Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2072106056', 'doi': 'https://doi.org/10.1002/ijc.10434', 'title': 'Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: Determination of efficacy and possible mechanisms of resistance', 'display_name': 'Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: Determination of efficacy and possible mechanisms of resistance', 'publication_year': 2002, 'publication_date': '2002-05-29', 'ids': {'openalex': 'https://openalex.org/W2072106056', 'doi': 'https://doi.org/10.1002/ijc.10434', 'mag': '2072106056', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12115582'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.10434', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10434', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10434', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005170300', 'display_name': 'Annemarie H. van Hattum', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annemarie H. van Hattum', 'raw_affiliation_strings': ['§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111812290', 'display_name': 'Hennie M.M. Schlüper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Hennie M.M. Schlüper', 'raw_affiliation_strings': ['§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109866614', 'display_name': 'Frederick H. Hausheer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126566', 'display_name': 'BioNumerik (United States)', 'ror': 'https://ror.org/02yq66p71', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210126566']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frederick H. Hausheer', 'raw_affiliation_strings': ['BioNumerik Pharmaceuticals, Inc., San Antonio, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'BioNumerik Pharmaceuticals, Inc., San Antonio, TX, USA', 'institution_ids': ['https://openalex.org/I4210126566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105878379', 'display_name': 'Herbert M. Pinedo', 'orcid': 'https://orcid.org/0000-0002-8980-371X'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Herbert M. Pinedo', 'raw_affiliation_strings': ['§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088663155', 'display_name': 'Epie Boven', 'orcid': 'https://orcid.org/0000-0001-9287-743X'}, 'institutions': [{'id': 'https://openalex.org/I865915315', 'display_name': 'Vrije Universiteit Amsterdam', 'ror': 'https://ror.org/008xxew50', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I865915315']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Epie Boven', 'raw_affiliation_strings': ['§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '§ Department of Medical Oncology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I865915315']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.581, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.798079, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '100', 'issue': '1', 'first_page': '22', 'last_page': '29'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/topotecan', 'display_name': 'Topotecan', 'score': 0.9717213}, {'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.93106306}, {'id': 'https://openalex.org/keywords/mitoxantrone', 'display_name': 'Mitoxantrone', 'score': 0.5836338}, {'id': 'https://openalex.org/keywords/sn-38', 'display_name': 'SN-38', 'score': 0.5590326}, {'id': 'https://openalex.org/keywords/abcg2', 'display_name': 'Abcg2', 'score': 0.5483948}], 'concepts': [{'id': 'https://openalex.org/C2781209748', 'wikidata': 'https://www.wikidata.org/wiki/Q419953', 'display_name': 'Topotecan', 'level': 3, 'score': 0.9717213}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.93106306}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.72083}, {'id': 'https://openalex.org/C2780427987', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian cancer', 'level': 3, 'score': 0.6502738}, {'id': 'https://openalex.org/C2780923524', 'wikidata': 'https://www.wikidata.org/wiki/Q239426', 'display_name': 'Mitoxantrone', 'level': 3, 'score': 0.5836338}, {'id': 'https://openalex.org/C2780508388', 'wikidata': 'https://www.wikidata.org/wiki/Q1750127', 'display_name': 'SN-38', 'level': 5, 'score': 0.5590326}, {'id': 'https://openalex.org/C512196', 'wikidata': 'https://www.wikidata.org/wiki/Q4650095', 'display_name': 'Abcg2', 'level': 5, 'score': 0.5483948}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.54543537}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4597559}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37521428}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36428362}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34641197}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.33068436}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.28892028}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20596698}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20391646}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.19932413}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.12455118}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.074478835}, {'id': 'https://openalex.org/C44312359', 'wikidata': 'https://www.wikidata.org/wiki/Q286958', 'display_name': 'ATP-binding cassette transporter', 'level': 4, 'score': 0.0694257}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000070997', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily G, Member 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077146', 'descriptor_name': 'Irinotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019772', 'descriptor_name': 'Topotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019772', 'descriptor_name': 'Topotecan', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.10434', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10434', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12115582', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.10434', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10434', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.73, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1495106561', 'https://openalex.org/W1502767888', 'https://openalex.org/W1515560162', 'https://openalex.org/W1572719338', 'https://openalex.org/W1828787736', 'https://openalex.org/W1838547618', 'https://openalex.org/W1910056530', 'https://openalex.org/W1913802169', 'https://openalex.org/W192877506', 'https://openalex.org/W1950125084', 'https://openalex.org/W1968953597', 'https://openalex.org/W1986010069', 'https://openalex.org/W1986040702', 'https://openalex.org/W1986944635', 'https://openalex.org/W1999506028', 'https://openalex.org/W2008902935', 'https://openalex.org/W2012306261', 'https://openalex.org/W2018185888', 'https://openalex.org/W2023555639', 'https://openalex.org/W2031083024', 'https://openalex.org/W2037336128', 'https://openalex.org/W2076268045', 'https://openalex.org/W2077902171', 'https://openalex.org/W2095696085', 'https://openalex.org/W2108349673', 'https://openalex.org/W2112929496', 'https://openalex.org/W2118207487', 'https://openalex.org/W2120892494', 'https://openalex.org/W2125205754', 'https://openalex.org/W2127819051', 'https://openalex.org/W2152326762', 'https://openalex.org/W2161663775', 'https://openalex.org/W2168392730'], 'related_works': ['https://openalex.org/W3145858193', 'https://openalex.org/W2513282705', 'https://openalex.org/W2215145163', 'https://openalex.org/W2154259319', 'https://openalex.org/W2098393177', 'https://openalex.org/W2072106056', 'https://openalex.org/W2058235299', 'https://openalex.org/W2028066947', 'https://openalex.org/W1972477507', 'https://openalex.org/W1692544167'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 95], 'novel': [2], 'camptothecin': [3], 'derivative': [4], 'BNP1350': [5, 44, 86, 104, 223, 237], '(7‐[2‐trimethylsilyl)ethyl]‐20(': [6], 'S': [7], ')‐camptothecin),': [8], 'also': [9], 'known': [10], 'as': [11, 210], 'Karenitecin,': [12], 'has': [13], 'been': [14], 'developed': [15], 'for': [16, 212, 231, 254], 'superior': [17], 'oral': [18], 'bioavailability': [19], 'and': [20, 35, 57, 136, 169, 183, 216, 251], 'increased': [21], 'lactone': [22], 'stability.': [23], 'In': [24, 154, 171, 180, 219], 'our': [25], 'study,': [26], 'we': [27, 79, 234], 'describe': [28], 'the': [29, 81, 125, 185, 194, 204, 214, 217], 'antiproliferative': [30], 'effects': [31], 'of': [32, 89, 124, 187], 'BNP1350,': [33], 'SN‐38': [34, 53], 'topotecan': [36, 63, 90, 115, 241], 'in': [37, 77, 92, 98, 246], '4': [38], 'human': [39, 73, 127, 248], 'ovarian': [40, 74, 128, 249], 'cancer': [41, 75, 129, 206, 250], 'cell': [42, 130], 'lines.': [43], 'was': [45, 58, 105, 108, 190, 197], 'found': [46], 'to': [47, 71, 141, 221, 226], 'be': [48, 227], 'slightly': [49], 'more': [50, 60, 163], 'potent': [51, 61], 'than': [52, 62, 111], '(': [54, 64, 116], 'p': [55, 65, 117], '<0.01)': [56], 'considerably': [59], '<0.01).': [66], 'We': [67, 119], 'extended': [68], 'these': [69], 'studies': [70], 'well‐established': [72], 'xenografts': [76, 101], 'which': [78, 107], 'compared': [80], 'growth': [82, 96], 'inhibition': [83, 97], 'induced': [84, 102], 'by': [85, 103, 243], 'with': [87, 156], 'that': [88, 112, 236], 'given': [91], 'equitoxic': [93], 'schedules.': [94], 'all': [99, 151], '3': [100], '≥75%,': [106], 'significantly': [109], 'better': [110], 'resulting': [113], 'from': [114], '<0.05).': [118], 'then': [120], 'selected': [121], 'BNP1350‐resistant': [122], 'variants': [123, 147], 'A2780': [126], 'line,': [131], '2780K4': [132, 157, 182], '(resistance': [133, 138], 'factor:': [134, 139], '41)': [135], '2780K32': [137, 159, 173, 200], '90),': [140], 'analyze': [142], 'possible': [143], 'resistance': [144, 207], 'mechanisms.': [145], 'These': [146], 'exhibited': [148], 'cross‐resistance': [149], 'against': [150, 165, 178], 'camptothecins': [152], 'tested.': [153], 'comparison': [155], 'cells,': [158], 'cells': [160, 174, 201], 'were': [161, 175], 'relatively': [162], 'resistant': [164], 'SN‐38,': [166], 'topotecan,': [167, 222], 'DX‐8951f': [168], 'BNP1350.': [170], 'addition,': [172], 'highly': [176], 'cross‐resistant': [177], 'mitoxantrone.': [179], 'both': [181, 213], '2780K32,': [184], 'amount': [186], 'topoisomerase': [188], 'I': [189], 'not': [191, 225], 'changed': [192], 'but': [193], 'catalytic': [195], 'activity': [196], 'reduced.': [198], 'Furthermore,': [199], 'clearly': [202], 'overexpressed': [203], 'breast': [205], 'protein': [208], '(BCRP),': [209], 'demonstrated': [211], 'gene': [215], 'protein.': [218], 'contrast': [220], 'proved': [224], 'a': [228], 'good': [229], 'substrate': [230], 'BCRP.': [232, 255], 'Overall,': [233], 'conclude': [235], 'offers': [238], 'advantages': [239], 'over': [240], 'expressed': [242], 'high': [244], 'efficacy': [245], 'experimental': [247], 'poor': [252], 'affinity': [253], '©': [256], '2002': [257], 'Wiley‐Liss,': [258], 'Inc.': [259]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2072106056', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-09T03:51:44.295312', 'created_date': '2016-06-24'}