Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint

Name: Work Video:
Duration: 3 min 30 s
Beth A. Baber-Furnari; Nick Rhind; Michael N. Boddy; Paul Shanahan; Antonia López-Girona; Paul Russell
{'id': 'https://openalex.org/W2072868975', 'doi': 'https://doi.org/10.1091/mbc.11.1.1', 'title': 'Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint', 'display_name': 'Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2072868975', 'doi': 'https://doi.org/10.1091/mbc.11.1.1', 'mag': '2072868975', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10637286', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/14752'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.11.1.1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc14752?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058051259', 'display_name': 'Beth A. Baber-Furnari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beth A. Baber-Furnari', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004708181', 'display_name': 'Nick Rhind', 'orcid': 'https://orcid.org/0000-0003-1758-7736'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nick Rhind', 'raw_affiliation_strings': ['#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037'], 'affiliations': [{'raw_affiliation_string': '#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038849297', 'display_name': 'Michael N. Boddy', 'orcid': 'https://orcid.org/0000-0001-7618-4449'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael N. Boddy', 'raw_affiliation_strings': ['#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037'], 'affiliations': [{'raw_affiliation_string': '#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065544363', 'display_name': 'Paul Shanahan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Shanahan', 'raw_affiliation_strings': ['#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037'], 'affiliations': [{'raw_affiliation_string': '#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037376307', 'display_name': 'Antonia López-Girona', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Antonia Lopez-Girona', 'raw_affiliation_strings': ['#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037'], 'affiliations': [{'raw_affiliation_string': '#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012431295', 'display_name': 'Paul Russell', 'orcid': 'https://orcid.org/0000-0001-8575-1046'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Russell', 'raw_affiliation_strings': ['#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037'], 'affiliations': [{'raw_affiliation_string': '#N##N#1#N#Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California, 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.252, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.824487, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '1', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cdc25', 'display_name': 'Cdc25', 'score': 0.7729144}, {'id': 'https://openalex.org/keywords/chek1', 'display_name': 'CHEK1', 'score': 0.7609528}, {'id': 'https://openalex.org/keywords/checkpoint-kinase-2', 'display_name': 'Checkpoint Kinase 2', 'score': 0.6843316}, {'id': 'https://openalex.org/keywords/mitotic-exit', 'display_name': 'Mitotic exit', 'score': 0.5523009}, {'id': 'https://openalex.org/keywords/dna-re-replication', 'display_name': 'DNA re-replication', 'score': 0.53364193}], 'concepts': [{'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.9422035}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7911861}, {'id': 'https://openalex.org/C2778583388', 'wikidata': 'https://www.wikidata.org/wiki/Q3775177', 'display_name': 'Cdc25', 'level': 5, 'score': 0.7729144}, {'id': 'https://openalex.org/C50001416', 'wikidata': 'https://www.wikidata.org/wiki/Q17861750', 'display_name': 'CHEK1', 'level': 5, 'score': 0.7609528}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.7261313}, {'id': 'https://openalex.org/C2910325170', 'wikidata': 'https://www.wikidata.org/wiki/Q14912280', 'display_name': 'Checkpoint Kinase 2', 'level': 5, 'score': 0.6843316}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6652936}, {'id': 'https://openalex.org/C6391034', 'wikidata': 'https://www.wikidata.org/wiki/Q6881916', 'display_name': 'Mitotic exit', 'level': 5, 'score': 0.5523009}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.5445117}, {'id': 'https://openalex.org/C67419583', 'wikidata': 'https://www.wikidata.org/wiki/Q5205768', 'display_name': 'DNA re-replication', 'level': 5, 'score': 0.53364193}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.48777658}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.47495008}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.44310334}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.43044895}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.32547933}, {'id': 'https://openalex.org/C104690221', 'wikidata': 'https://www.wikidata.org/wiki/Q5165872', 'display_name': 'Control of chromosome duplication', 'level': 4, 'score': 0.2828554}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.24007657}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.22993416}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.21635234}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20021844}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.10584062}, {'id': 'https://openalex.org/C2910050888', 'wikidata': 'https://www.wikidata.org/wiki/Q4857068', 'display_name': 'Protein-Serine-Threonine Kinases', 'level': 4, 'score': 0.09186834}, {'id': 'https://openalex.org/C53420372', 'wikidata': 'https://www.wikidata.org/wiki/Q22299157', 'display_name': 'Anaphase', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016203', 'descriptor_name': 'CDC2 Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000071877', 'descriptor_name': 'Checkpoint Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016195', 'descriptor_name': 'G2 Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005982', 'descriptor_name': 'Glutathione Transferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016296', 'descriptor_name': 'Mutagenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014452', 'descriptor_name': 'Ubiquitins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020666', 'descriptor_name': 'ras-GRF1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020666', 'descriptor_name': 'ras-GRF1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020666', 'descriptor_name': 'ras-GRF1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.11.1.1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc14752', 'pdf_url': 'https://europepmc.org/articles/pmc14752?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14752', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10637286', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc14752', 'pdf_url': 'https://europepmc.org/articles/pmc14752?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1491086702', 'https://openalex.org/W1520947267', 'https://openalex.org/W1677118171', 'https://openalex.org/W1914194999', 'https://openalex.org/W1969308341', 'https://openalex.org/W1971908328', 'https://openalex.org/W1988488847', 'https://openalex.org/W1988876917', 'https://openalex.org/W1992848268', 'https://openalex.org/W1994909028', 'https://openalex.org/W1999275729', 'https://openalex.org/W2001928318', 'https://openalex.org/W2004008931', 'https://openalex.org/W2012015317', 'https://openalex.org/W2024218128', 'https://openalex.org/W2031292590', 'https://openalex.org/W2033950216', 'https://openalex.org/W2038340312', 'https://openalex.org/W2041834021', 'https://openalex.org/W2046897840', 'https://openalex.org/W2048729396', 'https://openalex.org/W2049041716', 'https://openalex.org/W2049508647', 'https://openalex.org/W2049601397', 'https://openalex.org/W2051928958', 'https://openalex.org/W2056387850', 'https://openalex.org/W2056652776', 'https://openalex.org/W2059729638', 'https://openalex.org/W2066883617', 'https://openalex.org/W2068091028', 'https://openalex.org/W2073285068', 'https://openalex.org/W2076314401', 'https://openalex.org/W2078692898', 'https://openalex.org/W2081995373', 'https://openalex.org/W2084147994', 'https://openalex.org/W2088683318', 'https://openalex.org/W2091782725', 'https://openalex.org/W2091829207', 'https://openalex.org/W2103143169', 'https://openalex.org/W2105016405', 'https://openalex.org/W2105592350', 'https://openalex.org/W2107389581', 'https://openalex.org/W2110629065', 'https://openalex.org/W2110740129', 'https://openalex.org/W2113684644', 'https://openalex.org/W2125155670', 'https://openalex.org/W2125239190', 'https://openalex.org/W2128804130', 'https://openalex.org/W2128994729', 'https://openalex.org/W213154533', 'https://openalex.org/W2147971204', 'https://openalex.org/W2159040452', 'https://openalex.org/W2159430776', 'https://openalex.org/W2166219128', 'https://openalex.org/W2171251720', 'https://openalex.org/W2194986544', 'https://openalex.org/W54191497'], 'related_works': ['https://openalex.org/W2625718430', 'https://openalex.org/W24995589', 'https://openalex.org/W2147971204', 'https://openalex.org/W2072868975', 'https://openalex.org/W2055206436', 'https://openalex.org/W2016479508', 'https://openalex.org/W1997759534', 'https://openalex.org/W1988876917', 'https://openalex.org/W1969308341', 'https://openalex.org/W1677118171'], 'abstract_inverted_index': {'The': [0], 'protein': [1, 107], 'kinase': [2, 41], 'Chk1': [3, 18], 'enforces': [4], 'the': [5, 20, 26, 31, 49, 98, 112, 137, 155, 159], 'DNA': [6, 15, 50, 65, 72, 99, 140, 160], 'damage': [7, 51, 66, 73, 100, 161], 'checkpoint.': [8, 52, 162], 'This': [9], 'checkpoint': [10, 57, 67, 101], 'delays': [11], 'mitosis': [12], 'until': [13], 'damaged': [14], 'is': [16, 45, 54], 'repaired.': [17], 'regulates': [19], 'activity': [21], 'and': [22, 108, 142, 149], 'localization': [23], 'of': [24, 128, 139, 147, 152, 158], 'Cdc25,': [25], 'tyrosine': [27, 40], 'phosphatase': [28], 'that': [29, 37, 42, 61, 90, 126], 'activates': [30], 'cdk': [32], 'Cdc2.': [33], 'Here': [34], 'we': [35], 'report': [36], 'Mik1,': [38], 'a': [39, 78, 85, 94], 'inhibits': [43], 'Cdc2,': [44], 'positively': [46], 'regulated': [47], 'by': [48], 'Mik1': [53, 75, 82, 91, 104, 106, 129, 153], 'required': [55], 'for': [56], 'response': [58], 'in': [59, 77, 84], 'strains': [60], 'lack': [62], 'Cdc25.': [63], 'Long-term': [64], 'arrest': [68], 'fails': [69], 'inΔmik1': [70], 'cells.': [71], 'increases': [74], 'abundance': [76, 130], 'Chk1-dependent': [79], 'manner.': [80], 'Ubiquitinated': [81], 'accumulates': [83], 'proteasome': [86], 'mutant,': [87], 'which': [88], 'indicates': [89], 'normally': [92], 'has': [93], 'short': [95], 'half-life.': [96], 'Thus,': [97], 'might': [102], 'regulate': [103], 'degradation.': [105], 'mRNA': [109], 'oscillate': [110], 'during': [111], 'unperturbed': [113], 'cell': [114], 'cycle,': [115], 'with': [116], 'peak': [117], 'amounts': [118], 'detected': [119], 'around': [120], 'S': [121], 'phase.': [122], 'These': [123], 'data': [124], 'indicate': [125], 'regulation': [127, 146, 151], 'helps': [131], 'to': [132, 136], 'couple': [133], 'mitotic': [134], 'onset': [135], 'completion': [138], 'replication': [141], 'repair.': [143], 'Coordinated': [144], 'negative': [145], 'Cdc25': [148], 'positive': [150], 'ensure': [154], 'effective': [156], 'operation': [157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072868975', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T16:27:43.815097', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
