Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2147971204', 'doi': 'https://doi.org/10.1091/mbc.10.4.833', 'title': 'Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1', 'display_name': 'Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1', 'publication_year': 1999, 'publication_date': '1999-04-01', 'ids': {'openalex': 'https://openalex.org/W2147971204', 'doi': 'https://doi.org/10.1091/mbc.10.4.833', 'mag': '2147971204', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10198041', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/25205'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.10.4.833', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc25205?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073810349', 'display_name': 'Beth Furnari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beth Furnari', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011956067', 'display_name': 'Alessandra Blasina', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alessandra Blasina', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038849297', 'display_name': 'Michael N. Boddy', 'orcid': 'https://orcid.org/0000-0001-7618-4449'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael N. Boddy', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074110726', 'display_name': 'Clare H. McGowan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Clare H. McGowan', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012431295', 'display_name': 'Paul Russell', 'orcid': 'https://orcid.org/0000-0001-8575-1046'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Russell', 'raw_affiliation_strings': ['Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.929, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 223, 'citation_normalized_percentile': {'value': 0.907312, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '10', 'issue': '4', 'first_page': '833', 'last_page': '845'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13526', 'display_name': '14-3-3 protein interactions', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cdc25', 'display_name': 'Cdc25', 'score': 0.8947594}, {'id': 'https://openalex.org/keywords/wee1', 'display_name': 'Wee1', 'score': 0.8070811}, {'id': 'https://openalex.org/keywords/chek1', 'display_name': 'CHEK1', 'score': 0.68959904}, {'id': 'https://openalex.org/keywords/checkpoint-kinase-2', 'display_name': 'Checkpoint Kinase 2', 'score': 0.56304693}], 'concepts': [{'id': 'https://openalex.org/C2778583388', 'wikidata': 'https://www.wikidata.org/wiki/Q3775177', 'display_name': 'Cdc25', 'level': 5, 'score': 0.8947594}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8121172}, {'id': 'https://openalex.org/C2781252693', 'wikidata': 'https://www.wikidata.org/wiki/Q7979264', 'display_name': 'Wee1', 'level': 5, 'score': 0.8070811}, {'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.7809801}, {'id': 'https://openalex.org/C50001416', 'wikidata': 'https://www.wikidata.org/wiki/Q17861750', 'display_name': 'CHEK1', 'level': 5, 'score': 0.68959904}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.6351365}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6257841}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.5681966}, {'id': 'https://openalex.org/C2910325170', 'wikidata': 'https://www.wikidata.org/wiki/Q14912280', 'display_name': 'Checkpoint Kinase 2', 'level': 5, 'score': 0.56304693}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.4588379}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.4145278}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.3981002}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.39402562}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29035854}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.25412428}, {'id': 'https://openalex.org/C2910050888', 'wikidata': 'https://www.wikidata.org/wiki/Q4857068', 'display_name': 'Protein-Serine-Threonine Kinases', 'level': 4, 'score': 0.16347283}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.0965679}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.08017182}], 'mesh': [{'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071877', 'descriptor_name': 'Checkpoint Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064447', 'descriptor_name': 'Checkpoint Kinase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006918', 'descriptor_name': 'Hydroxyurea', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006918', 'descriptor_name': 'Hydroxyurea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020687', 'descriptor_name': 'cdc25 Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1091/mbc.10.4.833', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188085164', 'display_name': 'Molecular Biology of the Cell', 'issn_l': '1059-1524', 'issn': ['1059-1524', '1939-4586'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319721', 'host_organization_name': 'American Society for Cell Biology', 'host_organization_lineage': ['https://openalex.org/P4310319721'], 'host_organization_lineage_names': ['American Society for Cell Biology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc25205', 'pdf_url': 'https://europepmc.org/articles/pmc25205?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25205', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10198041', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc25205', 'pdf_url': 'https://europepmc.org/articles/pmc25205?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1507334568', 'https://openalex.org/W1520947267', 'https://openalex.org/W1528493806', 'https://openalex.org/W1607596288', 'https://openalex.org/W1677118171', 'https://openalex.org/W1969308341', 'https://openalex.org/W1971040573', 'https://openalex.org/W1971180899', 'https://openalex.org/W1971908328', 'https://openalex.org/W1975849939', 'https://openalex.org/W1977541278', 'https://openalex.org/W1988876917', 'https://openalex.org/W1994909028', 'https://openalex.org/W2008096080', 'https://openalex.org/W2018876412', 'https://openalex.org/W2022670889', 'https://openalex.org/W2024218128', 'https://openalex.org/W2024923170', 'https://openalex.org/W2041834021', 'https://openalex.org/W2046049550', 'https://openalex.org/W2049508647', 'https://openalex.org/W2049601397', 'https://openalex.org/W2051928958', 'https://openalex.org/W2052598236', 'https://openalex.org/W2055157702', 'https://openalex.org/W2056652776', 'https://openalex.org/W2071075259', 'https://openalex.org/W2074889730', 'https://openalex.org/W2076314401', 'https://openalex.org/W2078692898', 'https://openalex.org/W2091782725', 'https://openalex.org/W2105592350', 'https://openalex.org/W2109345949', 'https://openalex.org/W2110629065', 'https://openalex.org/W2110740129', 'https://openalex.org/W2112782276', 'https://openalex.org/W2113684644', 'https://openalex.org/W2115518922', 'https://openalex.org/W2125239190', 'https://openalex.org/W2127849733', 'https://openalex.org/W2128994729', 'https://openalex.org/W2130290124', 'https://openalex.org/W2155487282', 'https://openalex.org/W2159430776', 'https://openalex.org/W2166642585', 'https://openalex.org/W2171251720', 'https://openalex.org/W2194986544', 'https://openalex.org/W63001887'], 'related_works': ['https://openalex.org/W2165529795', 'https://openalex.org/W2147288798', 'https://openalex.org/W2128994729', 'https://openalex.org/W2119460775', 'https://openalex.org/W2052034970', 'https://openalex.org/W2049508647', 'https://openalex.org/W2010683612', 'https://openalex.org/W1997759534', 'https://openalex.org/W1969308341', 'https://openalex.org/W1677118171'], 'abstract_inverted_index': {'In': [0, 65, 130], 'the': [1, 6, 13, 38, 60, 72, 87, 108, 126, 146], 'fission': [2], 'yeast': [3], 'Schizosaccharomyces': [4], 'pombe,': [5], 'protein': [7, 102], 'kinase': [8, 40, 103], 'Cds1': [9, 25, 56, 79, 91, 132, 158], 'is': [10, 22, 26, 105, 119], 'activated': [11], 'by': [12, 86, 171], 'S–M': [14, 88, 147], 'replication': [15, 89, 148], 'checkpoint': [16, 113, 166], 'that': [17, 36, 55, 62, 70, 104, 114], 'prevents': [18, 115], 'mitosis': [19, 116], 'when': [20], 'DNA': [21, 118], 'incompletely': [23], 'replicated.': [24], 'proposed': [27], 'to': [28, 81, 162, 168], 'regulate': [29, 169], 'Wee1': [30], 'and': [31, 49, 133, 149, 159], 'Mik1,': [32], 'two': [33], 'tyrosine': [34], 'kinases': [35], 'inhibit': [37], 'mitotic': [39, 83], 'Cdc2.': [41, 64], 'Here,': [42], 'we': [43], 'present': [44], 'evidence': [45], 'from': [46], 'in': [47, 50, 67, 98, 125, 127, 155, 164], 'vivo': [48, 68], 'vitro': [51, 128], 'studies,': [52], 'which': [53, 75], 'indicates': [54], 'also': [57, 92, 122], 'inhibits': [58], 'Cdc25,': [59], 'phosphatase': [61], 'activates': [63], 'an': [66], 'assay': [69], 'measures': [71], 'rate': [73], 'at': [74], 'Cdc25': [76, 124, 136, 141, 170], 'catalyzes': [77], 'mitosis,': [78], 'contributed': [80], 'a': [82, 101], 'delay': [84], 'imposed': [85], 'checkpoint.': [90], 'inhibited': [93, 123], 'Cdc25-dependent': [94], 'activation': [95], 'of': [96], 'Cdc2': [97], 'vitro.': [99], 'Chk1,': [100], 'required': [106], 'for': [107], 'G': [109, 150], '2': [110, 151], '–M': [111, 152], 'damage': [112, 153], 'while': [117], 'being': [120], 'repaired,': [121], 'assay.': [129], 'vitro,': [131], 'Chk1': [134, 160], 'phosphorylated': [135], 'predominantly': [137], 'on': [138], 'serine-99.': [139], 'The': [140], 'alanine-99': [142], 'mutation': [143], 'partially': [144], 'impaired': [145], 'checkpoints': [154], 'vivo.': [156], 'Thus,': [157], 'seem': [161], 'act': [163], 'different': [165], 'responses': [167], 'similar': [172], 'mechanisms.': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147971204', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T19:17:44.851153', 'created_date': '2016-06-24'}