 CYP2C19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064098', 'descriptor_name': 'Esomeprazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016015', 'descriptor_name': 'Logistic Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064750', 'descriptor_name': 'Rabeprazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013988', 'descriptor_name': 'Ticlopidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/fjc.0b013e31828ecf44', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61167191', 'display_name': 'Journal of Cardiovascular Pharmacology', 'issn_l': '0160-2446', 'issn': ['0160-2446', '1533-4023'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23474843', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1498861344', 'https://openalex.org/W1507268483', 'https://openalex.org/W1568290973', 'https://openalex.org/W1570992506', 'https://openalex.org/W1588578206', 'https://openalex.org/W1878265155', 'https://openalex.org/W1952796400', 'https://openalex.org/W1964551540', 'https://openalex.org/W1982771665', 'https://openalex.org/W1985059672', 'https://openalex.org/W1987761929', 'https://openalex.org/W1991117746', 'https://openalex.org/W1993185182', 'https://openalex.org/W2000128405', 'https://openalex.org/W2005092027', 'https://openalex.org/W2006941946', 'https://openalex.org/W2007602661', 'https://openalex.org/W2012268722', 'https://openalex.org/W2012817118', 'https://openalex.org/W2021241943', 'https://openalex.org/W2021341882', 'https://openalex.org/W2026682151', 'https://openalex.org/W2028743450', 'https://openalex.org/W2028938803', 'https://openalex.org/W2032247889', 'https://openalex.org/W2033472664', 'https://openalex.org/W2037355442', 'https://openalex.org/W2041821332', 'https://openalex.org/W2043755243', 'https://openalex.org/W2045800911', 'https://openalex.org/W2046852461', 'https://openalex.org/W2052922809', 'https://openalex.org/W2058874291', 'https://openalex.org/W2063080730', 'https://openalex.org/W2067520379', 'https://openalex.org/W2067889182', 'https://openalex.org/W2071687773', 'https://openalex.org/W2076472818', 'https://openalex.org/W2082149672', 'https://openalex.org/W2083325871', 'https://openalex.org/W2090989590', 'https://openalex.org/W2099022345', 'https://openalex.org/W2105005467', 'https://openalex.org/W2108591353', 'https://openalex.org/W2109577952', 'https://openalex.org/W2116291745', 'https://openalex.org/W2119186881', 'https://openalex.org/W2119546780', 'https://openalex.org/W2121169735', 'https://openalex.org/W2121695082', 'https://openalex.org/W2122844568', 'https://openalex.org/W2130350603', 'https://openalex.org/W2143777566', 'https://openalex.org/W2145425156', 'https://openalex.org/W2152184208', 'https://openalex.org/W2152376036', 'https://openalex.org/W2159098683', 'https://openalex.org/W2159858918', 'https://openalex.org/W2163961571', 'https://openalex.org/W2164386459', 'https://openalex.org/W2170125927', 'https://openalex.org/W2608052100', 'https://openalex.org/W270778111', 'https://openalex.org/W300595399', 'https://openalex.org/W4249056819', 'https://openalex.org/W71090043'], 'related_works': ['https://openalex.org/W3142695008', 'https://openalex.org/W2556413836', 'https://openalex.org/W2318237589', 'https://openalex.org/W2171080388', 'https://openalex.org/W2104172162', 'https://openalex.org/W2075280081', 'https://openalex.org/W2073108797', 'https://openalex.org/W2008260329', 'https://openalex.org/W1987884676', 'https://openalex.org/W1967156887'], 'abstract_inverted_index': {'The': [0, 89, 172], 'aim': [1], 'of': [2, 10, 23, 78, 174, 182, 193, 203], 'this': [3], 'study': [4], 'is': [5], 'to': [6, 44], 'investigate': [7], 'the': [8, 20, 97, 104, 112, 191, 201], 'effect': [9, 22, 199], 'CYP2C19': [11, 160], 'polymorphism': [12, 81], 'and': [13, 38, 40, 68, 107, 134, 141, 190], 'cotherapy': [14, 167], 'with': [15, 170], 'rabeprazole': [16, 31, 66, 196], 'or': [17, 32, 195], 'esomeprazole': [18, 33, 72, 194], 'on': [19, 138, 200], 'antiplatelet': [21], 'clopidogrel.': [24, 204], 'Patients': [25], 'receiving': [26], 'clopidogrel': [27, 60, 64, 70], '75': [28], 'mg': [29], '±': [30, 94, 101, 109], 'underwent': [34], 'genotyping': [35], 'for': [36, 87], 'CYP2C19*2': [37, 187], 'CYP2C19*3,': [39], 'vasodilator-stimulated': [41], 'phosphoprotein': [42], 'testing': [43], 'measure': [45], 'platelet': [46, 120], 'reactivity': [47, 121], 'index': [48], '(PRI).': [49], 'Two': [50], 'hundred': [51], 'thirty-nine': [52], 'consecutive': [53], 'patients': [54, 75, 137], 'were': [55, 168], 'enrolled': [56], 'as': [57, 124], 'follows:': [58], '92': [59], '(C': [61], 'group),': [62], '94': [63], '+': [65, 71], '(CR),': [67], '53': [69], '(CE).': [73], 'Forty-five': [74], 'had': [76], 'loss': [77], 'function': [79], '(LOF)': [80], '(43': [82], 'heterozygous;': [83], '2': [84], 'homozygous': [85], 'mutant': [86], 'CYP2C19*2).': [88], 'mean': [90], 'PRI': [91, 125], 'was': [92, 127, 148, 178], '20.7%': [93], '21.9%': [95], 'in': [96, 103, 111, 129, 150, 180], 'C': [98], 'group,': [99, 106], '19.1%': [100], '20.9%': [102], 'CR': [105], '24.5%': [108], '22.9%': [110], 'CE': [113], 'group': [114], '(P': [115, 144], '=': [116, 145], 'NS).': [117, 146], 'High': [118], 'on-treatment': [119], '(HPR),': [122], 'defined': [123], '>50%,': [126], 'observed': [128], '12': [130], '(13.0%),': [131], '13': [132], '(13.8%),': [133], '10': [135], '(18.9%)': [136], 'C,': [139], 'CR,': [140], 'CE,': [142], 'respectively': [143], 'HPR': [147], 'similar': [149], 'rapid': [151], 'metabolizers': [152], 'between': [153], 'groups.': [154], 'On': [155], 'multivariate': [156], 'logistic': [157], 'regression,': [158], 'neither': [159], 'LOF': [161, 188], 'alleles': [162], 'nor': [163], 'proton': [164, 175], 'pump': [165, 176], 'inhibitor': [166], 'associated': [169], 'HPR.': [171], 'use': [173, 192], 'inhibitors': [177], 'indicated': [179], '30.6%': [181], 'recipients.': [183], 'As': [184], 'a': [185], 'conclusion,': [186], 'allele': [189], 'have': [197], 'no': [198], 'action': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2073108797', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-24T14:44:29.876616', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
