Title: Effect of chromate ion on the membrane of established human cells as measured by uptake of a permeant lipophilic cation
Abstract: Cells from the established human cell line NHIK3025 concentrate the permeant lipophilic cation triphenylmethylphosphonium (TPMP+) against a concentration gradient, indicating the existence of an electrical potential across the cell membrane (interior negative). Cells exposed to potassium chromate or dichromate (7.7 μmol Crl) for 2 h subsequently showed reduced uptake of TPMP+, whereas similar exposure to a trivalent chromium salt (7.7 μmoll chromic chloride) had similar uptake of TPMP+ as control cells. These preliminary results suggest that a primary effect of chromate on these cells is to reduce the electrical potential across the cell membrane.
Publication Year: 1987
Publication Date: 1987-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 2
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