CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole

Name: Work Video:
Duration: 3 min 30 s
Kyoichi Adachi; Takashi Katsube; Akira Kawamura; Toshiharu Takashima; Mika Yuki; Kazutoshi Amano; Shunji Ishihara; R Fukuda; Makoto Watanabe; Yoshikazu Kinoshita
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[24], 'Aim:': [28], 'To': [29], 'determine': [30], 'effect': [32], 'genotype': [35, 61, 122, 192], 'status': [36, 62, 193], 'on': [37, 87, 99, 116], 'intragastric': [38, 77], 'pH': [39, 144, 160, 178], 'during': [40, 145, 163], 'dosing': [41, 165], 'with': [42, 177], 'lansoprazole': [43, 164], 'or': [44], 'rabeprazole.': [45, 203], 'Subjects': [46, 110], 'and': [47, 97, 136, 171], 'methods:': [48], 'The': [49, 142, 173], 'subjects': [50], 'were': [51, 111], '20': [52], 'male': [53], 'volunteers': [54], 'without': [55, 84], 'Helicobacter': [56], 'pylori': [57], 'infection.': [58], 'Their': [59], 'was': [63, 79, 148, 166], 'determined': [64], 'by': [65, 151, 198, 202], 'a': [66, 92, 104, 182], 'polymerase': [67], 'chain': [68], 'reaction‐restriction': [69], 'fragment': [70], 'length': [71], 'polymorphism': [72], 'method.': [73], 'Twenty‐four‐hour': [74], 'monitoring': [75], 'acidity': [78], 'performed': [80], 'three': [81, 114], 'times:': [82], 'once': [83, 86, 98], 'medication,': [85], 'last': [89, 101], 'day': [90, 102], '7‐day': [93, 105], 'course': [94, 106], 'rabeprazole,': [96], 'lansoprazole.': [108], 'Results:': [109], 'divided': [112], 'into': [113], 'groups': [115], 'basis': [118], 'their': [120], 'status:': [123], 'homozygous': [124], 'extensive': [125, 131], 'metabolizers': [126, 132, 138], '(homo‐EMs,': [127], 'n': [128, 134, 140], '=7),': [129], 'heterozygous': [130], '(hetero‐EMs,': [133], '=9),': [135], 'poor': [137], '(PMs,': [139], '=4).': [141], 'median': [143, 159, 188], 'rabeprazole': [146], 'administration': [147], 'not': [149, 201], 'influenced': [150], 'genotype.': [153], 'On': [154], 'other': [156], 'hand,': [157], 'PMs': [162], 'higher': [167], 'than': [168], 'homo‐EMs': [170], 'hetero‐EMs.': [172], 'percentage': [174], 'time': [176], '&lt;': [179], '4.0': [180], 'had': [181], 'similar': [183], 'tendency': [184], 'to': [185], 'that': [186], 'pH.': [189], 'Conclusion:': [190], 'influences': [194], 'gastric': [195], 'acid': [196], 'suppression': [197], 'lansoprazole,': [199], 'but': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1967156887', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-09T07:39:53.676025', 'created_date': '2016-06-24'}
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